Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer
ConclusionWe identified ERLIN2 and CDK5RAP3 as ERS-related genes with important prognostic and immunologic values, and classified patients between high- and low-risk subgroups, which provided new prognostic markers, immunotherapeutic targets, and basis for prognostic assessments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research

Analyses of lncRNA and mRNA profiles in recurrent atrial fibrillation after catheter ablation
ConclusionsThe recurrence of atrial fibrillation after catheter ablation may be associated with immune responses and fibrosis, with the extracellular matrix playing a crucial role. TMEM51-AS1-201 has been identified as a potential key target for AF recurrence after catheter ablation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research

Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles
ConclusionsJGP intervention improves ILI by restoring gut microbiota and modifying its metabolic profiles. These results provide a novel insight into the mechanism of JGP in treating ILI and the scientific basis to support its clinical application. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research

Influence of vaccination on critical COVID-19 patients with acute respiratory failure: a retrospective cohort study
ConclusionsVaccination status did not significantly influence mortality rates, the occurrence of ARDS, or the viral shedding duration in COVID-19 patients with acute respiratory failure. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research

Specific mortality in patients with diffuse large B-cell lymphoma: a retrospective analysis based on the surveillance, epidemiology, and end results database
ConclusionThe most significant predictor of DLBCL-specific mortality is the age of the patient, followed by the Ann Arbor stage and the administration of chemotherapy. This predictive model has the potential to facilitate the identification of high-risk DLBCL patients by clinicians, ultimately leading to improved prognosis. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research

Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials
ConclusionCompared with other interventions, intravenous dexmedetomidine infusion during non-cardiac and non-neurosurgical procedures may significantly reduce the risk of postoperative delirium and cognitive dysfunction. The results of subgroup analysis reveal a consistent preventive effect on postoperative delirium in both general and non-general anaesthesia groups. Meanwhile, continuous infusion during general anaesthesia was more effective in reducing the risk of cognitive dysfunction. Despite such findings, hypotension and bradycardia were more frequent in patients who received dexmedetomidine during surgery. (Source: ...
Source: European Journal of Medical Research - April 18, 2024 Category: Research Source Type: research

HE4-based nomogram for predicting overall survival in patients with idiopathic pulmonary fibrosis: construction and validation
In this study, prognostic nomograms were generated based on the results of the cox regression analysis. We identified the HE4 protein level increased in IPF patients, but not the HE4 gene expression. The increased expression of HE4 correlated positively with a poor prognosis for patients with IPF. The HR and 95% CI were 2.62 (1.61 –4.24) (p <  0.001) in the training set. We constructed a model based on the risk-score = 0.16222182 * HE4 + 0/0.37580659/1.05003609 (for GAP index 0–3/4–5/6–8) + (− 1.1183375). In both training and validation sets, high-risk patients had poor prognoses (HR: 3.49, 95...
Source: European Journal of Medical Research - April 16, 2024 Category: Research Source Type: research

Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification
AbstractGlycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function of glycolytic signature in papillary RCC has not been well elucidated. In the present study, the glycolysis-immune predictive signature was constructed and validated  using WGCNA, glycolysis-immune clustering analysis. PPI network of DEGs was constructed and visualized. Functional enrichments and patients’ overall survival were analyzed. QRT-PCR experiments were performed to detect hub genes’ expression and distribution, siRNA technology was used to silenc e t...
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
ConclusionMXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study
ConclusionDyslipidemia was high among the study participants. Overweight, obesity, central adiposity, and high blood pressure were significantly associated with dyslipidemia in cardiac patients. This alarms the need for lipid profile assessment for patients periodically, with treatment follow-up to monitor any rising patterns and cardiovascular-related risks. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Effects of ankle –foot orthoses on gait parameters in post-stroke patients with different Brunnstrom stages of the lower limb: a single-center crossover trial
ConclusionsPost-stroke patients with lower Brunnstrom stages benefitted more from AFO, particularly in gait asymmetry. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels
ConclusionsDisrupted interactions between GPR43 and NLRP3 expression in peripheral blood leukocytes, associated with reduced intestinal GM-derived SCFAs, especially acetic acid, may be involved in AF development and left atrial enlargement by enhancing circulating inflammation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Photodynamic therapy upregulates expression of HIF-1 α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer
ConclusionsPDT might improve the clinical response of ICIs by upregulating tumor HIF-1 α and PD-L1 expressions in NSCLC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Associations between Life ’s Essential 8 and post-stroke depression and all-cause mortality among US adults
ConclusionsA negative correlation was discovered between LE8 score and PSD and all-cause mortality risk among US adults. We need to conduct large-scale prospective studies to further validate our results. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Replication study identified EFEMP1 association with varicose vein predisposition among Indians
ConclusionThis study identifiesEFEMP1 as a potential gene related to the risk of varicose veins in Indians. It also highlights that evaluating the maximum number of variants of a gene rather than focusing solely on replicating single variations offers a more comprehensive and nuanced understanding of the genetic factors contributing to a complex trait like varicose veins. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research