Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda.
Authors: Gui F, Lan T, Zhao Y, Guo W, Dong Y, Fang D, Liu H, Li H, Wang H, Hao R, Cheng X, Li Y, Yang P, Sahu SK, Chen Y, Cheng L, He S, Liu P, Fan G, Lu H, Hu G, Dong W, Chen B, Jiang Y, Zhang Y, Xu H, Lin F, Slipper B, Postma A, Jackson M, Abate BA, Tesfaye K, Demie AL, Bayeleygne MD, Degefu DT, Chen F, Kuria PK, Kinyua ZM, Liu TX, Yang H, Huang F, Liu X, Sheng J, Kang L Abstract The fall armyworm (FAW), Spodoptera frugiperda, is a destructive pest native to America and has recently become an invasive insect pest in China. Because of its rapid spread and great risks in China, understanding of FAW genetic backgrou...
Source: Protein and Cell - October 29, 2020 Category: Cytology Tags: Protein Cell Source Type: research

The function and regulation of TET2 in innate immunity and inflammation.
Authors: Cong B, Zhang Q, Cao X Abstract TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been widely recognized to be an important regulator for normal hematopoiesis especially myelopoiesis. Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. Recent studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic activity. Here, we focus on the functions ...
Source: Protein and Cell - October 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Deciphering primate retinal aging at single-cell resolution.
Authors: Wang S, Zheng Y, Li Q, He X, Ren R, Zhang W, Song M, Hu H, Liu F, Sun G, Sun S, Liu Z, Yu Y, Chan P, Zhao GG, Zhou Q, Liu GH, Tang F, Qu J PMID: 33051815 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - October 21, 2020 Category: Cytology Tags: Protein Cell Source Type: research

A world renowned psychophysiologist: Kaoliang Chow.
Authors: Zhang L, Wang L, Guo B, Qian Y, Liu Q PMID: 33058013 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - October 21, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy.
Authors: Khawar MB, Liu C, Gao F, Gao H, Liu W, Han T, Wang L, Li G, Jiang H, Li W PMID: 33048320 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - October 15, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Authors: Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K Abstract In the original publication there are few errors in Figure 1. The correct Figure 1 is provided in this correction. PMID: 33029721 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - October 9, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Authors: Koppula P, Zhuang L, Gan B Abstract The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation. However, cancer cells with high expression of SLC7A11 (SLC7A11high) also have to endure the significant cost associated with SLC7A11-mediated metabolic reprogramming, leading to glucose- and g...
Source: Protein and Cell - October 3, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Gut microbes in cardiovascular diseases and their potential therapeutic applications.
Authors: Jin L, Shi X, Yang J, Zhao Y, Xue L, Xu L, Cai J Abstract Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the comp...
Source: Protein and Cell - September 30, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.
Authors: Tao W, Wang X, Zhang G, Guo M, Ma H, Zhao D, Sun Y, He J, Liu L, Zhang K, Wang Y, Weng J, Ma X, Jin T, Zhu S PMID: 32978728 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 29, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Origin of the Chinese word for "cell": an unusual but wonderful idea of a mathematician.
Origin of the Chinese word for "cell": an unusual but wonderful idea of a mathematician. Protein Cell. 2020 Sep 21;: Authors: Zhang H PMID: 32955708 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 23, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Pioneer of prostate cancer: past, present and the future of FOXA1.
Authors: Teng M, Zhou S, Cai C, Lupien M, He HH Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American men. While androgen deprivation has remained as the cornerstone of prostate cancer treatment, resistance ensues leading to lethal disease. Forkhead box A1 (FOXA1) encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors. Through direct interactions with the Androgen Receptor (AR), FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells. FOXA1 also possesse...
Source: Protein and Cell - September 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Role of gut microbiota in identification of novel TCM-derived active metabolites.
Authors: Lin TL, Lu CC, Lai WF, Wu TS, Lu JJ, Chen YM, Tzeng CM, Liu HT, Wei H, Lai HC Abstract Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and funct...
Source: Protein and Cell - September 18, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Correction to: Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis.
Authors: Wen L, Zhao F, Qiu Y, Cheng S, Sun JY, Fang W, Rayner S, McVoy MA, Jiang XJ, Tang Q, Li FC, Hu F, Luo MH Abstract In the original publication the email addresses of corresponding authors have not been displayed. The correct email addresses of corresponding authors are provided in this correction. Fang-Cheng Li (sjwklfc@126.com), Fei Hu (neuron111@163.com), Min-Hua Luo (luomh@wh.iov.cn). PMID: 32929699 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 18, 2020 Category: Cytology Tags: Protein Cell Source Type: research

The nuclear bodies formed by histone demethylase KDM7A.
Authors: Ming H, Wang Q, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Liu Z, Dang Y, Wen B PMID: 32935279 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 18, 2020 Category: Cytology Tags: Protein Cell Source Type: research

The impact of aging and COVID-19 on our immune system: a high-resolution map from single cell analysis.
Authors: Yang J, Li H PMID: 32894404 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 9, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Tsen-Hwang Shaw: Founder of Vertebrate Zoology in China.
Authors: Wei F, Wang D PMID: 32886314 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 6, 2020 Category: Cytology Tags: Protein Cell Source Type: research

