Screening and evaluation of key genes in contributing to pathogenesis of hepatic fibrosis based on microarray data
ConclusionsThis study revealed crucial information on the molecular mechanisms of HF and laid a foundation for subsequent genes validation and functional studies, which could contribute to the development of novel diagnostic markers and provide new therapeutic targets for the clinical treatment of HF. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 17, 2020 Category: Research Source Type: research

Pelvic rotation parameters related to in-brace correction in patients with idiopathic scoliosis
ConclusionsFor lumbar IS, ARF and PRF have negative effects on IBC, coronal and sagittal rotation of the pelvis is related to IBC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 17, 2020 Category: Research Source Type: research

Clinical significance of dysregulation of miR-381 in pediatric acute myeloid leukemia
AbstractBackgroundmicroRNA-381 is dysregulated in a variety of cancers. However, its clinical significance in pediatric acute myeloid leukemia (AML) is still unclear. The purpose of this study was to detect the expression level of miR-381 in pediatric AML patients and to explore its potential clinical significance.MethodsThe levels of miR-381 in bone marrow and serum of 102 pediatric AML patients were measured by quantitative real-time polymorperase chain reaction (qRT-PCR). The diagnostic value of serum miR-381 in pediatric AML patients was evaluated by the receiver operating characteristic (ROC) curve. A Chi square test ...
Source: European Journal of Medical Research - September 16, 2020 Category: Research Source Type: research

Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy
ConclusionsWe identified key genes along with the pathways that were most closely related to IgAN initiation and progression. Our results provide a more detailed molecular mechanism for the development of IgAN and novel candidate gene targets of IgAN. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 7, 2020 Category: Research Source Type: research

The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal –fetal transmission: a systematic review and meta-analysis
AbstractBackgroundCoronavirus is challenging the global health care system from time to time. The pregnant state, with alterations in hormone levels and decreased lung volumes due to a gravid uterus and slightly immunocompromised state may predispose patients to a more rapidly deteriorating clinical course and can get a greater risk of harm for both the mother and fetus. Therefore, this systematic review was aimed to assess the effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and its possibility of vertical maternal –fetal transmission.MethodsA systematic search was conducted on P...
Source: European Journal of Medical Research - September 4, 2020 Category: Research Source Type: research

Imaging evaluation of nano-hydroxyapatite/polyamide 66 strut in cervical construction after 1-level corpectomy: a retrospective study of 520 patients
AbstractBackgroundThe application of nano-hydroxyapatite/polyamide 66(n-HA/PA66) struts has become reliable in anterior cervical corpectomy and fusion (ACCF) as a source of sufficient segmental stability. This was a retrospective and long-term imaging evaluation of the n-HA/PA66 strut in 1-level ACCF.MethodsThe patients between June 2006 and December 2014, who underwent 1-level ACCF using an n-HA/PA66 strut, were reviewed. The neurological status was assessed using the Japanese Orthopedic Association (JOA) score and axial pain was evaluated using a Visual Analogue Scale (VAS) score and the radiographic parameters were dete...
Source: European Journal of Medical Research - September 1, 2020 Category: Research Source Type: research

How to follow-up a patient who received tocilizumab in severe COVID-19: a case report
ConclusionsAn overlapping effect of hyperinflammation, hypoxic organ injury and drug-related toxicity warrants a long-term follow-up for COVID-19 survivors. In addition, residual IL-6 receptors blockage may mask new infections. A standardized approach to follow-up for COVID-19 survivors is urgently needed. Current and future research should also investigate the impact of experimental therapies on lung tissue healing and regeneration, as well as long-term treatment toxicities. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 27, 2020 Category: Research Source Type: research

Comparison of a flexible versus rigid bone cement injection system in unilateral percutaneous vertebroplasty
ConclusionsApplication of flexible cement injector is safe and feasible, compared with the application of straight bone cement injector, without prolonging the operative time, radiation exposure time and the incidence of bone cement leakage; it has the advantages of good long-term effect and low incidence of vertebral fracture recurrence. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 25, 2020 Category: Research Source Type: research

