LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2/ARE axis
ConclusionCollectively, our data unveiled the lncRNA NEAT1 promotes matrix degradation by regulating Nrf2/ARE signaling pathway, suggesting a potential therapeutic for IVD in the future. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 21, 2021 Category: Research Source Type: research

Zone-dependent acute circulatory changes in abdominal organs and extremities after resuscitative balloon occlusion of the aorta (REBOA): an experimental model
AbstractIntroductionResuscitative endovascular balloon occlusion of the aorta (REBOA) may be used in severely injured patients with uncontrollable bleeding. However, zone-dependent effects of REBOA are rarely described. We compared the short-term zone- and organ-specific microcirculatory changes in abdominal organs and the extremity during occlusion of the aorta in a standardized porcine model.MethodsMale pigs were placed under general anesthesia, for median laparotomy to expose intra-abdominal organs. REBOA placement occurred in Zone 1 (from origin left subclavian artery to celiac trunk), Zone 2 (between the coeliac trunk...
Source: European Journal of Medical Research - January 21, 2021 Category: Research Source Type: research

Prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC)
This study attempts to evaluate the prognostic role of PHYH for overall survival (OS) in clear cell renal cell carcinoma (ccRCC) by means of publicly available data from The Cancer Genome Atlas (TCGA). Clinical pathologic features and PHYH expression were downloaded from the TCGA database and relationships between them were analyzed by univariate and multivariate Cox regression analyses. Gene Set Enrichment Analysis (GSEA) and gene –gene interactions were also performed between tissues with different PHYH expression levels. PHYH expression levels were significantly lower in patient with ccRCC compared with normal tis...
Source: European Journal of Medical Research - January 19, 2021 Category: Research Source Type: research

MiR-206 regulates the progression of osteoporosis via targeting HDAC4
ConclusionsMiR-206 could be used as a new potential diagnostic biomarker for osteoporosis, and in in vitro cell experiments, miR-206 may regulate osteoblast cell proliferation and apoptosis by targeting HDAC4. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 18, 2021 Category: Research Source Type: research

Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats
AbstractObjectiveThe aim of this study was to detect the expression of interleukin (IL)-1 β and transforming growth factor (TGF)-β1 in the colonic tissue and serum of irritable bowel syndrome (IBS) rats, as well as the distribution and expression of corticotropin-releasing factor (CRF) in the spinal cord and brain of the visceral hypersensitivity rats, thus to ascertain the mechanism o f visceral hypersensitivity signal conduction pathway.MethodsThe expression of IL-1 β and TGF-β1 in the colonic tissue and serum of IBS rats was screened by the liquid chip technology and verified by RT-PCR technology. Th...
Source: European Journal of Medical Research - January 13, 2021 Category: Research Source Type: research

Extended liver resection in mice: state of the art and pitfalls —a systematic review
ConclusionThrough the overview, laid out in the selected publications, this paper reviews the shift of the extended liver resection model from rat to the mouse, describes the state of the art in the experimental setting, and discusses the possible limitations and pitfalls. Clearly, the extended liver resection in mice is a reproducible, practical and easy to learn method. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 9, 2021 Category: Research Source Type: research

Multiorgan failure with fatal outcome after stem cell tourism
ConclusionsThe case of the patient presented here draws attention to the worst possible outcome of stem cell tourism. To effectively combat this issue, professionals and patients should be empowered with the right knowledge on possible side effects. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 9, 2021 Category: Research Source Type: research

Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis
ConclusionsOxycodone is superior to other analgesics within 24  h after laparoscopic surgery, but its adverse effects should be carefully considered. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 9, 2021 Category: Research Source Type: research

