When is the best time to take Vitamin D?
VITAMIN D supplements can help keep people healthy by regulating the amount of phosphate and calcium in the body. So when is the best time to take vitamin D? (Source: Daily Express - Health)
Source: Daily Express - Health - January 15, 2021 Category: Consumer Health News Source Type: news

Calcium-Induced Autonomic Denervation Linked to Lower Post-op AF Calcium-Induced Autonomic Denervation Linked to Lower Post-op AF
Intraoperative injection of calcium chloride into the four major atrial ganglionated plexi reduced the incidence of early postoperative atrial fibrillation in a proof-of-concept study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 14, 2021 Category: Consumer Health News Tags: Cardiology News Source Type: news

Better chest CT CAC reporting avoids unnecessary exams
Reporting coronary artery calcium (CAC) on routine chest CT could help clinicians...Read more on AuntMinnie.comRelated Reading: Machine-learning model predicts adverse cardiac outcomes CCTA, functional tests stratify heart disease risk by age Coronary calcium predicts events, death, in younger adults ARRS: Ungated CT calcium scores downgrade cardiac risk Coronary calcium usually ignored on chest CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 13, 2021 Category: Radiology Source Type: news

Host a Specialised Endocrinology Network for Bone and Mineral
The Society’s Clinical Committee, working with our Bone and Calcium Endocrine Network, and in association with the NHSEI Clinical Reference Group, propose setting up a network of bone and mineral hubs across the UK.  It has become clear from the GIRFT process, and other available data, that significant variance is present in the outcomes and quality of clinical endocrinology services across the UK. The specialised endocrinology networks for bone and mineral aim to more standardise care in this area. It is envisaged that there would be a number of specific objectives for this sy...
Source: Society for Endocrinology - January 12, 2021 Category: Endocrinology Source Type: news

Mechanisms in the kidney that control magnesium and calcium levels discovered
(Massachusetts General Hospital) The gene KCTD1 directs production of a protein that functions in the kidney to maintain a normal balance of magnesium and calcium in blood. Loss of KCTD1 impairs the ability of the kidney to properly absorb magnesium and calcium from urine in the kidney, leading to abnormally low magnesium and calcium blood levels, thereby triggering the parathyroid glands to secrete excess parathyroid hormone that in turn leads to metabolic bone disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 12, 2021 Category: Biology Source Type: news

Three-site study highlight effectiveness of FEND nasal calcium rich salts
(World Scientific) In apaper published in Molecular Frontiers Journal, researchers from Cambridge, Massachusetts and Bangalore, India study the effectiveness of FEND product to significantly improve airway hygiene by reducing and suppressing respiratory droplets potentially containing airborne pathogens and other contaminants. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 11, 2021 Category: Infectious Diseases Source Type: news

Lithium pollution of a white dwarf records the accretion of an extrasolar planetesimal
We report the detection of lithium, sodium, potassium, and calcium in the atmosphere of the white dwarf Gaia DR2 4353607450860305024, which we ascribe to the accretion of a planetesimal. Using model atmospheres, we determine abundance ratios of these elements, and, with the exception of lithium, they are consistent with meteoritic values in the Solar System. We compare the measured lithium abundance with measurements in old stars and with expectations from Big Bang nucleosynthesis. (Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Kaiser, B. C., Clemens, J. C., Blouin, S., Dufour, P., Hegedus, R. J., Reding, J. S., Bedard, A. Tags: Astronomy, Geochemistry, Geophysics, Planetary Science reports Source Type: news

New drug form may help treat osteoporosis, calcium-related disorders
(Purdue University) Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Fellow scientists honor James Putney Jr.
Fellow scientists honored NIEHS scientist James Putney Jr., Ph.D., for 40 years of lasting contributions to the study of calcium signaling. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Fires, flooding before settlement may have formed the Amazon's rare patches of fertility
(University of Oregon) Phosphorous, calcium and charcoal in spotty patches of fertile soil in the Amazon rainforest suggest that natural processes such as fires and river flooding, not the ingenuity of indigenous populations, created rare sites suitable for agriculture, according to new research. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 4, 2021 Category: International Medicine & Public Health Source Type: news

Janssen Initiates Rolling Submission of a Biologics License Application to U.S. FDA for BCMA CAR-T Therapy Ciltacabtagene Autoleucel (cilta-cel) for the Treatment of Relapsed and/or Refractory Multiple Myeloma
December 21, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the initiation of a rolling submission of its Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of adults with relapsed and/or refractory multiple myeloma.“We are committed to innovation in cell therapy and advancing the science of multiple myeloma to improve patients’ lives,” said Pete...
Source: Johnson and Johnson - December 21, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

