GSE214089 HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene
Contributors : Yuning Cheng ; Ruixiang Yang ; Yue Zhou ; Jiyin Wang ; Tongjia Zhang ; Shujie Wang ; Hui Li ; Wei Jiang ; Xiaowei ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is highly prevalent worldwide and characterized by glucose and lipid metabolism disorders. However, the pathogenic mechanisms have not been fully established. Here, we found that HMG-box transcription factor 1 (HBP1) is involved in T2DM and that its deficiency in mice aggravates the features of diabetes. In addition, we undertook ...
Source: GEO: Gene Expression Omnibus - September 27, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE138014 Activation of Acsl4 might promote dedifferentiation in β cell lack of Rictor/mTORC2
Contributors : Canqi Cui ; Yanyu GuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe here identified Acsl4, a new target of mTORC2, could rescue the impaired β cell proliferation, but not deficient insulin secretion induced by loss of Rictor. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE138071 Integrative proteomics of primary hepatocytes during dedifferentiation
In this study, we perform ubiquitinome phosphorylated proteome, whole cell proteome and transcriptome simultaneously during the five different time points of dedifferentiation in vitro quantified over 6000 modified sites mapping to over 2000 proteins. And comprehensive analysis of these datasets provides novel insight in this field. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

GSE151747 eiCLIP analysis of RBFOX2 in primary mouse hepatocytes
Contributors : Santiago Vernia ; Yi-Fang Wang ; Nejc Haberman ; Helen A PatersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRbfox2 is required for maintaining hepatic cholesterol levels under high fructose. Here we carry out an enhanced iCLIP (eiCLIP) protocol in order to determine the targets of Rbfox2 in primary mouse hepatocytes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE151748 RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD
Contributors : Santiago Vernia ; Yi-Fang Wang ; Helen A PatersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRbfox2 is required for maintaining hepatic metabolic homeostasis, here we carry out RNAseq to of WT and aged matched littermate Rbfox2 knockout mice under high fructose in order to determine changes in alternative splicing and mRNA expression caused by knockout of this splicing factor in this metabolic environment. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE151750 RNAseq of liver of CD and HFD fed mice in fed or fasted conditions
Contributors : Santiago Vernia ; Yi-Fang Wang ; Helen A PatersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe liver is key for maintaining metabolic homeostasis between feeding and fasting in healthy conditions. However, this is dysregulated during high fat diet feeding. What are the transcriptomic changes required for rapid adaptation of the liver to respond to feeding and fasting and how is this altered in the development of metabolic disease? (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE151752 RNAseq of livers from WT mice or livers with Rbfox2 knockout fed CD with 30% (w/v) Fructose in the drinking water
Contributors : Santiago Vernia ; Yi-Fang Wang ; Helen A PatersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRbfox2 is required for maintaining hepatic metabolic homeostasis. Here we carry out RNAseq to of WT and aged matched litter mate Rbfox2 knockout mice under CD or HFD in order to determine changes in alternative splicing and mRNA expression caused by knockout of this splicing factor in the context of metabolic health and disease. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE151753 Characterization of the role of RBFOX2 in the liver
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere we investigate the role of the splicing factor RBFOX2 in the liver. Our work describes a new regulatory mechanism where RBFOX2 controls cholesterol level, by coordinating the inclusion/exclusion of alternatively spliced exons in the liver.This SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE157895 Transcriptomic and epigenetic analysis of iPSC-endothelial cells treated with statin
Contributors : Chun Liu ; Yu LiuSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn the present study we created and analyzed endothelial cells from two separate iPSC clones from the PBMCs of three different normal individuals using footprint-free Sendai virus, under highly coontroled differentiation and treatment (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE159727 Multiomic Evaluation of Metastasis Evolution, from Primary, CTC, to Metastatic Tumors
Contributors : Jia-Yang Chen ; Chun-Tsai Su ; Chien-Yi Tung ; Muh-Hwa Yang ; Ying-Chih ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetastasis is the most important cause of cancer-related death and it has been the most important issue both in basic and clinical cancer researches. Through in vivo spontaneous metastasis animal model, we successfully cultivated and expanded the metastasis lineage cells for genomic, methylomic, and transcriptomic analyses based on the high efficiency and excellent viability of a modified CTC-capturing system together with primary and metasta...
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE162616 Single-Cell Transcriptomic Atlas of Human Hepatic ILCs Reveals the Enrichment of ILC2 in Liver Cancer
Contributors : Huan Liu ; Rongrong Qin ; Qiang Huang ; Rui SunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere, we show the scRNA-seq-based analysis of 9 ILC samples sorted by flow cytometry, from blood, healthy livers, hepatocellular carcinoma (HCC) tumors, and HCC tumor-adjacent liver tissues.  Unbiased transcriptional clustering revealed seven distinct ILC subpopulations in healthy liver and six in liver cancer, among which there were two tissue-resident NK cell subpopulations (CXCR6+CD16+ and CXCR6+CD16-) in healthy liver but only one tissue-resident NK cell subpopulation...
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE174374 5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
Contributors : Yuexiu Zhang ; Li-Sheng Zhang ; Chuan He ; Jianrong LiSeries Type : OtherOrganism : Homo sapiensCytosine-5 methylation (m5C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA m5C methylation in innate immunity remains elusive. Here we show that depletion of NSUN2, an m5C methyltransferase, significantly inhibits the replication and gene expression of a wide range of RNA and DNA viruses. Notably, we found that this antiviral effect is largely driven by an enhanced type I interferon (IFN) respons...
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE179236 Transcriptomic signatures of the aging brain at single-cell resolution
Contributors : Kenneth L Chiou ; Michael J Montague ; Michael L Platt ; Jay Shendure ; Noah Snyder-MacklerSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaAging is a major risk factor for neurodegenerative diseases that impose tremendous burdens on people and societies today. To understand trajectories of neurological aging in a primate, we generated one of the most comprehensive brain transcriptional datasets to date in a unique population of naturalistic, behaviorally phenotyped rhesus macaques. In this experiment, we generated 71,863 single-nucleus RNA-seq transcriptomes from th...
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Macaca mulatta Source Type: research

GSE179328 Transcriptomic signatures of the aging brain at bulk-tissue resolution
Contributors : Kenneth L Chiou ; Alex R DeCasien ; Michael J Montague ; Michael L Platt ; Noah Snyder-MacklerSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaAging is a major risk factor for neurodegenerative diseases that impose tremendous burdens on people and societies today. To understand trajectories of neurological aging in a primate, we generated one of the most comprehensive brain transcriptional datasets to date in a unique population of naturalistic, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expressio...
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Macaca mulatta Source Type: research

GSE179330 Links to disease and the social environment in the aging brain transcriptome
Series Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Macaca mulatta Source Type: research