Urinary sodium-to-potassium ratio: a simple and useful indicator of diet quality in population-based studies
This study was conducted to investigate whether urinary Na-to-K ratio could be related to habitual dietary patterns, in a general population.MethodsThis study was conducted in the framework of the Tehran Lipid and Glucose Study (2014 –2017) on 1864 adult men and women. Urinary Na and K concentrations were measured in the morning spot urine samples. Dietary intakes of the participants were assessed using a validated 147-item Food Frequency Questionnaire (FFQ) and major dietary patterns were obtained using principal component an alysis. Mediterranean dietary pattern and Dietary Approaches to Stop Hypertension (DASH) sc...
Source: European Journal of Medical Research - January 6, 2021 Category: Research Source Type: research

Prevalence and associated factor of Campylobacter species among less than 5-year-old children in Ethiopia: a systematic review and meta-analysis
ConclusionIn our study, Campylobacter species among children under 5 years of age in Ethiopia were significantly high. Contact with domestic animals, illiterate mothers and consumption of animal products were significantly associated with prevalence of Campylobacter species (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 3, 2021 Category: Research Source Type: research

Airborne transmission of COVID-19 and the role of face mask to prevent it: a systematic review and meta-analysis
This study aimed to investigate the airborne transmission of COVID-19 and the role of face mask to prevent it.MethodsA systematic search for English-language literature was done via PUBMED/Medline and Google Scholar up to October 2020. There was two search strategy; for airborne transmission and the role of face mask for prevention of SARS-CoV-2 infection. Based on a fixed and random effects model, the RR and 95% CI were used to evaluate the combined risk. This meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Guidelines.ResultsAfter eligibility assessment, four articles wit...
Source: European Journal of Medical Research - January 2, 2021 Category: Research Source Type: research

Convergence of scaffold-guided bone regeneration and RIA bone grafting for the treatment of a critical-sized bone defect of the femoral shaft
ConclusionThis case report shows a promising translation of scaffold-based TE from bench to bedside. Preliminary evidence indicates that the use of medical-grade scaffolds is safe and has the potential to improve bone healing. Further, its synergistic effects when combined with ABG and BMP-2 show the potential of mPCL –TCP scaffolds to support new bone formation in segmental long bone defects. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 21, 2020 Category: Research Source Type: research

The majority of conversion total hip arthroplasties can be considered a primary replacement: a matched cohort study
ConclusionsThe majority of conversion total hip arthroplasties can be considered a primary replacement. Predicting outcomes for THA should focus on patient frailty and technical difficulties dealing with infection, stability and loss of bone stock and should discard the conversion versus revision terminology. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 11, 2020 Category: Research Source Type: research

The role of phagocytic leukocytes following flexible ureterenoscopy, for the treatment of kidney stones: an observational, clinical pilots-study
ConclusionsThis study demonstrates that following FURS for the treatment of kidney stones, monocytes are rapidly activated and produce potent reactive oxygen intermediates. Interestingly, the pattern of expression in neutrophils suggests that these cells are deactivated in response to the treatment. The leukocyte biomarkers assessed during this investigation may have a role in monitoring the ‘normal’ post-operative response, as no complications occurred in any of the patients; or may help predict potential infectious complications (e.g. urosepsis) that can occur during the post-operative period. This data, howe...
Source: European Journal of Medical Research - December 11, 2020 Category: Research Source Type: research

Evaluation of intra- and interobserver reliability in the assessment of the ‘critical trochanter angle’
ConclusionAnalyses concerning intra- and interobserver reliability in the assessment of the CTA showed ‘very good’ and ‘good’ results, respectively. In view of these findings, the use of the CTA as an additional preoperative parameter to assess the risk of intraoperative stem malalignment seems to be justified. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 10, 2020 Category: Research Source Type: research

The treatment of complex intra-articular distal radius fractures with turning radius and distal volaris radius plate fixation
ConclusionTreatment of the intra-articular distal radius fractures accompanying dorsally displaced free fragments with turning of the radius and the DVR plate system via the distal palmar approach is effective and has no obvious complications. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 7, 2020 Category: Research Source Type: research