One in Five Patients Hospitalized With COVID - 19 Dies
Statins, angiotensin - converting enzyme inhibitors, and calcium channel blockers tied to lower risk for death (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - December 16, 2020 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Nephrology, Nursing, Pathology, Pharmacy, Pulmonology, Geriatrics, Journal, Source Type: news

Voco Introduces Provicol QM Aesthetic Translucent Zinc Oxide, Non-Eugenol Temporary Cement with Calcium Hydroxide
Introducing Provicol QM Aesthetic, a zinc oxide-based transparent non-eugenol temporary cement that secures provisional crowns and bridges without affecting the overlying color of the restoration.This zinc oxide-based formula promotes anti-bacterial properties as well as an ideal adhesion and strength with a semi-elastic consistency that allows for easy clean up. Distinct from resin-based temporary cements, zinc-oxide cements do not permanently bond to composite core build-ups, therefore simplifying the removal of temporaries..The new and innovative glass matrix with polyhedral particles allows for a translucency only achi...
Source: Dental Technology Blog - December 16, 2020 Category: Dentistry Source Type: news

Regenerative Endodontic Procedures, Disinfectants and Outcomes: A Systematic Review
 Prim Dent J. 2020 Dec;9(4):65-84. doi: 10.1177/2050168420963302.AbstractAims: This systematic review aims to identify and synthesise available evidence to determine the clinical and radiographic outcomes of REP involving any disinfection irrigant together with a non-antibiotic intracanal medicament.Methods: Experimental and observational studies evaluating the outcomes of REP in immature non-vital permanent teeth in 6-16 year olds, where the protocol used any type of disinfectant irrigant together with a non-antibiotic intracanal medicament (non-setting calcium hydroxide) were included. Data was n...
Source: Dental Technology Blog - December 10, 2020 Category: Dentistry Source Type: news

Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not
That future cardiovascular risk tracks closely with plaque burden, but not so much with whether the coronary disease is obstructive, may never have been so clearly illustrated.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - December 8, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

What Areas of the Physical Examination are Important in the Pre-participation Physical Examination?
Discussion Participation in organized or non-organized, recreational to elite sports activities can provide excellent recreational and leisure time activities and improve physical and mental health for participants. The Aspen Institute in 2018 reported that more kids are being physically active, more are trying different sports, and multisports play is increasing rather than strict specialization. Unfortunately they note that there is an economic inequality with children from lower-socioeconomic circumstances playing less organized sports. About 70% of children and youth participate in an individual or team sport, but unfo...
Source: PediatricEducation.org - December 7, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Janssen Presents First Data from the Phase 1 Study of the GPRC5DxCD3 Bispecific Talquetamab in Patients with Relapsed or Refractory Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today initial data for the Phase 1 first-in-human dose escalation study of talquetamab (JNJ-64407564) for the treatment of relapsed or refractory multiple myeloma (NCT03399799). Talquetamab is a first-in-class, and the only investigational bispecific antibody that targets both GPRC5D, a novel multiple myeloma target, and CD3 on T-cells. Initial results for both the subcutaneous (SC) and intravenous (IV) formulations show encouraging clinical activity against the GPRC5D target, which is highly expressed on multip...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Updated Results from the Phase 1 Study of the BCMAxCD3 Bispecific Teclistamab Show Preliminary Efficacy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
This study evaluated the ability of teclistamab to induce cytotoxicity and T-cell activation.About TeclistamabTeclistamab is an investigational bispecific antibody targeting both BCMA and CD3. BCMA, B-cell maturation antigen, is expressed at high levels on multiple myeloma cells.[3],[4],[5],[6],[7] Teclistamab redirects CD3-positive T-cells to BCMA-expressing myeloma cells to induce cytotoxicity of the targeted cells.5,6 Results from preclinical studies demonstrate that teclistamab kills myeloma cell lines and bone marrow-derived myeloma cells from heavily pretreated patients.6 Teclistamab is currently being evaluated in a...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Early, Deep, Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) Observed in Phase 1b/2 CARTITUDE-1 Study Show Potential of BCMA CAR-T in Treatment of Heavily Pretreated Patients with Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the combined Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory multiple myeloma. These data, presented as an oral presentation at the American Society of Hematology (ASH) 2020 Annual Meeting (Abstract #177), continued to demonstrate a very hig...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Vitamin D regulates calcium in intestine differently than previously thought
(Rutgers University) A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2020 Category: International Medicine & Public Health Source Type: news

