Corneal Cross-Linking: An Effective Treatment Option for Pellucid Marginal Degeneration.
Conclusions: The data reported in literature is limited at this time, consisting mostly of retrospective studies with short term follow up. Further research is needed to evaluate refractive effects of combined CXL and excimer laser procedures. PMID: 31449434 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 28, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Outer Retinal Healing After Internal Limiting Membrane Peeling in Diabetic Macular Oedema with Vitreomacular Interface Abnormality Using Three Different Dyes.
Conclusion: ICG resulted in a greater percentage of deteriorated EZ/ELM integrity at 6 months after surgery in cases with pre-treatment ELM interruption. Therefore, ICG should be used with caution in cases with ELM disruption, yet, further studies are recommended. PMID: 31423860 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 21, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene and Diabetic Retinopathy.
Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene and Diabetic Retinopathy. Semin Ophthalmol. 2019 Aug 15;:1 Authors: Joob B, Wiwanitkit V PMID: 31416385 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 18, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Is Inverse Prism Therapy Comparable to Conventional Prism Therapy for Improving Newcastle Scores in Patients with Basic Intermittent Exotropia?
Conclusion: The two types of prism therapy showed comparable improvements in NCS. PMID: 31402742 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 15, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Outcomes of Using Sutureless, Scleral-Fixated Posterior Chamber Intraocular Lenses.
Authors: Kansal V, Onasanya O, Colleaux K, Rawlings N Abstract Background. Implantation of sutureless, scleral-fixated posterior chamber intraocular lenses (SSFIOL) is a promising option in the surgical management of patients unable to undergo standard cataract surgery due to insufficient capsular support. The purpose of this study was to describe the indications, visual outcomes and complications of SSFIOL implantation. Methods. Retrospective, investigational cohort study of 112 consecutive SSFIOL implantations between July 2013 and August 2017. Pre-operative ocular morbidity, operative indications, postoperative ...
Source: Seminars in Ophthalmology - August 10, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Corneal Neurotization: Review of a New Surgical Approach and Its Developments.
Conclusions: The least morbid, simplest, most expedient and successful surgical approaches will ultimately become the most utilized. PMID: 31370735 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 4, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Interferon Alfa 2b for Ocular Surface Squamous Neoplasia: Factors Influencing the Treatment Response.
CONCLUSION: Clock hour involvement of ocular surface by OSSN determines the response to IFN. Interferon alfa 2b is an effective immunotherapy agent for tumors ≤6 clock hours of ocular surface in 82% cases and serves as an immunoreducing agent for larger tumors involving>6 clock hours of ocular surface in 26% cases. PMID: 31370766 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 4, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

CORRELATIONS between Functional and Structural Tests Measured by Spectral Domain Optical Coherence Tomography in Severe Glaucoma.
Discussion: Mean, superior, inferonasal, superonasal, and superotemporal GC-IPL thicknesses and mean c/d ratio, vertical c/d ratio and cup volume were found to be correlated with BCVA in patients with severe glaucoma. PMID: 31361521 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - August 1, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Descemet's Membrane Endothelial Keratoplasty with Split Corneal Grafts: The Influence of Tamponade Material and Endothelial Storage Time.
Authors: Genc S, Tulu Aygun B, Esen F, Yildirim Y, Agca A Abstract Purpose: The aim of this study was to describe the clinical outcome of Descemet's membrane endothelial keratoplasty (DMEK) performed with split corneal grafts and to evaluate the influence of tamponade material and endothelial storage time on DMEK success. Material and Method: The records of 43 patients who underwent DMEK surgery with a split corneal graft were reviewed. Diagnosis of the patients, preoperative and postoperative best-corrected visual acuity (BCVA), corneal and endothelial storage time, tamponade material, complications, and success r...
Source: Seminars in Ophthalmology - July 31, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Clinical Manifestations of Strabismus in Patients with Primary Congenital Glaucoma.
Authors: Jin SW, Ryu WY Abstract Purpose: To determine the clinical manifestations and risk factors of developing strabismus in primary congenital glaucoma (PCG) patients who underwent glaucoma surgery. Methods: A retrospective case-series study of 54 PCG patients who were followed for at least 3 years after glaucoma surgery. The subjects were divided into 2 groups based on the occurrence of strabismus. Age at glaucoma diagnosis and surgery, visual acuity, intraocular pressure, amblyopia, cup-disc ratio, and orthoptic status were compared between the 2 groups. Results: Twenty of 54 patients (37.0%) developed s...
