Photodynamic therapy with paclitaxel-encapsulated indocyanine green-modified liposomes for breast cancer
ConclusionThe PDT therapy with ICG-Lipo-PTX may be an effective treatment for breast cancer. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction
ConclusionStimulation of tumor-infiltrating lymphocytes in SC was feasible, which led to increased apoptosis in tumor cells. Induced mitochondrial dysfunction did not play a significant role in the activation and function of TILs in SC of HNSCC. Moreover, high glucose concentration did not promote cytotoxic T cell activity in HNSCC SC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression
DiscussionTaken together, our findings suggest the role of SARS-CoV-2 M-protein in altering the cellular communication between cancer cells and other non-cancer cells inside the tumor microenvironment via EV. Specifically, M-proteins induced the ability of EV derived from triple-negative BCC to promote the functions of non-cancer cells, such as tissue stem cells, in tumorigenesis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

The histologic features, molecular features, detection and management of serrated polyps: a review
This article provides a comprehensive summary of the epidemiology, histologic features, molecular features, and detection methods for various serrated polyps, along with recommendations for their management and surveillance. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

SMMF: a self-attention-based multi-parametric MRI feature fusion framework for the diagnosis of bladder cancer grading
ConclusionOur proposed SMMF framework combined with MP-MRI information can accurately predict the pathological grading of BCa and can better assist physicians in diagnosing BCa. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Experimental evidence for anti-metastatic actions of apigenin: a mini review
Cancer metastasis is responsible for the majority of cancer-related deaths. Accordingly, to reduce metastasis remains a vital challenge in clinical practice, and phytochemicals have taken an attention as anti-metastatic agents. Apigenin, a plant flavone, showed anti-cancer effects against in various animal models, moreover its potentials inhibiting tumor metastasis have been reported. Herein, we analyzed the overall features at what apigenin inhibited metastasis and its action modes. We searched for articles in MEDLINE (Pubmed), EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) through March 2023. Total 6...
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Prediction of tumor lysis syndrome in childhood acute lymphoblastic leukemia based on machine learning models: a retrospective study
ConclusionWe developed the first TLS prediction model for pediatric ALL to assist clinicians in risk stratification at diagnosis and in developing personalized treatment protocols. This study is registered on the China Clinical Trials Registry platform (ChiCTR2200060616).Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2200060616. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

The prognostic value of absolute lymphocyte count and neutrophil ‐to‐lymphocyte ratio for patients with metastatic breast cancer: a systematic review and meta‐analysis
ConclusionLow ALC and elevated NLR were observed to be significantly associated with adverse OS and PFS in MBC, indicating that ALC and NLR may act as potential prognostic biomarkers of MBC patients. Meanwhile, our results will also provide some novel evidence and research clues for the selection and development of clinical treatment strategies for MBC patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021224114. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis
ConclusionOverall, the miR-3919/DJ-1 axis may be involved in the effects of SFN on the malignant biological behavior of PCa cells, which might be a new therapeutic target in PCa. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort
DiscussionThis longitudinal study confirms the inverse association between active smoking, a known risk factor for BC, and MBD among post-menopausal women. The inclusion of smoking habits in the existing BC risk prediction models could be evaluated in future studies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Dark horse target Claudin18.2 opens new battlefield for pancreatic cancer
Pancreatic cancer is one of the deadliest malignant tumors, which is a serious threat to human health and life, and it is expected that pancreatic cancer may be the second leading cause of cancer death in developed countries by 2030. Claudin18.2 is a tight junction protein expressed in normal gastric mucosal tissues, which is involved in the formation of tight junctions between cells and affects the permeability of paracellular cells. Claudin18.2 is highly expressed in pancreatic cancer and is associated with the initiation, progression, metastasis and prognosis of cancer, so it is considered a potential therapeutic target...
Source: Frontiers in Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Reverse-sequence endoscopic nipple-sparing mastectomy with immediate implant-based breast reconstruction: an improvement of conventional minimal access breast surgery
ConclusionR-E-NSM improves cosmetic outcomes and efficiency of C-E-NSM, reduces medical costs, and has a trend of lower surgical complications while maintaining the safety of oncology. It is a safe and feasible option for oncological procedures that deserves to be promoted and widely adopted in practice. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Imaging classification of prostate cancer with extracapsular extension and its impact on positive surgical margins after laparoscopic radical prostatectomy
ConclusionsEPE imaging classification and biopsy GG were associated with PSM after laparoscopic radical prostatectomy, and their combination can significantly improve the accuracy of predicting PSM. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Looking beyond year 1 in the molecular era of pediatric brain tumor diagnosis: confirmatory testing of germline variants found on tumor sequencing
ConclusionClinically validated molecular profiling of pediatric brain tumors identifies patients who warrant further germline evaluation. Despite this, only a subset of these patients underwent the indicated confirmatory sequencing. Further work is needed to identify barriers and facilitators to this testing, including the role of genetic counseling and consideration of upfront paired somatic-germline testing. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Identification of hub genes within the CCL18 signaling pathway in hepatocellular carcinoma through bioinformatics analysis
ConclusionExogenous CCL18 promotes LM3 and MHCC-97H cells proliferation, migration, invasion, stemness, and immune evasion. The high expression of BMI1, CCR3, CDC25C, CFL1, LDHA, and RAC1 can serve as a biomarkers for immune evasion in HCC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research