Primary gastroduodenal tuberculosis complicated with acute pancreatitis: a rare case report and literature review
ConclusionsClinicians must remember that even in the absence of immunodeficiency, as in this case, tuberculosis can affect any part of the gastrointestinal tract. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 7, 2020 Category: Research Source Type: research

Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis
ConclusionsAs a result of a potentially critical role of obesity in determining the severity of COVID-19, it is important to collect anthropometric information for COVID-19 patients, especially the younger group. However, obesity may not be associated with hospital mortality, and efforts to understand the impact of obesity on the mortality of COVID-19 patients should be a research priority in the future. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 2, 2020 Category: Research Source Type: research

Lower trapezius myocutaneous flap repairs adjacent deep electrical burn wounds
ConclusionThe authors report two cases of patients who were burned by high voltage. We used lower trapezius myocutaneous flaps to repair their wounds, which achieved satisfactory clinical results. This study has provided a reliable surgical method for the clinical treatment of deep electrical burn wounds in the neck, shoulders and back. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 1, 2020 Category: Research Source Type: research

Fracture fixation strategy and specific muscle tissue availability of neutrophilic granulocytes following mono- and polytrauma: intramedullary nailing vs. external fixation of femoral fractures
ConclusionThe reduction of PMNL invasion into the nearby muscle tissue of a monotrauma femur fracture stabilized by intramedullary nailing supports the advantages found in everyday clinical practice and therefore underlines the usage of nailing. For the polytrauma situation, the fixation seems to play a minor role, possibly due to a generalized immune reaction. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 26, 2020 Category: Research Source Type: research

Clinical, epidemiological, and laboratory characteristics of mild-to-moderate COVID-19 patients in Saudi Arabia: an observational cohort study
ConclusionsThis study provides an understanding of the features of non-ICU COVID-19 patients in Saudi Arabia. Further national collaborative studies are needed to streamline screening and treatment procedures for COVID-19. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 25, 2020 Category: Research Source Type: research

Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skin
ConclusionHYAL is a bioactive enzyme that exerts multiple effects on the HA-metabolism as well as on the structural cells of the skin. Our results indicate that HYAL promotes wound healing and exerts a dose-dependent induction of HA-synthesis in structural cells of the skin. Herein, interestingly the most significant induction of HAS and HA were observed for the lowest concentration of HYAL. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 23, 2020 Category: Research Source Type: research

Sulfadiazine plasma concentrations in women with pregnancy-acquired compared to ocular toxoplasmosis under pyrimethamine and sulfadiazine therapy: a case –control study
AbstractBackgroundDosing recommendations for the treatment of pregnancy-acquired toxoplasmosis are empirical and widely based on experimental data. There are no pharmacological data on pregnant women with acuteToxoplasma gondii infection under treatment with pyrimethamine (PY) and sulfadiazine (SA) and our study intends to tighten this gap.MethodsIn this retrospective case –control study, we included 89 pregnant women with primaryToxoplasma infection (PT) treated with PY (50  mg first dose, then 25 mg/day), SA (50 mg/kg of body weight/day), and folinic acid (10–15 mg per week). These were co...
Source: European Journal of Medical Research - November 23, 2020 Category: Research Source Type: research

Correction to: Treatment of the mandibular shift in an adult woman and the diagnostic value of joint space index: a case report
An amendment to this paper has been published and can be accessed via the original article. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 12, 2020 Category: Research Source Type: research

Successful treatment of severe pneumonia, pyopneumothorax with severe acute respiratory distress syndrome, and septic shock: a case report
ConclusionsThere is a low successful clinical treatment rate for patients with pneumonia, pyopneumothorax with severe ARDS and septic shock. The successful treatment of this patient benefited from early and effective empirical therapy, targeted drug selection in the later stage, adequate closed thoracic drainage, repeated bronchial lavage, early CRRT, an appropriate respiratory support mode and parameter setting, immunotherapy and nutritional support therapy. This paper proposes a reference diagnosis and treatment solution for similar cases. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 11, 2020 Category: Research Source Type: research

