Comparative efficacy and safety of targeted therapy and immunotherapy for HER2-positive breast cancer: a systematic review and network meta-analyses
ConclusionOur study highlights the prominent role of targeted therapies and immunotherapies in treating HER2-positive breast cancer. The efficacy of trastuzumab-containing regimens was superior to other treatment options, while maintaining a comparable safety profile. Based on these findings, trastuzumab-containing regimens emerge as a preferable and recommended choice in clinical practice for managing HER2-positive breast cancer.Systematic Review RegistrationPROSPERO, identifier CRD42023414348. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report
Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, often characterized by nonspecific clinical presentations and late diagnosis, which contribute to its poor prognosis. It is commonly detected at advanced stages, leading to low survival rates. Surgical resection is the primary treatment, with the extent of surgery depending on the T stage of the cancer. In advanced cases, surgery is only considered if it can potentially be curative. Despite various treatment approaches for advanced GBC, survival outcomes remain poor. In our case series, we introduce a novel treatment approach combining cytoreductive sur...
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Risk factors associated with false negative rate of sentinel lymph node biopsy in endometrial cancer: a systematic review and meta-analysis
ConclusionsAlternative injection techniques (other than the cervix), Tc-99m dye tracer, and the absence of postoperative pathologic ultrastaging are risk factors for a high FNR in endometrial cancer patients who undergo SLNB; therefore, we should be vigilant for missed diagnosis of metastatic lymph nodes after SLNB in such populations.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023433637. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer
The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway. We summarized the literature on Keap1-Nrf2 signaling pathway and summarized the following three aspects: structure, function pathway, and cancer and clinical application status. This signaling pathway is similar to a double-edged sword: on the one hand, Nrf2 activity can protect cells from oxidative and electrophilic stress; on the other hand, increasing Nrf2 activity can enhance the survival and proliferation of can...
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Contrast-enhanced ultrasound combined with elastic imaging for predicting the efficacy of concurrent chemoradiotherapy in cervical cancer: a feasibility study
ConclusionsUsing contrast-enhanced ultrasound and elastography to predict the efficacy and disease progression of concurrent chemoradiotherapy is feasible. In addition, the combination of SCC-Ag with contrast-enhanced ultrasound and elastography can further enhance the efficiency of predicting disease progression. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Clinical outcomes of intermittent panitumumab based-therapy for previously treated older patient with metastatic colorectal cancer: a case report and review of literature
BackgroundMetastatic colorectal cancer is one of the most common causes of cancer death worldwide, and its incidence increases with age. Treating an older RAS and BRAF wild-type patient represents a challenge for the medical oncologist, even more so for those patients defined as “vulnerable” and undergoing at least two lines of therapy. In this context, recent evidence supports the role of retreatment with anti-EGFR inhibitors and the use of liquid biopsy. However, frequent skin toxicity constitutes a limitation of therapy, especially in older people. Since it has been described that continuous administration of these ...
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients
ConclusionOur findings revealed an increased risk of presentation of PC at an earlier age in patients with higher African ancestry compared to patients with lower African ancestry in our Hispanic/Latino patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Analysis of the treatment and prognosis of 266 cases of extranodal natural killer/T-cell lymphoma, nasal type in a single medical center
ConclusionStages of the disease and whether CR was achieved following treatment are important factors determining the survival and prognosis of patients with ENKTL. Further researches focusing on disease onset and mechanisms of drug resistance will contribute to better management of ENKTL. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Approach to a cerebral hernia caused by an intratumoral hemorrhage of a cystic oligodendroglioma: a case report
This study presents a case of cerebral herniation subsequent to cystic oligodendroglioma (COD) and sudden intratumoral hemorrhage. Following initial emergency treatment and evaluation, we successfully circumvented the solid component of the tumor and proceeded with cystic puncture and external drainage to prevent the incidence of brain herniation and mitigate the severity of associated symptoms. Based on preoperative examination results, the cystic glioma was successfully resected, and the patient experienced an uneventful recovery. According to the pathological findings, the oligodendroglioma was classified as World Healt...
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study
We report a case of recurrent retroperitoneal leiomyosarcoma in a male who achieved a rapid and robust but transient clinical response to low-dose iodine-125 brachytherapy. A FANCD2 frameshift mutation was detected by gene sequencing in the cancerous tissue. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Radical nephrectomy for a giant chromophobe renal cell carcinoma diagnosed > 17 years previously: a case report and literature review
We report a case involving a 59-year-old female who underwent a difficult radical nephrectomy 17 years after being diagnosed with malignant tumors due to primary renal cell carcinoma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Integrated analysis of scRNA-seq and bulk RNA-seq reveals that GPRC5A is an important prognostic gene in pancreatic cancer and is associated with B-cell Infiltration in pancreatic cancer
ConclusionGPRC5A is an independent risk factor in PC and correlated with B cell immune infiltration in PC. These outcomes indicated that GPRC5A is a viable target for treating PC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets
The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. In colorectal cancer (CRC), it is involved in different processes including tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. However, conflicting data regarding Eph receptors in CRC, especially in its putative role as an oncogene or a suppressor gene, make the precise role of Eph-ephrin interaction confusing in CRC development. In this review, we provide an overview of the literature and highlight evidence that collaborates with these ambiguous roles of the Eph/ephrin system in CRC, as wel...
Source: Frontiers in Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
The Radiation Therapy Technology Evidence Matrix: a framework to visualize evidence development for innovations in radiation therapy
We present the rtTEM and illustrate its application, using emerging and mature RT technologies as examples. The model breaks down the type of claim along the vertical axis and the strength of the evidence for that claim on the horizontal axis, both of which are inherent in clinical hypothesis testing. This simplified view allows for stakeholders to understand where the evidence is and where it is heading. Ultimately, the value of an innovation is typically demonstrated through superiority studies, which we have divided into three key categories – administrative, toxicity and control, to enable more detailed visibility of...
Source: Frontiers in Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Wnt/ β-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target
This article offers a thorough analysis of the Wnt/β-Catenin signaling pathway’s function and its therapeutic implications in HCC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
