Total hip arthroplasty for intertrochanteric fracture fixation failure
ConclusionTHA as salvage treatment for failed internal fixation of intertrochanteric femoral fractures in elderly patients significantly reduced hip pain and restored joint function, and early clinical outcomes were satisfactory. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 27, 2019 Category: Research Source Type: research

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB
ConclusionsOur study provides the first insight into molecular epidemiology of MDR-TB in Kuwait and identified several potential clusters of local transmission of MDR-TB involving 2 –6 subjects which had escaped detection by routine surveillance studies. Prospective detection of resistance-conferring mutations can identify possible cases of local transmission of MDR-TB in low MDR-TB settings. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 5, 2019 Category: Research Source Type: research

MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction
ConclusionsMiR-495 might be a potential diagnostic biomarker for sepsis patients, and overexpression of miR-495 alleviated sepsis-induced inflammation and cardiac dysfunction. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 26, 2019 Category: Research Source Type: research

Effectiveness of an osteopathic treatment on the autonomic nervous system: a systematic review of the literature
ConclusionThe included published studies represent a good level of evidence. Due to a small number of subjects and no follow-ups, the methodological quality is rated as moderate. A significant change on the ANS was shown in studies including High-Velocity Low-Amplitude Techniques (HVLAT). No statement could be drawn in studies in which they used cranial osteopathic techniques due to the lack of methodological quality. A significant change on the ANS is shown in the treatment of the suboccipital region. In studies which evaluated the effectiveness of mobilization in the cervical and thoracic region, no statement could be di...
Source: European Journal of Medical Research - October 25, 2019 Category: Research Source Type: research

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease
AbstractBackgroundAcute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD.MethodPatients with ACVD admitted in our hospitals between January 2013 and September 2017 were enrolled in this study (n = 245, including 176 cerebral infarctions and 69 cerebral hemorrhages). Their thyroid hormones were measured and compared wi...
Source: European Journal of Medical Research - October 24, 2019 Category: Research Source Type: research

Distribution of Modic changes in patients with low back pain and its related factors
ConclusionsType II changes are the most common, followed by type I. Modic changes mostly occur in L4/5 and L5/S1; young, male, lower-grade disk degeneration, normal physiological curvature of the lumbar spine, and normal endplate concave angle were associated with type I changes; gender and lumbar curvature were the most relevant factors for different types. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 9, 2019 Category: Research Source Type: research

Biomechanical comparison of bi- and tricortical k-wire fixation in tension band wiring osteosynthesis
ConclusionThis study confirms for the first time biomechanical superiority of tricortical k-wire fixation in the olecranon when using a TBW and may justify the clinical use of this method. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 8, 2019 Category: Research Source Type: research

Cost effectiveness of bilateral risk-reducing mastectomy and salpingo-oophorectomy
ConclusionsRisk-reducing surgery inBRCA-mutation carriers is frequently not cost-covering for the executing hospitals in the German health-care system. Thus, appropriate concepts are required to ensure a nationwide care. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 14, 2019 Category: Research Source Type: research

The impact of medical documentation assistants on process performance measures in a surgical emergency department
ConclusionsMedical documentation assistants are a viable way of improving the performance of surgical emergency departments. Depending on the goals of the hospital, medical documentation assistants can be used for an array of measures such as decreasing patients ’ waiting and flow times or increasing physicians’ time spent on medical treatment. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 6, 2019 Category: Research Source Type: research

Delay of transfer from the intensive care unit: a prospective observational analysis on economic effects of delayed in-house transfer
ConclusionDelay in discharge from the ICU is a common problem of economic relevance. The main reason is a lack of appropriate floor beds. Patients from certain specific departments are at a higher risk to be discharged with delay. A solution to this problem lies in the focus on the downstream units. A proper use of the scarce resources is to be pursued because of ethical as well as economic reasons in an increasingly aging population. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 3, 2019 Category: Research Source Type: research

Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis
AbstractBackgroundPrimary cardiac angiosarcoma (PCAS) is a rare type of tumour. Furthermore, descriptions of the demographic features and prognostic factors of PCAS patients have been poorly reported.MethodsA population cohort study was conducted using retrospectively extracted data from the SEER (Surveillance, Epidemiology and End Results) database for patients with histological diagnoses of PCAS; the extracted information included demographic, treatment and outcome data.ResultsA total of 168 cases of PCAS from 1973 to 2013 were included. The mean age at diagnosis was 44.4  ± 15.5 years. PCAS was...
Source: European Journal of Medical Research - August 19, 2019 Category: Research Source Type: research

