GSE249783 Characterization of age-associated gene expression changes in mouse sweat glands [FP_YO]
Contributors : Alexandra Zonnefeld ; Chang-Yi Cui ; Dimitrios Tsitsipatis ; Yulan Piao ; Jinshui Fan ; Krystyna Mazan-Mamczarz ; Yutong Xue ; Fred E Indig ; Supriyo De ; Myriam GorospeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEvaporation of sweat on the skin surface is the major mechanism for dissipating heat in humans. The secretory capacity of sweat glands (SWGs) declines during aging, leading to heat intolerance in the elderly, but the mechanisms responsible for this decline remain incompletely understood. We investigated the molecular changes accompanying SWG agin...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE249784 Characterization of age-associated gene expression changes in mouse sweat glands
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE250224 Senescent Characteristics of Human Corneal Endothelial Cells upon Ultraviolet-A Exposure
Conclusion: In this study, where senescence was induced by UV-A, a more physiological stress for hCEnCs compared to IR, we determined that UV-A modulated the expression of many genes and proteins typically altered upon IR treatment, a more conventional method of senescence induction, even though UV- A also modulated specific pathways unrelated to IR. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE252175 Multi-Omics molecular subtyping based on commensal microbiome predicts molecular characteristics and therapeutic response in Triple-Negative Breast Cancer [scRNA-seq]
Contributors : Feng Qi ; Jia Li ; Na Gao ; Wenxing QinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe thoroughly analyzed the molecular subtyping of Triple-Negative Breast Cancer and its different manifestations, and located T cells and Tumor cells related to the survival of breast cancer through single cell sequencing and space transcriptome according to our score, and finally investigated their relationship with the therapeutic efficacy, providing a scientific basis for the treatment of triple negative breast cancer. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE252176 Multi-Omics molecular subtyping based on commensal microbiome predicts molecular characteristics and therapeutic response in Triple-Negative Breast Cancer [Spatial Transcriptome seq]
Contributors : Feng Qi ; Jia Li ; Na Gao ; Wenxing QinSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe thoroughly analyzed the molecular subtyping of Triple-Negative Breast Cancer and its different manifestations, and located T cells and Tumor cells related to the survival of breast cancer through single cell sequencing and space transcriptome according to our score, and finally investigated their relationship with the therapeutic efficacy, providing a scientific basis for the treatment of triple negative breast cancer. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE252651 Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response [CRISPR]
Contributors : Tekle Pauzaite ; Niek Wit ; Rachel Seear ; James A NathanSeries Type : OtherOrganism : Homo sapiensThe ubiquitination and proteasome-mediated degradation of Hypoxia Inducible Factors (HIFs) is central to metazoan oxygen-sensing, but the involvement of deubiquitinating enzymes (DUBs) in HIF signalling is less clear. Here, using a bespoke DUBs sgRNA library we conduct CRISPR/Cas9 mutagenesis screens to determine how DUBs are involved in HIF signalling. Alongside defining DUBs involved in HIF activation or suppression, we identify USP43 as a DUB required for efficient activation of a HIF response. USP43 is h...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE252654 Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response [RNA-seq]
Contributors : Tekle Pauzaite ; Niek Wit ; Rachel Seear ; James A NathanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ubiquitination and proteasome-mediated degradation of Hypoxia Inducible Factors (HIFs) is central to metazoan oxygen-sensing, but the involvement of deubiquitinating enzymes (DUBs) in HIF signalling is less clear. Here, using a bespoke DUBs sgRNA library we conduct CRISPR/Cas9 mutagenesis screens to determine how DUBs are involved in HIF signalling. Alongside defining DUBs involved in HIF activation or suppression, we identify USP43 as a DUB required for effic...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE252655 Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response
Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE254010 Reproduction-associated pathways in females of gibel carp (Carassius gibelio) shed light on the molecular mechanisms of the coexistence of asexual and sexual reproduction
Contributors : Florian Jacques ; Tom áš Tichopád ; Martin Demko ; Vojtěch Bystrý ; Kristína Civáňová Křížová ; Mária Seifertová ; Kristýna Voříšková ; Md Mehedi Hasan Fuad ; Lukáš Vetešník ; Andrea ŠimkováSeries Type : Expression profiling by high throughput sequencingOrganism : Carassius auratus ; Carassius gibelio ; Cyprinus carpioGibel carp (Carassius gibelio) is a cyprinid fish that originated in eastern Eurasia and is considered as invasive in European freshwater ecosystems. The populations of gibel carp in Europe are mostly composed of asexually reproducing triploid females (i.e., ...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Carassius auratus Carassius gibelio Cyprinus carpio Source Type: research

GSE254302 Single-cell transcriptomic analysis of decidual immune cell landscape in the occurrence of adverse pregnancy outcomes induced by Toxoplasma gondii infection
In this study, we employed single-cell RNA sequencing to analyze the changes in human decidual immune cells following T. gondii infection. Our results showed that the proportion of 17 decidual immune cell clusters and the expressi on levels of 21 genes were changed after T. gondii infection. Differential gene analysis demonstrated that T. gondii infection induced the differential expression of 279, 312, and 380 genes in decidual NK, dMφ, and dT cells, respectively. Our findings first revealed that several previously unknown molecules in decidual immune cells changed following T. gondii infection. This result revealed that...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE255738 Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection
Contributors : Bigley Tarin ; Andrei Belean ; Michael Paley ; Elisha RobersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections as well as the temporal dissociation between acute infection and autoimmune disease onset have made establishing a causal association challenging. We have shown that murine roseolovirus (MRV), which is highly related to human roseoloviruses, induces thymic atrophy and disruption of central tolerance after neonatal infecti...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE255830 Gene expression and T cell repertoire profile at single cell level of peripheral blood T cells after treatment with a personalized neoantigen vaccine (GNOS-PV02) and Pembrolizumab for advanced hepatocellular carcinoma.
Contributors : Daniel Shu ; Renzo PeralesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTo further characterize the T cell response to the neoantigen vaccine, we performed single-cell RNA and T cell receptor (scRNA/TCR-seq) of peripheral blood T cells at the 12-week post-vaccination time point. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE256184 Transciptomic changes in Mycobacterium tuberculosis (Mtb) infected hepatocytes at early and late time points of infection
Contributors : Rajesh S Gokhale ; Debasisa Mohanty ; Vinay K Nandicoori ; Binayak Sarkar ; Jyotsna SinghSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMycobacterium tuberculosis (Mtb), although primarily a pulmonary pathogen, can disseminate to various other organs of the body causing extra pulmonary tuberculosis (EPTB). In the present study, we have shown that hepatocytes, the major parenchyma cells of the liver, get robustly infected by Mtb. Using a combination of in-vitro, ex-vivo and animal models; we demonstrate that Mtb utilizes hepatocytes as a replicative niche, modulates ...
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE259273 Therapeutic targeting ERR γ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE260627 Compare transcriptome profile of reference strain and mutant of HapX during A.niger grown on maltose
Contributors : Joanna E Kowalczyk ; Mao Peng ; Ronald P de VriesSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus nigerTranscriptome analysis was performed to identify the differentially expressed genes between hapX mutant and reference strains during their growth on maltose (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Aspergillus niger Source Type: research