Fellow scientists honor James Putney Jr.
<div class="rxbodyfield">Fellow scientists honored NIEHS scientist James Putney Jr., Ph.D., for 40 years of lasting contributions to the study of calcium signaling.</div> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - January 6, 2021 Category: Environmental Health Source Type: news

Fires, flooding before settlement may have formed the Amazon's rare patches of fertility
(University of Oregon) Phosphorous, calcium and charcoal in spotty patches of fertile soil in the Amazon rainforest suggest that natural processes such as fires and river flooding, not the ingenuity of indigenous populations, created rare sites suitable for agriculture, according to new research. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 4, 2021 Category: International Medicine & Public Health Source Type: news

Janssen Initiates Rolling Submission of a Biologics License Application to U.S. FDA for BCMA CAR-T Therapy Ciltacabtagene Autoleucel (cilta-cel) for the Treatment of Relapsed and/or Refractory Multiple Myeloma
December 21, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the initiation of a rolling submission of its Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of adults with relapsed and/or refractory multiple myeloma.“We are committed to innovation in cell therapy and advancing the science of multiple myeloma to improve patients’ lives,” said Peter Lebowitz, M.D....
Source: Johnson and Johnson - December 21, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

One in Five Patients Hospitalized With COVID - 19 Dies
Statins, angiotensin - converting enzyme inhibitors, and calcium channel blockers tied to lower risk for death (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - December 16, 2020 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Nephrology, Nursing, Pathology, Pharmacy, Pulmonology, Geriatrics, Journal, Source Type: news

Voco Introduces Provicol QM Aesthetic Translucent Zinc Oxide, Non-Eugenol Temporary Cement with Calcium Hydroxide
Introducing Provicol QM Aesthetic, a zinc oxide-based transparent non-eugenol temporary cement that secures provisional crowns and bridges without affecting the overlying color of the restoration.This zinc oxide-based formula promotes anti-bacterial properties as well as an ideal adhesion and strength with a semi-elastic consistency that allows for easy clean up. Distinct from resin-based temporary cements, zinc-oxide cements do not permanently bond to composite core build-ups, therefore simplifying the removal of temporaries..The new and innovative glass matrix with polyhedral particles allows for a translucency only achi...
Source: Dental Technology Blog - December 16, 2020 Category: Dentistry Source Type: news

Regenerative Endodontic Procedures, Disinfectants and Outcomes: A Systematic Review
 Prim Dent J. 2020 Dec;9(4):65-84. doi: 10.1177/2050168420963302.AbstractAims: This systematic review aims to identify and synthesise available evidence to determine the clinical and radiographic outcomes of REP involving any disinfection irrigant together with a non-antibiotic intracanal medicament.Methods: Experimental and observational studies evaluating the outcomes of REP in immature non-vital permanent teeth in 6-16 year olds, where the protocol used any type of disinfectant irrigant together with a non-antibiotic intracanal medicament (non-setting calcium hydroxide) were included. Data was n...
Source: Dental Technology Blog - December 10, 2020 Category: Dentistry Source Type: news

Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not Calcium Burden Drives CV Risk Whether CAD Is Obstructive or Not
That future cardiovascular risk tracks closely with plaque burden, but not so much with whether the coronary disease is obstructive, may never have been so clearly illustrated.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - December 8, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

What Areas of the Physical Examination are Important in the Pre-participation Physical Examination?
Discussion Participation in organized or non-organized, recreational to elite sports activities can provide excellent recreational and leisure time activities and improve physical and mental health for participants. The Aspen Institute in 2018 reported that more kids are being physically active, more are trying different sports, and multisports play is increasing rather than strict specialization. Unfortunately they note that there is an economic inequality with children from lower-socioeconomic circumstances playing less organized sports. About 70% of children and youth participate in an individual or team sport, but unfo...
Source: PediatricEducation.org - December 7, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Janssen Presents First Data from the Phase 1 Study of the GPRC5DxCD3 Bispecific Talquetamab in Patients with Relapsed or Refractory Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today initial data for the Phase 1 first-in-human dose escalation study of talquetamab (JNJ-64407564) for the treatment of relapsed or refractory multiple myeloma (NCT03399799). Talquetamab is a first-in-class, and the only investigational bispecific antibody that targets both GPRC5D, a novel multiple myeloma target, and CD3 on T-cells. Initial results for both the subcutaneous (SC) and intravenous (IV) formulations show encouraging clinical activity against the GPRC5D target, which is highly expressed on multiple m...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Updated Results from the Phase 1 Study of the BCMAxCD3 Bispecific Teclistamab Show Preliminary Efficacy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
This study evaluated the ability of teclistamab to induce cytotoxicity and T-cell activation.About TeclistamabTeclistamab is an investigational bispecific antibody targeting both BCMA and CD3. BCMA, B-cell maturation antigen, is expressed at high levels on multiple myeloma cells.[3],[4],[5],[6],[7] Teclistamab redirects CD3-positive T-cells to BCMA-expressing myeloma cells to induce cytotoxicity of the targeted cells.5,6 Results from preclinical studies demonstrate that teclistamab kills myeloma cell lines and bone marrow-derived myeloma cells from heavily pretreated patients.6 Teclistamab is currently being evaluated in a...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Early, Deep, Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) Observed in Phase 1b/2 CARTITUDE-1 Study Show Potential of BCMA CAR-T in Treatment of Heavily Pretreated Patients with Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the combined Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory multiple myeloma. These data, presented as an oral presentation at the American Society of Hematology (ASH) 2020 Annual Meeting (Abstract #177), continued to demonstrate a very high ov...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Vitamin D regulates calcium in intestine differently than previously thought
(Rutgers University) A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2020 Category: International Medicine & Public Health Source Type: news

Vitamin D: At risk groups to get free Vitamin D - are you eligible?
VITAMIN D is essential for regulating the amount of calcium and phosphate in the body. Now a new Government initiative will see at-risk groups given a winter supply of Vitamin D. But are you eligible? (Source: Daily Express - Health)
Source: Daily Express - Health - November 28, 2020 Category: Consumer Health News Source Type: news

The effect of administration of dietary supplement with calcium and vitamins D3 and B6 on calcium homeostasis and falls incidence in patients with high fracture risk undergoing medical rehabilitation - Marchenkova LA, Fesyun AD, Gerasimenko MY, Makarova EV.
Elimination of vitamin D and calcium deficiencies is of particular importance in older patients undergoing medical rehabilitation after a serious illness, surgery or injury and having a high risk of fractures. Preventing falls and fractures, including duri... (Source: SafetyLit)
Source: SafetyLit - November 23, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Targeting calcium overload could improve stroke outcomes, research suggests
(University of Virginia Health System) Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 23, 2020 Category: Biology Source Type: news