The value of tranexamic acid for patients with preoperative anemia in primary total knee arthroplasty
AbstractBackgroundPreoperative anemia is relatively common in patients undergoing primary total knee arthroplasty (TKA), and is associated with higher medical costs due to blood transfusions.MethodsWe aimed to discuss the efficiency of tranexamic acid (TXA) administration for blood loss control in preoperatively anemic patients undergoing primary TKA. We retrospectively reviewed the clinical data regarding a consecutive series of primary unilateral TKA patients with preoperative anemia. Patients were divided into TXA group (received TXA peri-operatively) and control group (did not receive TXA). Outcome measures included dr...
Source: European Journal of Medical Research - August 12, 2019 Category: Research Source Type: research

Nickel –titanium arched shape-memory alloy connector combined with bone grafting in the treatment of scaphoid nonunion
ConclusionUsing Ni –Ti arched shape-memory alloy connector in combination with autologous bone grafting provided a new modality to treat scaphoid nonunions in a less traumatic, convenient to operate and satisfactory manner in treatment outcomes, and thus is worthy of further application. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 27, 2019 Category: Research Source Type: research

Dok-3 deficient mice display different immune clustering and Tim-3 expression
ConclusionsAlthough Dok-3−/− mice display different immune clustering and Tim-3 expression, the mechanism still needs further study. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 27, 2019 Category: Research Source Type: research

Early prolonged ambulatory cardiac monitoring in stroke (EPACS): an open-label randomised controlled trial
ConclusionsEarly, prolonged, patch-based monitoring after an index stroke or TIA is superior to short-duration Holter monitoring in the detection of PAF and likely cost-effective for preventing recurrent strokes.Trial registrationhttp://www.isrctn.com. Unique identifier: ISRCTN 50253271. Registered 21 January 2016 (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 26, 2019 Category: Research Source Type: research

Pacing-induced cardiomyopathy in chronic right ventricular apical pacing: a midterm follow-up study
AbstractBackgroundData concerning the effect of chronic right ventricular pacing in patients with normal left ventricular ejection fraction (LVEF%) are contradictory. The aim of this study is to evaluate the prevalence of pacing-induced cardiomyopathy (PICM) at midterm follow-up after permanent pacemaker implantation (PPM).MethodsA series of 170 patients were submitted to PPM within our facility. Inclusion criteria were the absence of structural heart disease and a preserved LVEF% (>  45%) at the time of PPM. A midterm clinical and echocardiographic follow-up was performed, and data were collected and analyzed re...
Source: European Journal of Medical Research - July 22, 2019 Category: Research Source Type: research

IL-22 production of effector CD4 + T-cells is altered in SLE patients
ConclusionCD134+ and PD-1+CD4+ T-cells have mainly a Th1 effector T-cell signature. A lower proportion produces also IL-21 and IL-22. The impaired capacity to produce IFN- γ and IL-22 in SLE patients may contribute to the pathogenesis of the disease. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 22, 2019 Category: Research Source Type: research

Identification of key genes involved in myocardial infarction
ConclusionsThe conserved genes in the pathogenesis of MI were identified, benefit for target therapy. Meanwhile, some specific genes may be used as markers for the prediction of recurrent MI. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 3, 2019 Category: Research Source Type: research

The impact of CYP21A2 (P30L/I172N) genotype on female fertility in one family
ConclusionsDespite significant improvements over the last years in achieving fertility in female patients with SV CAH, it is highly dependent upon the severity of virilization and the metabolic control. The role of P30L mutation in infertility and unsuccessfully assisted reproduction remains to be elucidated. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 19, 2019 Category: Research Source Type: research

Protective functions of myricetin in LPS-induced cardiomyocytes H9c2 cells injury by regulation of MALAT1
ConclusionMyricetin possessed an anti-inflammatory function against LPS-induced lesions in cardiomyocytes. Mechanically, myricetin up-regulated MALAT1, blocked LPS-evoked activation of nuclear factor- κB (NF-κB) inflammatory pathway, and, finally, exerted cardio-protective effects. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 26, 2019 Category: Research Source Type: research

Clinical versus histological grading in the assessment of cutaneous graft versus host disease
ConclusionsConfirming the diagnosis of GvHD is still a valuable reason for taking a skin biopsy, but this study shows that histologic grading of GvHD in the skin biopsy has no additional value for clinicians in current practice. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 10, 2019 Category: Research Source Type: research