Source: Seminars in Ophthalmology - July 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

An Objective Evaluation of the Upper Eyelid Position after Phacoemulsification Cataract Surgery.
Authors: Marqués-Fernández V, Garcia-Zamora M, Calabuig-Goena M, Diez-Montero C, Schellini SA, Khandekar R, Galindo-Ferreiro A Abstract Purpose: To objectively measure the upper eyelid position following phacoemulsification cataract surgery and to identify the determinants of postoperative transient ptosis. Methods: This is a single arm prospective study of patients who underwent cataract surgery from January to May 2017 at a tertiary Eye Hospital in Spain. Data comprised of: the type of anesthesia, the duration that the speculum remained in place and the total surgical time (duration of the procedure...
Source: Seminars in Ophthalmology - July 19, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Intravitreal Ziv-Aflibercept: A Comprehensive Review.
Conclusion: Further prospective, randomized studies of ziv-aflibercept are needed, particularly in eyes with nAMD. PMID: 31314638 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 19, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

The Effect of Eplerenone in Chronic Central Serous Chorioretinopathy Refractory to Photodynamic Therapy.
Conclusions: This study has shown that eplerenone is safe and effective in cases of chronic CSCR, refractory to previous PDT. PMID: 31309849 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 18, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Review of Machine Learning Techniques for Keratoconus Detection and Refractive Surgery Screening.
Authors: Lin SR, Ladas JG, Bahadur GG, Al-Hashimi S, Pineda R Abstract Various machine learning techniques have been developed for keratoconus detection and refractive surgery screening. These techniques utilize inputs from a range of corneal imaging devices and are built with automated decision trees, support vector machines, and various types of neural networks. In general, these techniques demonstrate very good differentiation of normal and keratoconic eyes, as well as good differentiation of normal and form fruste keratoconus. However, it is difficult to directly compare these studies, as keratoconus represents...
Source: Seminars in Ophthalmology - July 16, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Postoperative Capsular Bag Distension Syndrome - Risk Factors and Treatment.
Conclusion:Nd:YAG posterior capsulotomy, and in some cases anterior capsulotomy, is accepted as a standard and effective CBDS treatment. Surgical approach could be beneficial in cases suspected of Propionibacterium acnes presence or when it is impossible to perform Nd:YAG posterior capsulotomy. PMID: 31298075 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 14, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Application of the Balloon Snake in the Volume Measurement of Subretinal Fluid in Central Serous Chorioretinopathy.
Conclusion: The Balloon Snake-based method produced accurate and time-efficient volume measurement of SRF in patients with CSC. PMID: 31288617 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 12, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Retrospective Study of Transcleral Cyclophotocoagulation Using the Slow Coagulation Technique for the Treatment of Refractory Glaucoma.
Conclusions: Diode laser TSCPC using the slow coagulation technique is a safe and effective technique for lowering IOP in patients with refractory glaucoma in Chinese eyes. PMID: 31284800 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 11, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

The Role of Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene in Diabetic Retinopathy in a Tunisian Population.
In this study, we investigated the association of two polymorphisms (rs869109213 and rs2070744) in the eNOS gene and one polymorphism BglII in the α2β1 integrin gene (ITGA2) with the risk of diabetic retinopathy (DR) in a Tunisian population. Methods: The study investigated of 110 type 2 diabetes mellitus (T2DM) and 127 DR patients. The genotypes of the eNOS 4b/4a (rs869109213) and -786T/C (rs2070744) polymorphisms and of the BglII polymorphism of ITGA2 were studied using the PCR or PCR-RFLP method. Results: The genotype distributions of the two polymorphisms in eNOS 4b4a and eNOS (-786T/C) were significantly di...
Source: Seminars in Ophthalmology - July 2, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Factors Affecting Myopic Regression after Laser in Situ Keratomileusis and Laser-Assisted Subepithelial Keratectomy for High Myopia.
Authors: Liu M, Gao H, Shi W Abstract To evaluate the factors affecting the amount of myopic regression after laser refractive surgery for high myopia, we retrospectively reviewed medical records of 1591 eyes with high myopia treated by laser in situ keratomileusis or laser-assisted subepithelial keratectomy at Shandong Eye Hospital between January 2008 and December 2012. Thirty-five eyes suffering a postoperative myopic shift of manifest spherical equivalent (MSE) of 0.25 diopter (D) or greater were included in this study. The mean refractive error was -9.34 ± 1.89 D before surgery, and the mean r...
