Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
In this study, we identified the phosphatase PPP6C as a negative regulator of cGAS-mediated innate immune response. PPP6C is constitutively associated with cGAS in un-stimulated cells. DNA virus infection causes rapid disassociation of PPP6C from cGAS, resulting in phosphorylation of human cGAS S435 or mouse cGAS S420 in its catalytic pocket. Mutation of this serine residue of cGAS impairs its ability to synthesize cGAMP upon DNA virus infection. In vitro experiments indicate that S420-phosphorylated mcGAS has higher affinity to GTP and enzymatic activity. PPP6C-deficiency promotes innate immune response to DNA virus in va...
Source: Protein and Cell - June 1, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Tsai Chiao: The founder of physiology and aviation, aerospace and navigation medicine in China.
Authors: Wang Y, Li Z, Qian Y, Guo B PMID: 32474701 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - June 1, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in.
In this study, we show that CERTIS effectively labeled the paraspeckle lncRNA NEAT1 without disturbing its physiological properties and could monitor the endogenous expression variation of NEAT1. In addition, CERTIS displayed superior performance on both short- and long-term tracking of NEAT1 dynamics in live cells. We found that NEAT1 and paraspeckles were sensitive to topoisomerase I specific inhibitors. Moreover, RNA Immunoprecipitation (RIP) of the MS2-tagged NEAT1 lncRNA successfully revealed several new protein components of paraspeckle. Our results support CERTIS as a tool suitable to track both spatial and temporal...
Source: Protein and Cell - May 30, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding.
Authors: Fu D, Zhao D, Zhang W, Zhang G, Li M, Zhang Z, Wang Y, Sun D, Jiao P, Chen C, Guo Y, Rao Z PMID: 32451720 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 28, 2020 Category: Cytology Tags: Protein Cell Source Type: research

FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice.
Authors: Gao H, Zheng C, Du J, Wu Y, Sun Y, Han C, Kee K, Rao Y PMID: 32451721 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 28, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance.
We report that the loss of 4.1N correlated with progress in clinical stage, as well as poor survival in EOC patients. The loss of 4.1N induces EMT in adherent EOC cells and its expression inhibits anoikis resistance and EMT by directly binding and accelerating the degradation of 14-3-3 in suspension EOC cells. Furthermore, the loss of 4.1N could increase the rate of entosis, which aggravates cell death resistance in suspension EOC cells. Moreover, xenograft tumors in nude mice also show that the loss of 4.1N can aggravate peritoneal dissemination of EOC cells. Single-agent and combination therapy with a ROCK inhibitor and ...
Source: Protein and Cell - May 27, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Mapping the epigenetic modifications of DNA and RNA.
Authors: Zhao LY, Song J, Liu Y, Song CX, Yi C Abstract Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for t...
Source: Protein and Cell - May 24, 2020 Category: Cytology Tags: Protein Cell Source Type: research

SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery.
Authors: Sun L, Dang W PMID: 32435977 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data.
Authors: Shao X, Lu X, Liao J, Chen H, Fan X Abstract For multicellular organisms, cell-cell communication is essential to numerous biological processes. Drawing upon the latest development of single-cell RNA-sequencing (scRNA-seq), high-resolution transcriptomic data have deepened our understanding of cellular phenotype heterogeneity and composition of complex tissues, which enables systematic cell-cell communication studies at a single-cell level. We first summarize a common workflow of cell-cell communication study using scRNA-seq data, which often includes data preparation, construction of communication network...
Source: Protein and Cell - May 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis.
Authors: Zhang C, Wang K, Hu Z, Yang L, Wei B, Li S, Qin X, Yang P, Yu H PMID: 32415480 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 19, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters.
Authors: Gao M, Huang J, Jiang X, Yuan Y, Pang H, Luo S, Wang N, Yao C, Lin Z, Pu D, Zhang S, Sun P, Liu Z, Xiao Y, Wang Q, Hu Z, Yin H PMID: 32410006 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 17, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes.
Authors: Cui Z, Liu Y, Wan W, Xu Y, Hu Y, Ding M, Dou X, Wang R, Li H, Meng Y, Li W, Jiang W, Li Z, Li Y, Tan M, Ma DK, Ding Y, Liu JO, Luo C, Yu B, Tang Q, Dang Y PMID: 32399897 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 15, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Pioneer to exploration and construction of Jilin Province's higher medical laboratory education and talent training system.
Authors: Han H, Han X, Wu S, Lin B, Cheng X, Hou Q, Li Y PMID: 32394198 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 14, 2020 Category: Cytology Tags: Protein Cell Source Type: research

