GSE115567 mRNA Expression Data from Murine Hearts of Wild type (WT) C57Bl/6 mice housed under a 12h light: 12h dark or 12h light: 4h blue: 8h dark cycle for 4 weeks
Contributor : Tami A MartinoSeries Type : Expression profiling by arrayOrganism : Mus musculusMice are on a C57Bl/6N background strain, hearts were collected at ZT07, following 4 weeks under a 12h light: 12h dark (LD) or 12h light: 4h blue: 8h dark (LBD) cycle.The microarray approach allows the investigation of gene expression changes of all genes in WT LD vs. WT LBD hearts. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE115568 mRNA expression data from murine myocardial ischemia/reperfusion (mI/R) hearts following sleeptime or waketime captopril chronotherapy
Contributor : Tami A MartinoSeries Type : Expression profiling by arrayOrganism : Mus musculusMice are 14 days post-mI/R (10 weeks old) on a C57Bl/6N background strain, hearts were collected at ZT15, following administration of saline placebo, sleeptime captopril (ZT01), or waketime captopril (ZT11) I.P. from day 7-14 post-mI/R.The microarray approach allows the investigation of gene expression changes of all genes in placebo vs. sleeptime vs. waketime vs. sham hearts. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE115569 mRNA expression data from murine hearts of control or melatonin-treated young wild type (WT) C57Bl/6 mice
Contributor : Tami A MartinoSeries Type : Expression profiling by arrayOrganism : Mus musculusMice are 4 weeks old on a C57Bl/6N background strain, hearts were collected at ZT15, following 1 week daily administration of melatonin at 4mg/L (human equivalent of 5mg dose) in the drinking water from ZT12-15.The microarray approach allows the investigation of gene expression changes of all genes in WT control vs. WT melatonin-treated hearts. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE115570 RNA sequencing of Cryptococcus neoformans H99 treated with eltrombopag
Contributors : Hao-Tai Ko ; Ying-Lien ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans var. grubii H99The gene expression of C. neoformans H99 treated with eltrombopag (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cryptococcus neoformans var. grubii H99 Source Type: research

GSE115579 RNA-Seq analysis of hearts from NBCe1 Na-HCO3 cotransporter cardiac conditional knockout (K) vs wild-type (W) mice
Contributors : K Vairamani ; V Prasad ; Y Wang ; W Huang ; Y Chen ; M Medvedovic ; J N Lorenz ; G E ShullSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe purpose of this study was to investigate the hypothesis that cardiomyocyte-specific loss of the electrogenic NBCe1 Na+-HCO3- cotransporter is cardioprotective during in vivo ischemia-reperfusion (IR) injury. An NBCe1 (Slc4a4 gene) cardiac conditional knockout mouse (KO) model was prepared by gene targeting. Cardiovascular performance of wild-type (WT) and cardiac-specific NBCe1 KO mice was analyzed by intraventricular pressure mea...
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115581 miRNAs expression patterns during mouse retina development
Contributor : YISHEN WANGSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; Mus musculus ; Rattus norvegicusThe goal of this study was to gain a detailed postnatal expression pattern of miRNAs involving time points and to identify miRNAs essential for retinal development in the mouse. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Mus musculus Rattus norvegicus Source Type: research

