Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
CONCLUSIONS: KCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC.PMID:38689322 | DOI:10.1186/s40001-024-01844-1 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Wei Zhang Xiao-Song Chen Ying Wei Xiao-Min Wang Xian-Jin Chen Bang-Teng Chi Lin-Qing Huang Rong-Quan He Zhi-Guang Huang Qi Li Gang Chen Juan He Mei Wu Source Type: research
Arginine and its metabolites stimulate proliferation, differentiation, and physiological function of porcine trophoblast cells through β-catenin and mTOR pathways
In conclusion, our results suggested that arginine could promote cell proliferation and physiological function by regulating the metabolic pathway. Further studies showed that arginine and its metabolites modulate cell function mainly through β-catenin and mTOR pathways.PMID:38689278 | DOI:10.1186/s12917-024-04023-w (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Shuai Li Xiangyang Ye Xiaolu Wen Xuefen Yang Li Wang Kaiguo Gao Hao Xiao Zongyong Jiang Source Type: research
In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
Biol Trace Elem Res. 2024 Apr 30. doi: 10.1007/s12011-024-04188-3. Online ahead of print.ABSTRACTMedullary thyroid cancer (MTC) is a highly aggressive and chemotherapy-resistant cancer originating from the thyroid's parafollicular C cells. Due to its resistance to conventional treatments, alternative therapies such as boric acid have been explored. Boric acid, a boron-based compound, has shown anticarcinogenic effects, positioning it as a potential treatment option for MTC. TT medullary thyroid carcinoma cell line (TT cells) and human thyroid fibroblast (HThF cells) were utilized for the cell culture experiments. Cell viab...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Onurcan Y ıldırım M ücahit Seçme Yavuz Dodurga G ülçin Abban Mete Semin Melahat Fenkci Source Type: research
Experimental optical properties explained by density functional theory of the natural red algae for dye-sensitized solar cells application
Environ Sci Pollut Res Int. 2024 Apr 30. doi: 10.1007/s11356-024-33461-0. Online ahead of print.ABSTRACTThe present study investigates the usage of a novel natural dye derived from red algae of Morocco in dye-sensitized solar cells (DSSCs) for the first time. The main pigments responsible for sensitizing the semiconductor TiO2 coatings in the red algae were identified as phycoerythrin, carotenoid, and chlorophyll. The efficiency of a DSSC made from red algae was compared to that of a solar cell made from chlorophyll alone. The photovoltaic performance of the DSSC was evaluated through photocurrent density to photovoltage (...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Rania Anoua Samira Touhtouh Mohamed El Jouad Abdelowahed Hajjaji Mina Bakasse Bouchta Sahraoui Przemys ław Płóciennik Anna Zawadzka Source Type: research
The Role of miR-150-5p/SOCS1 Pathway in Arsenic-Induced Pyroptosis of LX-2 Cells
This study aims to explore the mechanism of pyroptosis of human hepatocyte LX-2 cells induced by NaAsO2 through the miR-150-5p/SOCS1 pathway. LX-2 cells were transfected with different concentrations of NaAsO2, miR-150-5p inhibitor, and SOCS1 agonist. Cell activity, cell pyroptosis, and the expression of related genes and proteins were detected by scanning electron microscopy, CCK-8, qRT-PCR, western blot, and immunofluorescence. Compared with the control group, 10 µmol/L and 20 µmol/L NaAsO2 significantly elevated the protein expression levels of the pyroptosis-related proteins NLRP3, GSDMD, GSDMD-N, caspase1, and cleav...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Mengyao Zhang Linzhi Li Shugang Li Source Type: research
Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation
Commun Biol. 2024 Apr 30;7(1):515. doi: 10.1038/s42003-024-06196-4.ABSTRACTAdaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia at 32 °C). We show that hypothermic preconditioning at 32 °C for 72 hours improves the differentiation of skeletal muscle myoblasts using both C2C12 and primary myoblasts isolated from 3 month and 18-month-old mice. We analyzed the cold-shock proteome of myoblasts exposed to hypothermia (32 °C for 6 and 48 h) and identified significant changes in pathways related to RNA processing and central carbon...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Paulami Dey Srujanika Rajalaxmi Pushpita Saha Purvi Singh Thakur Maroof Athar Hashmi Heera Lal Nistha Saini Nirpendra Singh Arvind Ramanathan Source Type: research
Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF- κB pathway
