A recombinant adenovirus vector containing the synNotch receptor gene for the treatment of triple-negative breast cancer
In this study, we developed a recombinant replication-deficient adenoviral vector (Ad-CD44-N-HIF-3α4), which contains a gene encoding a synthetic Notch (synNotch) receptor composed of the extracellular domain of CD44 (CD44-ECD) and the hypoxia-inducible factor (HIF)-3α4 connected by the Notch core regulatory region. CD44 is a transmembrane glycoprotein and known as a CSC marker in breast cancer and other malignancies. HIF-3α4 is a dominant-negative regulator of HIF-1α and HIF-2α and inhibits hypoxia-inducing effect. Both CD44 and HIF signals contribute cancer stemness and maintaining CSCs in breast cancer. The CD44-EC...
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Breast density and estradiol are associated with distinct different expression patterns of metabolic proteins in normal human breast tissue in vivo
ConclusionsMetabolic proteins may be targetable for breast cancer prevention. Depending on risk factor, this may, however, require different approaches as breast density and estradiol induce distinct different expression patterns in the breast. Additionally, metabolic proteins from the extracellular space may indeed be further explored as therapeutic targets for breast cancer treatment. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Clinical effect and follow-up of laparoscopic radical proximal gastrectomy for upper gastric carcinoma
ConclusionLaparoscopic radical proximal gastrectomy is safe and effective treatment option for upper gastric cancer. Tubular esophagogastric anastomosis has more advantages in restoring postoperative gastrointestinal function and reducing reflux, but it has a higher incidence of postoperative anastomotic stenosis compared with traditional esophagogastrostomy. The application of indocyanine green tracer technique in laparoscopic radical proximal gastrectomy has positive significance. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Comparative cardiotoxicity risk of pembrolizumab versus nivolumab in cancer patients undergoing immune checkpoint inhibitor therapy: A meta-analysis
ConclusionTo our knowledge, this is the first meta-analysis to compare the cardiotoxicity potentials of nivolumab and pembrolizumab. In contrast to previous reports, the overall findings here demonstrated that nivolumab-induced cardiotoxicity was more commonly reported in the literature than pembrolizumab; however, myocarditis seemed more likely to occur with pembrolizumab therapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
HPV genotyping of cervical histologic specimens of 61, 422 patients from the largest women hospital in China
ConclusionsThe prevalence of HPV genotypes in Chinese population was different from that in Western population. Some hrHPV types were identified in cervical precancerous lesions and cancers, which are not included in current HPV vaccines. These data provide baseline knowledge for future HPV vaccine development. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Advances in molecular and cell therapy for immunotherapy of cholangiocarcinoma
Cholangiocarcinoma (CCA) is a highly malignant tumor of the hepatobiliary system that has failed to respond to many traditional therapies to a certain extent, including surgery, chemotherapy and radiotherapy. In recent years, the new therapeutic schemes based on immunology have fundamentally changed the systemic treatment of various malignant tumors to a certain extent. In view of the immunogenicity of CCA, during the occurrence and development of CCA, some immunosuppressive substances are released from cells and immunosuppressive microenvironment is formed to promote the escape immune response of its own cells, thus enhan...
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
The nodal positivity rate in breast pCR patients with initially, clinically node-negative breast cancer after neoadjuvant systemic therapy: A systematic review and meta-analysis
ConclusionOur results suggested that cN0 patients who achieve bpCR may be exempt from axillary surgery in the HR+/HER2-, HR+/HER2+, and HR-/HER2- subtypes because of the extremely low probability of residual axillary lymph node disease. However, the safety of omitting axillary surgery needs to be further confirmed by prospective studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42022351739. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Multimodality MRI radiomics analysis of TP53 mutations in triple negative breast cancer
ConclusionsRadiomics-based analysis with the SVM model is recommended for the detection of TP53 mutations in TNBC. Furthermore, T1WI- and T2WI-related features could be used as noninvasive biomarkers for predicting TP53 mutations. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Innovative method with two-stage surgery for Ewing sarcoma with personalized distal clavicle reconstruction: A case report and diagnosis review
A 13-year-old boy presented with a growing lump on his left clavicle for 5 months. The plain radiograph revealed an osteolytic mass with aggressive periosteal reaction, suggesting a malignant lesion. The results of advanced imaging and histopathological examinations revealed that the patient had Ewing sarcoma without metastasis. The two-stage surgery was as follows: resection–observation–reconstruction. The underlying rationale was that Ewing sarcoma has a high recurrence. After 2 years of resection, the patient had remission, and he currently has a personal 3D-printed titanium implant with intact shoulder function. (S...
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Identification of a novel defined inflammation-related long noncoding RNA signature contributes to predicting prognosis and distinction between the cold and hot tumors in bladder cancer
ConclusionOur study showed that inflammation-related LncRNAs are closely related with BLCA, and inflammation-related lncRNA can accurately predict patient prognosis and effectively differentiate between hot and cold tumors, thus improving individualized immunotherapy for BLCA patients. Therefore, this study provides an effective predictive model and a new therapeutic target for the prognosis and clinical treatment of BLCA, thus facilitating the development of individualized tumor therapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Near-infrared fluorescence imaging of hepatocellular carcinoma cells regulated by β-catenin signaling pathway
ConclusionsOur study uncovers a mechanism that links the distribution and expression of the membrane transporters OATP2B1 and ABCG2 to the tumor-specific accumulation of MHI-148, and provides evidence supporting a regulating role of the β-catenin signaling pathway in OATP2B1 and ABCG2- induced retention of MHI-148 inHCC tissues, and strategy targeting key components of MHI-148 transport machinery may be a potential approach to improve HCC imaging. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers
ConclusionThis analysis comprehensively identified FBXW7 alterations in colorectal cancer patients and uncovered the molecular, clinicopathological, and immune-related patterns of FBXW7-altered CRC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Proton versus photon radiation therapy: A clinical review
While proton radiation therapy offers substantially better dose distribution characteristics than photon radiation therapy in certain clinical applications, data demonstrating a quantifiable clinical advantage is still needed for many treatment sites. Unfortunately, the number of patients treated with proton radiation therapy is still comparatively small, in some part due to the lack of evidence of clear benefits over lower-cost photon-based treatments. This review is designed to present the comparative clinical outcomes between proton and photon therapies, and to provide an overview of the current state of knowledge regar...
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
How do serum lipid levels change and influence progression-free survival in epithelial ovarian cancer patients receiving bevacizumab treatment?
ConclusionSerum lipid levels changed variously in EOC patients receiving bevacizumab treatment. A prediction model for PFS of EOC patients receiving bevacizumab treatment was constructed, and it can be beneficial in determining the prognosis, selecting a treatment plan, and monitoring these patients’ long-term care. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Development and validation of a nomogram model for lung cancer based on radiomics artificial intelligence score and clinical blood test data
ConclusionThe nomogram model integrating AI and clinical data can accurately predict lung cancer, especially for the squamous cell carcinoma subtype. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