GSE115590 Gene expression after HOS cells treated with DGKZ (diacylglycerol kinase zeta)-silencing by a microarray profiling (Affymetrix)
Series Type : Expression profiling by arrayOrganism : Homo sapiensDGKZ could promote proliferation and inhibit apoptosis in osteosarcoma,both in vivo and in vitro.To identify downstream molecular mechanism of DGKZ in proliferation of osteosarcoma, we performed a microarray profiling (Affymetrix) in human HOS cells treated with DGKZ knockdown. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE115594 ML29755 RNA-seq data
Contributors : Frederike Bensch ; Elly L van der Veen ; Marjolijn N Lub-de Hooge ; Annelies Jorritsma-Smit ; Ronald Boellaard ; Iris C Kok ; Sjoukje F Oosting ; Carolina P Schr öder ; T N Hiltermann ; Anthonie J van der Wekken ; Harry M Groen ; Thomas C Kwee ; Sjoerd G Elias ; Jourik A Gietema ; Sandra Sanabria Bohorquez ; Alex de Crespigny ; Simon-Peter Williams ; Christoph Mancao ; Adrienne H Brouwers ; Bernard M Fine ; Elisabeth E de VriesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProgrammed death-ligand 1 (PD-L1) expression has been associated with response to PD-1/PD-L1...
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115607 ChIP-Seq analysis of estrogen deprived MCF7 cells treated with H3B-5942 and standards of care compounds
Contributors : Craig Furman ; Zhenhua J WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this experiment was to interrogate the potential transcriptional impact of H3B-5942 by investigating its influence on genome-wide DNA-binding modes of ERa in MCF7 cells using chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-Seq). Affects of H3B-5942 on chromatin recruitment were compared to results from treatment with E2, 4-OHT, and fulvestrant. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115608 Transcriptional profiling of Ishikawa cells treated with H3B-5942, E2, or standard of care compounds
The objective of this experiment was to determine the affect of H3B-5942 treatment on global gene expression in an estrogen-deprived setting (agonist mode) and to compare to treatment with a saturated analog of H3B-5942, GDC-0810, and standard of care agents tamoxifen and fulvestrant. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115609 Transcriptional profiling of MCF7 cells treated with H3B05942, E2, or standard of care compounds
The objective of this experiment was to compare the affect of H3B-5942 treatment on global gene expression and to compare to treatment with standard of care agents tamoxifen and fulvestrant. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115611 Discovery of Selective Estrogen Receptor Covalent Antagonists (SERCAs) for the treatment of ERa(WT) and ERa(MUT) breast cancer.
Series Type : Expression profiling by array ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115618 Comparison of global gene expression in homeostatic and regenerating endothelium of the adult mouse aorta
We report the global transcript levels in an endothelial-enriched cell fraction from homeostatic and regenerating mouse aorta. These data provide insight into the molecular regulation of endothelial lining regenerating inside a large artery. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115627 E14.5-born neurons at P3 repress L4 neuron-type and induce L2/3 neuron-type genes upon Kir2.1 in utero electroporation
Contributors : V Ilaria ; T LudovicSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExperimental in vivo hyperpolarization of E14.5 apical progenitors shifted their transcriptional programs with precocious generation of intermediate progenitors, and a forward shift in the laminar, molecular, morphological and circuit features of their neuronal progeny. In particular, we reported an overall repression of L4-type neuronal genes and a premature induction of L2/3-type neuronal genes following Kir2.1 overexpression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115628 Single Cell sequencing of E14.5, E15.5 and E14.5 Kir electroporated cortical neurons.
Contributors : V Ilaria ; T LudovicSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExperimental in vivo hyperpolarization of E14.5 apical progenitors shifted their transcriptional programs with precocious generation of intermediate progenitors, and a forward shift in the laminar, molecular, morphological and circuit features of their neuronal progeny. In particular, we reported an overall repression of L4-type neuronal genes and a premature induction of L2/3-type neuronal genes following Kir2.1 overexpression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115640 Tbx5 paralogues during zebrafish development
Conclusions: This study is a detailed analysis of the different transcriptomes of zebrafish deficient in the Tbx5 paralogues and the differential gene expression that occurs as a result of downregulation of the paralogues, both individually and separately. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research

