How to get rid of visceral fat: Vitamin D and calcium help to burn more belly fat
HOW TO get rid of visceral fat: When trying to lose those extra layers of fat around the belly area, knowing the exact science of how the body works is the best starting point. Numerous studies have shown that by increasing your vitamin D and calcium levels, whether through supplementation or food, can help to burn belly fat. How? (Source: Daily Express - Health)
Source: Daily Express - Health - April 12, 2021 Category: Consumer Health News Source Type: news

Leaking calcium in neurons an early sign of Alzheimer ’s pathology
New findings about early pathological changes in the brain may provide strategies to slow or prevent the progression of Alzheimer ’s, Yale researchers report. (Source: Yale Science and Health News)
Source: Yale Science and Health News - April 8, 2021 Category: Universities & Medical Training Source Type: news

Leaking calcium in neurons an early sign of Alzheimer's pathology
(Yale University) Leaking calcium in neurons an early sign of Alzheimer's pathologyNew Haven, Conn. -- Alzheimer's disease is known for its slow attack on neurons crucial to memory and cognition. But why are these particular neurons in aging brains so susceptible to the disease's ravages, while others remain resilient? (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 8, 2021 Category: International Medicine & Public Health Source Type: news

Here's why you need trace minerals to boost your overall well-being
(Natural News) The human body needs minerals to function properly. In fact, there are two types of minerals — macrominerals and trace minerals. The body needs macrominerals, such as calcium, phosphorus, magnesium, sodium, potassium and sulfur, in large amounts; hence the name. Although the body only needs a small amount of trace minerals, they still... (Source: NaturalNews.com)
Source: NaturalNews.com - April 7, 2021 Category: Consumer Health News Source Type: news

Vitamin D, Calcium, and Implications for Cardiovascular Health Vitamin D, Calcium, and Implications for Cardiovascular Health
Should vitamin D and calcium supplementation be recommended for cardiovascular health? This paper reviews currently available evidence to provide updated recommendations.Journal of the American College of Cardiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 6, 2021 Category: Intensive Care Tags: Cardiology Journal Article Source Type: news

Calcium-sensing receptor of immune cells and diseases
(Compuscript Ltd) In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2021.0009, Wenxiu Liu, Yutong Guo, Yue Liu, Jiaxing Sun and Xinhua Yin from The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China consider calcium-sensing receptors of immune cells and diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 27, 2021 Category: International Medicine & Public Health Source Type: news

Low dietary calcium intake does not modify fracture risk but increases falls frequency: the results of GO Study - Pluskiewicz W, Adamczyk P, Drozdzowska B.
The aim of the study was to verify the thesis that dietary calcium intake influences the risk of osteoporotic fractures established by online available calculators. MATERIAL: The study was performed in 521 postmenopausal women aged over 55 years recruited ... (Source: SafetyLit)
Source: SafetyLit - March 26, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Photoinduced receptor confinement drives ligand-independent GPCR signaling
Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photoinstructive matrix with ultrasmall lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y2 receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After in situ confinement, changes ...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Sanchez, M. F., Els-Heindl, S., Beck-Sickinger, A. G., Wieneke, R., Tampe, R. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news

Erratum for the Report "PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release" by C. Giorgi, K. Ito, H.-K. Lin, C. Santangelo, M. R. Wieckowski, M. Lebiedzinska, A. Bononi, M. Bonora, J. Duszynski, R. Bernardi, R. Rizzuto, C. Tacchetti, P. Pinton, P. P. Pandolfi
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Tags: Errata Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profi...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

FAU researchers break bonds in molecular nitrogen with calcium
(University of Erlangen-Nuremberg) A research team at FAU has demonstrated that calcium, a metal commonly found in nature is able to break the highly-stable nitrogen bond and can do so at minus 60 ° C which is a significant discovery in terms of the bond-breaking capabilities of calcium, which had been largely disregarded in the past. But their findings could also form the basis for developing industrial processes in the future. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 17, 2021 Category: Biology Source Type: news

