GSE175911 AOS10-FMT could rescure the adverse effects induced by high fat diet on the testis
We report the side-effects of High fat diet on the testis, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as spermatogenesis,lipid metabolism and oxidative stress (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE175940 AOS10-FMT could rescure the adverse effects induced by high fat diet on the Colon
We report the side-effects of High fat diet on the colon, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE176110 AOS10-FMT could rescure the adverse effects induced by high fat diet on the Spleen
We report the side-effects of High fat diet on the spleen, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as inflammation (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE180992 Gene expression analysis in the presence or absence of N-terminal tag (9myc) of Swd2 in Saccharomyces cerevisiae
In conclusion, we suggest that the abundance of Swd2 is important to regulate the protein stability of Set1 and the regulation of gene expression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Saccharomyces cerevisiae Source Type: research
GSE184556 Transcriptome profiling of oxidase knockout mice response to gingival inflammation using RNA-seq
Contributors : Juhi Bagaitkar ; Eric C RouchkaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic defects in neutrophil function or trafficking are highly associated with oral inflammation and periodontitis. The leukocyte NADPH oxidase enzymes complex is a multi-subunit enzyme that has been described to play important immunomodulatory roles in limiting the inflammatory responses of neutrophils and macrophages. Here, we determined the impact of loss of NADPH oxidase dependent reactive oxygen species (ROS) generation in gingival inflammatory responses using a model of ligature indu...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE195829 miRNA seq mouse liver HFD, PCB126, Aroclor1260 exposure
Contributors : Belinda J Petri ; Kellianne M Piell ; Bandrida Wahlang ; Kimberly Z Head ; Kalina Andreeva ; Eric C Rouchka ; Jianmin Pan ; Shesh N Rai ; Matthew C Cave ; Carolyn M KlingeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusExposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated biphenyls (PCBs) is associated with liver injury in human populations and with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. Exposure of HFD-fed male mice to the non-dioxin-like (NDL) PCB mixture Aroclor1260 or to dio...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
GSE197489 Group B Streptococcal transcriptome when interacting with brain endothelial cells
Contributors : Bailey E Bridgers ; Madelyn L Armstrong ; Eric R Espinal ; Mustafa Divyapicigil ; Thomas A Hooven ; Alexander J Westermann ; Till Sauerwein ; Konrad U Foerstner ; Alexandra Schubert-Unkmeir ; Brandon J Kim ; Nadine Vollmuth ; Abigail Gildea ; Jacob Wood ; Guilia BarbieriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Streptococcus sp. 'group B'We have conducted RNA-seq analysis on Group B Streptococcus (GBS) when interacting with human stem-cell (hSC) derived BECs. The study contains a control group for GBS and a control group for BECs each with three biologic...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Streptococcus sp. 'group B' Source Type: research
GSE201389 COP1 SUPPRESSOR 6 promotes photomorphogenesis by repressing the transcription and activity of PIF4 and PIF5
In this study, we report COP1 SUPPRESSOR 6 (CSU6) function as positive regulator of light signaling. Loss of CSU6 function largely rescued the cop1-6 constitutively photomorphogenic phenotype. The hypocotyl length of csu6 mutant seedlings was shorter in the dark, but longer than that of wide-type in the light. CSU6 not only associated with the promoter regions of PIF4 and PIF5 to inhibit their expression during the day, but also directly interacts with both PIF4 and PIF5 to repress their transcriptional activity. CSU6 negatively controls a large group of PIF4- and PIF5-mediated genes' expression. Mutations in PIF4 and/or P...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE217055 Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program
Contributors : Longfei Gao ; Heather Lee ; Joshua Goodman ; Lei DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe niche is typically considered as a pre-established structure sustaining stem cells. Therefore, the regulation of its formation remains largely unexplored. It is unknown whether distinct molecular mechanisms control the establishment versus maintenance of a stem cell niche. To address this, we compared perinatal with adult bone marrow mesenchymal stromal cells (MSCs), a key component of the hematopoietic stem cell (HSC) niche. MSCs exhibited an enrichment in genes...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE217056 Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program
Contributors : Longfei Gao ; Heather Lee ; Joshua Goodman ; Lei DingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe niche is typically considered as a pre-established structure sustaining stem cells. Therefore, the regulation of its formation remains largely unexplored. It is unknown whether distinct molecular mechanisms control the establishment versus maintenance of a stem cell niche. To address this, we compared perinatal with adult bone marrow mesenchymal stromal cells (MSCs), a key component of the hematopoietic stem cell (HSC) niche. MSCs exhibited an enrichment in genes...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE217057 Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE224813 Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia [CUT & TAG]
Contributors : Xuelan Chen ; Qi Zhang ; Chong Chen ; Yu LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAcute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia, that is generally driven by PML-RARA, resulting from a balanced chromosomal translocation t(15;17) (q24.1;q21.2). However, approximately 2% of APL patients carry other variants of RARA-fusions, which pose challenges for diagnosis and treatment. Here, we report a novel t(14;17) translocation in an APL patient that gave rise to a new fusion gene, STRN3-RARA. STRN3 forms a complex c...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE224815 Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia [RNA-seq]
Contributors : Xuelan Chen ; Qi Zhang ; Chong Chen ; Yu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia, that is generally driven by PML-RARA, resulting from a balanced chromosomal translocation t(15;17) (q24.1;q21.2). However, approximately 2% of APL patients carry other variants of RARA-fusions, which pose challenges for diagnosis and treatment. Here, we report a novel t(14;17) translocation in an APL patient that gave rise to a new fusion gene, STRN3-RARA. STRN3 forms a complex called the stri...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE224816 Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusHere we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE233546 Nuclear export is a limiting factor in eukaryotic mRNA metabolism
Contributors : Jason M M üller ; Katharina Moos ; Till Baar ; Kristina Zumer ; Achim TreschSeries Type : OtherOrganism : Homo sapiensThe eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by sequencing of RNA (SLAM-seq) in the nuclear and cytosolic compartments. We develop a model that reliably quantifies mRNA synthesis, nuclear export, and nuclear and cytosolic degradation rates on a genome-wide scale. We find that nuclear degradatio...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
