GSE233342 Single cell microarray analysis of mouse primordial germ cells with Prdm14 mutation.
Contributors : Kazuki Kurimoto ; Yukihiro Yabuta ; Mitinori SaitouSeries Type : Expression profiling by arrayOrganism : Mus musculusPrdm14 is a critical gene for specifying mouse primordial germ cells (PGCs). The changes in expression in mouse PGCs caused by mutations of the Prdm14 gene were investigated at the single-cell level using microarray analysis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
GSE233657 Robust Host Engineering: Enhancing Escherichia coli ´s Abiotic Stress Resistance through Ornithine Lipid Membrane Modification
Contributors : Leidy P Bedoya P érez ; Omar A Aguilar Vera ; José Utrilla Carreri ; Christian SohlenkampSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliTranscriptome analysis revealed that strains had differentially expressed stress and membrane-related genes compared to the control strain (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Escherichia coli Source Type: research
GSE234507 Effects of deletioin of cholesterol efflux genes Abca1 and Abcg1 on other gene expressions in macrophages
Contributors : Rajendra S Apte ; Mitsukuni YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusATP binding cassette subfamily member 1 (ABCA1) and G1 (ABCG1) are cholesterol efflux transporter to prevent excess intracellular cholesterol accumulation. We here report the deletion of Abca1 and Abcg1 results in the significant increased expression of Cd38, a multi-faceted ectoenzyme with NADase activity. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE234641 Effects of selective elimination of senescent cells on RPE/choroid complex in mice with subretinal drusenoid deposits
Contributors : Rajendra S Apte ; Mitsukuni YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe target deletion of ATP binding cassette subfamily member 1 (ABCA1) and G1 (ABCG1) in myeloid cells leads to subretinal drusenoid deposits in mice (Abca1/g1 -m/-m). We here report the selective elimination of p16-positive cells results in the significant eduction in myeloid markers, pro-inflammatory cytokines and prostaglandin biosynthetic enzymes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE235944 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [HiC]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : OtherOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critical role of spatio-temporal genome architectur...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE235946 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [RNA-seq]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critic...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE235947 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE236372 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [ChIP-seq]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we unco...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE236373 p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response [PCHiC]
Contributors : Fran çois Serra ; Andrea Nieto-Aliseda ; Llorenç Rovirosa ; Mónica Cabrera-Pasadas ; Lucía Fanlo ; Aleksey Lazarenkov ; Blanca Urmeneta ; Andrei L Okorokov ; Peter Fraser ; Jose L Sardina ; Alfonso Valencia ; Biola M JavierreSeries Type : OtherOrganism : Homo sapiensActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, using a multi-omics integration framework, we uncover the critical role of spatio-temporal genome architectur...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE237742 The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
Contributors : O Maksimenko ; N KlimenkoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterCTCF is the main architectural protein found in the majority of examined bilaterians. CTCFs of various organisms contain unstructured N-terminal dimerization domain (DD) along with clusters consisting of eleven zinc-finger domains of C2H2 type. The Drosophila (dCTCF) and human (hCTCF) CTCF share sequence homology only in five C2H2 domains that specifically bind to conserved 15 bp motif. By using CTCFattP(mCh) platform to introduce desired changes in the Drosophila CTCF ge...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Drosophila melanogaster Source Type: research
GSE237770 Coordination of histone chaperones for parental histone segregation and epigenetic inheritance
Contributors : Yimeng Fang ; Xu Hua ; Zhiguo Zhang ; Songtao JiaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Schizosaccharomyces pombeChromatin-based epigenetic memory relies on the accurate distribution of parental histone tetramers to newly replicated DNA strands, serving as templates for chromatin structure duplication. Mcm2, a subunit of the replicative helicase, and the Dpb3/4, subunits of polymerase epsilon, govern parental histone deposition to the lagging and leading strands, respectively. However, their contribution to epigenetic inheritance remains controversial. He...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Schizosaccharomyces pombe Source Type: research
GSE239464 Characterization of immortalized human lacrimal gland epithelial cells in 2D and 3D cell culture models
Contributors : Gleixner Sophie ; Arnold Philipp ; Blavet NicolasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn humans, the lacrimal gland produces the aqueous component of the tear film, which e.g. moistens and nourishes the ocular surface to maintain ophthalmic health.Decreased production of the aqueous component leads to the development of dry eye disease, which affects over 250 million people worldwide.Despite the impact on patients, the availability of primary human material to study underlying disease mechanisms is severely constrained.Here, we report the development of an...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239481 Defining Cis-regulatory Elements and Transcription Factors that Control Human Cortical Interneuron Development
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239889 VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusClear cell renal cell carcinoma (ccRCC) is an aggressive disease characterized by dysregulated hypoxia signaling, metabolic defects, and a complex tumor microenvironment (TME) highly enriched in lymphoid and myeloid immune cells. Loss of the oxygen sensing gene, von Hippel Lindau (VHL), is a critical early event in ccRCC pathogenesis and promotes stabilization of hypoxia inducible factors (HIF) that upregulate pro-growth signaling pathways, including angiogenesis and aerobic glycolysis. However, whether VHL loss in cancer ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE240627 SMARCA4 loss and mutated β-catenin induce proliferative lesions in the murine embryonic cerebellum
Contributors : Carolin G öbel ; Melanie Schoof ; Dörthe Holdhof ; Michael Spohn ; Ulrich SchüllerSeries Type : Methylation profiling by arrayOrganism : Mus musculusAlmost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) subgroup are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20 % of WNT MB but their functional role is mostly unknown. We therefore amended previously described Blbp-cre::Ctnnb1(ex3)fl/wt mice by the introduction of a floxed Smarca4 allele. In co...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by array Mus musculus Source Type: research
