Adjuvant Pembrolizumab in Patients with Stage IIIA/N2 Non-Small Cell Lung Cancer Completely Resected after Neoadjuvant Concurrent Chemoradiation: A Prospective, Open-Label, Single-Arm, Phase 2 Trial
CONCLUSION: Adjuvant pembrolizumab may offer durable disease control in a subset of stage IIIA/N2 NSCLC patients after neoadjuvant CCRT and surgery.PMID:38697848 | DOI:10.4143/crt.2024.084 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Junghoon Shin Sehhoon Park Kyung Hwan Kim Eui-Cheol Shin Hyun Ae Jung Jong Ho Cho Jong-Mu Sun Se-Hoon Lee Yong Soo Choi Jin Seok Ahn Jhingook Kim Keunchil Park Young Mog Shim Hong Kwan Kim Jae Myoung Noh Yong Chan Ahn Hongryull Pyo Myung-Ju Ahn Source Type: research
Copper recovery from waste printed circuit boards using pyrite as the bioleaching substrate
In this study, using pyrite as a bacterial substrate for bioleaching WPCBs and recovering Cu was explored. The results showed that the WPCBs bioleaching using pyrite as the bacterial substrate was feasible. Mechanical crushing was a suitable WPCBs pretreatment method. The optimal WPCBs and pyrite pulp densities were respectively found to be 1.25% (w/v) and 1.0% (w/v), and the suitable nitrogen source ratio ((NH4)2SO4: (NH4)2HPO4) was deemed as 2 g/L: 2 g/L, achieving a Cu2+ leaching efficiency of 95.60 ± 1.57% in 14 d. Copper in the bioleaching solution can be directly recovery via electrodeposition. The Cu recovery effic...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Zexiang Xie Qaisar Mahmood Shaohui Zhang Source Type: research
Ureibacillus aquaedulcis sp. nov., isolated from freshwater well and reclassification of Lysinibacillus yapensis and Lysinibacillus antri as Ureibacillus yapensis comb. nov. and Ureibacillus antri comb. Nov
Arch Microbiol. 2024 May 2;206(5):242. doi: 10.1007/s00203-024-03970-0.ABSTRACTA Gram-stain-positive aerobic, rod-shaped, spore-producing bacterium forming colonies with convex elevation and a smooth, intact margin was isolated from a freshwater sample collected from a well situated in an agricultural field. The 16S rRNA gene sequence of the isolated strain BA0131T showed the highest sequence similarity to Lysinibacillus yapensis ylb-03T (99.25%) followed by Ureibacillus chungkukjangi 2RL3-2T (98.91%) and U. sinduriensis BLB-1T (98.65%). The strain BA0131T was oxidase and catalase positive and urease negative. It also test...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Amit Yadav Ruchi Teware Agrima Bhatt Yash Bhavsar Akanksha Maurya Vipool Thorat Venkata Ramana Vemuluri Kiran Kirdat Source Type: research
Surface PD-1 expression in T cells is suppressed by HNRNPK through an exonic splicing silencer on exon 3
CONCLUSIONS: Our study revealed a novel evolutionarily conserved regulatory mechanism of PD-1 expression. The splicing factor HNRNPK markedly promoted PDCD1 exon 3 skipping by binding to the ESS on PDCD1 exon 3, resulting in decreased expression of flPD-1 and increased expression of sPD-1 in T cells.PMID:38698180 | DOI:10.1007/s00011-024-01887-4 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Jiayun Wang Lingyan Yan Xu Wang Rong Jia Jihua Guo Source Type: research
DAP1-2: a synthetic peptide targeting IL-1R1 receptor effectively suppresses IL-1 β in vitro
Immunol Res. 2024 May 2. doi: 10.1007/s12026-024-09485-6. Online ahead of print.ABSTRACTThe pathological manifestation of the inflammatory process primarily stems from the heightened release of pro-inflammatory cytokines, with IL-1β standing out as a pivotal cytokine. The excessive presence of IL-1β disrupts immune signaling, thereby assuming a pathogenic and exacerbating role in the pathophysiology of numerous inflammatory diseases. Regulating IL-1β levels becomes crucial, and the IL-1Ra molecule serves this purpose by binding to the IL-1R1 receptor, thereby impeding the binding of IL-1β. Several pharmaceuticals have ...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Ellen De-Pieri Rubya Pereira Zaccaron Camille Generoso Mezzari Mariana de Melo Cardoso Laura De Roch Casagrande Paulo Cesar Lock Silveira Ricardo Andrez Machado-de- Ávila Source Type: research
Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis
We examined the association between intra-peritoneal exosomes, particularly exosomal micro-RNAs (exo-miRNAs), and IP-chemo sensitivity. MKN45 cells that were cultured with intra-peritoneal exosomes from patients who did not respond to IP therapy with PTX (IPnon-respond group) exhibited resistance to PTX compared with exosomes from responding patients (IPrespond group) (p = 0.002). A comprehensive search for exo-miRNAs indicated that miR-493 was significantly up-regulated in exosomes from the IPnon-respond group compared with those collected from the IPrespond group. The expression of miR-493 in PTX-resistant MKN45 cells (M...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Masahiro Makinoya Kozo Miyatani Yoshiaki Matsumi Yu Sakano Shota Shimizu Yuji Shishido Takehiko Hanaki Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Naruo Tokuyasu Shuichi Takano Teruhisa Sakamoto Toshimichi Hasegawa Hiroaki Saito Yuji Nakayama Mitsuh Source Type: research
The establishment of a multiple myeloma clinical registry in the Asia-Pacific region: The Asia-Pacific Myeloma and Related Diseases Registry (APAC MRDR)
