NIH Director's Seminar Series: Long-range synaptic and local receptor-mediated control of dopaminergic neuron excitability – dendrites, soma and axons
Dopamine-releasing neurons located in the midbrain play a central role in reward and motor learning behaviors. Their dysfunction is implicated in an array of disorders from addiction to Parkinson ’ s Disease (PD). The Cellular Neurophysiology Section headed by Dr. Zayd Khaliq examines the circuit, synaptic and intrinsic mechanisms that contribute to the firing patterns that underlie dopamine-dependent behaviors. The first part of the lecture will discuss the ionic and modulatory mechanisms of firing patterns observed in dopaminergic neurons of the substantia nigra during aversive behaviors. Axons of dopaminergic neurons ...
Source: Videocast - All Events - June 6, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video

Translating Thought into Blood Flow in the Brain: Capillaries as Sensors of Neural Activity
NIH Director's Wednesday Afternoon Lecture Series The Nelson laboratory ’ s research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neurons and how these mechanisms are disrupted in small vessel disease (SVD) — a major cause of stroke and dementia. Dr. Nelson and colleagues have unraveled many of the major mechanisms that control cerebrovascular function, including the discovery of local calcium signals ( “ sparks ” ), which counter-intuitively oppose vasoconstriction. They have recently shown that brain capillaries ac...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video

B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

CC Grand Rounds: 1) Transcriptional and Functional Consequences of Noncoding RNA-Mediated Crosstalk Between Interferon and Calcium in Sj ö gren ’ s Syndrome and 2) Gene Therapy for Salivary Gland Hypofunction
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/17/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 21, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video