Vitamin D: At risk groups to get free Vitamin D - are you eligible?
VITAMIN D is essential for regulating the amount of calcium and phosphate in the body. Now a new Government initiative will see at-risk groups given a winter supply of Vitamin D. But are you eligible? (Source: Daily Express - Health)
Source: Daily Express - Health - November 28, 2020 Category: Consumer Health News Source Type: news

The effect of administration of dietary supplement with calcium and vitamins D3 and B6 on calcium homeostasis and falls incidence in patients with high fracture risk undergoing medical rehabilitation - Marchenkova LA, Fesyun AD, Gerasimenko MY, Makarova EV.
Elimination of vitamin D and calcium deficiencies is of particular importance in older patients undergoing medical rehabilitation after a serious illness, surgery or injury and having a high risk of fractures. Preventing falls and fractures, including duri... (Source: SafetyLit)
Source: SafetyLit - November 23, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Targeting calcium overload could improve stroke outcomes, research suggests
(University of Virginia Health System) Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 23, 2020 Category: Biology Source Type: news

Vegans, vegetarians and pescetarians may be at higher risk of bone fractures
(BMC (BioMed Central)) Compared with people who ate meat, vegans with lower calcium and protein intakes on average, had a 43% higher risk of fractures anywhere in the body (total fractures), as well as higher risks of site-specific fractures of the hips, legs and vertebrae, according to a study published in the open access journal BMC Medicine. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 22, 2020 Category: Biology Source Type: news

How rotavirus causes severe gastrointestinal disease
(Baylor College of Medicine) Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects. This is the first virus identified to activate ADP-mediated intercellular calcium waves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2020 Category: International Medicine & Public Health Source Type: news

Rotavirus induces intercellular calcium waves through ADP signaling
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), observed in cell lines and human intestinal enteroids. Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic receptors on neighboring cells. ICWs were blocked by P2Y1 antagonists or CRISPR-Cas9 knockout of the P2Y1 receptor. Blocking the ADP signal re...
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Chang-Graham, A. L., Perry, J. L., Engevik, M. A., Engevik, K. A., Scribano, F. J., Gebert, J. T., Danhof, H. A., Nelson, J. C., Kellen, J. S., Strtak, A. C., Sastri, N. P., Estes, M. K., Britton, R. A., Versalovic, J., Hyser, J. M. Tags: Microbiology, Molecular Biology, Online Only r-articles Source Type: news

Riding the calcium waves
(Source: ScienceNOW)
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Hurtley, S. M. Tags: Microbiology, Molecular Biology twis Source Type: news

Effect of tip insertion depth and irradiation parameters on the efficacy of cleaning calcium hydroxide from simulated lateral canals using Er:YAG laser- or ultrasonic-activated irrigation
This study aimed to compare the efficacy of removing calcium hydroxide [Ca(OH)2] paste from lateral canals using LAI or ultrasonic-activated irrigation (UAI), and to examine the effect of tip insertion depth and laser irradiation parameters on cleaning efficacy.Materials and methodsRadiopaque Ca(OH)2 paste (Calcipex II) was injected into lateral canals 6  mm from the root apex in 192 J-shaped simulated root canal models. LAI (Erwin AdvErl; 30 or 70 mJ; 10 or 20 pulses per second; laser tip R200T or R600T) and UAI (ENAC SE10; output setting: 3) were performed 3 times for 20 s. The laser tip was placed at 8–0...
Source: Dental Technology Blog - November 17, 2020 Category: Dentistry Source Type: news

Oral symptoms caused by toxic plants containing calcium oxalate - Miyamoto M, Noma M, Ishii J, Yoshihara S.
A one-year-old girl presented to our emergency room with lip swelling after biting the fruit of a wild plant. The plant was identified as Arisaema serratum through an internet search based on the photo taken by the guardian ( Figure, A). Her vital signs we... (Source: SafetyLit)
Source: SafetyLit - November 12, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Astronomical context of Solar System formation from molybdenum isotopes in meteorite inclusions
Calcium-aluminum–rich inclusions (CAIs) in meteorites are the first solids to have formed in the Solar System, defining the epoch of its birth on an absolute time scale. This provides a link between astronomical observations of star formation and cosmochemical studies of Solar System formation. We show that the distinct molybdenum isotopic compositions of CAIs cover almost the entire compositional range of material that formed in the protoplanetary disk. We propose that CAIs formed while the Sun was in transition from the protostellar to pre–main sequence (T Tauri) phase of star formation, placing Solar System ...
Source: ScienceNOW - November 12, 2020 Category: Science Authors: Brennecka, G. A., Burkhardt, C., Budde, G., Kruijer, T. S., Nimmo, F., Kleine, T. Tags: Astronomy, Geochemistry, Geophysics, Planetary Science reports Source Type: news

