Progress of the acyl-Coenzyme A thioester hydrolase family in cancer
In recent years, the acyl-Coenzyme A thioester hydrolase family (ACOTs) has received wide attention as a key link in lipid metabolism. This family is a class of enzymes that catalyze the hydrolysis of fatty acyl-Coenzyme A, disrupting the thioester bond present within acyl-CoA ester molecules to produce free fatty acids (FFA) and the corresponding coenzyme A (CoA). Such enzymes play a very important role in lipid metabolism through maintaining appropriate levels of intracellular FFA and fatty acyl-CoA as well as CoA. It is broadly divided into two distinct subgroups, the type-I α/β-hydrolase fold enzyme superfamily and t...
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Prevention of cisplatin-induced hearing loss in children: achievements and challenges for evidence-based implementation of sodium Thiosulfate
Ototoxicity is a devastating direct, irreversible side effect of platinum use in children with cancer, with its consequent effect on speech, language and social development, quality of life and adult productivity. Cisplatin, an essential chemotherapeutic agent for the treatment of solid tumors in children, is a DNA cross-linking agent. Which causes hearing loss in 50-70% of cisplatin treated children. Fortunately, to prevent hearing loss, sodium thiosulfate (STS), which binds to cisplatin, and reduces the superoxides in both tumor and outer hair cells of the cochlea has now been discovered to be an effective and safe otopr...
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Liver transplantation vs liver resection in HCC: promoting extensive collaborative research through a survival meta-analysis of meta-analyses
ConclusionOverall, the study underscores the superior survival outcomes associated with LT over LR in HCC treatment, supported by comprehensive meta-analysis and clustering analysis. There was no difference in survival or recurrence rate between salvage LT and primary LT. Therefore, considering the organ shortage, HCC can be resected and transplanted in case of recurrence. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Case report: Isolated axillary lymph node metastasis in high-risk endometrial cancer
ConclusionAxillary lymph node metastasis as the first site of recurrence is rare, even in high-risk endometrial cancer. In addition to systemic chemotherapy, aggressive locoregional treatment can potentially maximize the chance of long-term disease control. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Risk factors analysis and the establishment of nomogram prediction model for PICC-related venous thrombosis in patients with lymphoma: a double-center cohort-based case-control study
ConclusionsPatients should be advised to undergo color Doppler ultrasound system testing within two week after the implantation of a PICC catheter to detect PICC-RVTE at an early stage. The validated nomogram can be used to predict the risk of catheter-related thrombosis (CRT) in patients with lymphoma who received at least one chemotherapy after PICC catheterization, no bleeding tendency, no recent history of anticoagulant exposure and no severe heart, lung, renal insufficiency. This model has the potential to assist clinicians in formulating individualized treatment strategies for each patient. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Development of a nomogram for predicting the high-risk groups of solid-pseudopapillary neoplasms of the pancreas
ConclusionThe nomogram model based on clinical symptoms, inflammatory markers, and imaging features had a high application value in the preoperative prediction of the high-risk groups of SPNs. A novel nomogram of the affiliated hospital of Jilin University-SPNs risk model was proposed for routine application to guide the patient counseling in clinical practice. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Editorial: The predictive benefits of inflammatory markers in cancers of the liver
(Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Preoperative prediction for early recurrence of hepatocellular carcinoma using machine learning-based radiomics
ConclusionThe CECT-based radiomics may be helpful to non-invasively reveal the potential connection between CECT images and early recurrence of HCC. The combination of radiomics and clinical factors could boost model performance. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Single brain metastases – prognostic factors and impact of residual tumor burden on overall survival
ConclusionWhen complete intracranial tumor resection RTB=0 is achieved, patients with solitary BM have a favorable outcome compared to singular BM. Singular BM was confirmed as independent risk factor. There is a strong presumption that complete resection leads to an improved oncological prognosis. Patients with solitary BM tend to benefit with a favorable outcome following complete resection. Hence, surgical resection should be considered as a treatment option for patients presenting with either no or minimal extracranial disease. Furthermore, the highly favorable impact of postoperative RT on OS was demonstrated and conf...
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Case report: Isolated eyelid metastasis of ccRCC 5 years after receiving radical nephrectomy
ConclusionsAlthough the probability of eyelid metastasis rate is very low, tumor metastasis to the eyelid skin is possible after radical nephrectomy. Therefore, any rash like changes on the skin during the review procedure cannot be ignored by the physician. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers
This study discusses the key roles of some lncRNAs and miRNAs in the growth and advancement of pancreatic carcinoma. Because they are involved not only in the premature identification, chemo-resistance and prognostication, also their roles as potential biomarkers for better management of PDAC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignancies
SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family of substrate-recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with ubiquitin-mediated degradation in the mammalian cell cycle components and other target proteins involved in cell cycle progression, signal transduction, and transcription. Being an oncogene in solid tumors and hematological malignancies, it is frequently associated with drug resistance and poor disease outcomes. In the current review, we discussed the novel role of SKP2 in different hematological malignancies. Further, we performed a limited in-sil...
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Mechanism of action of nadofaragene firadenovec-vncg
Effective bladder-preserving therapeutic options are needed for patients with bacillus Calmette-Guérin unresponsive non–muscle-invasive bladder cancer. Nadofaragene firadenovec-vncg (Adstiladrin®) was approved by the US Food and Drug Administration as the first gene therapy in urology and the first intravesical gene therapy indicated for the treatment of adult patients with high-risk bacillus Calmette-Guérin–unresponsive non–muscle-invasive bladder cancer with carcinoma in situ with or without papillary tumors. The proposed mechanism of action underlying nadofaragene firadenovec efficacy is likely due to the pleio...
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Association of cancer diagnosis with disability status among older survivors of colorectal cancer: a population-based retrospective cohort study
ConclusionsOur findings suggest that a CRC diagnosis is independently associated with a small increase in the risk of developing poor DS after accounting for other known factors. The study identified risk factors for developing poor DS in CRC survivors, including Hispanic and Black race/ethnicity, age, sex, histologic stage, and comorbidities. These findings underscore the importance of consistent physical function assessments, particularly among subsets of older survivors of CRC who are at higher risk of disability, to prevent developing poor DS. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
Corrigendum: Influence of body composition assessment with bioelectrical impedance vector analysis in cancer patients undergoing surgery
(Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 14, 2024 Category: Cancer & Oncology Source Type: research
