Comparison of the relative diagnostic performance of 68Ga-DOTA-IBA and 18F-NaF for the detection of bone metastasis
ConclusionThe diagnostic efficacy of 68Ga-DOTA-IBA for bone metastasis lesions is comparable to that of 18F-NaF. This finding holds significant clinical importance in terms of diagnosis of bone metastasis and selecting treatment plans for patients with malignant tumors (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Cost-effectiveness analysis of amivantamab plus chemotherapy versus chemotherapy alone in NSCLC with EGFR Exon 20 insertions
ConclusionsCompared with chemotherapy alone, amivantamab plus chemotherapy is not a cost-effective first-line treatment choice for NSCLC patients with EGFR exon 20 insertions. The costly price of amivantamab is one of the major reasons for the high cost of this combined treatment strategy. Therefore, it is imperative to take into account the high cost of amivantamab in the subsequent clinical application and strive to attain a relative equilibrium between its significant clinical benefit and economic encumbrance. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up
ConclusionLong-term analysis confirmed that in CCRT, cisplatin administration with sinusoidal chrono-modulated infusion was not superior to the constant infusion rate in terms of long-term toxicity and prognosis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Practical management of disease-related manifestations and drug toxicities in patients with multiple myeloma
Multiple myeloma (MM) is a very heterogeneous disease with multiple symptoms and clinical manifestations. MM affects mainly elderly patients and is difficult to manage in the presence of comorbidities, polypharmacy, frailty and adverse events of disease-targeted drugs. The rapid changes in MM treatment resulting from constant innovations in this area, together with the introduction of numerous new drugs with distinct mechanisms of action and toxicity profiles, have led to an increased complexity in the therapeutic decision-making and patient management processes. The prolonged exposure to novel agents, sometimes in combina...
Source: Frontiers in Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
A comprehensive review of the role of bone marrow biopsy and PET-CT in the evaluation of bone marrow involvement in adults newly diagnosed with DLBCL
Diffuse large B cell lymphoma (DLBCL) is one of the most prevalent subtypes of non-Hodgkin lymphoma (NHL) and is known for commonly infiltrating extra-nodal sites. The involvement of the bone marrow by lymphoma cells significantly impacts the staging, treatment, and prognosis among the extra-nodal sites in DLBCL. Bone marrow biopsy has been considered the standard diagnostic procedure for detecting bone marrow involvement. However, advancements in imaging techniques, such as positron emission tomography-computed tomography (PET-CT), have shown an improved ability to detect bone marrow involvement, making the need for bone ...
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Comparison of indocyanine green and blue-stained glue for preoperative localization for pulmonary nodules
ConclusionsIG and BSG both offer similarly high levels of clinical safety and efficacy when applied for preoperative CT-guided PN localization, with IG being less expensive than BSG. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Corrigendum: Recent status and trends of nanotechnology in cervical cancer: a systematic review and bibliometric analysis
(Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system
Prostate cancer is a major contributor to male cancer-related mortality globally. It has a particular affinity for the skeletal system with metastasis to bones seriously impacting prognosis. The identification of prostate cancer biomarkers can significantly enhance diagnosis and patient monitoring. Research has found that cancer and metastases exhibit abnormal expression of numerous non-coding RNA. Some of these RNA facilitate prostate cancer bone metastasis by activating downstream signaling pathways, while others inhibit this process. Elucidating the functional processes of non-coding RNA in prostate cancer bone metastas...
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis
ConclusionsOur findings do not support a genetic link between PS and cancers. More population-based and experimental investigations will be required better to understand the complicated relationship between PS and cancers. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Gastric cancer with brain metastasis: from molecular characteristics and treatment
Gastric cancer is one of the cancers with increasing incidence and ranks fourth globally among the most frequent causes of cancer-related mortality. Early gastric cancer is often asymptomatic or presents with atypical symptoms, and the majority of patients present with advanced disease upon diagnosis. Brain metastases are present in approximately 1% of gastric cancer patients at the time of diagnosis, which significantly contributed to the overall mortality of the disease worldwide. Conventional therapies for patients with brain metastases remain limited and the median overall survival of patients is only 8 months in advan...
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Renal pelvis metastasis following surgery for breast angiosarcoma: a case report and literature review
This article reports the medical records of a patient diagnosed with breast angiosarcoma who underwent radical mastectomy and was found to have multiple lung metastases 3 years after surgery and renal pelvic metastasis 4 years after surgery. The patient underwent robot-assisted laparoscopic radical nephroureterectomy and sleeve resection of the intramural segment of the ureter, and postoperative pathology and immunohistochemical staining confirmed the diagnosis of renal pelvic metastasis of breast angiosarcoma. The patient received anlotinib for lung metastases following surgery and was followed up for 4 months after surge...
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Construction and validation of log odds of positive lymph nodes (LODDS)-based nomograms for predicting overall survival and cancer-specific survival in ovarian clear cell carcinoma patients
ConclusionPredictive nomograms were constructed and validated to evaluate the OS and CSS of OCCC patients. These nomograms may provide valuable prognostic information and guide postoperative personalized care in OCCC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Evaluation of the neoadjuvant chemotherapy response in osteosarcoma using the MRI DWI-based machine learning radiomics nomogram
ConclusionThe nomogram based on combined radiomics and clinical features outperformed standalone clinical or radiomics model, offering enhanced accuracy in evaluating NAC response in osteosarcoma. It held significant promise for clinical applications. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Efficacy and safety of consolidation chemotherapy after adjuvant therapy in stage IB-IIA cervical cancer patients with risk factors: a retrospective single-center study
ConclusionConsolidation chemotherapy after adjuvant therapy provided survival benefits in stage IB-IIA CC patients with high risk factors, particularly those with ≥2 metastatic lymph nodes. However, related hematologic toxicities should be alerted in patient management. The actual efficacy and safety of consolidation chemotherapy still need to be investigated in more well-designed clinical trials. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Malignant transformation of primary ameloblastoma of skull: case report and review of current literature
ConclusionPrimary AM or AMCa of the skull is increasingly being described in the literature, but detailed reports on the malignant transformation of primary AM of the skull are lacking. The pathogenesis of this condition remains unclear. Aggressive treatment and close follow-up may be crucial for preventing disease recurrence and malignant transformation. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
