The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization

CONCLUSION: These results suggest that sevoflurane can regulate microglial M1 polarization by activating the cGAS/STING signaling pathway and increasing immune factor release, thus accelerating the neuronal necroptosis induced by calcium overload.PMID:38688381 | DOI:10.1016/j.cellsig.2024.111195

Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Qi Zhang Yanan Li Yanqin Liu Xin Wang Yonghui Yang Lei Shi Source Type: research