A practical guide to amplicon and metagenomic analysis of microbiome data.
Authors: Liu YX, Qin Y, Chen T, Lu M, Qian X, Guo X, Bai Y Abstract Advances in high-throughput sequencing (HTS) have fostered rapid developments in the field of microbiome research, and massive microbiome datasets are now being generated. However, the diversity of software tools and the complexity of analysis pipelines make it difficult to access this field. Here, we systematically summarize the advantages and limitations of microbiome methods. Then, we recommend specific pipelines for amplicon and metagenomic analyses, and describe commonly-used software and databases, to help researchers select the appropriate t...
Source: Protein and Cell - May 14, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Authors: Zhang L, Zhao Y, Gao R, Li J, Yang X, Gao Y, Zhao W, Gurcha SS, Veerapen N, Batt SM, Besra KK, Xu W, Bi L, Zhang X, Guddat LW, Yang H, Wang Q, Besra GS, Rao Z Abstract Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme for Mtb cell wall synthesis. Analysis of drug resistance mutations suggests that EmbB is the main target of the front-line anti-TB drug, ethambutol. Herei...
Source: Protein and Cell - May 5, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.
In conclusion, our findings of the vivo-seq analysis indicate the key role of the strength of synaptic transmission possesses neurons in V1 of light sensory. PMID: 32350740 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - May 2, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Non-enzymatic covalent modifications: a new link between metabolism and epigenetics.
Authors: Zheng Q, Maksimovic I, Upad A, David Y Abstract Epigenetic modifications, including those on DNA and histones, have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic pathways. In turn, metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin modifications. Recently, non-enzymatic covalent modifications (NECMs) by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple mechanisms. Here, w...
Source: Protein and Cell - May 2, 2020 Category: Cytology Tags: Protein Cell Source Type: research

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma.
Authors: Dai X, Liu J, Wei W PMID: 32323143 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 25, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation.
We report atomic structures of a herpesvirus hexameric terminase complex in both the apo and ADP•BeF3-bound states. Each subunit of the hexameric ring comprises three components-the ATPase/terminase pUL15 and two regulator/fixer proteins, pUL28 and pUL33-unlike bacteriophage terminases. Distal to the nuclease domains, six ATPase domains form a central channel with conserved basic-patches conducive to DNA binding and trans-acting arginine fingers are essential to ATP hydrolysis and sequential DNA translocation. Rearrangement of the nuclease domains mediated by regulatory domains converts DNA translocation mode to cleav...
Source: Protein and Cell - April 25, 2020 Category: Cytology Tags: Protein Cell Source Type: research

High resolution structure of hexameric herpesvirus DNA-packaging motor elucidates revolving mechanism and ends 20-year fervent debate.
Authors: Guo P PMID: 32314326 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Structures of a P4-ATPase lipid flippase in lipid bilayers.
Authors: He Y, Xu J, Wu X, Li L PMID: 32303992 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 19, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
Authors: Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R, Lin X PMID: 32303993 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 19, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Authors: Wang N, Chen W, Zhu L, Zhu D, Feng R, Wang J, Zhu B, Zhang X, Chen X, Liu X, Yan R, Ni D, Zhou GG, Liu H, Rao Z, Wang X PMID: 32285350 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 15, 2020 Category: Cytology Tags: Protein Cell Source Type: research

BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy.
Authors: Li E, Li X, Huang J, Xu C, Liang Q, Ren K, Bai A, Lu C, Qian R, Sun N Abstract Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However, the biological rhythm regulation system in mouse is very different from that of humans. Whether BMAL1 plays a role in regulating human heart function remains unclear. Here we generated a BMAL1 knockout human embryonic stem cell (hESC) model and further derived human BMAL1 deficient cardiomyocytes. We show that BMAL1 deficient hESC-derived cardiomyo...
Source: Protein and Cell - April 12, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Progress towards revealing the mechanism of herpesvirus capsid maturation and genome packaging.
Authors: Li Z, Yu X PMID: 32270449 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 11, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Structural changes of a bacteriophage upon DNA packaging and maturation.
Authors: Chen W, Xiao H, Wang X, Song S, Han Z, Li X, Yang F, Wang L, Song J, Liu H, Cheng L PMID: 32266588 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 9, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
In this study we demonstrated that blood flow change could be perceived and transmitted in a primary cilia dependent manner to control the hemodynamic responsive klf2 gene expression and subsequent activation of Notch signaling in the endocardium. First we showed that both homologues of human gene KLF2 in zebrafish, klf2a and klf2b, could respond to hemodynamic alteration and both were required for Notch signaling activation and heart regeneration. Further experiments indicated that the upregulation of klf2 gene expression was mediated by endocardial primary cilia. Overall, our findings reveal a novel aspect of mechanical ...
Source: Protein and Cell - April 8, 2020 Category: Cytology Tags: Protein Cell Source Type: research

The expanded development and application of CRISPR system for sensitive nucleotide detection.
Authors: Jia F, Li X, Zhang C, Tang X PMID: 32246439 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - April 5, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Memory T cells: strategies for optimizing tumor immunotherapy.
Authors: Liu Q, Sun Z, Chen L Abstract Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This ...
Source: Protein and Cell - March 31, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Recent advances in CRISPR research.
Authors: Chen B, Niu Y, Wang H, Wang K, Yang H, Li W PMID: 32200531 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 23, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon.
Authors: Mao J, Xu K, Han J, Feng G, Zhang Y, Li W PMID: 32193872 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity.
Authors: Ho Y, Hu P, Peel MT, Chen S, Camara PG, Epstein DJ, Wu H, Liebhaber SA Abstract The anterior pituitary gland drives highly conserved physiologic processes in mammalian species. These hormonally controlled processes are central to somatic growth, pubertal transformation, fertility, lactation, and metabolism. Current cellular models of mammalian anteiror pituitary, largely built on candidate gene based immuno-histochemical and mRNA analyses, suggest that each of the seven hormones synthesized by the pituitary is produced by a specific and exclusive cell lineage. However, emerging evidence...
Source: Protein and Cell - March 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis.
Authors: Wen L, Zhao F, Qiu Y, Cheng S, Sun JY, Fang W, Rayner S, McVoy MA, Jiang XJ, Tang Q, Li FC, Hu F, Luo MH PMID: 32189197 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 20, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver.
Authors: He B, Peng W, Huang J, Zhang H, Zhou Y, Yang X, Liu J, Li Z, Xu C, Xue M, Yang H, Huang P PMID: 32185621 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 19, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Pioneer of burn medicine in China: Professor Li Ao and "Li Ao spirit".
Pioneer of burn medicine in China: Professor Li Ao and "Li Ao spirit". Protein Cell. 2020 Mar 14;: Authors: Liao Y, Zou Q, Gu J PMID: 32172499 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 18, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Seven facts and five initiatives for gut microbiome research.
Authors: Li D, Gao C, Zhang F, Yang R, Lan C, Ma Y, Wang J PMID: 32172500 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 18, 2020 Category: Cytology Tags: Protein Cell Source Type: research

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway.
Authors: Xu S, Kim J, Tang Q, Chen Q, Liu J, Xu Y, Fu X Abstract With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in biomedical research. In addition, significant progress has been made for the clinical development of CRISPR/CAS9 based gene therapies of human diseases, several of which are entering clinical trials. Here we report that CAS9 protein can function as a genome mutator independent of any exogenous guide RN...
Source: Protein and Cell - March 16, 2020 Category: Cytology Tags: Protein Cell Source Type: research

HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma.
Authors: Wang X, Waschke BC, Woolaver RA, Chen SMY, Chen Z, Wang JH Abstract Immunotherapy has been applied successfully to treat B-cell lymphomas in preclinical models or clinical settings. However, immunotherapy resistance is a major challenge for B-cell lymphoma treatment. To overcome this issue, combinatorial therapeutic strategies have been pursued to achieve a better efficacy for treating B-cell lymphomas. One of such strategies is to combine immunotherapy with histone deacetylase (HDAC) inhibitors. HDAC inhibitors can potentially increase tumor immunogenicity, promote anti-tumor immune responses, or reverse ...
Source: Protein and Cell - March 13, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser910 site. Mechanistically, ERK5 increased the expression of the transcription factor USF1, which could transcriptionally upregula...
Source: Protein and Cell - March 9, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.
Authors: Tang J, Zhou B, Scott MJ, Chen L, Lai D, Fan EK, Li Y, Wu Q, Billiar TR, Wilson MA, Wang P, Fan J Abstract In the original publication the bands in Fig. 1J and Fig. 2B were not visible. The correct versions of Fig. 1J and Fig. 2B are provided in this correction. PMID: 32125673 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - March 5, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Puzzle of highly pathogenic human coronaviruses (2019-nCoV).
Authors: Li J, Liu W PMID: 32088858 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - February 25, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Electric field-driven building blocks for introducing multiple gradients to hydrogels.
Authors: Xu G, Ding Z, Lu Q, Zhang X, Zhou X, Xiao L, Lu G, Kaplan DL Abstract Gradient biomaterials are considered as preferable matrices for tissue engineering due to better simulation of native tissues. The introduction of gradient cues usually needs special equipment and complex process but is only effective to limited biomaterials. Incorporation of multiple gradients in the hydrogels remains challenges. Here, beta-sheet rich silk nanofibers (BSNF) were used as building blocks to introduce multiple gradients into different hydrogel systems through the joint action of crosslinking and electric field. The blocks ...
Source: Protein and Cell - February 14, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Correction to: Core transcriptional signatures of phase change in the migratory locust.
Authors: Yang P, Hou L, Wang X, Kang L Abstract In the original publication the photo of the gregarious adult locust in Fig. 1A is incorrect. The correct photo of adult migratory locust is provided in this correction. PMID: 32026283 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - February 8, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
Authors: Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G, Peng J, Yu FX PMID: 32008206 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - February 4, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system.
Authors: Huang H, Zhang X, Lv J, Yang H, Wang X, Ma S, Shao R, Peng X, Lin Y, Rong Z PMID: 32002793 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - February 1, 2020 Category: Cytology Tags: Protein Cell Source Type: research

The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
Authors: Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T PMID: 31970665 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - January 25, 2020 Category: Cytology Tags: Protein Cell Source Type: research

TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation.
Authors: Yu G, Wang F, You M, Xu T, Shao C, Liu Y, Liu R, Deng M, Qi Z, Wang Z, Liu J, Yao Y, Chen J, Sun Z, Hao S, Guo W, Zhao T, Yu Z, Zhang Q, Zhao Y, Chen F, Yu S PMID: 31970666 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - January 25, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis.
Authors: Jiang HY, Najmeh S, Martel G, MacFadden-Murphy E, Farias R, Savage P, Leone A, Roussel L, Cools-Lartigue J, Gowing S, Berube J, Giannias B, Bourdeau F, Chan CHF, Spicer JD, McClure R, Park M, Rousseau S, Ferri LE Abstract While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metastasis is entirely unknown. Hence, we sought to determine the effects of NOD1 on metastasis. NOD1 expression in paired human primary colon cancer, huma...
Source: Protein and Cell - January 22, 2020 Category: Cytology Tags: Protein Cell Source Type: research

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model.
αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model. Protein Cell. 2020 Jan 16;: Authors: Martinez-Redondo P, Guillen-Guillen I, Davidsohn N, Wang C, Prieto J, Kurita M, Hatanaka F, Zhong C, Hernandez-Benitez R, Hishida T, Lezaki T, Sakamoto A, Nemeth AN, Hishida Y, Esteban CR, Shojima K, Huang L, Shokhirev M, Nuñez-Delicado E, Campistol JM, Guillen-Vicente I, Rodriguez-Iñigo E, Lopez-Alcorocho JM, Guillen-Vicente M, Church G, Reddy P, Guillen-Garcia P, Liu GH, Belmonte JCI PMID: 31950348 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Source: Protein and Cell - January 19, 2020 Category: Cytology Tags: Protein Cell Source Type: research

Research journey of respirasome.
Authors: Wu M, Gu J, Zong S, Guo R, Liu T, Yang M Abstract Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1, scientists have gradually uncovered the mysterious veil of ...
Source: Protein and Cell - January 12, 2020 Category: Cytology Tags: Protein Cell Source Type: research