Source: Seminars in Ophthalmology - July 2, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Accuracy of Intraocular Lens Power Calculation in Eyes Filled with Silicone Oil.
Authors: Kanclerz P, Grzybowski A Abstract Silicone oil (SO) is used mainly when managing complex retinal detachments, commonly with proliferative vitreoretinopathy, as well as a hemostatic agent in proliferative diabetic retinopathy. Combined lens exchange and pars plana vitrectomy remains preferred by many surgeons; however, sequential surgery might be advantageous to minimize the postoperative anterior chamber inflammatory response, particularly in proliferative diabetic retinopathy or retinal detachment. The aim of the study was to evaluate the optimal method of intraocular lens (IOL) calculation in eyes filled...
Source: Seminars in Ophthalmology - July 2, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Choroidal Changes at the Leakage Site in Acute Central Serous Chorioretinopathy.
Conclusion: Subfoveal and leak site choroidal profile could predict the eccentricity of leakage in CSCR. PMID: 31257974 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - July 2, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

New Observations regarding the Assessment of Cilioretinal Arteries Coexistence with Optic Disc Pit.
Conclusion: Based on the high percentage of CRAs coexistence with ODP and the excessive frequency of their emergence from ODP (83.3%), it is supported that ODP as a developmental disorder could go along with further anatomic peculiarities, that also include the presence of multiple CRAs. PMID: 31244378 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Percentage Choroidal Thickness: Another View on Analysis of Choroidal Thickness Using Spectral-domain Optical Coherence Tomography.
Authors: Maltsev DS, Kulikov AN, Burnasheva MA, Chhablani J Abstract Purpose: To present an analysis of the percentage choroidal thickness (PCT) and evaluate PCT profile in eyes with different axial length (AL). Methods: Axial length (AL) measurements and spectral domain optical coherence tomography examinations, including radial 9-mm scan and 4 circle scans with diameter of 3.0, 5.0, 7.0, and 9.0 mm, centered on the fovea, were performed in 35 eyes of 35 individuals (13 male, 22 female, mean age 32.2 ± 7.1 years). Average choroidal thickness (CT) and PCT (the ratio of the average CT to the subfoveal CT) wer...
Source: Seminars in Ophthalmology - June 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Intraoperative Optical Coherence Tomography in Vitreoretinal Surgery.
Authors: Ung C, Miller JB Abstract Intraoperative OCT (iOCT) is an emerging modality capable of displaying real-time OCT images to the surgeon during surgery. The use of iOCT during vitreoretinal surgery improves our understanding of the tissue alterations that occur during surgical manipulations, which may impact surgical decision-making. We review the current iOCT modalities and clinical applications of iOCT. PMID: 31240975 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 28, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy.
Authors: Ong Tone S, Jurkunas U Abstract Fuchs endothelial corneal dystrophy (FECD) is characterized by the progressive degeneration of the corneal endothelium (CE). The purpose of this article is to review the diagnostic tools available to image and assess the CE in FECD. Slit-lamp biomicroscopy with specular reflection and retroillumination are important techniques to assess the CE. Objective diagnostic tests, such as retroillumination photographic analysis, specular microscopy, in vivo confocal microscopy (IVCM), and anterior segment optical coherence tomography, are valuable tools to evaluate the CE in FECD. Sp...
Source: Seminars in Ophthalmology - June 21, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Methods for Assessing Corneal Opacity.
Conclusion: Although a number of techniques for assessing corneal opacity have been reported in the literature, none have been widely adopted, highlighting the fact that there is still a need for an accessible, objective and easy to use method for quantifying corneal opacity. PMID: 31188043 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 14, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Anterior Segment Applications of Optical Coherence Tomography Angiography.
Conclusions: OCT-A is a noninvasive technology with recent applications in the anterior segment. Several pilot studies have been performed on various anterior segment structures and disease states however standardization of image acquisition techniques is still needed. Future imaging could allow noninvasive and serial monitoring of pathology as well as recurrence after therapeutic intervention. PMID: 31188047 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 14, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Current Stem-Cell Approaches for the Treatment of Inherited Retinal Degenerations.