"To live a meaningful life, be yourself and make yourself": Haoyan Jen-a pioneer of China's environmental microbiology.
"To live a meaningful life, be yourself and make yourself": Haoyan Jen-a pioneer of China's environmental microbiology. Protein Cell. 2020 Sep 04;: Authors: Zhang X, Liu H PMID: 32888182 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - September 6, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Structure of intact human MCU supercomplex with the auxiliary MICU subunits.
Authors: Zhuo W, Zhou H, Guo R, Yi J, Zhang L, Yu L, Sui Y, Zeng W, Wang P, Yang M PMID: 32862359 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 31, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype.
Authors: Liao Y, Li H, Cao H, Dong Y, Gao L, Liu Z, Ge J, Zhu H Abstract Fibrotic remodeling is an adverse consequence of immune response-driven phenotypic modulation of cardiac cells following myocardial infarction (MI). MicroRNA-146b (miR-146b) is an active regulator of immunomodulation, but its function in the cardiac inflammatory cascade and its clinical implication in fibrotic remodeling following MI remain largely unknown. Herein, miR-146b-5p was found to be upregulated in the infarcted myocardium of mice and the serum of myocardial ischemia patients. Gain- and loss-of-function experiments demonstrated that m...
Source: Protein and Cell - August 29, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2.
We report here that neurons from R106W MeCP2 RTT human iPSCs as well as human embryonic stem cells after MeCP2 knockdown exhibit consistent and long-lasting impairment in maturation as indicated by impaired action potentials and passive membrane properties as well as reduced soma size and spine density. Moreover, RTT-inherent defects in neuronal maturation could be pan-neuronal and occurred in neurons with both dorsal and ventral forebrain features. Knockdown of MeCP2 led to more severe neuronal deficits as compared to RTT iPSC-derived neurons, which appeared to retain partial function. Strikingly, consistent deficits in n...
Source: Protein and Cell - August 29, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China.
Authors: Yang J, Niu P, Chen L, Wang L, Zhao L, Huang B, Ma J, Hu S, Wu L, Wu G, Huang C, Bi Y, Tan W PMID: 32808156 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Debao Wang, the founder of nucleic acid biology and industry in People's Republic of China.
Authors: Ma Z, Wang X, Li Y PMID: 32808157 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Is oral microbiome of children able to maintain resistance and functional stability in response to short-term interference of ingesta?
Authors: Wei F, Sun X, Gao Y, Dou H, Liu Y, Su L, Luo H, Zhu C, Zhang Q, Tong P, Ren W, Xun Z, Guo R, Guan Y, Li S, Qi Y, Qin J, Chen F, Zheng S PMID: 32808158 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction.
Authors: Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH, Zhang W, Song M, Qu J PMID: 32809106 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency.
Authors: Huang X, Bashkenova N, Yang J, Li D, Wang J PMID: 32812113 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis.
Authors: Liang X, Tao C, Pan J, Zhang L, Liu L, Zhao Y, Fan Y, Cao C, Liu J, Zhang J, Lam SM, Shui G, Jin W, Li W, Zhao J, Li K, Wang Y Abstract RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout of Rnf20 (ASKO) in mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs of hyperinsulinemia, normal insulin sensitivity and improved glucose tolerance were obser...
Source: Protein and Cell - August 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma.
Authors: Jia W, Rajani C, Xu H, Zheng X Abstract Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) are the second and third most common causes of death by cancer, respectively. The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol, smoking, diet, obesity and diabetes. Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC. However, the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors. In ...
Source: Protein and Cell - August 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

KIF2C: a novel link between Wnt/ ╬▓-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
In this study, we found that KIF2C expression was significantly upregulated in HCC, and that KIF2C up-regulation was associated with a poor prognosis. Utilizing both gain and loss of function assays, we showed that KIF2C promoted HCC cell proliferation, migration, invasion, and metastasis both in vitro and in vivo. Mechanistically, we identified TBC1D7 as a binding partner of KIF2C, and this interaction disrupts the formation of the TSC complex, resulting in the enhancement of mammalian target of rapamycin complex1 (mTORC1) signal transduction. Additionally, we found that KIF2C is a direct target of the Wnt/β-catenin ...
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis.
Authors: Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y, Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH, Gu Y, Xu X PMID: 32748350 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.
Authors: Wang J, Shuai L, Wang C, Liu R, He X, Zhang X, Sun Z, Shan D, Ge J, Wang X, Hua R, Zhong G, Wen Z, Bu Z PMID: 32749592 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Authors: Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X, Shan J, Shen Z, Tong Y, Xu L, Chen Y, Liu Y, Zou G, Lavillete D, Zhao Z, Wang R, Zhu L, Xiao G, Lan K, Li H, Xu K Abstract Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spectrum antiviral effects against various RNA viruses, including influenza A virus, Zika virus,...
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Potential treatment of COVID-19 by inhibitors of human dihydroorotate  dehydrogenase.
Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase. Protein Cell. 2020 Aug 06;: Authors: Xu Y, Jiang H PMID: 32761523 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1.
In this study, we illustrated the roles the acetylated and deacetylated forms of TBK1 play in antiviral innate responses and clarified the post-translational modulations involved in the interaction between TBK1 and HDAC3. PMID: 32772249 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