Dinitrogen complexation and reduction at low-valent calcium
Here we report that attempted preparation of low-valent CaI complexes in the form of LCa-CaL (where L is a bulky β-diketiminate ligand) under dinitrogen (N2) atmosphere led to isolation of LCa(N2)CaL, which was characterized crystallographically. The N22 anion in this complex reacted in most cases as a very potent two-electron donor. Therefore, LCa(N2)CaL acts as a synthon for the low-valent CaI complex LCa-CaL, which was the target of our studies. The N22 anion could also be protonated to diazene (N2H2) that disproportionated to hydrazine and N2. The role of Ca d orbitals for N2 activation is discussed. (Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Rösch, B., Gentner, T. X., Langer, J., Färber, C., Eyselein, J., Zhao, L., Ding, C., Frenking, G., Harder, S. Tags: Chemistry reports Source Type: news

Calcium catches dinitrogen
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

What Are the Causes of Secondary Amenorrhea?
Discussion The first sign of puberty in females is breast budding (Tanner stage II) which normally occurs from 8-13 years. Menarche usually occurs within 2 years of breast budding occurring usually at Tanner stage III-IV breast development. Menarche occurs for most girls from 10-15 years. Most cycles range between 21-45 days. Age> 13 years without acquisition of secondary sexual characteristics,> 15 years before menarche or 5 years after acquisition of secondary sexual characteristics or cycles longer than 45 days are indications for evaluation. After menarche is it not uncommon to have anovulatory cycles that are ir...
Source: PediatricEducation.org - March 8, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Umbrella Review Reveals Links Between Diet, Colorectal Cancer
Review of meta - analyses of prospective observational studies reveals lower risk with higher intakes of dietary fiber, dietary calcium, yogurt (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 2, 2021 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Internal Medicine, Oncology, Journal, Source Type: news

Umbrella Review Reveals Links Between Diet, Colorectal Cancer
TUESDAY, March 2, 2021 -- Higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of red meat and alcohol are associated with a lower risk for colorectal cancer (CRC), according to a review published online Feb. 16 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 2, 2021 Category: Pharmaceuticals Source Type: news

Deep-learning algorithm can detect, quantify aortic valve calcium
Researchers from South Korea reported that their artificial intelligence (AI...Read more on AuntMinnie.comRelated Reading: Echo helps identify flossing-induced heart disease 3D printing enhances planning of TAVR procedures CT helps predict TAVR outcomes 4D CT sheds light on post-TAVR treatment strategies AR, 3D printing make waves in cardiac care (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 9, 2021 Category: Radiology Source Type: news

Vaithianathan receives $1.9 million grant for retinal research
(University of Tennessee Health Science Center) Thirumalini Vaithianathan, PhD, assistant professor in the Department of Pharmacology, Addiction Science, and Toxicology at the University of Tennessee Health Science Center, has spent a decade studying molecular signaling involved in vision. She has just received $1.9 million from the National Eye Institute for her project titled, " Dynamics of calcium signals control neurotransmitter release in retinal ribbon Synapses " . (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 4, 2021 Category: International Medicine & Public Health Source Type: news

Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU
February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said C...
Source: Johnson and Johnson - February 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Genetic approach to elucidate the role of cyclophilin D in traumatic brain injury pathology - Readnower RD, Hubbard WB, Kalimon OJ, Geddes JW, Sullivan PG.
Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade. Studies consistently demonstrate that mitochondrial dysfunction, including mitochondrial calcium... (Source: SafetyLit)
Source: SafetyLit - January 29, 2021 Category: International Medicine & Public Health Tags: TBI Source Type: news

Automated AI algorithm uses routine imaging to predict cardiovascular risk
(Brigham and Women's Hospital) Investigators teamed up to develop and evaluate a deep learning system that may help change this. The system automatically measures coronary artery calcium from CT scans to help physicians and patients make more informed decisions about cardiovascular prevention. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 29, 2021 Category: International Medicine & Public Health Source Type: news

When is the best time to take Vitamin D?
VITAMIN D supplements can help keep people healthy by regulating the amount of phosphate and calcium in the body. So when is the best time to take vitamin D? (Source: Daily Express - Health)
Source: Daily Express - Health - January 15, 2021 Category: Consumer Health News Source Type: news

Calcium-Induced Autonomic Denervation Linked to Lower Post-op AF Calcium-Induced Autonomic Denervation Linked to Lower Post-op AF
Intraoperative injection of calcium chloride into the four major atrial ganglionated plexi reduced the incidence of early postoperative atrial fibrillation in a proof-of-concept study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 14, 2021 Category: Consumer Health News Tags: Cardiology News Source Type: news