Impact of lockdown on COVID-19 prevalence and mortality during 2020 pandemic: observational analysis of 27 countries
ConclusionsThe findings indicate that 15  days after the lockdown, daily cases of COVID-19 and the growth factor of the disease showed a declined trend, but there was no significant decline in the prevalence and mortality. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 10, 2020 Category: Research Source Type: research

A meta-analysis of the impact of COVID-19 on liver dysfunction
AbstractBackgroundThe novel coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to a worldwide pandemic. Except representative manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients have also shown different levels of liver injury or liver dysfunction. The aim of our study was to explore the probable clinical severity and mortality of COVID-19 patients and their liver dysfunction.MethodA combination of computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. Review Manager 5.3 ...
Source: European Journal of Medical Research - November 4, 2020 Category: Research Source Type: research

Multimodality lymphatic imaging of postoperative chylothorax in an infant with Noonan syndrome: a case report
ConclusionsApplication of multimodality imaging allows for greater individualization of treatment and should be considered in patients with complex cases such as those with syndromes associated with a higher incidence of chylothorax. IRB Number: HSC-MS-13 –0754, December 10, 2013 (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - November 4, 2020 Category: Research Source Type: research

Correction to: The role of passive immunization in the age of SARS-CoV-2: an update
An amendment to this paper has been published and can be accessed via the original article. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 30, 2020 Category: Research Source Type: research

Fibroblast-like cells change gene expression of bone remodelling markers in transwell cultures
ConclusionThe multilayer cultures are able to induce significant expression changes in fibroblast-like cells depending on the nature of cellular origin without the addition of any further stimulus. This system might be a useful tool to get more in vivo like results regarding fibroblast-like cell cultures. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 29, 2020 Category: Research Source Type: research

The penetration effect of HMME-mediated low-frequency and low-intensity ultrasound against the Staphylococcus aureus bacterial biofilm
ConclusionsLow-frequency and low-intensity sinusoidal ultrasound significantly increased the permeability of the biofilms, which was positively correlated with the time and the intensity of ultrasound. Simultaneous action of ultrasound and HMME was the most effective way to increase the permeability of the biofilms. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 22, 2020 Category: Research Source Type: research

Treatment of the mandibular shift in an adult woman and the diagnostic value of joint space index: a case report
ConclusionsA condyle position displacement could be an indication of functional deviation. JSI analysis is a quantitative and convenient choice to compare condyle relative positions. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 22, 2020 Category: Research Source Type: research

Development of a quantitative segmentation model to assess the effect of comorbidity on patients with COVID-19
AbstractBackgroundThe coronavirus disease 2019 (COVID-19) has brought a global disaster. Quantitative lesions may provide the radiological evidence of the severity of pneumonia and further to assess the effect of comorbidity on patients with COVID-19.Methods294 patients with COVID-19 were enrolled from February, 24, 2020 to June, 1, 2020 from six centers. Multi-task Unet network was used to segment the whole lung and lesions from chest CT images. This deep learning method was pre-trained in 650 CT images (550 in primary dataset and 100 in test dataset) with COVID-19 or community-acquired pneumonia and Dice coefficients in ...
Source: European Journal of Medical Research - October 12, 2020 Category: Research Source Type: research

Prevalence and distribution of resistance and enterotoxins/enterotoxin-like genes in different clinical isolates of coagulase-negative Staphylococcus
ConclusionAntimicrobial resistant determinants and SEs are co-present in clinical CoNS isolates that confer selective advantage for colonization and survival in hospital settings. The coexistence of insertion elements and antibiotic resistance indicate their role in pathogenesis and infectious diseases. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 12, 2020 Category: Research Source Type: research

Heart rate at discharge in patients with acute decompensated heart failure is a predictor of mortality
ConclusionsPatients hospitalized for ADHF seem to have a better prognosis, when heart rate at discharge is  
Source: European Journal of Medical Research - October 8, 2020 Category: Research Source Type: research