Different treatment strategies for acromioclavicular dislocation injuries: a nationwide survey on open/minimally invasive and arthroscopic concepts
ConclusionThis study shows a distinct difference in treatment of AC joint injuries depending on the training of the physician. Further, the need for high-quality studies arises to define the optimal treatment of type III lesions. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 23, 2019 Category: Research Source Type: research

Visceral artery aneurysms: evolving interdisciplinary management and future role of the abdominal surgeon
AbstractBackgroundVisceral artery aneurysms (VAA) are rare vascular lesions. Clinically silent VAA are increasingly detected by cross-sectional imaging but some lesions are at risk for rupture with severe bleeding. The aim of the present study was to evaluate the trends in the interdisciplinary management at a tertiary center.MethodsPatients who underwent treatment for VAA at University Hospital of Bonn between 2005 and 2018 were enrolled in this retrospective study. Demographic, clinical, VAA-specific data as well as information on therapy, early and long-term outcome were collected and statistically analyzed.ResultsForty...
Source: European Journal of Medical Research - February 28, 2019 Category: Research Source Type: research

Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study
ConclusionsEHE is a rare malignant vascular tumor that can occur in any site of the body. Surgery is the primary choice of treatment, and pathologic evaluation is the gold standard for diagnosis. Metastases and unresectability are associated with poor prognosis. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 28, 2019 Category: Research Source Type: research

Short exposure to tranexamic acid does not affect, in vitro, the viability of human chondrocytes
ConclusionA prolonged exposure to TXA may cause cartilage damage, thus its topical application can be expanded also to clinical scenarios that include retention of native cartilage chondrocytes, only if it is limited to few minutes and used at concentrations of 70  mg/ml or less. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 22, 2019 Category: Research Source Type: research

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better
ConclusionsPatients with depressed executive functioning showed the greatest benefit from the MC intervention regarding cognitive functioning. Age and psychological functioning seem less important for cognitive performance improvements post-MC intervention. Hence, severely depressed cognitive functioning in patients is not a contraindication for PMVR using MitraClip. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 22, 2019 Category: Research Source Type: research

Influence of blood glucose fluctuation, C-peptide level and conventional risk factors on carotid artery intima –media thickness in Chinese Han patients with type 2 diabetes mellitus
ConclusionsBlood glucose fluctuation is an independent risk factor associated with CIMT in T2DM patients, in addition to conventional risk factors, such as smoking, high UA level and 2  h C-peptide. Therefore, more attention should be given to the change of CIMT and the complications. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 20, 2019 Category: Research Source Type: research

Detection of serum MCP-1 and TGF- β1 in polymyositis/dermatomyositis patients and its significance
ConclusionSerum MCP-1 and TGF- β1 levels increased in PM/DM patients, and were closely correlated to the complication of ILD. This finding can be used for distinguishing between pulmonary infections and ILD, providing a new diagnostic method for the early prediction of DM/PM complicated with ILD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 14, 2019 Category: Research Source Type: research

Hemodynamic consequences of intravenously given E. coli suspension: observations in a fulminant sepsis model in pigs, a descriptive case –control study
ConclusionsThese results may serve as additional pathophysiological information of hemodynamic changes occurring during hypodynamic sepsis and may contribute to a better understanding of the pathomechanism of septic multiple organ failure. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 13, 2019 Category: Research Source Type: research

The assessment of the kinematics of the rescuer in continuous chest compression during a 10-min simulation of cardiopulmonary resuscitation
AbstractBackgroundIn pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC –CPR). The proper performance of the procedure is a survival predictor for patients with cardiac arrest (CA). The purpose of the study was a prospective assessment of the kinematics of the rescuer’s body with consideration given to the depth and rate of chest compression (CC) as the indicator of properly performed CC maneuver by professional and non-p...
Source: European Journal of Medical Research - February 8, 2019 Category: Research Source Type: research

Human umbilical cord mesenchymal stem cells implantation accelerates cutaneous wound healing in diabetic rats via the Wnt signaling pathway
ConclusionThe activation of the Wnt signaling pathway promotes the healing of diabetic skin wound by the regulation of proliferation and differentiation of hUCMSCs on the CCLDADM scaffold. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 8, 2019 Category: Research Source Type: research