GSE115643 EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
Contributors : Adam Stevens ; Stefan MyerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and solid tumors. To investigate to what extent EVI1 function might be regulated by posttranslational modifications, we carried out mass spectrometry- and antibody-based analyses and uncovered an ATM-mediated double phosphorylation of EVI1 at the carboxy-terminal S858/...
Source: GEO: Gene Expression Omnibus - June 12, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115548 Dual bioaugmentation with Desulfitobacterium hafniense Y51 and redox-trained fermenting communities for decontamination of PCE polluted river sediment: a microcosm study
Contributors : Ye Tian ; Raquel Vargas-L ópezSeries Type : Expression profiling by arrayOrganism : Desulfitobacterium hafniense ; Desulfitobacterium hafniense Y51The physiology of D. hafniense strain Y51 under close to natural conditions were examined: D. hafniense Y51 was subjected to a variety of limiting conditions (carbon or electron acceptor) or ammonium deprivation, in chemostat. Its physiology was assessed by transcriptomic and proteomic analyses and compared to that in batch culture. Electron donor/acceptor-limited growth conditions cause a switch to alternative metabolic pathways allowing the organism with ...
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Desulfitobacterium hafniense Desulfitobacterium hafniense Y51 Source Type: research

GSE104759 RNA-sequencing of human mammary epithelial cells (HMLEs) transduced in vitro with a shRNA against SOX4 or a scrambled shRNA in untreated and TGF- β-treated (16 hours) conditions
Contributors : S Vervoort ; A R Louren ço ; P J CofferSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to identify SOX4- and TGF-beta dependent genes, human mammary epithelial cells (HMLEs) were transduced with shRNA scrambled (control) or shRNA targeting SOX4 (TRCN0000018213, Sigma Aldrich, St. Louis, MS) and selected with puromycin for at least 2 weeks. SOX4 knockdown was confirmed by qRTPCR and western blotting. Cells were plated in 6 well plates and either left untreated or treated with TGF-beta (2.5ng/ml) for 16 hours in biological duplicate (different passages). S...
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE104760 SMAD3 and SOX4 binding profiling in human breast cell lines
Contributors : S Vervoort ; A R Louren ço ; P J CofferSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn order to identify genes co-bound by SOX4 and SMAD3 in the context of breast cancer, different breast cell lines (HMLEs, MDA-MB-231 or HCC-1954) were used. Due to low endogenous expression levels for SOX4 in HMLEs in untreated conditions, doxycycline-dependent SOX4 overexpression was obtained by transducing HMLE cells with pIINDUCER21-SOX4 vector..Cells were plated and SOX4 and SMAD3 chromatine-immunoprecipitation was performed in untreated conditions, TGF-beta ...
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE104761 The interplay between SOX4 and SMAD3 in the context of breast cancer
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE114814 Next Generation Sequencing for Quantitative Transcriptomic Profiling of TLR7 deficiency in Neurons
Contributors : Yun-Fen Hung ; Chiung-Ya Chen ; Yi-Ping HsuehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to compare gene expression of mouse cultured cortical and hippocampal neurons in response of TLR7 defiency at mature stage (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115546 Evaluation of induced cellular cytokine profile in response to Rifampin-mono resistant Mycobacterium tuberculosis strain
Contributors : Farzam Vaziri ; Parvaneh Ravan ; Shima Hadifar ; Ava Behrouzi ; Abolfazl Fateh ; Seyed D SiadatSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensComparing of induced cellular cytokine profile in response to Rifampin-mono resistant and H37Rv Mycobacterium tuberculosis strains (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 11, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research

GSE115538 Identifying Lsr2 binding sites in Streptomyces venezuelae
Contributors : Emma Gehrke ; Marie ElliotSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Streptomyces venezuelaeThe goal of this work was to determine where Lsr2 binds within the S. venezuelae chromosome, and to differentiate between direct versus indirect effects by comparing our ChIP-seq results with RNA-seq results (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Streptomyces venezuelae Source Type: research