Authors: Terrell D, Comander J Abstract Stem cells provide a promising new therapeutic approach for the treatment of multiple acquired and inherited retinal conditions. While to date, there have been numerous clinical trials examining the ability of stem cells to treat the geographic atrophy found in advanced non-neovascular age-related macular degeneration, fewer clinical trials have specifically examined stem-cell therapy for inherited retinal disease. Moreover, it remains to be seen if human stem cells will be able to regenerate the lost retinal cell populations that represent a final common pathway for most of ...
Source: Seminars in Ophthalmology - June 14, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

"For Mass Eye and Ear Special Issue" Adaptive Optics in the Evaluation of Diabetic Retinopathy.
"For Mass Eye and Ear Special Issue" Adaptive Optics in the Evaluation of Diabetic Retinopathy. Semin Ophthalmol. 2019 Jun 12;:1-9 Authors: AbdelAl O, Ashraf M, Sampani K, Sun JK Abstract Retinal imaging is a fundamental tool for clinical and research efforts in the evaluation and management of diabetic retinopathy. Adaptive optics (AO) is an imaging technique that enables correction of over 90% of the optical aberrations of an individual eye induced primarily by the tear film, cornea and lens. The two major tasks of any AO system are to measure the optical imperfections of the eye and to the...
Source: Seminars in Ophthalmology - June 14, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

The Role of Botulinum Toxin in the Treatment of Strabismus.
Discussion: Despite its transient kinetics, BTA can have permanent effects on ocular alignment, promoting binocularity and reduction of diplopia, and can serve as a primary treatment or a muscle sparing option in patients at risk of anterior segment ischemia or need for future surgeries. PMID: 31177893 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 12, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Advances in Immunotherapy and Periocular Malignancy.
Authors: Habib LA, Wolkow N, Freitag SK, Yoon MK Abstract Immunotherapy has significantly advanced the field of oncology in recent decades. Understanding normal immunosurveillance, as well as the ways in which tumor cells have evolved to evade it, has provided the knowledge for development of drugs that allow one's own immune system to target and destroy malignant cells (immunotherapy). Cutaneous malignancies are particularly sensitive to this class of drugs. In a very sensitive anatomic region such as the periocular tissue, where surgical excision may come with significant morbidity, this technology has had a stro...
Source: Seminars in Ophthalmology - June 12, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Real-Time Multiplex PCR Analysis in Infectious Uveitis.
Discussion: Real-time multiplex PCR is a highly sensitive and specific laboratory assay that allows for rapid and reliable molecular diagnosis of causative agents in infectious uveitis. This in turn facilitates swift initiation of effective therapy and prevents long-term ocular damage and vision loss. PMID: 31177936 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 12, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Review of Next-Generation Sequencing (NGS): Applications to the Diagnosis of Ocular Infectious Diseases.
Conclusion: NGS is a novel technology for identifying the pathogens responsible for ocular infections with the potential to improve the accuracy and speed of diagnosis and hastening the selection of the best therapy. PMID: 31170015 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 8, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Characteristics of Perifoveal Exudative Vascular Anomalous Complex in Korean Patients.
Conclusions: The clinical characteristics of PEVAC in Korean patients were similar to those reported in patients of other ethnicities. Further studies are needed to better understand the nature of this newly described clinical entity. PMID: 31165650 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 7, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Diagnosis and Imaging of Optic Nerve Head Drusen.
Authors: Gise R, Gaier ED, Heidary G Abstract The presence of optic nerve swelling in pediatric patients is a frequent cause for referral to pediatric ophthalmologists and neuro-ophthalmologists because this finding can be the harbinger of serious neurologic disease including brain tumor, demyelinating disease, infiltrative disease of the optic nerve, or idiopathic intracranial hypertension. Optic nerve head drusen (ONHD) are common and can be particularly difficult to distinguish from true optic nerve swelling in pediatric patients because the ONHD are typically buried beneath the substance of the optic nerve. Cor...
Source: Seminars in Ophthalmology - June 5, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

For Massachusetts Eye and Ear Special Issue: Updates on Therapies for Multiple Sclerosis for the Ophthalmologist.
