Interplay between hormonal and mechanical signals in mammary morphodynamics

Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tcb.2024.03.004
Source: Trends in Cell Biology - Category: Cytology Authors: Source Type: research