Comparison of McGrath, Pentax, and Macintosh laryngoscope in normal and cervical immobilized manikin by novices: a randomized crossover trial
AbstractBackgroundThe aim of this study was to compare tracheal intubation performance regarding the time to intubation, glottic view, difficulty, and dental click, by novices using McGrath videolaryngoscope (VL), Pentax Airway Scope (AWS) and Macintosh laryngoscope in normal and cervical immobilized manikin models.MethodsThirty-five anesthesia nurses without previous intubation experience were recruited. Participants performed endotracheal intubation in a manikin model at two simulated neck positions (normal and fixed neck via cervical immobilization), using three different devices three times each. Performance parameters...
Source: European Journal of Medical Research - August 20, 2020 Category: Research Source Type: research

The stability of carbapenems before and after admixture to PMMA-cement used for replacement surgery caused by Gram-negative bacteria
ConclusionsIn contrast to the results of meropenem and imipenem in solution, both antibiotics remain stable in solid form and mostly stable in the cement after PMMA polymerization. The low degradation levels of both antibiotics after exposure to temperatures  >  100 °C allow the conclusion that they can potentially be used for an application in PMMA cements. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 18, 2020 Category: Research Source Type: research

Antimicrobial peptides in human synovial membrane as (low-grade) periprosthetic joint infection biomarkers
ConclusionsOur results implicate AMPs as promising and specific biomarkers for the histological diagnosis of PJI. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 17, 2020 Category: Research Source Type: research

Face masks: benefits and risks during the COVID-19 crisis
ConclusionEpidemiologists currently emphasize that wearing MNC will effectively interrupt airborne infections in the community. The government and the politicians have followed these recommendations and used them to both advise and, in some cases, mandate the general population to wear MNC in public locations. Overall, the results seem to suggest that there are some clinically relevant scenarios where the use of MNC necessitates more defined recommendations. Our critical evaluation of the literature both highlights the protective effects of certain types of face masks in defined risk groups, and emphasizes their potential ...
Source: European Journal of Medical Research - August 12, 2020 Category: Research Source Type: research

Multidisciplinary inpatient rehabilitation improves the long-term functional status of geriatric hip-fracture patients
ConclusionThe results of this study reveal a significantly better outcome concerning both, short-term and long-term functional status after 3, 6 and 12  months for geriatric hip-fracture patients, who underwent an inpatient treatment in a rehabilitation center following the initial therapy. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 10, 2020 Category: Research Source Type: research

Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis
AbstractBackgroundMore severe cases of COVID- 19 are more likely to be hospitalized and around one-fifth, needing ICU admission. Understanding the common laboratory features of COVID-19 in more severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. This systematic review and meta-analysis aimed to compare the laboratory test findings in severe vs. non-severe confirmed infected cases of COVID-19.MethodsElectronic databases were systematically searched in PubMed, EMBASE, Scopus, Web of Science, and Google Scholar from the beginning of 2019 to 3...
Source: European Journal of Medical Research - August 3, 2020 Category: Research Source Type: research

Electroacupuncture pretreatment alleviates myocardial injury through regulating mitochondrial function
ConclusionThe present study revealed that electroacupuncture pre-treatment of PC6 could effectively alleviate bupivacaine-induced myocardial mitochondrial damage, thereby providing a theoretical basis for clinical studies and applications of this treatment method. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 1, 2020 Category: Research Source Type: research

A preclinical animal model for evaluating the sealing capacity of covered stent grafts in acute vessel perforation
ConclusionsThe novel rabbit iliac artery perforation models, as described in this report, represent promising animal testing approaches. While their setting is very similar to the real-life context encountered in humans, all three models are based on an animal model that is ideally suited for evaluating the sealing capacity and performance of new medical devices for humans. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 29, 2020 Category: Research Source Type: research

Comparative efficacy of treatments for patients with knee osteoarthritis: a network meta-analysis
ConclusionsHyaluronic acid combined with platelet-rich plasma showed the best efficacy in improving stiffness, physical function, and total scores, while platelet-rich plasma appeared the best in terms of pain reduction. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - July 20, 2020 Category: Research Source Type: research

