Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14- α demethylase of Leishmania donovani: A comprehensive in vitro and in silico study
Int J Biol Macromol. 2024 May 1:132034. doi: 10.1016/j.ijbiomac.2024.132034. Online ahead of print.ABSTRACTParthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P. hysterophorus. Anydroparthenin was extracted from the leaves of P. hysterophorus and characterized through detailed analysis of 1H, 13C NMR, and HRMS. Dye-base...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Diksha Kumari Parampreet Kour Chetan Paul Singh Rinku Choudhary Syed Mudassir Ali Sagar Bhayye Yogesh P Bharitkar Kuljit Singh Source Type: research
An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal
Biomech Model Mechanobiol. 2024 May 3. doi: 10.1007/s10237-024-01846-2. Online ahead of print.ABSTRACTNumerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal women and also to simulate the response to different drug treatments. These models simulate the menopausal oestrogen decline by altering certain signalling pathways. However, they do not consider the simultaneous effect that ageing can have on cell function and bone remodelling, and thus on bone loss. Considering ageing and oestrogen decline together is important for designing osteoporosis treatments ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Roc ío Ruiz-Lozano Jos é Luis Calvo-Gallego Peter Pivonka Michelle M McDonald Javier Mart ínez-Reina Source Type: research
Comparative Proteomics Identified EXOSC1 as a Target Protein of Anticancer Peptide LVTX-8 in Nasopharyngeal Carcinoma Cells
In this study, a series of in vitro cell experiments such as cell toxicity, colony formation, and cell migration assays were performed to exam the anticancer activity of LVTX-8 in NPC cells (5-8F and CNE-2). The results suggested that LVTX-8 significantly inhibited cell proliferation and migration of NPC cells. To find the potential molecular targets for the anticancer capability of LVTX-8, high-throughput proteomic and bioinformatics analysis were conducted on NPC cells. The results identified EXOSC1 as a potential target protein with significantly differential expression levels under LVTX-8+/LVTX-8- conditions. The resul...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ganghua Zhu Lingxiang Wang Xingyao Wang Xiaoping Dong Shu Yang Jiaqi Wang Siyuan Xu Yong Zeng Source Type: research
Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist JHU083 drives tumor immunity in myeloid-rich prostate and bladder cancer tumors
Cancer Immunol Res. 2024 May 3. doi: 10.1158/2326-6066.CIR-23-1105. Online ahead of print.ABSTRACTGlutamine metabolism in tumor microenvironments critically regulates anti-tumor immunity. Using glutamine-antagonist prodrug JHU083, we report potent tumor growth inhibition in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating monocytes (TIMs). We show JHU083-mediated glutamine antagonism in tumor microenvironments induces TNF, pro-inflammatory, and mTORC1 signaling in intratumoral TAM clusters. JHU083-reprogrammed TAMs also exhibit increased tumor cell phagocytosis and diminishe...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Monali Praharaj Fan Shen Alex J Lee Liang Zhao Thomas R Nirschl Debebe Theodros Alok K Singh Xiaoxu Wang Kenneth M Adusei Kara A Lombardo Raekwon A Williams Laura A Sena Elizabeth A Thompson Ada Tam Srinivasan Yegnasubramanian Edward J Pearce Robert D Leo Source Type: research
Concentration-Dependent Effects of Boric Acid on Osteogenic Differentiation of Vascular Smooth Muscle Cells
Biol Trace Elem Res. 2024 May 3. doi: 10.1007/s12011-024-04204-6. Online ahead of print.ABSTRACTVascular calcification can be triggered by oxidative stress and inflammation. Although boron possesses antioxidant and anti-inflammatory properties, its effect on osteogenic differentiation of vascular smooth muscle cells (VSMCs) has yet to be examined. Therefore, we aimed to investigate the effect of boric acid (BA), the main form of boron in body fluids, on the osteogenic differentiation of VSMCs. Following the isolation of VSMCs, the effects of BA on cell proliferation were determined by MTT. The impact of various BA concentr...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Osama Al Khalif G ülay Sezer Source Type: research
Paradoxical and bimodal immune-mediated dermatological side effects of TNF- α inhibitors: A comprehensive review
In this study, we evaluate the immune-mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer-reviewed research on the effects of TNF-α inhibitors in the treatment of skin diseases, as well as adverse effects of these drugs and some of the main causes of these effects.EXPERT OPINION: DMARDs are very effective in improving control of the above diseases. TNF-α inhibitors are an important group of DMARDs that are widely used. The paradoxical adverse events (PAEs) associated with the use of TNF-α inhibitors are divided into three categories: true paradoxical, borderline paradoxical, and non-p...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Elham Behrangi Farzan Moodi Alireza Jafarzadeh Azadeh Goodarzi Source Type: research
Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis
CONCLUSIONS: NADK is over-expressed in LUAD patients. Knockdown of NADK inhibited the proliferation of LUAD cells both in vitro and in vivo and promotes the Erastin/RSL3-induced ferroptosis of LUAD cells by down-regulating the NADPH/FSP1 axis.PMID:38700533 | DOI:10.1007/s00432-024-05752-z (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiangpeng Meng Fang Peng Shijie Yu Xinming Chi Wenchi Wang Shujuan Shao Source Type: research
Curcumin and its anti-colorectal cancer potential: From mechanisms of action to autophagy
Phytother Res. 2024 May 3. doi: 10.1002/ptr.8220. Online ahead of print.ABSTRACTColorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, a...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Aranka Brockmueller Vicen ç Ruiz de Porras Mehdi Shakibaei Source Type: research
Yogurt Prevents Colorectal Tumorigenesis in Apc < sup > Min/+ < /sup > Mice
CONCLUSION: Yogurt protects against intestinal polyposis in ApcMin/+ mice, and d-Lac may partially account for the chemopreventive effects above.PMID:38700077 | DOI:10.1002/mnfr.202300737 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiaojing Li Jin Qian Qinglong Liu Min Guo Hao Zhang Haitao Li Wei Chen Source Type: research
Photobiomodulation of Gingival Cells Challenged with Viable Oral Microbes
J Dent Res. 2024 May 3:220345241246529. doi: 10.1177/00220345241246529. Online ahead of print.ABSTRACTThe oral cavity, a unique ecosystem harboring diverse microorganisms, maintains health through a balanced microflora. Disruption may lead to disease, emphasizing the protective role of gingival epithelial cells (GECs) in preventing harm from pathogenic oral microbes. Shifting GECs' response from proinflammatory to antimicrobial could be a novel strategy for periodontitis. Photobiomodulation therapy (PBMT), a nonpharmacologic host modulatory approach, is considered an alternative to drugs. While the host cell response induc...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: J Tanum H E Kim S M Lee A Kim J Korostoff G Hwang Source Type: research
Fracture haematoma proteomics
CONCLUSION: The early fxH proteome of the ETC group was characterized by the expression of immunomodulatory, mainly pro-inflammatory, proteins, whereas the early fxH proteome of the DCO group was more regenerative and osteogenic in nature. These findings match clinical observations, in which enhanced surgical trauma after multiple trauma causes dysbalanced inflammation, potentially leading to reduced tissue regeneration, and gained insights into regulatory mechanisms of fracture healing after severe trauma.PMID:38699779 | DOI:10.1302/2046-3758.135.BJR-2023-0323.R1 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Rald V M Groven Christel Kuik Johannes Greven Ümit Mert Freek G Bouwman Martijn Poeze Taco J Blokhuis Markus Huber-Lang Frank Hildebrand Berta Cillero-Pastor Martijn van Griensven Source Type: research
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells
CONCLUSIONS: In summary, vaspin observably reduces HG-mediated inhibition of PDLSCs OD by modulating the TGF-β1/Smad signaling pathway. Vaspin may be a potential therapeutic for periodontal tissue regeneration in diabetic patients.PMID:38699861 | DOI:10.1111/jre.13254 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Zhihui Jing Xinran Feng Xin Li Xiaoyu Zhang Chunling Pan Source Type: research
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
CONCLUSION: TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.PMID:38699653 | PMC:PMC11063473 | DOI:10.2147/CMAR.S447549 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ahmet Bozdag Tuncay Kuloglu Gokhan Artas Suleyman Aydin Source Type: research
Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102395. doi: 10.1016/j.rpth.2024.102395. eCollection 2024 Mar.ABSTRACTThe University of North Carolina Symposia on Hemostasis began in 2002, with The First Symposium on Hemostasis with a Special Focus on FVIIa and Tissue Factor. They have occurred biannually since and have maintained the primary goal of establishing a forum for the sharing of outstanding advances made in the basic sciences of hemostasis. The 2024 11th Symposium on Hemostasis will bring together leading scientists from around the globe to present and discuss the latest research related to coagulation factors and pla...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Maria Aleman Gowthami M Arepally Trevor Baglin Lorena Buitrago Pavel Davizon-Castillo Sanjana Dayal Matthew J Flick Gloria Gerber Yohei Hisada Krasimir Kolev Ana O'Loghlen Alireza R Rezaie Erica M Sparkenbaugh Evi X Stavrou Bet ül Ünlü Gregory M Vercel Source Type: research
Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor
CONCLUSION: CDK5 has been identified as a critical target for pulmonary endothelial injury of SAP-ALI. QYD may partially alleviate microtubule disassembly by targeting the CDK5/NFAT5/GEF-H1 signaling pathway, thus relieving SAP-induced pulmonary microvascular endothelial cell injury.PMID:38699595 | PMC:PMC11063490 | DOI:10.2147/JIR.S451755 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Yinan Cao Fan Li Zhenxuan Sun Jin Liu Jie Liu Qi Yang Peng Ge Yalan Luo Hailong Chen Source Type: research