CONCLUSION: circ_PABPC1 promotes the malignancy of GC cells through binding to ILK to activate NF-κB signaling pathway .PMID:38688434 | DOI:10.1016/j.yexcr.2024.114058 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Siqi Yan Zhu Wang Dongqiang Lan Junjie Niu Xiaolan Jian Fengjiao He Weizhi Tang Chunhong Hu Wei Liu Source Type: research
ONE-GO: Direct detection of context-dependent GPCR activity
Cell Res. 2024 Apr 30. doi: 10.1038/s41422-024-00966-9. Online ahead of print.NO ABSTRACTPMID:38688989 | DOI:10.1038/s41422-024-00966-9 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Aleksey Raskovalov Donggyun Kim Vadim Cherezov Source Type: research
Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
The objectives of this research were investigating the effects of these compounds on the pathogenesis and progress of Alzheimer's disease in cells modeled by formaldehyde. MTT, flow cytometry, and RT-PCR were used to investigate the toxicity, survival rate and apoptosis of the cells, and the expression level of PP2A, GSK3, NMDAR, BACE1, and APP genes, respectively. Also, the total antioxidant capacity of the modeled cells was measured. The results showed that the two compounds as well as the plants extract and essential oil were able to increase the percentage of cell survival; among them, Thymus vulgaris essential oil had...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Saba Foroughi Kahin Shahanipour Ramesh Monajemi Ali Mohammad Ahadi Source Type: research
TNFAIP2 as an emerging therapeutic target in cancer therapy and its underlying mechanisms
Pharmacol Res. 2024 Apr 28:107199. doi: 10.1016/j.phrs.2024.107199. Online ahead of print.ABSTRACTTNFα-induced protein 2 (TNFAIP2), upregulated under TNFα stimulation, was initially thought to participate in angiogenesis. Still, more and more studies have found that TNFAIP2 plays multiple roles in various physiological and pathological scenarios. The representative functions of TNFAIP2 include motivating the inflammatory response, promoting angiogenesis, facilitating cell proliferation, adhesion, migration, and inducing tunnel nanotube formation. The expression of TNFAIP2 is abnormal in most cancers and can enhance drug ...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Zhanqi Fu Yuan Yuan Source Type: research
Study on PTFE superhydrophobic coating modified by IC@dMSNs and its enhanced antibacterial effect
CONCLUSION: Compared with PTFE, PTFE-SiO2 and PTFE-IC@dMSNs catheters have good characterization performance, cell compatibility, and anticoagulant properties. PTFE SiO2 and PTFE-IC@dMSNs catheters have good antibacterial performance and tissue safety against E. coli and S. aureus. Relatively, PTFE-SiO2 and PTFE-IC@dMSNs catheter has better antibacterial properties and histocompatibility and has potential application prospects in anti-bacterial catheter development and anticoagulation.PMID:38688357 | DOI:10.1016/j.jare.2024.04.026 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Weixing Zhang Juan Du Fariha Kanwal Khalid Mujasam Batoo Mehwish Aslam Cihui Liu Tonghe Zhu Sajjad Hussain Muhammad Fayyaz Ur Rehman Ruilan Wang Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Evaluation of stromal myofibroblasts in oral submucous fibrosis and its malignant transformation: An immunohistochemical study
CONCLUSIONS: The expression of MFs exhibited a gradual increase as the disease progressed from mild to malignant transformation, indicating the contributory role of MFs in the fibrogenesis and potential tumorigenesis associated with OSF.PMID:38687943 | DOI:10.4103/jcrt.jcrt_498_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Ziyi Liu Wenwu Hu Zhongyan Shan Sixuan Liu Zhigang Yao Hongzhi Quan Source Type: research
Combination low-dose cyclophosphamide with check-point blockade and ionizing radiation promote an abscopal effect in mouse models of melanoma
CONCLUSIONS: Compared with traditional strategies, for the first time, we demonstrated that a triple treatment strategy remarkably increased the number of radiation-induced tumor-infiltrating CD8 + T-cells, effectively decreasing infiltrating Tregs, and promoting an abscopal effect. Thus, we describe a novel and effective therapeutic approach by combining multiple strategies to target several tumor-mediated immune inhibitory mechanisms.PMID:38687945 | DOI:10.4103/jcrt.jcrt_616_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Xing Luo Ming Zeng Source Type: research
Effect of stability of PTEN on hepatocellular carcinoma
CONCLUSIONS: On the one hand, our study revealed that CRISPR-Cas12a might play an important role in the screening and prognosis of HCC as a new clinical method to detect PTEN mutation.PMID:38687946 | DOI:10.4103/jcrt.jcrt_349_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yilin Hu Hongliang Mei Tianji Luan Huiling Sun Qiping Lu Rong Liu Source Type: research
