GSE203535 Dual SMAD inhibition enhances the longevity of human epididymis epithelial cells
Contributors : Giuliana Castello Coatti ; Shih-Hsing Leir ; Alekh Paranjapye ; Ann HarrisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPrimary human epididymis epithelial (HEE) cells are valuable reagents for functional studies on the human epididymis. We used them previously to determine the transcriptional networks that establish cell identity along the length of the epididymis from caput, corpus and cauda. These studies on HEE cells and organoids derived from them revealed important cellular properties. However, similar to other primary cells, HEE cells undergo replicative se...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE219230 Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Contributors : Edurne S Jos é-Enériz ; Naroa Gimenez-Camino ; Obdulia Rabal ; Leire Garate ; Estibaliz Miranda ; Fernando García ; Elena Sáez ; Amaia Vilas-Zornoza ; Patxi S Martín-Uriz ; Luis V Valcárcel ; Esteban Tamariz-Amador ; Nicolás Martinez-Calle ; María J Larrayoz ; María J Calasanz ; Javier Muñoz ; José I Martín-Subero ; Antonio Pineda-Lucena ; Julen Oyarzabal ; Xabier Agirre ; Felipe PrósperSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite the development of novel therapies for acute myeloid leukemia (AML), outcomes remain poor for most pati...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE225805 Choline intake in pregnancy and lactation modifies liver transcriptome profile in the offspring of female rats with nonalcoholic fatty liver disease
Contributors : Joanna Miko łajczyk-Stecyna ; Ewelina Żuk ; Agata Chmurzynska ; Małgorzata Blatkiewicz ; Karol Jopek ; Marcin RucinskiSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusThe aim of the study was to analyze the impact of choline intake during pregnancy and/or lactation on histological alternation and gene expression profile in the liver of NAFLD dam progeny. We hypothesized that offspring of mothers suffering from non-alcoholic fatty liver (NAFLD) is more prone to develop fatty liver, because of suboptimal intrauterine environment. The performed analyses included histological exam...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

GSE228041 RNAseq and WGBS of Vaccinium corymbosum
Contributors : Zejia Wang ; Qikun LiuSeries Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Vaccinium corymbosum ; Vaccinium darrowiiWe did whole-genome methylation sequencing for 21 Vaccinium samples. This project attempts to analyze the improvement breeding process of cultivated blueberry from two aspects of heredity and epigenetic inheritance. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Expression profiling by high throughput sequencing Vaccinium corymbosum Vaccinium darrowii Source Type: research

GSE230157 Targeting of lncRNA Morrbid inhibits abdominal aortic aneurysm by regulating macrophage-mediated vascular inflammation.
Contributors : Caiyun He ; Fan YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the possible target gene of morrbid, we detected the mRNA expression in bone marrow derived macrophages(BMDMs) with deletion of Morrbid by RNA-seq. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE232678 Gene expression profiling of RKO cells with or without SQLE knockdown.
Contributors : Xinxiang Li ; Qi LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRKO cells (WT or SQLE knockdown) were harvested and mRNA were extracted for high-throughput sequencing. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE232829 Mina53 regulates the neural stem cell pool by acting as an argnine demethlysae
Contributors : Jie Sun ; Wen YiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the function Mina53 in the regulation of neural stem cells proliferation and differentiation, we collect neural stem cells which Mina53 has been knocked down by shRNA. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE233332 Risk assessment of parabens in a transcriptomics-based in vitro system
In conclusion, cytotoxicity and gene expression alterations of ethylparaben occurred at concentrations of approximately three orders of magnitude above human blood concentrations; moreover, the substance fitted wel l into a scenario where toxicity increases with the alkyl chain length, and gene expression changes only occur at cytotoxic or close to cytotoxic concentrations. Therefore, no evidence was obtained suggesting that in vivo DART with ethylparaben would lead to different results as the methyl- or propy l derivates. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE235101 Transcriptional control of central T cell tolerance by NR4A family transcription factors
Contributors : Christopher D Scharer ; Julie Zikherman ; James L Mueller ; Hailyn V NielsenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe diverse T cell receptor (TCR) repertoire – generated randomly through VDJ recombination early in development – is inherently self-reactive. Clonal deletion and diversion to regulatory T cell (Treg) fate are key central tolerance mechanisms engaged during thymic selection. The NR4A family of transcription factors has been implicated in both, but the extent of its contribution to clonal deletion and the transcriptional mechanisms at play rem...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE237070 Single-cell RNA sequencing of human various osteosarcoma tissues
Contributors : Yun Liu ; Mingwei He ; Wenyu Feng ; Tianyu Xie ; Haijun Tang ; Qingjun WeiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensWe performed the scRNA-seq analysis of 2 primary osteosarcoma tissues ,2 osteosarcoma lymphoid tissues, 4 adjacent tissues of osteosarcoma based on the 10X Genomics platform. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE238212 Diurnal gene expression profiles in mouse brain tissues constituting the central dopamine system
We examined diurnal gene expression profiles across key brain areas constituting the central DA pathways in mice by use of microarray analyses to identify rhythmically expressed genes according to the time of day (TOD). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE241385 CSF single cell transcriptomic changes associated with post-acute sequelae of SARS CoV 2 infection
Contributors : William Hu ; Milota Kaluzova ; Alice Dawson ; Victor Sotelo ; Julia Papas ; Alexander Lemenze ; Carol Shu ; Mini Jomartin ; Ashima Nayyar ; Sabiha HussainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNatural history and mechanisms for persistent cognitive symptoms (also known as “brain fog”) following acute and often mild COVID-19 are unknown. In a large prospective cohort of people who recovered from acute COVID-19 in the New York City/New Jersey area, we found the presence of cognitive dysfunction to closely associate with fatigue symptoms and, in som...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE242238 Mina53 regulates the neural stem cell pool by acting as an arginine demethylase
Contributors : Jie Sun ; Wen YiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo investigate the function Mina53 in the regulation of neural stem cells proliferation and differentiation, we collect neural stem cells which Mina53 has been knocked down by shRNA. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE242312 A systematic screen identifies Saf5 as a link between splicing and transcription in fission yeast
Contributors : Borao Sonia ; Vega Montserrat ; Boronat Susanna ; Hidalgo Elena ; Hummer Stefan ; Ayte JoseSeries Type : Expression profiling by high throughput sequencingOrganism : Schizosaccharomyces pombeSplicing is an important step of gene expression regulation in eukaryotes, as there are many mRNA precursors that can be alternatively spliced in different tissues, at different cell cycle phases or under different external stimuli. We have developed several life constructs that allow the quantification of fission yeast splicing in vivo on intact cells, and we have compared their splicing efficiency in a wild type ...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Schizosaccharomyces pombe Source Type: research

GSE246242 Immediate myeloid depot for SARS-CoV-2 in the human lung
Contributors : M élia Magnen ; Ran You ; Arjun A Rao ; Ryan T Davis ; Lauren Rodriguez ; Olivier Bernard ; Camille R Simoneau ; Lisiena Hysenaj ; Kenneth H Hu ; Mazharul Maishan ; Catharina Conrad ; Oghenekevwe M Gbenedio ; Christina Love ; Prescott G Woodruff ; David J Erle ; Carolyn M Hendrickson ; Caroly n S Calfee ; Michael A Matthay ; Jeroen P Roose ; Anita Sil ; Melanie Ott ; Charles R Langelier ; Matthew F Krummel ; Mark R LooneySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic1, considerable ...
Source: GEO: Gene Expression Omnibus - May 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research