Authors: Bakaeva T, Prasad S Abstract In the past decade, the available disease-modifying therapies for multiple sclerosis have broadened significantly, providing physicians and patients with multiple options with different mechanisms of action, administration routes, and risk-benefit profiles. Multiple sclerosis often presents with ophthalmic manifestations due to inflammatory demyelination of the afferent and efferent visual pathways, and evidence of disease can factor into the decision to initiate or substitute a particular therapy. Furthermore, some of these drugs have toxicities that can manifest with ophthalm...
Source: Seminars in Ophthalmology - June 5, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT).
Authors: Gaier ED, Gise R, Heidary G Abstract Amblyopia refers to visual impairment resulting from perturbations in visual experience during visual development, typically secondary to strabismus, uncorrected refractive error, and/or deprivation. Amblyopia has traditionally been considered a cortical disease, but the depth of our understanding of this complex neurodevelopmental condition is limited by our ability to appreciate structural pathophysiology in the visual pathway. Recent advances in Optical Coherence Tomography (OCT) have facilitated numerous studies of the structural changes in the retina and optic nerv...
Source: Seminars in Ophthalmology - June 5, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Review of OCT Angiography in Glaucoma.
Authors: Werner AC, Shen LQ Abstract There is growing evidence that vascular dysfunction plays a role in the pathogenesis of glaucoma. The details of this relationship have remained elusive partially due to limitations in our ability to assess blood flow in the optic nerve. Optical coherence tomography angiography (OCTA) has emerged as a promising new technology well positioned to become the first clinically suitable test of optic nerve perfusion. OCTA uses the motion of red blood cells as an intrinsic contrast agent to create reproducible images of microvascular networks rapidly and non-invasively. A significant b...
Source: Seminars in Ophthalmology - June 5, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Disc Configuration as a Risk and Prognostic Factor in NAION: The Impact of Cup to Disc Ratio, Disc Diameter, and Crowding Index.
Conclusions: DD and CI did not show value as either prognostic or risk factors. Glial tissue may be a part of the content of the optic disc as important as axons. Our results are in line with the latest studies about NAION pathophysiology. Contrary to classic thinking, these papers have not found smaller disc diameters, but smaller values of lamina cribosa depth in NAION patients. PMID: 31162995 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 5, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Microperimetry in Three Inherited Retinal Disorders.
Conclusions: Microperimetry is a valuable tool for monitoring functional aspects of central retina in an individual patient, especially in combination with other modalities such as OCT, autofluorescence, and acuity and thus may contribute to evaluating the efficacy of gene treatments. Variability of the MP parameters raises some cautions in application of MP as an outcome measure in treatment trials that may have small sample sizes. Nonetheless, we suspect that MP will continue to have a rightful place in future gene therapy trials. PMID: 31146612 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 1, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Review of the Role of Cytogenetics in the Diagnosis of Orbital Rhabdomyosarcoma.
Authors: Cortes Barrantes P, Jakobiec FA, Dryja TP Abstract Rhabdomyosarcoma (RMS) is the most common sarcoma of childhood and adolescence. Approximately 10% arise in the orbit, where the embryonal type is most common variant. The alveolar variant is less frequent and has a worse prognosis. Cytogenetic studies have revealed that most alveolar rhabdomyosarcomas have translocations involving the PAX and the FOX01 genes, giving rise to fusion genes that contribute to lack of differentiation and proliferation of the tumor cells. However, approximately 20% of alveolar rhabdomyosarcomas lack translocations and have been ...
Source: Seminars in Ophthalmology - June 1, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Pharmaceutical Formulation Methods for Improving Retinal Drug Delivery.
Authors: Stryjewski TP, Stefater JA, Eliott D Abstract Clinical pharmacology training for clinicians typically focuses on a drug's Active Pharmaceutical Ingredient. However, pharmaceutical formulation, the process of optimizing manufacturing methods and excipients to make a final drug product, is a critical process in determining whether a potential drug can become a realistic, routinely used therapeutic agent. This review focuses on the formulation methods used in commonly prescribed retina drug products. PMID: 31146619 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - June 1, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Conjunctival Melanoma in Asian Indians: A Study of 42 Patients.
Authors: Kaliki S, Vasanthapuram VH, Mishra DK Abstract Purpose: To describe the clinical features, treatment, and outcomes of conjunctival melanoma in Asian Indians. Methods: Retrospective study of 42 patients. Results: The mean age at presentation of conjunctival melanoma was 43 years (median, 45 years; range, 9-78 years). There were 20 (48%) males and 22 (52%) females. Nineteen patients (45%) had a known history of a preexisting pigmented conjunctival lesion. Bulbar conjunctiva (n = 28; 67%) was the most common tumor epicenter, and medial ocular surface quadrant (n = 15; 36%) was more commonly involved. The mean...