Better chest CT CAC reporting avoids unnecessary exams
Reporting coronary artery calcium (CAC) on routine chest CT could help clinicians...Read more on AuntMinnie.comRelated Reading: Machine-learning model predicts adverse cardiac outcomes CCTA, functional tests stratify heart disease risk by age Coronary calcium predicts events, death, in younger adults ARRS: Ungated CT calcium scores downgrade cardiac risk Coronary calcium usually ignored on chest CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 13, 2021 Category: Radiology Source Type: news

Host a Specialised Endocrinology Network for Bone and Mineral
The Society’s Clinical Committee, working with our Bone and Calcium Endocrine Network, and in association with the NHSEI Clinical Reference Group, propose setting up a network of bone and mineral hubs across the UK.  It has become clear from the GIRFT process, and other available data, that significant variance is present in the outcomes and quality of clinical endocrinology services across the UK. The specialised endocrinology networks for bone and mineral aim to more standardise care in this area. It is envisaged that there would be a number of specific objectives for this sy...
Source: Society for Endocrinology - January 12, 2021 Category: Endocrinology Source Type: news

Mechanisms in the kidney that control magnesium and calcium levels discovered
(Massachusetts General Hospital) The gene KCTD1 directs production of a protein that functions in the kidney to maintain a normal balance of magnesium and calcium in blood. Loss of KCTD1 impairs the ability of the kidney to properly absorb magnesium and calcium from urine in the kidney, leading to abnormally low magnesium and calcium blood levels, thereby triggering the parathyroid glands to secrete excess parathyroid hormone that in turn leads to metabolic bone disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 12, 2021 Category: Biology Source Type: news

Three-site study highlight effectiveness of FEND nasal calcium rich salts
(World Scientific) In apaper published in Molecular Frontiers Journal, researchers from Cambridge, Massachusetts and Bangalore, India study the effectiveness of FEND product to significantly improve airway hygiene by reducing and suppressing respiratory droplets potentially containing airborne pathogens and other contaminants. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 11, 2021 Category: Infectious Diseases Source Type: news

Lithium pollution of a white dwarf records the accretion of an extrasolar planetesimal
We report the detection of lithium, sodium, potassium, and calcium in the atmosphere of the white dwarf Gaia DR2 4353607450860305024, which we ascribe to the accretion of a planetesimal. Using model atmospheres, we determine abundance ratios of these elements, and, with the exception of lithium, they are consistent with meteoritic values in the Solar System. We compare the measured lithium abundance with measurements in old stars and with expectations from Big Bang nucleosynthesis. (Source: ScienceNOW)
Source: ScienceNOW - January 7, 2021 Category: Science Authors: Kaiser, B. C., Clemens, J. C., Blouin, S., Dufour, P., Hegedus, R. J., Reding, J. S., Bedard, A. Tags: Astronomy, Geochemistry, Geophysics, Planetary Science reports Source Type: news

New drug form may help treat osteoporosis, calcium-related disorders
(Purdue University) Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 6, 2021 Category: International Medicine & Public Health Source Type: news

Fellow scientists honor James Putney Jr.
Fellow scientists honored NIEHS scientist James Putney Jr., Ph.D., for 40 years of lasting contributions to the study of calcium signaling. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Fires, flooding before settlement may have formed the Amazon's rare patches of fertility
(University of Oregon) Phosphorous, calcium and charcoal in spotty patches of fertile soil in the Amazon rainforest suggest that natural processes such as fires and river flooding, not the ingenuity of indigenous populations, created rare sites suitable for agriculture, according to new research. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 4, 2021 Category: International Medicine & Public Health Source Type: news

Janssen Initiates Rolling Submission of a Biologics License Application to U.S. FDA for BCMA CAR-T Therapy Ciltacabtagene Autoleucel (cilta-cel) for the Treatment of Relapsed and/or Refractory Multiple Myeloma
December 21, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the initiation of a rolling submission of its Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of adults with relapsed and/or refractory multiple myeloma.“We are committed to innovation in cell therapy and advancing the science of multiple myeloma to improve patients’ lives,” said Pete...
Source: Johnson and Johnson - December 21, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