Neuroendocrine carcinoma of gallbladder: a case series and literature review
ConclusionsGallbladder NEC showed no noticeably specific features, and the diagnosis relied on the pathological and immunohistochemistrical results. For T1N0M0 gallbladder NEC, cholecystectomy might be enough. For patients in a late stage, the management of combined therapies might be optimal. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 4, 2019 Category: Research Source Type: research

TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over three  years in Yunnan, China
This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provide the basis for the early diagnosis of CS.MethodsThirty-three infants born to mothers with syphilis and six infants with CS were recruited. The toluidine red unheated serum test (TRUST) andTreponema pallidum particle agglutination (TPPA) titers were followed up after birth.ResultsThe results showed that serological response in the serum of infants with the TPPA titer decreased threefold at 3rd month, or the titer dropped to a minimum of 1:40 at 9th month was SPA. The TPPA t...
Source: European Journal of Medical Research - February 2, 2019 Category: Research Source Type: research

In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant
ConclusionOur results indicated that the investigated polycaprolactone-based implants have shown a regenerative and stable nasal dorsum augmentation after 6  months in vivo. Thus, we believe that customized polycaprolactone-based implants could become an alternative technique for nasal dorsum augmentation without the need for autologous cartilage grafts. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 28, 2019 Category: Research Source Type: research

Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway
ConclusionModern therapeutic strategies for tumor diseases target the efficient modulation of specific signaling and transcription pathways. In this respect, the therapeutic potential of protein kinase inhibitors has been repeatedly discussed. Our study showed that staurosporine induces apoptosis in pancreatic carcinoma cells via the intrinsic signaling pathway. Thus, staurosporine is a suitable positive control for in vitro apoptosis tests for the pancreatic cancer cell lines PaTu 8988t and Panc-1. Further clinical studies should analyze the impact of this finding on cancer treatment. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 28, 2019 Category: Research Source Type: research

Orthogeriatric treatment reduces potential inappropriate medication in older trauma patients: a retrospective, dual-center study comparing conventional trauma care and co-managed treatment
AbstractBackgroundMultimorbidity and polypharmacy are common challenges in the treatment of older trauma patients. Therefore, various integrated care models were developed over the last few years, merging the expertise of geriatricians and trauma surgeons. The aim of this study was to evaluate, if the number of prescriptions of potentially inappropriate medication (PIM) could be reduced in these patients by an interdisciplinary co-managed concept compared to conventional trauma care.MethodsWe conducted a retrospective, dual-center cohort study, including all patients aged 70  years and older admitted with a fracture o...
Source: European Journal of Medical Research - January 22, 2019 Category: Research Source Type: research

Hand osteoid osteoma: evaluation of diagnosis and treatment
ConclusionOsteoid osteoma is usually seen below 25  years, and rarely found over 40 years of age. There is male dominance with a male to female ratio of 3:1. Delay of diagnosis may be encountered because of many differential diagnoses. When OO is suspected, CT imaging should be taken before the MR imaging. Because of superiority in soft tissue ima ging, MR imaging should be an alternative tool in complex cases. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 21, 2019 Category: Research Source Type: research

Eradication of Acinetobacter baumannii / Enterobacter cloacae complex in an open proximal tibial fracture and closed drop foot correction with a multidisciplinary approach using the Taylor Spatial Frame ® : a case report
ConclusionsA multidisciplinary approach with orthopaedic surgeons for debridement, planning and establishing osseous and joint correction and consolidation, plastic surgeons for microvascular muscle flaps for soft tissue defect coverage as well as clinical microbiologists for the optimized anti-infective treatment is essential in these challenging rare cases.Level of evidenceLevel IV. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 19, 2019 Category: Research Source Type: research

Cardio-oncology: need for novel structures
AbstractCancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment has greatly improved survival and it is estimated that 15.5 million cancer survivors currently live in the USA. The number of cancer survivors is expected to increase by 68% until 2040. Moreover, the portion of cancer survivors at the age of 65 years or older will increase from 62% to approximately 73% in 2040 which in turn enhances comorbidities in cancer survivors. Increased s...
Source: European Journal of Medical Research - January 3, 2019 Category: Research Source Type: research

Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children
ConclusionBADGE exposure might enhance food sensitization in early childhood. Therefore, this should be strictly regulated, especially in younger children. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 26, 2018 Category: Research Source Type: research