The T-pod is as stable as supraacetabular fixation using 1 or 2 Schanz screws in partially unstable pelvic fractures: a biomechanical study
AbstractIntroductionUnstable fractures of the pelvis remain the predominant cause of severe hemorrhage, shock and early death in severely injured patients. The use of pelvic binders has become increasingly popular, particularly in the preclinical setting. There is currently insufficient evidence available about the stability of the pelvic binder versus supraacetabular fixation using 1 or 2 Schanz screws. We aimed to analyze the stability of the pelvic binder and supraacetabular fixateurs using either 1 or 2 Schanz screws in a cadaver model of an induced pelvic B-type fracture.Materials and methodsThe study was undertaken i...
Source: European Journal of Medical Research - July 18, 2020 Category: Research Source Type: research

Detection of arrhythmia using an implantable cardiac monitor following a cryptogenic stroke: a single-center observational study
ConclusionsThis study confirmed the feasibility of using an interdisciplinary and intersectoral therapeutic approach for monitoring CS patients with implanted ICMs. Further randomized studies are warranted to confirm these encouraging data. An open discussion concerning optimal care forms and opportunities for introducing digitizing care pathways appears warranted. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 29, 2020 Category: Research Source Type: research

The effects of aqueous extract of Maca on energy metabolism and immunoregulation
ConclusionsMaca possesses the Traditional Chinese Medicine (TCM) property of warm and appears to strengthen spleen function. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 29, 2020 Category: Research Source Type: research

The history and value of face masks
AbstractIn the human population, social contacts are a key for transmission of bacteria and viruses. The use of face masks seems to be critical to prevent the transmission of SARS-CoV-2 for the period, in which therapeutic interventions are lacking. In this review, we describe the history of masks from the middle age to modern times. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 23, 2020 Category: Research Source Type: research

Laparoscopic-based perivascular renal sympathetic nerve denervation: a feasibility study in a porcine model
This study aims to evaluate the effects and safety of laparoscopic-based perivascular renal sympathetic nerve denervation (RDN) in a porcine model fed a high-fat diet.MethodThirty-six high-fat diet-fed Bama minipigs were randomly divided into an RDN group (n = 18), in which minipigs received laparoscopic-based perivascular RDN, and a sham group (n = 18). All pigs were fed the high-fat diet after the operation to establish a model of obesity-induced hypertension. Bama pigs in the RDN and sham groups were killed at 3 time points [2 days after RDN (n = 6), day 90 (n =&thin...
Source: European Journal of Medical Research - June 18, 2020 Category: Research Source Type: research

Transitional fracture of the distal radius: a rare injury in adolescent athletes. Case series and literature review
ConclusionsThe primary treatment goal in transitional fractures is anatomic reduction of the articular surface. Non-operative treatment of transitional fractures of the distal radius is the most commonly reported treatment option. Additionally, different fixation options have been described, including the use of Kirschner wires (K-wires) and lag screws. The presented cases demonstrate that volar plate fixation followed by functional rehabilitation is a valuable treatment option in significantly displaced transitional fractures of the distal radius. Furthermore, we discuss the pathogenesis as well as the different treatment...
Source: European Journal of Medical Research - June 9, 2020 Category: Research Source Type: research

A mechanistic approach to prove the efficacy of combination therapy against New Delhi metallo- β-lactamases producing bacterial strain: a molecular and biochemical approach
ConclusionsThe therapeutic combination of streptomycin with amikacin and ciprofloxacin plays an important role in inhibiting NDM-1 producing bacterial strains. Therefore, these combinations can be used as effective future therapeutic candidates against NDM-1 producing bacterial cells. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 3, 2020 Category: Research Source Type: research

Shock wave lithotripsy, for the treatment of kidney stones, results in changes to routine blood tests and novel biomarkers: a prospective clinical pilot-study
ConclusionsChanges to routine blood tests and specific biomarkers, in the future, may be more useful for clinicians. In turn, identification of a panel of biomarkers could provide valuable data on “normal” physiological response after lithotripsy. Ultimately, studies could be expanded to identify or predict those patients at increased risk of developing post-operative complications, such as acute kidney injury or. These studies, however, need validating involving larger cohorts. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - June 1, 2020 Category: Research Source Type: research

