High-Risk Human Papilloma Virus Genotype Distribution and Correlation with Cervical Cytomorphological Data in Turkish and Immigrant Women in Mersin Province
New Microbiol. 2024 May;47(1):88-97.ABSTRACTHuman papilloma virus (HPV) is the most common sexually transmitted viral agent in the world and the most common cause of cervical cancer. HPV prevalence and genotype distribution vary by region and demographic data. In a province in the south of Turkey that constantly receives immigration, we aimed to determine the prevalence of high-risk HPV (HR-HPV) genotypes, evaluate the compatibility between cervical Pap smear cytology results patients and HR-HPVs, and make an up-to-date contribution to the elucidation of epidemiological data. In this single-centre study, a total of 12,641 ...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Murat Yaman Hacer Ece Arslan Özcan Ayfer Bakir Source Type: research
NKG2C+CD57+ natural killer with senescent features cells are induced in cutaneous leishmaniasis and accumulate in patients with lesional healing impairment
This study provides a broad understanding of the NK cell biology during Leishmania infection and reinforces the role of senescent cells in the adverse clinical outcomes of cutaneous leishmaniasis.PMID:38700066 | DOI:10.1093/cei/uxae040 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Luciana Polaco Covre Carlos Henrique Fantecelle Ariadne Mendes Queiroz Julia Miranda Fardin Pedro Henrique Miranda Sian Henson Alessandra Marcia da Fonseca-Martins Herbert Leonel de Matos Guedes David Mosser Aloisio Falqueto Arne Akbar Daniel Claudio Oliv Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
Nirmatrelvir/ritonavir treatment of patients with COVID-19 taking tacrolimus: case series describing the results of drug-drug interactions
We describe the cases of two patients treated with nirmatrelvir/ritonavir: a patient who had undergone kidney transplantation and another with a history of hematopoietic stem cell transplantation. Toxic concentrations of tacrolimus were induced in both. This case series highlights the risk associated with the concomitant administration of tacrolimus and nirmatrelvir/ritonavir.PMID:38698526 | DOI:10.1177/03000605241247705 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Dan Shen Yinhua Gong Yulan Qian Jianguo Zhu Jie Gao Source Type: research
Single-Cell Proteomics Accelerates toward Proteoforms
J Proteome Res. 2024 May 3;23(5):1545-1546. doi: 10.1021/acs.jproteome.4c00290.NO ABSTRACTPMID:38698756 | DOI:10.1021/acs.jproteome.4c00290 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Sarah N Sipe Nikolai Slavov Source Type: research
The Prognosis for Delayed Immune Recovery in HIV-Infected Children might be Associated with Pre-cART CD4 + T cell Count Irrespective of Co-Infection with Tuberculosis
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4243586. doi: 10.21203/rs.3.rs-4243586/v1.ABSTRACTBackground : Immune reconstitution following the initiation of combination antiretroviral therapy (cART) significantly impacts the prognosis of individuals infected with human immunodeficiency virus (HIV). Our previous studies have indicated that the baseline CD4 + T cells count and percentage before cART initiation are predictors of immune recovery in TB-negative children infected with HIV, with TB co-infection potentially causing a delay in immune recovery. However, it remains unclear whether these predictors consistently impact immu...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Funsho Ogunshola Ruhul Khan Musie Ghebremichael Source Type: research
Homeostasis of cytoplasmic crowding by cell wall fluidization and ribosomal counterions
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4138690. doi: 10.21203/rs.3.rs-4138690/v1.ABSTRACTIn bacteria, algae, fungi, and plant cells, the wall must expand in concert with cytoplasmic biomass production, otherwise cells would experience toxic molecular crowding 1,2 or lyse. But how cells achieve expansion of this complex biomaterial in coordination with biosynthesis of macromolecules in the cytoplasm remains unexplained 3 , although recent works have revealed that these processes are indeed coupled 4,5 . Here, we report a striking increase of turgor pressure with growth rate in E. coli , suggesting that the speed of cell wal...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Markus Basan Avik Mukherjee Yanqing Huang Seungeun Oh Carlos Sanchez Yu-Fang Chang Xili Liu Gary Bradshaw Nina Benites Johan Paulsson Marc Kirschner Yongjin Sung Jens Elgeti Source Type: research
Single-molecule RNA-FISH analysis reveals stochasticity in reactivation of latent HIV-1 regulated by Nuclear Orphan Receptors NR4A and cMYC
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4166090. doi: 10.21203/rs.3.rs-4166090/v1.ABSTRACTHIV-1 eradication strategies require complete reactivation of HIV-1 latent cells by Latency Reversing Agents (LRA). Current methods lack effectiveness due to incomplete proviral reactivation. We employed a single-molecule RNA-FISH (smRNA-FISH) and FISH-Quant analysis and found that proviral reactivation is highly variable from cell-to-cell, stochastic, and occurs in bursts and waves, with different kinetics in response to diverse LRAs. Approximately 1-5% of latent cells exhibited stochastic reactivation without LRAs. Through single-cel...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Annalena LaPorte Rajiv Pathak Carolina Eliscovich Laura Martins Rachel Nell Adam Spivak Masako Suzuki Vicente Planelles Robert Singer Ganjam Kalpana Source Type: research
