GSE247198 Epigenetic age oscillates during the day
Series Type : Methylation profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by array Homo sapiens Source Type: research
GSE248167 Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model
In conclusion, our novel TIDE-based subtyping method can serve as a powerful clinical tool for BC and pan-cancer patients, and potentially guiding personalized therapy decisions for selecting potential beneficiaries and excluding resistant patients of ICB therapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE249290 Integrative transcriptomic and proteomic profiling of the effects of cell confluency on gene expression
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a consequence of cell confluency, AGO2 protein translocates into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA sequencing, reve...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE255251 Integrative transcriptomic and proteomic profiling of subconfluent and confluent cancer cells
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a measure of cell confluency, we observed a profound translocation of AGO2 into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA s...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE255499 Replication-attenuated r3LCMV vectors potentiate tumor control via IFN-I
We report striking antitumoral effects by a nonlytic viral vector based on attenuated lymphocytic choriomeningitis virus (r3LCMV). We show in multiple tumor models that injection of tumor-bearing mice with this novel vector results in improved tumor control and survival. Importantly, r3LCMV also improved tumor control in immunodeficient Rag1-/- mice. Single cell RNA-Seq analyses, antibody blockade experiments, and KO models revealed a critical role for host IFN-I in the antitumoral efficacy of r3LCMV vectors. Collectively, these data demonstrate potent antitumoral effects by a replication-attenuated LCMV vector and unveil ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE262306 TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies
Contributors : Simone Minnie ; Olivia Waltner ; Geoffrey Hill ; Scott FurlanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusChronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (TPHEX), expressed granzymes, perforin, and IFN γ. Concurrent gene expression and DNA accessibility revealed that genes encoding these functional proteins correlated with BATF expression and motif accessibility. IFNγ+ TPHEX effectively kil...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Mus musculus Source Type: research
GSE262541 Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice
Contributors : Xinyi Zhou ; Qian Xiao ; Yaohui Liu ; Shuai Chen ; Xirong Xu ; Zhigang Zhang ; Yuchuan Hong ; Jie Shao ; Yuewen Chen ; Yu Chen ; Liping Wang ; Fan Yang ; Jie TuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAssessing and responding to threats is vital in everyday life. Unfortunately, many mental illnesses involve impaired risk assessment, affecting patients, families, and society. The brain processes behind these behaviors are not well understood. We developed a transgenic mouse model (DISC1-N) with a disrupted avoidance response in risky settings. Our stu...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE263911 AML1-ETO and CCND2 overexpression ¬ cooperate to drive acute myeloid leukemia initiation and progression
In conclusion, we confirmed that introduction of the CCND2 gene into the AML/ETO pre-leukemia mice can trigger the development of leukemia. We also confirmed that CCND2 overexpression resulted in the upregulation of the mTOR pathway and inhibiting the pathway may be a therapeutic agent for this subtype of leukemia. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
GSE263960 Interaction with Myeloma Suppresses Ciliogenesis and osteogenesis of Bone Marrow Stromal Cells
Contributors : Ying Xie ; Xiaozhi Liu ; Zhaoyun LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensImpaired bone marrow stromal cells (BMSCs) within the bone niche of multiple myeloma (MM) patients are implicated in the development of myeloma bone disease (MBD) and disease progression. However, the specific mechanisms are not yet fully understood. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE263961 HDGFR2 regulates osteogenic differentiation by balancing histone crotonoylation and acetylation modifications [Cut & Tag]
Contributors : Meilin Hu ; Yixuan WangSeries Type : OtherOrganism : Mus musculusEpigenetics regulates the expression of osteogenic genes and mediates the osteogenic differentiation of MSCs. It was found that hepatoma-derived growth factor (HDGFR2) is a histone methylated reader protein, which can recognize histone methylation modification and play an important "switch" role in gene transcriptional regulation. It is unclear whether HDGFR2 is involved in bone formation studies. Our study aims to investigate the effect of HDGFR2 on osteogenic differentiation and provide evidence for BMSCs as seed cells for tissue regenerati...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE263962 HDGFR2 regulates osteogenic differentiation by balancing histone crotonoylation and acetylation modifications [RNA-Seq]
Contributors : Meilin Hu ; Yixuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEpigenetics regulates the expression of osteogenic genes and mediates the osteogenic differentiation of MSCs. It was found that hepatoma-derived growth factor (HDGFR2) is a histone methylated reader protein, which can recognize histone methylation modification and play an important "switch" role in gene transcriptional regulation. It is unclear whether HDGFR2 is involved in bone formation studies. Our study aims to investigate the effect of HDGFR2 on osteogenic differentiation and provide evidence ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE264016 Porcine Rotavirus VP6 Protein Wrests IPEC-J2 METTL3-Mediated M6A Modification to Fight Antiviral Immune Response
Contributors : Yaxu Liang ; Xuejiao Zhu ; Ning Peng ; Xiang ZhongSeries Type : OtherOrganism : Porcine rotavirus ; Sus scrofaN6-methyladenosine (m6A), the most abundant mRNA modification, can regulate various mRNA metabolism to affect numerous physiological and pathophysiological processes, including immune function. However, the regulation of m6A methylation and its role in immune defense against virus infections remain unexplored. Here, we found that Porcine rotavirus (PoRV) infection decreased global m6A levels in host cells by downregulating m6A writer METTL3. Remarkably, knockdown of Mettl3 or m6A reader Ythdf2 en...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Other Porcine rotavirus Sus scrofa Source Type: research
GSE264018 Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms
Contributors : Hang Sun ; Bingwei Yang ; Qiong Li ; Yang SongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the dysfunction and progressive death of cerebral and spinal motor neurons. Preliminary epidemiological research has hinted at a relationship between environmental risks and the escalation of ALS, but the underlying reasons remain mostly mysterious. Here, we show that nano-size polystyrene plastics (PS) induce ALS-like symptoms and illustrate the related molecular mechanism. When exposed to ...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE264063 Tumor-induced Natural Killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints
Contributors : K évin Pouxvielh ; Marie Marotel ; Annabelle Drouillard ; Marine Villard ; Marion Moreews ; Anna Bossan ; Mathilde Poiget ; Liliane Khoryati ; Sarah Benezech ; Lucie Fallone ; Sarah Hamada ; Noémi Rousseaux ; Louis Picq ; Yamila Rocca ; Aurore Berton ; Marine Teixeira ; Anna-Laure M athieu ; Michelle Ainouze ; Uzma Hasan ; Alain Fournier ; Olivier Thaunat ; Antoine Marçais ; Thierry WalzerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNatural Killer (NK) cells often become dysfunctional during tumor progression but the molecular mechanisms und...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE264114 An Improved SNAP-ADAR Tool Enables Efficient RNA Base Editing to Interfere with Post-translational Protein Modification
Contributors : Karthika D Kiran Kumar ; Shubhangi Singh ; Stella M Schmelzle ; Paul Vogel ; Carolin Fruhner ; Alfred Hanswillemenke ; Adrian Brun ; Jacqueline Wettengel ; Yvonne F üll ; Lukas Funk ; Valentin Mast ; Josephine J Botsch ; Philipp Reautschnig ; Jin B Li ; Thorsten StafforstSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA base editing applies endogenous or engineered adenosine deaminases to introduce adenosine-to-inosine changes into a target RNA in a highly programmable manner. Recently, notable success was achieved for the repair of disease-causing guanosi...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