Dysregulation of miR-210 is involved in the development of diabetic retinopathy and serves a regulatory role in retinal vascular endothelial cell proliferation
ConclusionThe data of this study demonstrated that serum increased miR-210 serves as a diagnostic biomarker in DR patients and may have the ability to predict DR development and severity. The regulatory effect of miR-210 on vascular endothelial cell proliferation under high-glucose condition, indicating its therapeutic potential in the treatment of diabetic vascular diseases. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - May 29, 2020 Category: Research Source Type: research

Effect of glutathione-stabilized silver nanoparticles on expression of las I and las R of the genes in Pseudomonas aeruginosa strains
In this study, a total of 50P. aeruginosa isolates were recovered from clinical samples. According to the results, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration  (MBC) value of Ag-NPs againstP. aeruginosa was determined to be 512 –256 μg/ml, respectively, while the MIC and MBC value of GS–Ag-NPs againstP. aeruginosa clinical strains was determined in a range of 128 –256 μg/ml and 256–512 μg/ml, respectively. The mean expression level inlas R, las I genes inP. aeruginosa strains treated with ½ MIC of Ag-NPs was decreased by &minu...
Source: European Journal of Medical Research - May 20, 2020 Category: Research Source Type: research

The role of passive immunization in the age of SARS-CoV-2: an update
AbstractThe rapid spread of the corona virus pandemic is an existential problem for many people in numerous countries. So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. In this review, we describe the role of passive immunization in times of the corona virus. Passive immunization could be a bridging technology to improve the immune defense of critically ill patients until better approaches with effective medications are available. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - May 13, 2020 Category: Research Source Type: research

Logbooks alone are not enough: initial experience with implementing a logbook for medical students in a clinical internship in gynecology and obstetrics
ConclusionsIntroducing a logbook to optimize clinical teaching in internships may raise expectations that cannot always be met. In addition to adapting the learning objectives to a general framework that is less favorable in comparison with the Practical Year, the least that is required appears to be simultaneous and continuous mentoring of the lecturers, as well as an increase in staffing resources. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - May 8, 2020 Category: Research Source Type: research

Correction to: Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB
Discussion’ section. The errors in Table 1 involve the number of isolates tested for pyrazinamide and pyrazinamide susceptible isolates, ethambutol-susceptible isolates with a mutation and number of resistant isolates with a mutation for streptomycin. The error in Table 2 involves wrong codon number for a mutation in isolate KM17-01 in Cluster XII forgidB gene. The updated informations have been indicated inbold and also refer corrected Tables  1 and 2. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 21, 2020 Category: Research Source Type: research

Total arthroplasty with Ivory ® prosthesis versus resection–suspension arthroplasty: a retrospective cohort study on 82 carpometacarpal-I osteoarthritis patients over 4 years
ConclusionAs the high complication rate is compensated by a better functional outcome (enhanced range of motion and strength), we believe that prosthesis implantation can be a reasonable treatment option for carpometacarpal-I osteoarthritis in a particular patient group.Level of Evidence IIIl: Retrospective cohort study. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2020 Category: Research Source Type: research

Novel method for reduction of virus load in blood plasma by sonication
ConclusionsBuilding upon the information gained, an optimum inactivation can be reached via raising of power density up to 1200  W and simultaneous lowering of frequency down to 27 kHz. In addition, the combination of the two physical methods UV treatment and ultrasound may yield optimum results without the need of substance removal after the procedure. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 7, 2020 Category: Research Source Type: research

Higher incidence of acute respiratory distress syndrome in cardiac surgical patients with elevated serum procalcitonin concentration: a prospective cohort study
The objective of the study was to validate whether patients with higher serum PCT concentrations have a higher incidence of ARDS.MethodsThe study was a prospective, single-center, observational cohort study. All patients who received cardiac surgery with CPB were screened for study eligibility. Patients were assigned to the PCT-elevated cohort or the control cohort according to serum PCT concentration on the first postoperative day with a cut-off value of 7.0  ng/mL. Patients were followed up until the 7th postoperative day. The primary endpoint was the incidence of ARDS, which was diagnosed according to the Berlin de...
Source: European Journal of Medical Research - March 30, 2020 Category: Research Source Type: research