A thalamocortical top-down circuit for associative memory
The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are...
Source: ScienceNOW - November 12, 2020 Category: Science Authors: Pardi, M. B., Vogenstahl, J., Dalmay, T., Spano, T., Pu, D.-L., Naumann, L. B., Kretschmer, F., Sprekeler, H., Letzkus, J. J. Tags: Neuroscience reports Source Type: news

Follow your Endocrine Networks on Twitter
Each of our eight Endocrine Networks now has its own Twitter account, run by the Convenors. Follow them to share news, events, resources, and to keep up to date with your Network colleagues. Get the conversation going in advance of the Network meetings atSfE BES online!The Endocrine Networks are a platform for collaboration between basic and clinical researchers, clinical endocrinologists and endocrine nurses.Go to theMembers' Area to select and update your preferred Networks.Adrenal and Cardiovascular -@adrenalnetwork Dr Scott MacKenzie& Dr Mick O'Reilly Bone& Calcium -@b...
Source: Society for Endocrinology - November 10, 2020 Category: Endocrinology Source Type: news

What is the best way to get your hit of Vitamin D?
Vitamin D also helps regulate the amount of calcium and phosphate in our bodies; keeping bones, teeth and muscles healthy. However, around half of the UK population is deficient in it. (Source: the Mail online | Health)
Source: the Mail online | Health - November 9, 2020 Category: Consumer Health News Source Type: news

What strength Vitamin D should I take?
VITAMIN D helps to regulate the amount of calcium and phosphate in the body, and a lack of it can cause deformities and pain. What strength Vitamin D should I take? (Source: Daily Express - Health)
Source: Daily Express - Health - November 3, 2020 Category: Consumer Health News Source Type: news

Zero Coronary Artery Calcium Score: Desirable, but Enough? Zero Coronary Artery Calcium Score: Desirable, but Enough?
In this essay, the author argues that while coronary artery calcium is important in stratifying cardiovascular risk, even a zero calcium score must be evaluated in clinical context.Circulation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2020 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Clinical and radiographic evaluation of platelet-rich fibrin for revascularization of necrotic immature permanent teeth: A controlled clinical trial
Conclusionsplatelet-rich fibrin revascularization and calcium hydroxide apexification were successful clinically. Radiographically, platelet-rich fibrin showed significant quantitative measurements than calcium hydroxide apexification regarding all parameters.  (Source: Dental Technology Blog)
Source: Dental Technology Blog - October 27, 2020 Category: Dentistry Source Type: news

The 3p a day supplements to avoid high blood pressure - 'most effective natural remedy'
SUPPLEMENTS could be used to lower your risk, or even prevent some high blood pressure symptoms. This is useful and natural remedy to avoid the deadly signs and symptoms of hypertension. Should you consider adding calcium supplements to your diet, to prevent high blood pressure? (Source: Daily Express - Health)
Source: Daily Express - Health - October 17, 2020 Category: Consumer Health News Source Type: news

Phoslyra (calcium acetate)
Title: Phoslyra (calcium acetate)Category: MedicationsCreated: 10/16/2020 12:00:00 AMLast Editorial Review: 10/16/2020 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - October 16, 2020 Category: Drugs & Pharmacology Source Type: news

Calcium bursts kill drug-resistant tumor cells
(American Chemical Society) Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS'Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2020 Category: International Medicine & Public Health Source Type: news

CAC Helps ID CVD Risk in Women Receiving RT for Breast Cancer
THURSDAY, Oct. 15, 2020 -- For women with breast cancer, coronary artery calcium (CAC) detected on radiotherapy (RT)-planning computed tomography (CT) scan is associated with cardiovascular disease (CVD) risk, according to a study presented at the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 15, 2020 Category: Pharmaceuticals Source Type: news

Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles
Brains encode behaviors using neurons amenable to systematic classification by gene expression. The contribution of molecular identity to neural coding is not understood because of the challenges involved with measuring neural dynamics and molecular information from the same cells. We developed CaRMA (calcium and RNA multiplexed activity) imaging based on recording in vivo single-neuron calcium dynamics followed by gene expression analysis. We simultaneously monitored activity in hundreds of neurons in mouse paraventricular hypothalamus (PVH). Combinations of cell-type marker genes had predictive power for neuronal respons...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Xu, S., Yang, H., Menon, V., Lemire, A. L., Wang, L., Henry, F. E., Turaga, S. C., Sternson, S. M. Tags: Engineering, Neuroscience, Online Only r-articles Source Type: news