One in Five Patients Hospitalized With COVID - 19 Dies
Statins, angiotensin - converting enzyme inhibitors, and calcium channel blockers tied to lower risk for death (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - December 16, 2020 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Nephrology, Nursing, Pathology, Pharmacy, Pulmonology, Geriatrics, Journal, Source Type: news

Voco Introduces Provicol QM Aesthetic Translucent Zinc Oxide, Non-Eugenol Temporary Cement with Calcium Hydroxide
Introducing Provicol QM Aesthetic, a zinc oxide-based transparent non-eugenol temporary cement that secures provisional crowns and bridges without affecting the overlying color of the restoration.This zinc oxide-based formula promotes anti-bacterial properties as well as an ideal adhesion and strength with a semi-elastic consistency that allows for easy clean up. Distinct from resin-based temporary cements, zinc-oxide cements do not permanently bond to composite core build-ups, therefore simplifying the removal of temporaries..The new and innovative glass matrix with polyhedral particles allows for a translucency only achi...
Source: Dental Technology Blog - December 16, 2020 Category: Dentistry Source Type: news

Regenerative Endodontic Procedures, Disinfectants and Outcomes: A Systematic Review
 Prim Dent J. 2020 Dec;9(4):65-84. doi: 10.1177/2050168420963302.AbstractAims: This systematic review aims to identify and synthesise available evidence to determine the clinical and radiographic outcomes of REP involving any disinfection irrigant together with a non-antibiotic intracanal medicament.Methods: Experimental and observational studies evaluating the outcomes of REP in immature non-vital permanent teeth in 6-16 year olds, where the protocol used any type of disinfectant irrigant together with a non-antibiotic intracanal medicament (non-setting calcium hydroxide) were included. Data was n...
Source: Dental Technology Blog - December 10, 2020 Category: Dentistry Source Type: news

Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not
That future cardiovascular risk tracks closely with plaque burden, but not so much with whether the coronary disease is obstructive, may never have been so clearly illustrated.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - December 8, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

What Areas of the Physical Examination are Important in the Pre-participation Physical Examination?
Discussion Participation in organized or non-organized, recreational to elite sports activities can provide excellent recreational and leisure time activities and improve physical and mental health for participants. The Aspen Institute in 2018 reported that more kids are being physically active, more are trying different sports, and multisports play is increasing rather than strict specialization. Unfortunately they note that there is an economic inequality with children from lower-socioeconomic circumstances playing less organized sports. About 70% of children and youth participate in an individual or team sport, but unfo...
Source: PediatricEducation.org - December 7, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Janssen Presents First Data from the Phase 1 Study of the GPRC5DxCD3 Bispecific Talquetamab in Patients with Relapsed or Refractory Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today initial data for the Phase 1 first-in-human dose escalation study of talquetamab (JNJ-64407564) for the treatment of relapsed or refractory multiple myeloma (NCT03399799). Talquetamab is a first-in-class, and the only investigational bispecific antibody that targets both GPRC5D, a novel multiple myeloma target, and CD3 on T-cells. Initial results for both the subcutaneous (SC) and intravenous (IV) formulations show encouraging clinical activity against the GPRC5D target, which is highly expressed on multip...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Updated Results from the Phase 1 Study of the BCMAxCD3 Bispecific Teclistamab Show Preliminary Efficacy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
This study evaluated the ability of teclistamab to induce cytotoxicity and T-cell activation.About TeclistamabTeclistamab is an investigational bispecific antibody targeting both BCMA and CD3. BCMA, B-cell maturation antigen, is expressed at high levels on multiple myeloma cells.[3],[4],[5],[6],[7] Teclistamab redirects CD3-positive T-cells to BCMA-expressing myeloma cells to induce cytotoxicity of the targeted cells.5,6 Results from preclinical studies demonstrate that teclistamab kills myeloma cell lines and bone marrow-derived myeloma cells from heavily pretreated patients.6 Teclistamab is currently being evaluated in a...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Early, Deep, Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) Observed in Phase 1b/2 CARTITUDE-1 Study Show Potential of BCMA CAR-T in Treatment of Heavily Pretreated Patients with Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the combined Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory multiple myeloma. These data, presented as an oral presentation at the American Society of Hematology (ASH) 2020 Annual Meeting (Abstract #177), continued to demonstrate a very hig...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Vitamin D regulates calcium in intestine differently than previously thought
(Rutgers University) A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2020 Category: International Medicine & Public Health Source Type: news