GSE69740 Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a fusion partner independent manner
Contributors : Jolanta Grembecka ; Tomek Cierpicki ; Trupta Purohit ; Jingya WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChromosomal rearrangements of the Mixed Lineage Leukemia (MLL) gene result in fusion proteins which retain the N-terminal portion of MLL fused with one of more than 70 different fusion partners. The high diversity of MLL fusion partners raises a question whether it is possible to develop a general therapeutic strategy to block the oncogenic activity of MLL fusion proteins in a fusion partner independent manner. We have demonstrated that blocking the menin-ML...
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE109255 Effect of BRD4 deletion on the Transcriptome of Different Thymocyte Subpopulations
Contributors : Anne Gegonne ; Qing-Rong Chen ; Daoud Meerzaman ; Dinah SingerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy conditionally deleting BRD4 at various stages of thymic differentiation, we have established that BRD4 deficiency selectively affects a unique developmental subpopulation of thymocytes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE110245 mRNA Expression Data from Murine Hearts of Transgenic Clock delta 19/delta 19 mice (Clock mice) and Wild type (WT) mice Fed a High-Fat (HFD) or Standard Chow (SC) Diet for 24 weeks
Contributor : Tami A MartinoSeries Type : Expression profiling by arrayOrganism : Mus musculusMice are on a C57Bl/6J background strain, hearts were collected from Clock and WT mice at ZT07, following 24 weeks on either a HF or SC diet.The microarray approach allows the investigation of gene expression changes of all genes in Clock HFD vs. Clock SC vs. WT HFD vs. WT SC hearts. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE115439 Lsr2 binding sites and gene expression of wild type and lsr2 mutants of Streptomyces venezuelae during late development in liquid culture
Contributors : Emma Gehrke ; Marie ElliotSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Streptomyces venezuelaeThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Streptomyces venezuelae Source Type: research

GSE115509 mRNA-sequencing of U87 glioblastoma and DAOY medulloblastoma spheroidal aggregates undergoing electrotaxis
In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. We investigate two cell lines for glioblastoma and medulloblastoma (U87mg& DAOY, respectively), plated as spheroidal aggregates in matrigel-filled electrotaxis channels, and report opposing electrotactic responses. To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (So...
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115511 Drosophila melanogaster late third instar larval ovary and gonadal fatbody polyA+ RNA-Seq profiling.
Contributors : Sharvani Mahadevaraju ; Justin M Fear ; Brian OliverSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterHere we perform transcriptional profiling of late third instar larval ovaries and gonadal fatbody from Drosophila melanogaster w1118 flies. We designed this experiment to investigate the effect of protease treatment on dissected ovaries. We profiled ovaries without protease treatment with some fatbody still attached, fatbody alone dissected from around the ovaries, ovaries cleaned of fatbody using a papain/collagenase cocktail, and ovaries dissociated using a p...
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research

GSE115513 miRNA and colorectal cancer: associations with tumor phenotype and survival
This study takes a two pronged approach to addressing our hypotheses. While we propose to validate previously identified miRNAs that have been identified as associated with CRC (either by differential expression or from assessment of mutations), we will add to the field through discovery of new and important associations that may be unique to specific molecular phenotypes, to polyp to cancer progression, and to survival. We have analyzed the expression of 2006 human miRNAs using data derived from tumor and paired normal tissue at time of diagnosis from: 1975 people with incident colon cancer or rectal cancer and 290 polyps...
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE115515 Identification of chloroquine diphosphate as an autophagy inhibitor to treat PANC-1 cells [miRNA]
In this study, we used microarrays to detect differential expression of mRNAs, miRNAs, lncRNAs and circRNAs post autophagy suppression by chloroquine diphosphate in PANC-1 cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE115516 Identification of chloroquine diphosphate as an autophagy inhibitor to treat PANC-1 cells [mRNA, circRNA, lncRNA]
In this study, we used microarrays to detect differential expression of mRNAs, miRNAs, lncRNAs and circRNAs post autophagy suppression by chloroquine diphosphate in PANC-1 cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE115517 Identification of chloroquine diphosphate as an autophagy inhibitor to treat PANC-1 cells
Series Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE115522 Transcriptional dysregulation in a primary cortical neuron model of Huntington's disease
Contributor : Hiroko YanoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptional dysregulation in a primary cortical neuron model of Huntington's disease (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115523 The role of Twist1 in mutant huntingtin-induced transcriptional alterations
Contributor : Hiroko YanoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe role of Twist1 in mutant huntingtin-induced transcriptional alterations (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE115528 Time resolved transcriptome of isolated biofilm cells compared with planktonic cells
Contributors : Joaquin Caro-Astorga ; Elrike Frenzel ; Oscar P Kuipers ; Diego RomeroSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus cereus ATCC 14579Most differential expression point to attack and defense strategies, comprising structural and metabolic changes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bacillus cereus ATCC 14579 Source Type: research