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway,...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Venturini, V., Pezzano, F., Catala Castro, F., Häkkinen, H.-M., Jimenez-Delgado, S., Colomer-Rosell, M., Marro, M., Tolosa-Ramon, Q., Paz-Lopez, S., Valverde, M. A., Weghuber, J., Loza-Alvarez, P., Krieg, M., Wieser, S., Ruprecht, V. Tags: Cell Biology, Online Only r-articles Source Type: news

Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
Excitotoxicity induced by NMDA receptors (NMDARs) is thought to be intimately linked to high intracellular calcium load. Unexpectedly, NMDAR-mediated toxicity can be eliminated without affecting NMDAR-induced calcium signals. Instead, excitotoxicity requires physical coupling of NMDARs to TRPM4. This interaction is mediated by intracellular domains located in the near-membrane portions of the receptors. Structure-based computational drug screening using the interaction interface of TRPM4 in complex with NMDARs identified small molecules that spare NMDAR-induced calcium signaling but disrupt the NMDAR/TRPM4 complex. These i...
Source: ScienceNOW - October 8, 2020 Category: Science Authors: Yan, J., Bengtson, C. P., Buchthal, B., Hagenston, A. M., Bading, H. Tags: Neuroscience, Online Only r-articles Source Type: news

Allergan Aesthetics, an AbbVie Company, Acquires Innovative Luminera Dermal Filler Business
Acquisition Immediately Enhances Allergan Aesthetics' Leading International Dermal Filler Portfolio & Pipeline Adds HArmonyCa, a Dermal Filler Combining Hyaluronic Acid (HA) and Calcium Hydroxyapatite (CaHA) IRVINE, Calif., Oct. 7, 2020 -- (Healthcar... Devices, Dermatology, Acquisitions AbbVie, Allergan Aesthetics, Luminera , dermal filler (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 7, 2020 Category: Pharmaceuticals Source Type: news

CT scans can predict CVD risk in breast cancer patients
Clinicians used CT scans of coronary artery calcium to predict which patients...Read more on AuntMinnie.comRelated Reading: Radiation tied to breast cancer delays for Black women Women with DCIS have 3x the risk of breast cancer death Single radiotherapy dose effective for breast cancer Radiologists, AI make a great team in screening mammo AI software can cut screening mammography workload (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 7, 2020 Category: Radiology Source Type: news

Levosimendan Hints at Benefit in Unusual Form of Heart Failure Levosimendan Hints at Benefit in Unusual Form of Heart Failure
The calcium sensitizing agent, long explored in heart failure with few successes, showed efficacy signals in a narrowly defined subtype of HF with preserved ejection fraction.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 7, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Role of calcium and phosphorous concentration as an intrinsic factor in the development of skull fracture following road traffic accidents - Tamuli RP, Saikia B, Sarmah S, Patowary AJ.
INTRODUCTION: Traumatic brain injury (TBI) or head injury is one of the leading causes of morbidity and mortality globally. TBI includes a fractured skull as an indicator of insult which can affect the treatment outcome as well. The development of any frac... (Source: SafetyLit)
Source: SafetyLit - October 3, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Nasal calcium rich salts show reduction of exhaled aerosol particles up to 99%
(World Scientific) In a paper published in Molecular Frontiers Journal, researchers from Cambridge, Massachusetts have discovered a more effective way of eliminating airborne particles from airways using nasal calcium-rich salts called FEND, which have potential applications in the fight against Covid-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 29, 2020 Category: Infectious Diseases Source Type: news

‘The most effective natural remedy’ for high blood pressure - how to avoid deadly hyperten
SUPPLEMENTS could be used to lower your risk, or even prevent some high blood pressure symptoms. This is the "most effective natural remedy" to avoid the deadly signs and symptoms of hypertension. Should you consider adding calcium supplements to your diet, to prevent deadly high blood pressure symptoms? (Source: Daily Express - Health)
Source: Daily Express - Health - September 27, 2020 Category: Consumer Health News Source Type: news

Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease: a systematic review, BMJ Open
Conclusions: There is an abundance of the academic literature and media reports on the potential of drugs that could attenuate or exacerbate COVID-19 disease. This is leading to trials of repurposed drugs and uncertainty among patients and clinicians concerning continuation or cessation of prescribed medications. Our review indicates that the impact of currently prescribed drugs on ACE2 has been poorly studied in vivo, particularly in human lungs where the SARS-CoV-2 virus appears to enact its pathogenic effects. We found no convincing evidence to justify starting or stopping currently prescribed drugs to influence outcome...
Source: Current Awareness Service for Health (CASH) - September 24, 2020 Category: Consumer Health News Source Type: news