Limb ischemic preconditioning ameliorates renal microcirculation through activation of PI3K/Akt/eNOS signaling pathway after acute kidney injury
ConclusionsCollectively, the results demonstrate that LIPC ameliorates CM-induced renal vasocontraction and is mediated by activation of PI3K/Akt/eNOS signaling pathway. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 19, 2020 Category: Research Source Type: research

Clinical significance of miR-19b-3p in patients with sepsis and its regulatory role in the LPS-induced inflammatory response
This study investigated the clinical value of miR-19b-3p in sepsis patients, and explored its role in regulating inflammatory responses in HUVECs cells.Methods103 patients with sepsis and 98 healthy individuals were recruited. qRT-PCR was used for the measurement of miR-19b-3p level. Cell viability was evaluated using CCK-8. The protein levels of TNF- α and IL-6 were measured using ELISA. Receiver operating characteristic (ROC) curve and logistic regression analysis were constructed to evaluate the diagnostic and prognostic values of miR-19b-3p in sepsis patients.ResultsMiR-19b-3p level was significantly reduced in t...
Source: European Journal of Medical Research - March 18, 2020 Category: Research Source Type: research

Clinical significance of precedent asymptomatic non-sustained ventricular tachycardias on subsequent ICD interventions and heart failure hospitalization in primary prevention ICD patients
AbstractBackgroundThe prognostic implications of non-sustained ventricular tachycardia (NSVT) and their significance as therapeutic targets in patients without prior sustained ventricular arrhythmias remain undetermined. The aim of this study was to investigate the prognostic significance of asymptomatic NSVT in patients who had primary prevention implantable cardioverter-defibrillator (ICD) implantation due to ischemic or non-ischemic cardiomyopathy (ICM, NICM).MethodsWe enrolled 157 consecutive primary prevention ICD patients without previous appropriate ICD therapy (AIT). Patients were allocated to two groups depending ...
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome
ConclusionsIn conclusion, it was hypothesized that serum decreased expression of miR-145 may serve as a potential diagnostic biomarker in ACS patients. Overexpression of miR-145 may improve the endothelial injury and abnormal inflammation through targeting FOXO1, indicating that miR-145 serves as a candidate therapeutic target of ACS. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

Clinical study on the status of transient thyrotoxicosis after surgery for secondary hyperparathyroidism patients with end-stage renal disease and normal thyroid function
AbstractObjectiveSecondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD), and part of SHPT patients need receive parathyroidectomy (PTX). However, as an important postoperative complication of SHPT, thyrotoxicosis has received little attention. Therefore, in this article, we aimed to study the status of transient thyrotoxicosis after PTX for SHPT patients with ESRD and normal thyroid function.MethodsA total of 24 SHPT patients with preoperative normal thyroid function, normal thyroglobulin (Tg) and normal thyroid antibodies receiving PTX were enrolled from the Department of Endocrine...
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

Outcome of catheter ablation of non-reentrant ventricular arrhythmias in patients with and without structural heart disease
ConclusionsThe outcome of catheter ablation of non-reentrant VA in patients with SHD appears good and is comparable to patients without SHD. A slightly higher rate of repeat ablations was observed in patients with DCM. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

