GSE243973 Circulating monocyte counts coupled with a 4-gene signature at leukapheresis predict survival of lymphoma patients treated with CAR T
Contributors : Cristiana Carniti ; Nicole Caldarelli ; Luca Agnelli ; Tommaso Torelli ; Silva Ljevar ; Sadhana Jonnalagadda ; Giada Zanirato ; Eugenio Fardella ; Daniele Lorenzini ; Silvia Brich ; Anna Dodero ; Annalisa Chiappella ; Martina Magni ; Paolo CorradiniSeries Type : Expression profiling by arrayOrganism : Homo sapiensCD19-directed chimeric antigen receptor (CAR) T cells can induce durable remissions in relapsed/refractory large B-cell lymphomas (R/R LBCL), but 60% of patients still relapse. Biological mechanisms explaining lack of disease-response are largely unknown. To identify mechanisms of res...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE244205 TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
Contributors : Lingzhen Kong ; Shan Li ; Chen Cheng ; Abigael Cheruiyot ; Jiayi Yuan ; Yichan Yang ; Sydney Hwang ; Daniel Foust ; Ning Tsao ; Emily Wilkerson ; Nima Mosammaparast ; M B Major ; David W Piston ; Zhongsheng YouSeries Type : OtherOrganism : Homo sapiensThe protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered after the generation of cytosolic DNA and the activation of cGAS/STING. The resulting CaMKK2/AMPK activati...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE244359 Skeletal muscle methylation signatures of obese high- and low- responders to endurance exercise training
Contributors : Annette Sch ürmann ; Cora Weigert ; Andreas Birkenfeld ; Andreas Peter ; Martin Hrabe de Angelis ; Johannes Beckers ; Markus Jähnert ; Martin Irmler ; Meriem Ouni ; Thomas Goj ; Leona KovacSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe participants performed 8 weeks of superised aerobic endurance exercise. Skeletal muscle biopsise were taken at rest before and after intervention and matched analysis was performed. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research
GSE245180 Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture
Contributors : Elisabeth M van der Heijden ; Lucas Lefevre ; Anton Gossner ; Thomas Tzelos ; Tim Connelley ; Musa A HassanSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurus ; Theileria parvaAdministration of attenuated autologous Theileria parva infected cells can be used as an alternative to the infection-and-treatment method for inducing immunological protection against East Coast Fever. The mechanism of attenuation however has not been described. Using RNA sequencing, the transcriptomes of both host and parasite in uninfected (control), pathogenic (day 7 post-infection) and attenua...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bos taurus Theileria parva Source Type: research
GSE245436 The efficacy of LCMV-based cancer vaccines is unleashed by intratumoral injections of polyI:C
Conclusion Intratumoral injection of poly(I:C) sensitizes MHClow tumors to the anti-tumor effects of artLCMV-E7E6, resulting in a potent therapeutic synergy (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE245886 Analyses of lncRNA and mRNA profiles in the recurrent atrial fibrillation after Catheter Ablation
Contributors : Xiaomeng Chen ; Huaiguang TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur study aims to elucidate the role of lncRNA-mRNA regulatory networks in AF recurrence after catheter ablation. We performed RNA sequencing to profile the transcriptomes of 5 samples from atrial fibrillation recurrence and 5 samples from sinus rhythm maintenance. 96 differentially expressed genes (DEGs) and 203 differentially expressed long non-coding RNAs (DE-lncRNAs) were identified between atrial fibrillation recurrence group and sinus rhythm maintenance group. Gene Ontology (GO) analys...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246152 GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
In this study, which used patient-derived xenografts and paired cell lines of epithelioid hemangioendothelioma (EHE), it was found that EHE cells produce and release GDF-15. Furthermore, the mTOR inhibitor sirolimus was observed to inhibit GDF-15 expression and release by down-regulating ATF4 and ATF5 transcription factors. To assess the clinical relevance of GDF-15 in EHE, which can manifest as both relatively indolent and exceptionally aggressive forms, circulating GDF-15 levels were assessed in two independent cohorts of EHE patients, one retrospective and one prospective. The results provided evidence of an association...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246235 GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
In this study, which used patient-derived xenografts and paired cell lines of epithelioid hemangioendothelioma (EHE), it was found that EHE cells produce and release GDF-15. Furthermore, the mTOR inhibitor sirolimus was observed to inhibit GDF-15 expression and release by down-regulating ATF4 and ATF5 transcription factors. To assess the clinical relevance of GDF-15 in EHE, which can manifest as both relatively indolent and exceptionally aggressive forms, circulating GDF-15 levels were assessed in two independent cohorts of EHE patients, one retrospective and one prospective. The results provided evidence of an association...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246610 Conditionally Replicative Adenovirus as a Therapy for Malignant Peripheral Nerve Sheath Tumors
CONCLUSIONS: CRAds demonstrate selective binding and efficient replication in MPNST cells, leading to tumor cell lysis while sparing non-cancerous cells. These results suggest that oncolytic adenoviruses may have the potential as novel agents for MPNST therapy and thus warrant further investigation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
GSE246633 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [ATAC-seq]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcr...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246634 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [CUT & RUN]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcr...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246638 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [GRO-seq]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcription...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE246640 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [MeD-seq]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcriptional land...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246641 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [RAP-seq]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcr...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE246642 XIST dampens X chromosome activity in a SPEN-dependent manner during early human development [RNA-seq]
Contributors : Claire Rougeulle ; Charbel AlfeghalySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensXIST long non-coding RNA is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female pre-implantation embryos without triggering X chromosome silencing. The long non-coding RNA XACT co-accumulates with XIST on active Xs and may antagonize XIST function. Here we used human ES cells in a na ïve state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcriptional lands...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