Source: Seminars in Ophthalmology - May 30, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Intraocular Lens Techniques in Pediatric Eyes with Insufficient Capsular Support: Complications and Outcomes.
Authors: Cheung CS, VanderVeen DK Abstract Intraocular lens (IOL) implantation in pediatric eyes with insufficient capsular support is challenging and there are multiple IOL options. These include placement of an IOL within the capsular bag with a capsular tension ring, a scleral-fixated posterior-chamber IOL (PCIOL) with or without capsular tension segment or ring, an intra-scleral fixated IOL, an iris-sutured PCIOL, or an anterior chamber iris-fixated IOL. We reviewed 48 articles and 1 published abstract describing the surgical techniques, complications and visual outcomes of different IOL options in the manageme...
Source: Seminars in Ophthalmology - May 30, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

For Mass Eye and Ear Special Issue: Optical Coherence Tomography Angiography: Review of Current Technical Aspects and Applications in Chorioretinal Disease.
This article reviews technical aspects of OCT-A, its applications in chorioretinal disease, and known limitations of the technology. PMID: 31131663 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - May 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Responses of Types 1 and 2 Neovascularization in Age-Related Macular Degeneration to Anti-Vascular Endothelial Growth Factor Treatment: Optical Coherence Tomography Angiography Analysis.
Conclusion: OCTA analysis revealed different responses to anti-VEGF treatment depending on the location of neovascularization in neovascular AMD. Type 2 neovascularization was significantly regressed compared to type 1 neovascularization after anti-VEGF treatment. However, the changes in vascular density and visual outcome showed no significant differences between groups after 12 months of treatment. PMID: 31132283 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - May 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Outcomes and Complications Rate of Resident versus Attending Performed Eye Muscle Surgeries.
Conclusions: Success rate is similar in eye muscle surgeries performed by residents and attending consultants. However, perioperative complications are still more common among residents. PMID: 31132284 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - May 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Amniotic Membrane Transplant for Bullous Keratopathy: Confocal Microscopy & Anterior Segment Optical Coherence Tomography.
Amniotic Membrane Transplant for Bullous Keratopathy: Confocal Microscopy & Anterior Segment Optical Coherence Tomography. Semin Ophthalmol. 2019 May 27;:1-5 Authors: Siu GDJ, Kam KW, Young AL Abstract PURPOSE: To assess amniotic membrane retention after amniotic membrane transplant in bullous keratopathy patients and whether there were any corneal structural changes that may hinder further penetrating keratoplasty Methods: A retrospective study including 22 patients who have undergone amniotic membrane transplant from 1 Jan 1998 till 30 Jun 2016. Confocal microscopy and anterior segment optical co...
Source: Seminars in Ophthalmology - May 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Machine Learning in the Detection of the Glaucomatous Disc and Visual Field.
Authors: Smits DJ, Elze T, Wang H, Pasquale LR Abstract Glaucoma is the leading cause of irreversible blindness worldwide. Early detection is of utmost importance as there is abundant evidence that early treatment prevents disease progression, preserves vision, and improves patients' long-term quality of life. The structure and function thresholds that alert to the diagnosis of glaucoma can be obtained entirely via digital means, and as such, screening is well suited to benefit from artificial intelligence and specifically machine learning. This paper reviews the concepts and current literature on the use of machin...
Source: Seminars in Ophthalmology - May 29, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

A Review of Current Myopic Foveoschisis Management Strategies.
Authors: Dolar-Szczasny J, Święch-Zubilewicz A, Mackiewicz J Abstract Myopic foveoschisis (MF) is common in highly myopic eyes with posterior staphyloma, and optical coherence tomography is essential for establishing the diagnosis and monitoring disease progression. Untreated MF may lead to significant visual loss due to secondary complications. Vitrectomy with or without internal limiting membrane peeling followed by gas tamponade is the standard treatment; however, in recent years, new techniques, including macular buckling, have been introduced. We selected a total of 41 articles with 30 describing various mod...
Source: Seminars in Ophthalmology - May 9, 2019 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research