Voriconazole Metabolism is Associated with the Number of Skin Cancers Per Patient
Res Sq [Preprint]. 2024 Apr 19:rs.3.rs-4152279. doi: 10.21203/rs.3.rs-4152279/v1.ABSTRACTVoriconazole exposure is associated with skin cancer, but it is unknown how the full spectrum of its metabolizer phenotypes impacts this association. We conducted a retrospective cohort study to determine how variation in metabolism of voriconazole as measured by metabolizer status of CYP2C19 is associated with the total number of skin cancers a patient develops and the rate of development of the first skin cancer after treatment. There were 1,739 organ transplant recipients with data on CYP2C19 phenotype. Of these, 134 were exposed to...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Jacqueline I Ike Isabelle T Smith Dominique Mosley Christopher Madden Sarah Grossarth Briana R Halle Adam Lewis Frank Mentch Hakon Hakonarson Lisa Bastarache Lee Wheless Source Type: research
Supinoxin blocks Small Cell Lung Cancer Progression by Inhibiting Mitochondrial Respiration through the RNA Helicase DDX5
Res Sq [Preprint]. 2024 Apr 15:rs.3.rs-4169007. doi: 10.21203/rs.3.rs-4169007/v1.ABSTRACTDDX5 is a DEAD-box RNA helicase that is overexpressed and implicated in progression of several cancers 1-4. One of these is small cell lung cancer (SCLC). Our laboratory has demonstrated that the RNA helicase DDX5 is essential for the invasive growth of SCLC and mitochondrial respiration 5. SCLC is an extremely lethal, recalcitrant tumor 6,7, causing 250,000 deaths annually worldwide 8 and currently lacking effective treatments 9,10. Supinoxin (RX 5902), a compound having anti-cancer activity 11, is a known target of phosphor-DDX5 12,1...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Elizabeth Tran Subhadeep Das Matthew Russon Maria Zea Zheng Xing Sandra Torregrosa-Allen Heidi Cervantes Bennett Elzey Haley Harper Source Type: research
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo verbana
In this study, we report on the identification and characterization of a fatty acid aminohydrolase (FAAH) in the medicinal leech, Hirudo verbana . FAAH is the primary enzyme responsible for metabolizing the endocannabinoid signaling molecule arachidonoyl ethanolamide (anandamide or AEA) and therefore plays a critical role in regulating AEA levels in the nervous system. This Hirudo FAAH (HirFAAH) is expressed in the leech central nervous system (CNS) and is an orthologue of FAAH-2 observed in vertebrates. Functionally, HirFAAH has serine hydrolase activity based on activity-based protein profiling (ABPP) studies using the f...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Emily Kabeiseman Riley T Paulsen Brian D Burrell Source Type: research
An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal
Biomech Model Mechanobiol. 2024 May 3. doi: 10.1007/s10237-024-01846-2. Online ahead of print.ABSTRACTNumerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal women and also to simulate the response to different drug treatments. These models simulate the menopausal oestrogen decline by altering certain signalling pathways. However, they do not consider the simultaneous effect that ageing can have on cell function and bone remodelling, and thus on bone loss. Considering ageing and oestrogen decline together is important for designing osteoporosis treatments ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Roc ío Ruiz-Lozano Jos é Luis Calvo-Gallego Peter Pivonka Michelle M McDonald Javier Mart ínez-Reina Source Type: research
The laterality of skin cancer: a retrospective study
Arch Dermatol Res. 2024 May 3;316(5):148. doi: 10.1007/s00403-024-02877-6.NO ABSTRACTPMID:38700710 | DOI:10.1007/s00403-024-02877-6 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Andrew Cho Patrick Ting Ingrid Freeny Source Type: research
Impact of Lithium on the Immune System: An Investigation of T-Cell Subpopulations and Cytokine Responses in Rats
In conclusion, lithium adversely impacted the cellular defense system. Furthermore, apart from its anti-inflammatory properties, lithium exhibited cytokine-mediated inflammatory activities. Therefore, lithium's potential adverse effects on the immune system should be considered in immunodeficient patients and those with an inflammatory status treated with high doses of lithium.PMID:38700635 | DOI:10.1007/s12011-024-04202-8 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Erdal Matur Sibel Akyol Selmin Toplan Semra Ozdemir Ibrahim Akyaz ı Nuran Dar ıyerli Source Type: research
Photobiomodulation of Gingival Cells Challenged with Viable Oral Microbes
J Dent Res. 2024 May 3:220345241246529. doi: 10.1177/00220345241246529. Online ahead of print.ABSTRACTThe oral cavity, a unique ecosystem harboring diverse microorganisms, maintains health through a balanced microflora. Disruption may lead to disease, emphasizing the protective role of gingival epithelial cells (GECs) in preventing harm from pathogenic oral microbes. Shifting GECs' response from proinflammatory to antimicrobial could be a novel strategy for periodontitis. Photobiomodulation therapy (PBMT), a nonpharmacologic host modulatory approach, is considered an alternative to drugs. While the host cell response induc...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: J Tanum H E Kim S M Lee A Kim J Korostoff G Hwang Source Type: research