Occlusive dressing-induced secretomes influence the migration and proliferation of mesenchymal stem cells and fibroblasts differently
ConclusionOD-induced secretomes influence MSCs and fibroblasts and thereby possibly modulate wound healing and scar tissue formation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 26, 2018 Category: Research Source Type: research

Noise insertion in CT for cocaine body packing: where is the limit of extensive dose reduction?
ConclusionsOur results indicate that dose of abdominal CT for the detection of intracorporeal cocaine body packets can be markedly reduced to up to 5% of the initial dose while still providing sufficient image quality to detect ingested body packets. However, a minimum effective dose of 0.21  mSv (10% of initial dose) seems to be required to properly identify incidental findings. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 7, 2018 Category: Research Source Type: research

Transcanalicular laser dacryocystorhinostomy for acquired nasolacrimal duct obstruction: an audit of 104 patients
ConclusionsLaser-assisted DCR shows promising results with few complications. It seems well suited as a second-step procedure after failed recanalization and before external DCR. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 16, 2018 Category: Research Source Type: research

The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials
AbstractBackgroundThe effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial.MethodsPubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. We calculated the pooled standard mean difference (SMD) using a fixed effect model or random effect model to assess the effect of statin treatment on circulating CoQ10. The methodological quality of the studies was determined according to the Coch...
Source: European Journal of Medical Research - November 10, 2018 Category: Research Source Type: research

Early endothelial progenitor cells and vascular stiffness in psoriasis and psoriatic arthritis
ConclusionParameters of vascular stiffness are not significantly deteriorated in Ps/PsA. Thus, pulse wave analysis may not be suitable for CVR assessment in certain autoimmune-mediated diseases. Regenerative activity of the eEPC system/circulating eEPC numbers are not altered in Ps/PsA. One may conclude that malfunctions of the eEPC are not substantially involved in perpetuating the micro-/macrovascular alterations in Ps/PsA. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 9, 2018 Category: Research Source Type: research

MicroRNA profiling of diabetic atherosclerosis in a rat model
ConclusionThe present study identified DE-miRs and miRNA-gene networks enriched for lipid and glucose metabolic functions and pathways, and arpp19 and MDM4 as potential DA-related core target genes, suggesting DE-miRs and/or arpp19 and MDM4 could act as potential diagnostic markers or therapeutic targets for DA. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 3, 2018 Category: Research Source Type: research

Skarzynski Tinnitus Scale: validation of a brief and robust tool for assessing tinnitus in a clinical population
ConclusionsStatistical analysis shows that STS is a brief but robust tool well-suited to clinical practice. A feature of STS is that it takes into account the impact of tinnitus on the patient ’s psychological (emotional, cognitive) and functional domains as well as their ability to cope with tinnitus-related distress. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 1, 2018 Category: Research Source Type: research

A phase I –II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee
AbstractBackgroundA promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with severe osteoarthritis of the knee.MethodsA prospective, randomized, 3-arm, parallel group clinical trial was conducted. It included 24 patients with severe osteoarthritis of the knee (WOMAC score 65.9  ± 17). Before they entered the study, all the patients were under osteoarthritis control through the standard t...
Source: European Journal of Medical Research - October 24, 2018 Category: Research Source Type: research

Treatment of onychomycosis using a 1064-nm diode laser with or without topical antifungal therapy: a single-center, retrospective analysis in 56 patients
ConclusionsThe 1.064-nm diode laser is an effective and safe option for the treatment of onychomycosis. Of note, the combination with topical antifungals will increase overall treatment efficacy and reduce the time to healing. Particularly, patients with contraindications against systemic antifungals may benefit from this multimodal therapeutic approach. Our data, moreover, suggest that treatment efficacy is positively correlated with the total number of laser treatments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 24, 2018 Category: Research Source Type: research

Analysis of the bony geometry of the acromio-clavicular joint
AbstractBackgroundThe primary goal of this study was to analyse the anatomic configuration of the acromio-clavicular joint in a healthy population to be able to develop a classification in a second step. On the basis of the primary findings a secondary goal was to find potential clinical indications in refer to AC-joint dislocation and lateral clavicle fractures.MethodsThe upper thoracic aperture including both shoulder joints as well as both sterno-clavicular joints was retrospectively reformatted in a bone kernel in axial orientation with 0.6  mm slice thickness out of existing multiple trauma or post mortem compute...
Source: European Journal of Medical Research - October 23, 2018 Category: Research Source Type: research