A human circulating immune cell landscape in aging and COVID-19.
Authors: Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Han JJ, Belmonte JCI, Xiao C, Qu J, Wang H, Liu GH, Su W Abstract Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was r...
Source: Protein and Cell - August 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation.
This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets. We have identified HNF4G gene whose silencing most effectively repressed PDAC cell invasiveness. HNF4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor SMAD4. Increased HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC (log-rank P = 0.036; HR = 1.60, 95% CI = 1.03-2.47). We have found that Metformin suppresses HNF4G activity via AMPK-mediated ph...
Source: Protein and Cell - August 3, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing.
Authors: Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W, Liu GH, Long C, Niu Y Abstract Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors (BEs) composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid ...
Source: Protein and Cell - July 31, 2020 Category: Cytology Tags: Protein Cell Source Type: research

First progeria monkey model generated using base editor.
Authors: Reddy P, Shao Y, Hernandez-Benitez R, Nuñez Delicado E, Izpisua Belmonte JC PMID: 32729023 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 31, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.
Authors: Xia YK, Zeng YR, Zhang ML, Liu P, Liu F, Zhang H, He CX, Sun YP, Zhang JY, Zhang C, Song L, Ding C, Tang YJ, Yang Z, Yang C, Wang P, Guan KL, Xiong Y, Ye D Abstract Additional sex combs-like 1 (ASXL1) interacts with BRCA1-associated protein 1 (BAP1) deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone H2A ubiquitylation. Germline BAP1 mutations are found in a spectrum of human malignancies, while ASXL1 mutations recurrently occur in myeloid neoplasm and are associated with poor prognosis. Nearly all ASXL1 mutations are heterozygous frameshift or nonsense mutations in the middl...
Source: Protein and Cell - July 21, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators.
Authors: Han B, Zhang Y, Bi X, Zhou Y, Krueger CJ, Hu X, Zhu Z, Tong X, Zhang B Abstract Gene expression labeling and conditional manipulation of gene function are important for elaborate dissection of gene function. However, contemporary generation of pairwise dual-function knockin alleles to achieve both conditional and geno-tagging effects with a single donor has not been reported. Here we first developed a strategy based on a flipping donor named FoRe to generate conditional knockout alleles coupled with fluorescent allele-labeling through NHEJ-mediated unidirectional targeted insertion in zebrafish facilitated...
Source: Protein and Cell - July 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Authors: Xiao J, Xiong Y, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao X, Luo J, Song BL Abstract Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a nuclear form to modulate gene expression. To search for new genes regulating cholesterol metabolism, we perform a genome-wide CRISPR/Cas9 knockout screen and find that partner of site-1 protease (POST...
Source: Protein and Cell - July 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.
Authors: Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L, Sang Q PMID: 32666501 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Insights into epigenetic patterns in mammalian early embryos.
Authors: Xu R, Li C, Liu X, Gao S Abstract Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality, but the underlying molecular mechanisms remain elusive. For the past few years, unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development, taking advantage of multiple a...
Source: Protein and Cell - July 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients.
Authors: He J, Cai S, Feng H, Cai B, Lin L, Mai Y, Fan Y, Zhu A, Huang H, Shi J, Li D, Wei Y, Li Y, Zhao Y, Pan Y, Liu H, Mo X, He X, Cao S, Hu F, Zhao J, Wang J, Zhong N, Chen X, Deng X, Chen J PMID: 32671793 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Tso-Hsin Cheng: The founder of modern ornithology and zoogeography in China.
Authors: Lei F, Song G PMID: 32661923 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 16, 2020 Category: Cytology Tags: Protein Cell Source Type: research

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
Authors: Xu L, Li P, Hao X, Lu Y, Liu M, Song W, Shan L, Yu J, Ding H, Chen S, Yang A, Zeng YA, Zhang L, Jiang H Abstract Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth. However, for a significant portion of human cancer, how Hippo signaling is perturbed remains unknown. To answer this question, we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome. In our screen, Prosap was identified as a novel regulator of the Hippo pathway that potently aff...
Source: Protein and Cell - July 16, 2020 Category: Cytology Tags: Protein Cell Source Type: research

ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.
Authors: Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M, Song E, Liu GH PMID: 32661925 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 16, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Chia Chi Wang and his research on Protozoology.
Authors: Shi T, Fu L PMID: 32651834 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Fern botanist Ren-Chang Ching and his taxonomic system.
Authors: Xu X, Fu L PMID: 32651835 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Cellular metabolism and homeostasis in pluripotency regulation.
Authors: Liu K, Cao J, Shi X, Wang L, Zhao T Abstract Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling ...
Source: Protein and Cell - July 11, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation.
Authors: Yang X, Wang H, Xie E, Tang B, Mu Q, Song Z, Chen J, Wang F, Min J PMID: 32632529 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - July 8, 2020 Category: Cytology Tags: Protein Cell Source Type: research