The ultimate preoperative C-reactive protein-to-albumin ratio is a prognostic factor for survival after pancreatic cancer resection
AbstractBackgroundEmerging evidence indicates that an elevated C-reactive protein-to-albumin ratio (CAR) may be associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Further evidence showing that this ratio has significant prognostic value could contribute to current prediction models and clinical decision-making.MethodsData were analysed of consecutive patients who underwent curative pancreatic resection between 2013 and 2018 and were histologically diagnosed with PDAC. We investigated the relation between the ultimate preoperative CAR and overall survival.ResultsA total of 163 patients were analyse...
Source: European Journal of Medical Research - October 6, 2020 Category: Research Source Type: research

Comparison of three fixation methods for orotracheal intubation in 95 adults
ConclusionThe fixator method can significantly reduce intraoral injury and is more suitable for older people with weak tongue mucosa and loose teeth. These are worth popularizing among a wider group. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 1, 2020 Category: Research Source Type: research

The Nintendo ® Wii Fit Balance Board can be used as a portable and low-cost posturography system with good agreement compared to established systems
ConclusionsAccording to the literature, the raw data from the Wii Fit Balance Board are comparable to that obtained by laboratory-grade force platforms. We have found, however, that the yoga pose “tree,” as integrated into the Nintendo® Wii Fit Balance Board with its own scoring system, also correlates with the gold-standard Sensory Organization Test. It also correlates with two frequently used diagnostic and therapeutic devices. We, therefore, conclude that the Wii Fit Balance Board is suitable for the evaluation of postural stability and may be useful in preventing falls among the geriatric population.Lev...
Source: European Journal of Medical Research - September 23, 2020 Category: Research Source Type: research

Screening and evaluation of key genes in contributing to pathogenesis of hepatic fibrosis based on microarray data
ConclusionsThis study revealed crucial information on the molecular mechanisms of HF and laid a foundation for subsequent genes validation and functional studies, which could contribute to the development of novel diagnostic markers and provide new therapeutic targets for the clinical treatment of HF. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 16, 2020 Category: Research Source Type: research

Pelvic rotation parameters related to in-brace correction in patients with idiopathic scoliosis
ConclusionsFor lumbar IS, ARF and PRF have negative effects on IBC, coronal and sagittal rotation of the pelvis is related to IBC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 16, 2020 Category: Research Source Type: research

Clinical significance of dysregulation of miR-381 in pediatric acute myeloid leukemia
AbstractBackgroundmicroRNA-381 is dysregulated in a variety of cancers. However, its clinical significance in pediatric acute myeloid leukemia (AML) is still unclear. The purpose of this study was to detect the expression level of miR-381 in pediatric AML patients and to explore its potential clinical significance.MethodsThe levels of miR-381 in bone marrow and serum of 102 pediatric AML patients were measured by quantitative real-time polymorperase chain reaction (qRT-PCR). The diagnostic value of serum miR-381 in pediatric AML patients was evaluated by the receiver operating characteristic (ROC) curve. A Chi square test ...
Source: European Journal of Medical Research - September 15, 2020 Category: Research Source Type: research

Bioinformatics analysis reveals novel hub gene pathways associated with IgA nephropathy
ConclusionsWe identified key genes along with the pathways that were most closely related to IgAN initiation and progression. Our results provide a more detailed molecular mechanism for the development of IgAN and novel candidate gene targets of IgAN. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - September 6, 2020 Category: Research Source Type: research

The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal –fetal transmission: a systematic review and meta-analysis
AbstractBackgroundCoronavirus is challenging the global health care system from time to time. The pregnant state, with alterations in hormone levels and decreased lung volumes due to a gravid uterus and slightly immunocompromised state may predispose patients to a more rapidly deteriorating clinical course and can get a greater risk of harm for both the mother and fetus. Therefore, this systematic review was aimed to assess the effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and its possibility of vertical maternal –fetal transmission.MethodsA systematic search was conducted on P...
Source: European Journal of Medical Research - September 3, 2020 Category: Research Source Type: research

