GSE218418 Sox17-Erg cardiac iEC reprogramming
Series Type : Expression profiling by high throughput sequencing ; OtherOrganism :Bioinformatic Analyses of Sox17-Erg reprogramming (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Source Type: research

GSE222062 Genome-wide chromatin conformation capture (Hi-C) of primary murine nephron progenitor cells
Contributors : Alison Perl ; Yaping Liu ; Raphael KopanSeries Type : OtherOrganism :This series contains Hi-C data generated from postnatal day 0 mouse nephron progenitor cells (NPCs) isolated from three different genotypes representing control, low and high nephron number mouse lines. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Other Source Type: research

GSE222208 Oncostatin M signaling drives cancer-associated skeletal muscle wasting
Contributors : Serkan Kir ; Aylin Domaniku ; Samet Agca ; Batu Toledo ; Aynur Kashgari ; Sevval N BilgicSeries Type : Expression profiling by high throughput sequencingOrganism :Investigating muscle wasting in a murine model of cancer cachexia, we identified Oncostatin M (OSM) as a potential mediator of inflammatory responses in skeletal muscle. OSM is a member of the IL-6 family of cytokines and has crucial functions in cell growth, differentiation, and inflammation. Our results demonstrate that OSM induces muscle atrophy. To understand if its effect is specific or it is a general effect of IL6 family cytokines, prim...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE224324 Genome-wide chromatin accessibility (ATAC-Seq) of primary murine nephron progenitor cells.
Contributors : Alison Perl ; Praneet Chaturvedi ; Raphael KopanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism :This series contains ATAC-Seq data generated from mouse nephron progenitor cells (NPCs) isolated from different strains/mutants and developmental timepoints as indicated. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Source Type: research

GSE227869 Transcriptomic profile of Lin negative, LEPR positive cells of murine peri-implant fibrous tissue and peri-implant bone
Contributors : Suhardi Vincentius ; Oliver David ; Chinenov YuriiSeries Type : Expression profiling by high throughput sequencingOrganism :To investigate the transcriptomic profile difference between LEPR cells in peri-implant fibrous tissue and peri-implant bone (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE228194 ALK upregulates POSTN and WNT signaling to drive neuroblastoma
Contributors : Miller Huang ; Alvin Farrel ; John M Maris ; William A WeissSeries Type : Expression profiling by high throughput sequencingOrganism :The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE229022 Single nuclei gene expression profile for adult C. elegans and several longevity mutants
We presents a complete single-cell atlas of aging worms, encompassing both somatic and germ cell types. This atlas was built upon 178K nuclei across the worm lifespan at day 1, 6, 12, and 14 (100%, 99%, 61%, and 14% survival rates, respectively). The worms were aged under normal physiological conditions, without interfering with their reproductive processes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE230547 LSD1 in skeletal muscle
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism :This SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Source Type: research

GSE231791 Unraveling the Transcriptome Profile of Pulsed Electromagnetic Field (PEMF) Stimulation in Bone Regeneration Using an In Vitro Investigation Platform Based on a Perfusion Bioreactor and 3D Printed Bone Tissue-Like Scaffolds
Contributors : Farah Daou ; Francesco Favero ; Andrea Cochis ; Lia RimondiniSeries Type : Expression profiling by high throughput sequencingOrganism :A global transcriptome profiling was performed by RNA-seq on human BM-MSCs exposed to biomechanical stimulation (perfusion) and biophysical stimulation (PEMF stimualtion) and the set of pathways and upstream regulators were detected using bioinformtic tools to determine how biophysical stimulation induce biological effects. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE237506 Expression profile of shMCT-1 in 4T1 metastatic murine triple-negative breast cancer (TNBC) cell lines in response to anti-IL6R immunotherapy
Contributor : Hsin-Ling HsuSeries Type : Expression profiling by high throughput sequencingOrganism :Malignant T-cell amplified sequence (MCT-1 or MCTS1) is an oncoprotein that regulates translation re-initiation, ribosomal recycling, and tumorigenicity. Given that MCT-1 amplifies interleukin-6 (IL-6) trans-signaling by elevating interaction between interleukin-6 receptor (IL-6R) and glycoprotein 130 (gp130), we aimed to dissect whether targeting IL-6R alters transcriptional profile of TNBC cells with different MCT-1 background. Through RNA-seq, we have characterized that anti-IL6R immunotherapy suppressed genes involved ...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE247880 DNA methylation alterations across time and space in paediatric brain tumours
Contributors : Anna Wenger ; Sandra Ferreyra Vega ; Helena Car énSeries Type : Methylation profiling by genome tiling arrayOrganism :DNA methylation is increasingly used for tumour classification and has expanded upon the> 100 currently known brain tumour entities. A correct diagnosis is the basis for suitable treatment for patients with brain tumours, which is the leading cause of cancer-related death in children. DNA methylation profiling is required for diagnosis of certain tumours, and used clinically for paediatric brain tumours in several countries. We therefore evaluated if the methylation-based classification i...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Source Type: research

GSE248215 A complex pattern of gene expression in tissue affected by viperid snake envenoming: the emerging role of autophagy-related genes
Contributors : Ana Karina de Oliveira ; Alexandra Rucavado ; Teresa Escalante ; Jos é M Gutiérrez ; Jay W FoxSeries Type : Expression profiling by arrayOrganism :Cellular and inflammatory events were evaluated in mouse muscle after snake venoms Daboia russelii and Bothrops asper injection over time. A murine model of muscle necrosis based on venom injection was used to investigate up to 800 genes involved in fibrosis diseases and tissue regeneration using the multiplex RNA panel Fibrosis V2 from NanoString technology. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research

GSE249431 Neopetrotaurines A-C, Isoquinoline Alkaloids with an Unprecedented Taurine-Bridged Isoquinoline Quinone Moiety from the Sponge Neopetrosia sp.
Contributors : Yong Y Kim ; Javed Khan ; Dongdong Wang ; Kirk R GustafsonSeries Type : Expression profiling by high throughput sequencingOrganism :Neopetrotaurines A-C, isoquinoline quinone-linked isoquinoline alkaloids that possess a unique taurine bridge connecting the two bicyclic components, were isolated from a Neopetrosia sp. marine sponge. These new compounds have proton-deficient scaffolds, so their structure elucidation was facilitated by utilizing LR-HSQMBC and HMBC NMR experiments optimized to detect 4- and 5-bond long-range 1H-13C heteronuclear correlations. Neopetrotaurines A-C showed potent inhibition of tr...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE252397 Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Contributors : Ruf Wolfram ; Posma Jens ; Nguyen T SonSeries Type : Expression profiling by high throughput sequencingOrganism :Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia. Here we show that specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) prevents the the development of persistent aPL and circulating phospholipid-reactive B1 cells in latent viral infection and lupus prone MRL-lpr mice. NGS mRNA profiling of splenic DC in lupus mice treated with NAPc2 versus saline control...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

GSE252498 Disease-associated astrocyte epigenetic memory promotes CNS pathology [RNA-Seq of p300 KD, ACLY KD and scramble NOD-EAE mice]
Contributors : Hong-Gyun Lee ; Zhaorong Li ; Francisco J QuintanaSeries Type : Expression profiling by high throughput sequencingOrganism :Gene profiling of scramble, ACLY, and p300 KD astrocytes during NOD-EAE in B6 mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research