Analyzing RB and E2F During the G1–S Transition
The G1/S-phase restriction point is an important landmark in the mammalian cell division cycle. The key regulator of the G1/S transition is the retinoblastoma gene product (pRB). It prevents the transcription of genes required for S-phase progression by repressing E2F transcription factors. An increase in Cdk phosphorylation of pRB causes the release of E2F transcription factors and advancement into S phase. Here we describe two simple techniques used to assess pRB phosphorylation and E2F transcription during G1/S progression. (Source: Springer protocols feed by Cell Biology)
Source: Springer protocols feed by Cell Biology - June 10, 2014 Category: Cytology Source Type: news
“White Eye” Photos May Be Sign Of Serious Disease
BOSTON (CBS) – “Red Eyes” are a common frustration when it comes to taking pictures. But doctors are warning parents that “White Eyes” in a child’s photo can be an indication of a serious medical condition.
In rare cases, it can be a sign of retinoblastoma, a cancer of the eye. “It can spread outside the eye and be fatal if it is not picked up,” said Dr. Michael Hunt, a pediatric eye specialist.
That was Makenzie Foreman’s diagnosis. She had tumors in her left eye and began chemotherapy when she was just six months old. Her eye eventually had to be removed.
“It was obviously extremely emotional,...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 7, 2014 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Cancer Dr. Mallika Marshall retinoblastoma white eye Source Type: news
New way to enhance nerve growth following injury discovered
A mechanism to promote growth in damaged nerve cells as a means to restore connections after injury has been uncovered by scientists who have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system. "We made the surprising discovery that a protein called Retinoblastoma (Rb) is present in adult neurons," explains the lead researcher. "This protein appears to normally act as a brake -- preventing nerve growth." (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 22, 2014 Category: Science Source Type: news
Early detection of childhood eye cancer doesn't always improve survival, prevent eye loss
For the most common form of childhood eye cancer, unilateral retinoblastoma, shortening the time from the first appearance of symptoms to diagnosis of disease has no bearing on survival or stage of the disease, according to a study by researchers at Columbia University Mailman School of Public Health in partnership with the Hospital Infantil de Mexico. The results appear online in the journal Cancer Epidemiology, Biomarkers & Prevention. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 20, 2014 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news
Early detection of childhood eye cancer doesn't always improve survival, prevent eye loss
(Columbia University's Mailman School of Public Health) For the most common form of childhood eye cancer, unilateral retinoblastoma, shortening the time from the first appearance of symptoms to diagnosis of disease has no bearing on survival or stage of the disease, according to a study by researchers at Columbia University Mailman School of Public Health in partnership with the Hospital Infantil de Mexico. The results appear online in the journal Cancer Epidemiology, Biomarkers & Prevention. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 18, 2014 Category: Cancer & Oncology Source Type: news
Pancreatic cancer cell growth promoted by retinoblastoma dysfunction
Indiana University cancer researchers have discovered that a protein that normally suppresses tumors actually promotes the growth and spread of pancreatic cancer.Murray Korc, M.D., the Myles Brand Professor of Cancer Research at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues have shown that the retinoblastoma protein, a tumor suppressor, often malfunctions in pancreatic cancer. That dysfunction enables an inhibitory protein to promote pancreatic cancer growth. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 20, 2013 Category: Consumer Health News Tags: Pancreatic Cancer Source Type: news
IU cancer researchers: Retinoblastoma dysfunction promotes pancreatic cancer cell growth
(Indiana University) Indiana University cancer researchers have discovered that a protein that normally suppresses tumors actually promotes the growth and spread of pancreatic cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 16, 2013 Category: Global & Universal Source Type: news
Researchers unravel important role of Rb tumor suppressor in aggressive form of breast cancer
The retinoblastoma (Rb) protein plays a critical role in suppressing the multi-step process of cell migration through the bloodstream, lymphovascular invasion and the metastasis of an aggressive type of breast cancer to the lung, researchers at the University of Cincinnati (UC) Cancer Institute, the Cincinnati Cancer Center (CCC) and the UC Brain Tumor Center have found.The findings of Rb's role at multiple points in the disease process point to a potential new therapeutic target in patients with the most aggressive subset of breast cancer, known as basal-like breast carcinomas. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 6, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news
UC researchers unravel important role of Rb tumor suppressor in aggressive form of breast cancer
(University of Cincinnati Academic Health Center) The retinoblastoma protein plays a critical role in suppressing the multi-step process of cell migration through the bloodstream, lymphovascular invasion and the metastasis of an aggressive type of breast cancer to the lung, researchers at the University of Cincinnati (UC) Cancer Institute, the Cincinnati Cancer Center and the UC Brain Tumor Center have found. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 4, 2013 Category: Cancer & Oncology Source Type: news
Parents can check their kids for retinoblastoma using digital photography
Can parents use digital cameras and smart phones to potentially screen their children for the most common form of pediatric eye cancer? Baylor University and Harvard Medical School researchers believe so. In their study, published online this week in PLOS One, the researchers discovered, through the use of amateur digital photography, evidence of leukocoria or "white eye," the cardinal symptom of retinoblastoma, which can be seen in photographs during the earliest stages of the disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 8, 2013 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news
How Pictures Of Infant Boy's Eyes Helped Diagnose Cancer
A research chemist applied his analytical smarts to his son's eye cancer. By analyzing family photos starting with some taken just a few days after birth, the dad found that signs of retinoblastoma, a rare eye cancer, could be detected quite early.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - November 6, 2013 Category: Consumer Health News Source Type: news
JCI early table of contents for Nov. 1, 2013
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 1, 2013 in the JCI: "Liver tropism is key for B cell deletion immunotherapy," "Dysfunctional chemokine receptor promotes candidiasis," "Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction," "Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis," "Apelin is a positive regulator of ACE2 in failing hearts," and more. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 1, 2013 Category: Global & Universal Source Type: news
An unusual route to saving a child’s eye
Poppy Biagini (left) and Liam Klagges (right), each with the white glow of retinoblastoma in one eye. (Courtesy Dana Biagini and Amy Klagges)
All Poppy Biagini’s family knew was that something was off about her right eye. Liam Klagges’ family’s first sign that something was wrong was that his eyes didn’t always track properly, and that his left eyelid hung a little lower than his right.
Both children, it turns out, had a tumor called a retinoblastoma. Usually diagnosed in children younger than 5, it’s rare—only about 300 children in the United States are diagnosed with it every year—but grows...
Source: Thrive, Children's Hospital Boston - August 2, 2013 Category: Pediatrics Authors: Tom Ulrich Tags: All posts Cancer Allison O'Neill Ankoor Shah Dana-Farber/Boston Children's Cancer and Blood Disorders Center Darren Orbach Deborah VanderVeen intra-arterial (IA) MD our patients' stories PhD retinoblastoma Solid Tumors Center at Da Source Type: news
Occupational Exposure and Risk of Pediatric RetinoblastomaOccupational Exposure and Risk of Pediatric Retinoblastoma
What does the latest science tell us about the possible connection between mens' occupational exposures and the potential development of sporadic bilateral retinoblastoma in their children? Occupational and Environmental Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 12, 2013 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news
Link Suggested Between Tumor Suppressors And Starvation Survival
A particular tumor suppressor gene* that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, says a University of Colorado Boulder study. CU-Boulder Professor Min Han said the research team was interested in how a common tumor suppressor gene known as Retinoblastoma 1, or Rb, behaved under conditions of starvation... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