Effects of respiratory rate on venous-to-arterial CO 2 tension difference in septic shock patients undergoing volume mechanical ventilation
In this study, gapCO2 induced by hyperventilation significantly increased, while the central venous carbon dioxide pressure (PvCO2) and the partial pressure of CO2 (PaCO2) in arteries decreased. The decreasing trend of the PaCO2 was more obvious than that of the PvCO2. HCO3− and ctCO2 were markedly decreased, when the RR was increased (P 
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

miR-34a targets PAI-1 to regulate urinary microalbumin and renal function in hypertensive mice
AbstractBackgroundThe aim of the study is to investigate the effects of miR-34a targeted at PAI-1 on urinary microalbumin and renal function in hypertensive mice.MethodsTwenty specific-pathogen-free (SPF) BPN/3J mice were selected in normal group, and 120 SPF BPH/2J mice were evenly divided into model group, negative control group, miR-34a mimic group, miR-34a inhibitor group, Si-PAI-1 group, and miR-34a inhibitor  + Si-PAI-1 group. qRT-PCR was used to detect the expression of miR-34a and PAI-1 mRNA. The protein expressions of PAI-1, angiotensin-converting enzyme (ACE) and ACE2 were detected by Western blot. ...
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

Mechanism of HMGB1 –RAGE in Kawasaki disease with coronary artery injury
ConclusionsOn the whole, the findings of this study demonstrate that the expression of HMGB1/RAGE/NF- κB is altered at different stages of KD, suggesting that the HMGB1/RAGE/NF-κB signaling pathway plays an important role in vascular injury in KD. The results of this study may have important implications for the early warning of coronary artery lesions in KD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 17, 2020 Category: Research Source Type: research

In vitro antifungal resistance profile of Candida strains isolated from Saudi women suffering from vulvovaginitis
ConclusionThe emergence of resistantCandida strains necessitates conduction of the antifungal susceptibility test prior to deciding the medication regime. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 4, 2020 Category: Research Source Type: research

Total hip arthroplasty for intertrochanteric fracture fixation failure
ConclusionTHA as salvage treatment for failed internal fixation of intertrochanteric femoral fractures in elderly patients significantly reduced hip pain and restored joint function, and early clinical outcomes were satisfactory. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 27, 2019 Category: Research Source Type: research

Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB
ConclusionsOur study provides the first insight into molecular epidemiology of MDR-TB in Kuwait and identified several potential clusters of local transmission of MDR-TB involving 2 –6 subjects which had escaped detection by routine surveillance studies. Prospective detection of resistance-conferring mutations can identify possible cases of local transmission of MDR-TB in low MDR-TB settings. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 5, 2019 Category: Research Source Type: research

MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction
ConclusionsMiR-495 might be a potential diagnostic biomarker for sepsis patients, and overexpression of miR-495 alleviated sepsis-induced inflammation and cardiac dysfunction. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 26, 2019 Category: Research Source Type: research

Effectiveness of an osteopathic treatment on the autonomic nervous system: a systematic review of the literature
ConclusionThe included published studies represent a good level of evidence. Due to a small number of subjects and no follow-ups, the methodological quality is rated as moderate. A significant change on the ANS was shown in studies including High-Velocity Low-Amplitude Techniques (HVLAT). No statement could be drawn in studies in which they used cranial osteopathic techniques due to the lack of methodological quality. A significant change on the ANS is shown in the treatment of the suboccipital region. In studies which evaluated the effectiveness of mobilization in the cervical and thoracic region, no statement could be di...
Source: European Journal of Medical Research - October 25, 2019 Category: Research Source Type: research

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease
AbstractBackgroundAcute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD.MethodPatients with ACVD admitted in our hospitals between January 2013 and September 2017 were enrolled in this study (n = 245, including 176 cerebral infarctions and 69 cerebral hemorrhages). Their thyroid hormones were measured and compared wi...
Source: European Journal of Medical Research - October 24, 2019 Category: Research Source Type: research

Distribution of Modic changes in patients with low back pain and its related factors
ConclusionsType II changes are the most common, followed by type I. Modic changes mostly occur in L4/5 and L5/S1; young, male, lower-grade disk degeneration, normal physiological curvature of the lumbar spine, and normal endplate concave angle were associated with type I changes; gender and lumbar curvature were the most relevant factors for different types. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 9, 2019 Category: Research Source Type: research

Biomechanical comparison of bi- and tricortical k-wire fixation in tension band wiring osteosynthesis
ConclusionThis study confirms for the first time biomechanical superiority of tricortical k-wire fixation in the olecranon when using a TBW and may justify the clinical use of this method. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 8, 2019 Category: Research Source Type: research