Imaging evaluation of nano-hydroxyapatite/polyamide 66 strut in cervical construction after 1-level corpectomy: a retrospective study of 520 patients
AbstractBackgroundThe application of nano-hydroxyapatite/polyamide 66(n-HA/PA66) struts has become reliable in anterior cervical corpectomy and fusion (ACCF) as a source of sufficient segmental stability. This was a retrospective and long-term imaging evaluation of the n-HA/PA66 strut in 1-level ACCF.MethodsThe patients between June 2006 and December 2014, who underwent 1-level ACCF using an n-HA/PA66 strut, were reviewed. The neurological status was assessed using the Japanese Orthopedic Association (JOA) score and axial pain was evaluated using a Visual Analogue Scale (VAS) score and the radiographic parameters were dete...
Source: European Journal of Medical Research - August 31, 2020 Category: Research Source Type: research

How to follow-up a patient who received tocilizumab in severe COVID-19: a case report
ConclusionsAn overlapping effect of hyperinflammation, hypoxic organ injury and drug-related toxicity warrants a long-term follow-up for COVID-19 survivors. In addition, residual IL-6 receptors blockage may mask new infections. A standardized approach to follow-up for COVID-19 survivors is urgently needed. Current and future research should also investigate the impact of experimental therapies on lung tissue healing and regeneration, as well as long-term treatment toxicities. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 26, 2020 Category: Research Source Type: research

Comparison of a flexible versus rigid bone cement injection system in unilateral percutaneous vertebroplasty
ConclusionsApplication of flexible cement injector is safe and feasible, compared with the application of straight bone cement injector, without prolonging the operative time, radiation exposure time and the incidence of bone cement leakage; it has the advantages of good long-term effect and low incidence of vertebral fracture recurrence. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 24, 2020 Category: Research Source Type: research

Comparison of McGrath, Pentax, and Macintosh laryngoscope in normal and cervical immobilized manikin by novices: a randomized crossover trial
AbstractBackgroundThe aim of this study was to compare tracheal intubation performance regarding the time to intubation, glottic view, difficulty, and dental click, by novices using McGrath videolaryngoscope (VL), Pentax Airway Scope (AWS) and Macintosh laryngoscope in normal and cervical immobilized manikin models.MethodsThirty-five anesthesia nurses without previous intubation experience were recruited. Participants performed endotracheal intubation in a manikin model at two simulated neck positions (normal and fixed neck via cervical immobilization), using three different devices three times each. Performance parameters...
Source: European Journal of Medical Research - August 19, 2020 Category: Research Source Type: research

The stability of carbapenems before and after admixture to PMMA-cement used for replacement surgery caused by Gram-negative bacteria
ConclusionsIn contrast to the results of meropenem and imipenem in solution, both antibiotics remain stable in solid form and mostly stable in the cement after PMMA polymerization. The low degradation levels of both antibiotics after exposure to temperatures  >  100 °C allow the conclusion that they can potentially be used for an application in PMMA cements. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 17, 2020 Category: Research Source Type: research

Antimicrobial peptides in human synovial membrane as (low-grade) periprosthetic joint infection biomarkers
ConclusionsOur results implicate AMPs as promising and specific biomarkers for the histological diagnosis of PJI. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - August 16, 2020 Category: Research Source Type: research

Face masks: benefits and risks during the COVID-19 crisis
ConclusionEpidemiologists currently emphasize that wearing MNC will effectively interrupt airborne infections in the community. The government and the politicians have followed these recommendations and used them to both advise and, in some cases, mandate the general population to wear MNC in public locations. Overall, the results seem to suggest that there are some clinically relevant scenarios where the use of MNC necessitates more defined recommendations. Our critical evaluation of the literature both highlights the protective effects of certain types of face masks in defined risk groups, and emphasizes their potential ...
Source: European Journal of Medical Research - August 11, 2020 Category: Research Source Type: research