Vitamin D: At risk groups to get free Vitamin D - are you eligible?
VITAMIN D is essential for regulating the amount of calcium and phosphate in the body. Now a new Government initiative will see at-risk groups given a winter supply of Vitamin D. But are you eligible? (Source: Daily Express - Health)
Source: Daily Express - Health - November 28, 2020 Category: Consumer Health News Source Type: news

The effect of administration of dietary supplement with calcium and vitamins D3 and B6 on calcium homeostasis and falls incidence in patients with high fracture risk undergoing medical rehabilitation - Marchenkova LA, Fesyun AD, Gerasimenko MY, Makarova EV.
Elimination of vitamin D and calcium deficiencies is of particular importance in older patients undergoing medical rehabilitation after a serious illness, surgery or injury and having a high risk of fractures. Preventing falls and fractures, including duri... (Source: SafetyLit)
Source: SafetyLit - November 23, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Targeting calcium overload could improve stroke outcomes, research suggests
(University of Virginia Health System) Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 23, 2020 Category: Biology Source Type: news

Vegans, vegetarians and pescetarians may be at higher risk of bone fractures
(BMC (BioMed Central)) Compared with people who ate meat, vegans with lower calcium and protein intakes on average, had a 43% higher risk of fractures anywhere in the body (total fractures), as well as higher risks of site-specific fractures of the hips, legs and vertebrae, according to a study published in the open access journal BMC Medicine. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 22, 2020 Category: Biology Source Type: news

How rotavirus causes severe gastrointestinal disease
(Baylor College of Medicine) Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects. This is the first virus identified to activate ADP-mediated intercellular calcium waves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2020 Category: International Medicine & Public Health Source Type: news

Rotavirus induces intercellular calcium waves through ADP signaling
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), observed in cell lines and human intestinal enteroids. Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic receptors on neighboring cells. ICWs were blocked by P2Y1 antagonists or CRISPR-Cas9 knockout of the P2Y1 receptor. Blocking the ADP signal re...
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Chang-Graham, A. L., Perry, J. L., Engevik, M. A., Engevik, K. A., Scribano, F. J., Gebert, J. T., Danhof, H. A., Nelson, J. C., Kellen, J. S., Strtak, A. C., Sastri, N. P., Estes, M. K., Britton, R. A., Versalovic, J., Hyser, J. M. Tags: Microbiology, Molecular Biology, Online Only r-articles Source Type: news

Riding the calcium waves
(Source: ScienceNOW)
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Hurtley, S. M. Tags: Microbiology, Molecular Biology twis Source Type: news

Effect of tip insertion depth and irradiation parameters on the efficacy of cleaning calcium hydroxide from simulated lateral canals using Er:YAG laser- or ultrasonic-activated irrigation
This study aimed to compare the efficacy of removing calcium hydroxide [Ca(OH)2] paste from lateral canals using LAI or ultrasonic-activated irrigation (UAI), and to examine the effect of tip insertion depth and laser irradiation parameters on cleaning efficacy.Materials and methodsRadiopaque Ca(OH)2 paste (Calcipex II) was injected into lateral canals 6  mm from the root apex in 192 J-shaped simulated root canal models. LAI (Erwin AdvErl; 30 or 70 mJ; 10 or 20 pulses per second; laser tip R200T or R600T) and UAI (ENAC SE10; output setting: 3) were performed 3 times for 20 s. The laser tip was placed at 8–0...
Source: Dental Technology Blog - November 17, 2020 Category: Dentistry Source Type: news

Oral symptoms caused by toxic plants containing calcium oxalate - Miyamoto M, Noma M, Ishii J, Yoshihara S.
A one-year-old girl presented to our emergency room with lip swelling after biting the fruit of a wild plant. The plant was identified as Arisaema serratum through an internet search based on the photo taken by the guardian ( Figure, A). Her vital signs we... (Source: SafetyLit)
Source: SafetyLit - November 12, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news