CONCLUSION: The APAC MRDR is providing 'real-world' data to participating sites, clinicians and policy-makers to explore factors influencing outcomes and survival, and to support high quality studies. It is already a valuable resource that will continue to grow and support research and clinical collaboration in MM and related diseases across the APAC region.PMID:38698331 | DOI:10.1186/s12874-024-02227-0 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Naomi Aoki Pin-Yen Chen Wenming Chen Wee Joo Chng Gin Gin Gan Yeow Tee Goh Jian Hou Jeffrey Huang Kihyun Kim Je Jung Lee Jin Lu Zoe K McQuilten Chang Ki Min Elizabeth Moore Laura Oliver Neil A Waters Cameron Wellard Erica M Wood Su-Peng Yeh Andrew Spencer Source Type: research
Development of a prototypic, field-usable diagnostic tool for the detection of gram-positive cocci-induced mastitis in cattle
CONCLUSIONS: Our study shows that EF-Tu is a promising target for LFIA and we have delivered evidence that further evaluation could improve test parameters and fill the gap in the mastitis diagnostics market.PMID:38698383 | DOI:10.1186/s12917-024-04028-5 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Anna Dobrut Jakub Skibi ński Adrian Bekier Kamil Dro żdż Karolina Rudnicka Przemys ław Płociński Izabela Siemi ńska Monika Brzychczy-W łoch Source Type: research
The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-na ïve participants
CONCLUSION: Across 19 type 1 IFN genes, only IFNW1 was associated with HIV-1 study entry VL in a cohort of ART-naïve individuals in early stages of their infection, however, this was no longer significant in sensitivity analyses that controlled for population structures using LME.PMID:38698440 | DOI:10.1186/s12981-024-00610-x (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Sara Bohnstedt M ørup Preston Leung Cavan Reilly Brad T Sherman Weizhong Chang Maja Milojevic Ana Milinkovic Angelike Liappis Line Borgwardt Kathy Petoumenos Roger Paredes Shweta S Mistry Cameron R MacPherson Jens Lundgren Marie Helleberg Joanne Reekie D Source Type: research
Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside
CONCLUSIONS: Our study suggests that PDOs could be a reliable in vitro model to evaluate HIPEC schemes at individual-patient level and to develop more effective treatment strategies for CRCPM.PMID:38698446 | DOI:10.1186/s13046-024-03052-5 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Luca Varinelli Davide Battistessa Marcello Guaglio Susanna Zanutto Oscar Illescas Ewelina J Lorenc Federica Pisati Shigeki Kusamura Laura Cattaneo Giovanna Sabella Massimo Milione Alessia Perbellini Sara Noci Cinzia Paolino Elisabetta Khun Margherita Gala Source Type: research
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
CONCLUSIONS: These findings uncover a novel regulatory mechanism by which FCN3 enhances the sensitivity of HCC cells to ferroptosis, indicating that targeting FCN3-induced ferroptosis is a promising strategy for HCC treatment.PMID:38698462 | DOI:10.1186/s13046-024-03047-2 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Yanmei Yuan Junting Xu Quanxin Jiang Chuanxin Yang Ning Wang Xiaolong Liu Hai-Long Piao Sijia Lu Xianjing Zhang Liu Han Zhiyan Liu Jiabin Cai Fang Liu Suzhen Chen Junli Liu Source Type: research
CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy
CONCLUSION: CD8+MAIT cells are a potential predictive biomarker for patients with NSCLC responding to anti-PD-1 therapy. The correlation between CD8+MAIT cells and immunotherapy sensitivity may be ascribed to high CXCR6 expression.PMID:38698468 | DOI:10.1186/s13046-024-03046-3 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Jingjing Qu Binggen Wu Lijun Chen Zuoshi Wen Liangjie Fang Jing Zheng Qian Shen Jianfu Heng Jianya Zhou Jianying Zhou Source Type: research
Deciphering Muller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis
Eur J Med Res. 2024 May 3;29(1):265. doi: 10.1186/s40001-024-01847-y.ABSTRACTDiabetic retinopathy (DR), a leading cause of visual impairment, demands a profound comprehension of its cellular mechanisms to formulate effective therapeutic strategies. Our study presentes a comprehensive single-cell analysis elucidating the intricate landscape of Müller cells within DR, emphasizing their nuanced involvement. Utilizing scRNA-seq data from both Sprague-Dawley rat models and human patients, we delineated distinct Müller cell clusters and their corresponding gene expression profiles. These findings were further validated through...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Xiyuan Deng Ya Mo Xiuying Zhu Source Type: research
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
CONCLUSION: Our findings reveal the effectiveness of N-Ad-MSCs in differentiating into IPCs in vitro and controlling the hyperglycemia of STZ-induced diabetic rats in vivo compared to DM-Ad-MSCs.PMID:38698488 | DOI:10.1186/s40659-024-00502-4 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Omar I Badr Mohamed M Kamal Shohda A El-Maraghy Heba R Ghaiad Source Type: research
The role of CD98 heavy chain in cancer development
Histol Histopathol. 2024 Apr 16:18749. doi: 10.14670/HH-18-749. Online ahead of print.ABSTRACTThe glycoprotein CD98, or CD98 heavy chain (CD98hc), encoded by the SLC3A2 gene, plays a crucial role in cancer development and progression. CD98hc, forming heterodimeric complexes with various light chains, regulates neutral amino acid transport across cell membranes. The intricate interplay between CD98hc, integrins, and amino acid transporters shapes the tumor microenvironment and contributes to tumor growth. Elevated expression of CD98hc in various cancers correlates with poor prognosis, making it a potential prognostic marker...
Source: Histology and Histopathology - May 2, 2024 Category: Cytology Authors: Eunsun Park Hyesung Kim Seokho Yoon Bogun Jang Source Type: research