GSE115537 Gene expression of wild type and lsr2 mutants of Streptomyces venezuelae during late development in liquid culture
Contributors : Emma Gehrke ; Marie ElliotSeries Type : Expression profiling by high throughput sequencingOrganism : Streptomyces venezuelaeComparing gene expression of wild type and lsr2 mutants, to determine the effect of Lsr2 on Streptomyces development and metabolism (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Streptomyces venezuelae Source Type: research

GSE115486 Comparative gene expression analysis in the Arabidopsis thaliana root apex using RNA-seq and microarray transcriptome profiles
Contributors : Aparna Krishnamurthy ; Robert J Ferl ; Anna-Lisa PaulSeries Type : Expression profiling by arrayOrganism : Arabidopsis thalianaThe root apex is an important section of the plant root, involved in environmental sensing and cellular development. Analyzing the gene profile of root apex in diverse environments is important and challenging, especially when the samples are limiting and precious, such as in spaceflight. The feasibility of using tiny root sections for transcriptome analysis was examined in this study.To understand the gene expression profiles of the root apex, Arabidopsis thaliana Col-0 roots were s...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Arabidopsis thaliana Source Type: research

GSE83125 Major Facilitator Superfamily Domain Containing 7C (Mfsd7c) Mediates the Effects of Heme on Cell Metabolism, Motility and Transcription
Contributors : Yingzhong Li ; Marianna Kleyman ; Guangan Hu ; Walter Chen ; Dimitrios P Papageorgiou ; Lucas B Sullivan ; Mandeep Kaur ; Nikola Ivica ; Amanda del Rosario ; Charles A Whittaker ; Jianzhu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDysfunctional mutations of major facilitator superfamily domain containing 7C (Mfsd7c) are associated with Fowler's Syndrome. However, beyond its reported activity in heme importation, the function of Mfsd7c is unknown. Herein, we show that Mfsd7c forms complexes with proteins in both mitochondrial and cytoplasmic membranes including ...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE94154 Gene expression after 24h Cocoa Extract incubation in HT29 cells
Contributors : Carlos J Ciudad ; Carlota Oleaga ; Veronica NoeSeries Type : Expression profiling by arrayOrganism : Homo sapiensCocoa consumption is associated with beneficial effects on human health. This has been attributed to its polyphenol components and their oligomers, which have been shown to decrease the risk of cardiovascular and inflammatory diseases, metabolic disorders, and to play a role in cancer prevention. We tested cocoa modulation on the gene expression profile of colon cancer HT-29 cells using Affymetrix microarrays. Among the genes differentially expressed in HT-29 cells upon incubation with cocoa extra...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE95354 Differentially transcribed miRNAs in stress-induced premature senecence (SIPS)
Contributors : Lucia Terlecki-Zaniewicz ; Johannes Grillari ; Julie LatreilleSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensDetection of senescence-associated miRNAs differentially transcribed during early (D7) and late stages (D21) of human dermal fibroblast (HDF) senescence (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

