Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations
This article summarizes the current scientific evidence on the effects of supplementation with prebiotics, probiotics, and synbiotics on high-risk human papillomavirus (HPV) infections, precancerous lesions, and various stages of cervical cancer development and treatment while also examining the underlying molecular pathways involved. Our findings indicate that a higher dietary fiber intake is associated with a reduced risk of HPV infection, while certain probiotics have shown promising results in clearing HPV-related lesions. Additionally, certain strains of probiotics, prebiotics such as inulin and fructo-oligosaccharide...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis
ConclusionThe present study demonstrates that, in comparison to TAT, RH may confer superior survival benefits for patients with recurrent HCC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Therapeutic prospects of nectin-4 in cancer: applications and value
This article reviews the diagnostic potential, prognostic significance, and molecular role of Nectin-4 in tumors, with a focus on clinical trials in the field of Nectin-4-related tumor treatment and the development of new drugs targeting Nectin-4. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Feasibility of an MR-based digital specimen for tongue cancer resection specimens: a novel approach for margin evaluation
ConclusionThis proof of concept for volumetric assessment of resection margins using MR-DSs, demonstrates promising potential for further development. Overall, sensitivity is higher than specificity for inadequate margin detection, because of the radiologist’s tendency to overestimate tumor size. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Case report: Primary sarcoma of the mandible with a novel SLMAP-BRAF fusion
Primary sarcomas of the jaw are very rare tumor with unclear mechanism of tumorigenesis. Identification of genetic alterations contributes to better understanding of tumorigenesis and extension of tumor spectrum, as well as potential therapeutic targets application. Herein, we firstly report a case of primary sarcoma in the mandible with novel SLMAP-BRAF fusion. Morphologically, the tumor was composed of histiocyte-like cells, larger epithelioid cells, spindle cells and osteoclast-like giant cells with moderate atypia. Focally, it mimicked tenosynovial giant cell tumor or biphasic synovial sarcoma, and even giant cell tumo...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
A refined prediction model for survival in hepatocellular carcinoma patients treated with transarterial chemoembolization
ConclusionThis newly developed TP scoring system has the potential to be a useful tool in identifying ideal candidates of TACE and predicting OS with favorable performance and discrimination. However, further external validation is needed to confirm its effectiveness. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
FusionVAC22_01: a phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion
The DNAJB1-PRKACA fusion transcript was identified as the oncogenic driver of tumor pathogenesis in fibrolamellar hepatocellular carcinoma (FL-HCC), also known as fibrolamellar carcinoma (FLC), as well as in other tumor entities, thus representing a broad target for novel treatment in multiple cancer entities. FL-HCC is a rare primary liver tumor with a 5-year survival rate of only 45%, which typically affects young patients with no underlying primary liver disease. Surgical resection is the only curative treatment option if no metastases are present at diagnosis. There is no standard of care for systemic therapy. Peptide-...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Barriers to cervical cancer prevention in a safety net clinic: gaps in HPV vaccine provider recommendation and series completion among Ob/Gyn patients
ConclusionOur study demonstrated that many patients never had a provider discuss HPV vaccination with them and never received the HPV vaccine. Additionally, amongst those who did initiate HPV vaccination, completion of the series remains a key barrier. Ensuring that providers discuss HPV vaccination and that patients receive HPV vaccines, along with expanding access to and convenience of HPV vaccination are critical aspects of preventing cervical cancer. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Optimal response to tislelizumab plus chemotherapy in metastatic triple-negative breast cancer: a case report and literature review
Metastatic triple-negative breast cancer (mTNBC) has the worst prognosis among breast cancer subtypes. Immune checkpoint inhibitors (ICIs) plus chemotherapy have promising survival benefits. Herein, we report a 51-year-old woman whose metastatic lesions were diagnosed as triple-negative subtype and who received tislelizumab plus eribulin treatment and achieved excellent efficacy. To our knowledge, this study is the first attempt to present tislelizumab in combination with eribulin for mTNBC treatment. New treatments resulting in prolonged survival and durable clinical responses would benefit mTNBC patients. Then, we summar...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Current status and challenges in timely detection of cervical cancer in Mexico: expert consensus
Cervical cancer is a significant public health problem in low- and middle-income countries, accounting for 85% of new cases worldwide. Due to poorly organized screening programs, cervical cancer is more likely to develop in vulnerable groups who do not initiate or rarely undergo screening. Cervical cytology and detecting high-risk human papillomavirus types are the recommended screening tools. Further, these strategies allow for accurately identifying women at a higher risk of cervical cancer and establishing screening times. New detection tools, such as novel biomarkers or automatic HPV detection in the vagina or urine, c...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Second malignant neoplasms within 5 years from first primary diagnosis in pediatric oncology patients in Canada: a population-based retrospective cohort study
This study aims to assess the incidence, characteristics, management, and outcome of children who develop SMN malignancies within 5 years of diagnosis of their initial cancer.MethodThis is a retrospective cohort study of early Second Malignant Neoplasms (SMN) in pediatric oncology patients. The Cancer in Young People – Canada (CYP-C) national pediatric cancer registry was used and reviewed pediatric patients diagnosed with their first cancer from 2000-2015.ResultsA total of 20,272 pediatric patients with a diagnosis of a first malignancy were analyzed. Of them, 0.7% were diagnosed with a SMN within the first 5 years foll...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Impact of bias field correction on 0.35 T pelvic MR images: evaluation on generative adversarial network-based OARs ’ auto-segmentation and visual grading assessment
ConclusionThe bias field correction did not improve the anatomy visualization from a clinical point of view and the OARs’ auto-segmentation outputs generated by the GAN. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Predictive model of positive surgical margins after radical prostatectomy based on Bayesian network analysis
ConclusionThe predictive model of positive resection margin after radical prostatectomy based on Bayesian network demonstrated high accuracy and usefulness. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Centrosomes and associated proteins in pathogenesis and treatment of breast cancer
Breast cancer is the most prevalent malignancy among women worldwide. Despite significant advances in treatment, it remains one of the leading causes of female mortality. The inability to effectively treat advanced and/or treatment-resistant breast cancer demonstrates the need to develop novel treatment strategies and targeted therapies. Centrosomes and their associated proteins have been shown to play key roles in the pathogenesis of breast cancer and thus represent promising targets for drug and biomarker development. Centrosomes are fundamental cellular structures in the mammalian cell that are responsible for error-fre...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Locoregional recurrence and survival of breast −conserving surgery compared to mastectomy following neoadjuvant chemotherapy in operable breast cancer
ConclusionCompared with mastectomy, BCS after NAC may not increase the risk of local recurrence or mortality, BCS can be performed in selected patients with small tumor size and good response to NAC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
