WALS Lecture: Leveraging Genetics and Cell Signaling to Decipher Disorders of Excitability
Presentation Objectives: To understand how genetic testing illuminates the causes of a devastating disease, Sudden Unexpected Death in Childhood, and identifies dysfunctional calcium signaling as a major cause; To chart a course for how genetic analysis of neuropsychiatric disorders such as schizophrenia, Major Depressive Disorder and Bipolar Disorder will spur understanding the impact of non-coding variations in key signaling proteins; To appreciate how genetics highlights underappreciated signaling molecules that coordinate excitatory and inhibitory synaptic strength and provide a target for cannabidiol (CBD) action in e...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Microtissues stained to distinguish features
Microtissues that are stained to distinguish cell nuclei (blue), sarcomeric alpha-actinic (red) and myosin binding protein C (green). Researchers developed an algorithm that directly and noninvasively monitors the coupling of calcium waves, membrane voltage and mechanical contraction beat by beat ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 6, 2023 Category: Science Source Type: video
WALS Lecture: Richard Tsien, Ph.D.
As a physiologist/neurobiologist, I have long been fascinated by calcium channels. These membrane proteins regulate cellular Ca2+ entry in a voltage-dependent manner and thereby link the realms of electrical signaling and intracellular messengers. A single opening of a Ca2+ channel can allow thousands of calcium ions to enter a cell, thus generating a signal that may control transmitter release, excitability, metabolism, or gene expression. My colleagues and I have been active in discovering and classifying diverse types of Ca2+ channels, including the channels most critical for neurosecretion in the brain. By uncovering N...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Hypothalamic cell types and circuits that drive survival behaviors
The Aponte lab studies the role of genetically-identified neurons and their projections in behaviors that are essential for survival. Their ultimate goal is to understand how neurons in distinct hypothalamic circuits encode pain and the rewarding and addictive nature of food intake. To answer these questions, they use a combination of optogenetics, chemogenetics, electrophysiology, two- and single-photon fluorescence endomicroscopy, and behavioral assays to manipulate and measure the activity of these genetically-defined neuronal subpopulations in awake behaving mice. Recently, they showed how two of the lateral hypothalam...
Source: Videocast - All Events - December 1, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Long-range synaptic and local receptor-mediated control of dopaminergic neuron excitability – dendrites, soma and axons
Dopamine-releasing neurons located in the midbrain play a central role in reward and motor learning behaviors. Their dysfunction is implicated in an array of disorders from addiction to Parkinson ’ s Disease (PD). The Cellular Neurophysiology Section headed by Dr. Zayd Khaliq examines the circuit, synaptic and intrinsic mechanisms that contribute to the firing patterns that underlie dopamine-dependent behaviors. The first part of the lecture will discuss the ionic and modulatory mechanisms of firing patterns observed in dopaminergic neurons of the substantia nigra during aversive behaviors. Axons of dopaminergic neurons ...
Source: Videocast - All Events - June 6, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Translating Thought into Blood Flow in the Brain: Capillaries as Sensors of Neural Activity
NIH Director's Wednesday Afternoon Lecture Series
The Nelson laboratory ’ s research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neurons and how these mechanisms are disrupted in small vessel disease (SVD) — a major cause of stroke and dementia. Dr. Nelson and colleagues have unraveled many of the major mechanisms that control cerebrovascular function, including the discovery of local calcium signals ( “ sparks ” ), which counter-intuitively oppose vasoconstriction. They have recently shown that brain capillaries ac...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds
B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Transcriptional and Functional Consequences of Noncoding RNA-Mediated Crosstalk Between Interferon and Calcium in Sj ö gren ’ s Syndrome and 2) Gene Therapy for Salivary Gland Hypofunction
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/17/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 21, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Pushing the envelope in biological microscopy: High speed imaging at and beyond the diffraction limit
Director's Seminar Series
Dr. Hari Shroff will discuss his lab's, the Section of High Resolution Optical Imaging (HROS), efforts to improve structured illumination microscopy (SIM) and light-sheet microscopy. SIM doubles the spatial resolution of light microscopy, requiring lower light intensities and acquisition times than other super-resolution techniques. Dr. Shroff will present SIM implementations that enable resolution doubling in live samples> 10-20x thicker than possible with conventional SIM, as well as hardware modifications that enable effectively ‘ instant ’ SIM imaging at rates 10-100x faster than other SIM...
Source: Videocast - All Events - May 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Stephen E Straus Distinguished Lecture in the Science of Complementary Health Therapies: When Experts Disagree - the Art of Medical Decision Making
The National Center for Complementary and Alternative Medicine (NCCAM) will hold the sixth annual Stephen E. Straus Distinguished Lecture in the Science of Complementary Health Therapies. Speakers, Jerome Groopman, M.D., the Dina and Raphael Recanati chair of medicine at Harvard Medical School and chief of experimental medicine at Beth Israel Deaconess Medical Center and Pamela Hartzband, M.D., assistant professor of medicine at Harvard Medical School and attending physician in the division of endocrinology at Beth Israel Deaconess Medical Center will present “When Experts Disagree: The Art of Medical Decision Making.”...
Source: Videocast - All Events - December 4, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
CANCELED - Neural Circuit Dynamics During Virtual Navigation
Neuroscience Seminar Series
Dr. Tank Lab’s current focus is on persistent neural activity, a form of neural circuit dynamics that is associated with short-term memory. Persistent neural activity is a sustained increase or suppression of action potential firing elicited by a brief sensory stimulus or motor command. Across the population of participating neurons, the pattern of sustained changes in action potential firing is correlated with the information held in short term memory, while disruption of persistent activity produces deficits in memory-guided behavior. These characteristics suggest that the memory is actuall...
Source: Videocast - All Events - March 17, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