GSE98753 FBXL19 transcriptionally primes promoters of developmental genes via CDK8-Mediator recruitment [ChIP-seq 1]
Contributors : Emilia A Dimitrova ; Robert J KloseSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRegulatory elements called CpG islands (CGIs) are associated with the majority of mammalian gene promoters and have been proposed to play an important role in gene expression. The regulatory capacity of CGIs is thought to rely upon a family of proteins that recognise CGIs through their ZF-CxxC DNA binding domains to recruit chromatin-modifying activities to gene promoters. Through studying FBXL19, a poorly characterized ZF-CxxC domain-containing protein, we have discovered t...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE98754 FBXL19 transcriptionally primes promoters of developmental genes via CDK8-Mediator recruitment [ChIP-seq 2]
Contributors : Emilia A Dimitrova ; Robert J KloseSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRegulatory elements called CpG islands (CGIs) are associated with the majority of mammalian gene promoters and have been proposed to play an important role in gene expression. The regulatory capacity of CGIs is thought to rely upon a family of proteins that recognise CGIs through their ZF-CxxC DNA binding domains to recruit chromatin-modifying activities to gene promoters. Through studying FBXL19, a poorly characterized ZF-CxxC domain-containing protein, we have discovered t...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE98755 FBXL19 transcriptionally primes promoters of developmental genes via CDK8-Mediator recruitment [RNA-seq]
Contributors : Emilia A Dimitrova ; Robert J KloseSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRegulatory elements called CpG islands (CGIs) are associated with the majority of mammalian gene promoters and have been proposed to play an important role in gene expression. The regulatory capacity of CGIs is thought to rely upon a family of proteins that recognise CGIs through their ZF-CxxC DNA binding domains to recruit chromatin-modifying activities to gene promoters. Through studying FBXL19, a poorly characterized ZF-CxxC domain-containing protein, we have discovered that it specifi...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE98756 FBXL19 recruits CDK8-Mediator to CpG islands and primes developmental genes for activation during lineage commitment
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE103625 Multiple chromatin factors determine multiple waves of 3D contacts organizein the Drosophila genome during embryogenesis
We describe the dynamic and stepwise progression of chromatin organization into TADs that correlates with zygotic genome activation. The stability of TAD boundaries during embryogenesis is supported by insulator proteins. Moreover we characterize two types of chromatin loops that emerge with different developmental dynamics. Active loops can be detected before midblastula transition and are formed between highly transcribed genes over long distances, whereas repressive chromatin loops are formed after midblastula transition between Polycomb response elements (PREs) within Polycomb domains. CRISPR/Cas9 genome engineering re...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Other Drosophila melanogaster Source Type: research

GSE104434 Enteric bacteria increase the defenses against oxidative stress in Entamoeba histolytica
Contributors : Hugo Varet ; Yana Shaulov ; Odile Sismeiro ; Meirav Geffen ; Rachel Legendre ; Jean-Yves Copp ée ; Serge Ankri ; Nancy GuillenSeries Type : Expression profiling by high throughput sequencingOrganism : Entamoeba histolyticaCharacterization of the human microbiota is providing new insightsinto the complexity of host –parasite–bacterium relationships. Amoebiasis (an intestinal infection affecting a large proportion of the population in many countries worldwide) is caused by the amoebic parasite Entamoeba histolytica. During amoebiasis, the parasite encounters several types of stress as a resu...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Entamoeba histolytica Source Type: research

GSE104656 Effect of Pre- and Postnatal Exposure to urban PM2.5 on the Transcriptome of the Developing and Early-Life Mouse Lung
In this study, we investigated alterations of the transcriptome of the developing lung in a mouse model of gestational and early-life postnatal exposure to urban PM2.5 (from Sao Paulo, Brazil). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

GSE106307 human serum: Control vs. patients with repeated implantation failure
Contributor : Lin LiuSeries Type : Non-coding RNA profiling by arrayOrganism : Cytomegalovirus ; Homo sapiens ; Human alphaherpesvirus 1 ; Human alphaherpesvirus 2 ; Human immunodeficiency virus 1 ; Human polyomavirus 1 ; JC polyomavirus ; Lymphocryptovirus ; Macaca mulatta polyomavirus 1 ; Merkel cell polyomavirus ; RhadinovirusmicroRNAs profiling of human serum comparing control fertile women with women who had experienced repeated implantation failure after ovarian stimulation and IVF-ET.Repeated implantation failure was defined as women who had undergone ≥3 failed cycles with high-grade embryos were transferred. (So...
Source: GEO: Gene Expression Omnibus - June 8, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Cytomegalovirus Homo sapiens Human alphaherpesvirus 1 Human alphaherpesvirus 2 Human immunodeficiency virus 1 Human polyomavirus 1 JC polyomavirus Lymphocryptovirus Macaca mulatta polyomavirus 1 Merkel Source Type: research