Von-Hipple Lindau syndrome with family history: a case report and seventeen years follow-up study
ConclusionThe clinical presentation of VHL syndrome is atypical, and early identification and treatment of VHL syndrome is possible by genetic testing techniques. Multiple relapses occurred during the course of the disease, but early diagnosis and aggressive treatment allowed the patients to survive well. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research
Prostate cancer research: tools, cell types, and molecular targets
Multiple cancer cell types are found in prostate tumors. They are either luminal-like adenocarcinoma or less luminal-like and more stem-like non-adenocarcinoma and small cell carcinoma. These types are lineage related through differentiation. Loss of cancer differentiation from luminal-like to stem-like is mediated by the activation of stem cell transcription factors (scTF) such as LIN28A, NANOG, POU5F1 and SOX2. scTF expression leads to down-regulation of β2-microglobulin (B2M). Thus, cancer cells can change from the scTF˜B2Mhi phenotype of differentiated to that of scTF˙B2Mlo of dedifferentiated in the disease course....
Source: Frontiers in Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research
Sacituzumab Govitecan for the treatment of advanced triple negative breast cancer patients: a multi-center real-world analysis
ConclusionThe results of this real-world analysis showed that both safety and efficacy of sacituzumab govitecan in mTNBC patients are consistent with that previously reported in regulatory trials. The use of premedication and supportive measures was associated with a satisfactory toxicity profile. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research
Editorial: Multi-omics analysis of programmed cell death-mediated tumor microenvironment heterogeneity
(Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research
Nomogram to predict prognosis of head and neck rhabdomyosarcoma patients in children and adolescents
ConclusionWe constructed a prognostic nomogram model for predicting the OS in HNRMS patients in children and adolescents and this model presented practical and applicable clinical value to predict survival when choosing treatment strategies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
A case report of atypical chronic myeloid leukemia with complete hematological and major molecular response to Venetoclax/Azacitidine treatment
Atypical Chronic Myeloid Leukemia (aCML), a myeloproliferative neoplasm with poor prognosis, was reclassified as aCML by the ICC classification, and as MDS/MPN with neutrophilia by the WHO 2022 classification. Due to the heterogeneity of its clinical features and the lack of unique biomarkers, as well as limited treatment options, aCML currently lacks a standardized treatment protocol. In this case report, we reviewed a young man diagnosed with aCML who achieved complete clinical and hematologic remission subsequent to receiving a therapeutic regimen combining Venetoclax and Azacitidine. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Current status and progress of research on the ADP-dependent glucokinase gene
ADP-dependent glucokinase (ADPGK) produces glucose-6-phosphate with adenosine diphosphate (ADP) as the phosphate group donor, in contrast to ATP-dependent hexokinases (HKs). Originally found in archaea, ADPGK is involved in glycolysis. However, its biological function in most eukaryotic organisms is still unclear, and the molecular mechanism of action requires further investigation. This paper provides a concise overview of ADPGK’s origin, biological function and clinical application. It aims to furnish scientific information for the diagnosis and treatment of human metabolic diseases, neurological disorders, and maligna...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Unveiling the immunosuppressive landscape of pancreatic ductal adenocarcinoma: implications for innovative immunotherapy strategies
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), stands as the fourth leading cause of cancer-related deaths in the United States, marked by challenging treatment and dismal prognoses. As immunotherapy emerges as a promising avenue for mitigating PDAC’s malignant progression, a comprehensive understanding of the tumor’s immunosuppressive characteristics becomes imperative. This paper systematically delves into the intricate immunosuppressive network within PDAC, spotlighting the significant crosstalk between immunosuppressive cells and factors in the hypoxic acidic pancreatic tumor microenvi...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention
Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding ...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Image quality evaluation for a clinical organ-targeted PET camera
DiscussionDemonstrated ability to accurately reconstruct activity in tumors as small as 5 mm suggests that the Radialis PET technology may be well suited for emerging clinical applications such as image guided assessment of response to neoadjuvant systemic treatment (NST) in lesions smaller than 2 cm. Also, our results suggest that, while spatial resolution greatly influences the partial volume effect which degrades contrast recovery, optimized count rate performance and image reconstruction workflow may improve recovery coefficients for systems with comparable spatial resolution. We emphasize that recovery coefficient sho...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Novel frameless LINAC radiosurgery solution for uveal melanoma
ConclusionWe successfully developed a novel non-invasive frameless mask-based LINAC solution for SRS for uveal melanoma, or other ocular tumors. It is well tolerated with high set up accuracy. Future directions for this localization box would include a multi-center trial to assess the efficacy and reproducibility in the fabrication and execution of such a solution for UM therapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Prospective evaluation of patient-reported outcomes of invisible ink tattoos for the delivery of external beam radiation therapy: the PREFER trial
DiscussionIn the largest prospective trial on IIT-based radiotherapy setup to date, we found that patients prefer IITs to VITs. Additionally, IIT-based alignment is an effective and efficient strategy in comparison with tattooless setup. Standard incorporation of IITs for patient setup should be strongly considered. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Mechanisms of angiogenesis in tumour
This article summarizes recent studies on six processes of tumour angiogenesis and provides suggestions for developing more effective techniques to improve the efficacy of antiangiogenic treatment. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Research progress on the antitumor effects of harmine
Harmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects. Recent mechanistic studies have shown that harmine can inhibit cancer cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle regulation, angiogenesis, and the induction of tumor cell apoptosis. Furthermore, harmine reduces drug resistance when used in combination with chemotherapeutic drugs. Despite its remarkable antitumor activity, the application of harmi...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
TSC2 nonsense mutation in angiomyolipoma with epithelial cysts: a case report and literature review
ConclusionTo the best of our knowledge, this study represents the first analysis of genotype mutations in AMLEC, providing valuable insights for future clinical practice. These findings have significant potential in guiding the understanding and management of AMLEC, paving the way for further research and advancements in the field. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
