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HE4-based nomogram for predicting overall survival in patients with idiopathic pulmonary fibrosis: construction and validation
In this study, prognostic nomograms were generated based on the results of the cox regression analysis. We identified the HE4 protein level increased in IPF patients, but not the HE4 gene expression. The increased expression of HE4 correlated positively with a poor prognosis for patients with IPF. The HR and 95% CI were 2.62 (1.61 –4.24) (p <  0.001) in the training set. We constructed a model based on the risk-score = 0.16222182 * HE4 + 0/0.37580659/1.05003609 (for GAP index 0–3/4–5/6–8) + (− 1.1183375). In both training and validation sets, high-risk patients had poor prognoses (HR: 3.49, 95...
Source: European Journal of Medical Research - April 16, 2024 Category: Research Source Type: research

Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification
AbstractGlycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function of glycolytic signature in papillary RCC has not been well elucidated. In the present study, the glycolysis-immune predictive signature was constructed and validated  using WGCNA, glycolysis-immune clustering analysis. PPI network of DEGs was constructed and visualized. Functional enrichments and patients’ overall survival were analyzed. QRT-PCR experiments were performed to detect hub genes’ expression and distribution, siRNA technology was used to silenc e t...
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
ConclusionMXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study
ConclusionDyslipidemia was high among the study participants. Overweight, obesity, central adiposity, and high blood pressure were significantly associated with dyslipidemia in cardiac patients. This alarms the need for lipid profile assessment for patients periodically, with treatment follow-up to monitor any rising patterns and cardiovascular-related risks. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Effects of ankle –foot orthoses on gait parameters in post-stroke patients with different Brunnstrom stages of the lower limb: a single-center crossover trial
ConclusionsPost-stroke patients with lower Brunnstrom stages benefitted more from AFO, particularly in gait asymmetry. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels
ConclusionsDisrupted interactions between GPR43 and NLRP3 expression in peripheral blood leukocytes, associated with reduced intestinal GM-derived SCFAs, especially acetic acid, may be involved in AF development and left atrial enlargement by enhancing circulating inflammation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research

Photodynamic therapy upregulates expression of HIF-1 α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer
ConclusionsPDT might improve the clinical response of ICIs by upregulating tumor HIF-1 α and PD-L1 expressions in NSCLC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Associations between Life ’s Essential 8 and post-stroke depression and all-cause mortality among US adults
ConclusionsA negative correlation was discovered between LE8 score and PSD and all-cause mortality risk among US adults. We need to conduct large-scale prospective studies to further validate our results. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Replication study identified EFEMP1 association with varicose vein predisposition among Indians
ConclusionThis study identifiesEFEMP1 as a potential gene related to the risk of varicose veins in Indians. It also highlights that evaluating the maximum number of variants of a gene rather than focusing solely on replicating single variations offers a more comprehensive and nuanced understanding of the genetic factors contributing to a complex trait like varicose veins. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Genetically predicted dietary macronutrient intakes and atrial fibrillation risk: a Mendelian randomization study
ConclusionOur study provides evidence supporting a causal relationship between higher relative protein and carbohydrate intake and a lower risk of atrial fibrillation (AF). (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT
ConclusionsCirc-10720 acts as a ceRNA to adsorb miR-1238 and modulate ZEB2 to facilitate the proliferation, migration, invasion, and EMT of NSCLC cells.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing
ConclusionThis comprehensive analysis of somatic mutations in HGSOC provides insight into potential therapeutic targets and molecular pathways for targeted interventions. AP3S1 was identified as being a key player in tumor immunity and prognosis, thus providing new perspectives for personalized treatment strategies. The findings of this study contribute to the understanding of HGSOC pathogenesis and provide a foundation for improved outcomes in patients with this aggressive disease. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Tyrosine hydroxylase inhibits HCC progression by downregulating TGF β/Smad signaling
AbstractThe alteration of metabolic processes has been found to have significant impacts on the development of hepatocellular carcinoma (HCC). Nevertheless, the effects of dysfunction of tyrosine metabolism on the development of HCC remains to be discovered. This research demonstrated that tyrosine hydroxylase (TH), which responsible for the initial and limiting step in the bio-generation of the neuro-transmitters dopamine and adrenaline, et al. was shown to be reduced in HCC. Increased expression of TH was found facilitates the survival of HCC patients. In addition, decreased TH indicated larger tumor size, much more numb...
Source: European Journal of Medical Research - April 12, 2024 Category: Research Source Type: research

Time trajectories and within-subject correlations of matrix metalloproteinases 3, 8, 9, 10, 12, and 13 serum levels and their ability to predict mortality in polytraumatized patients: a pilot study
ConclusionsThe time trajectories of the highly varying individual MMP levels elucidate the involvement of these enzymes in the endogenous defense response following polytrauma. Similar time courses of MMP levels might indicate similar injury causes, whereas lead –lag effects reveal causative relations between several enzyme pairs. Finally, MMP10 abundantly released into circulation after polytrauma might have a protective effect against dying. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 10, 2024 Category: Research Source Type: research

Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
AbstractThe latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in anti-leukemia treatments. In the current project, we reviewed and summarized the current role of nanomedicine in the treatment and diagnosis of leukemia through a comparison made between traditional approaches applied in the treatment and diagnosis of leukemia via the existing investigations about the ferroptosis molecular mechanisms involved in various anti-tumor treatments. The application of nanotechnology and other novel technologies may provide a new direction in ferroptosis-...
Source: European Journal of Medical Research - April 9, 2024 Category: Research Source Type: research