L-type calcium channel blockers may contribute to heart failure, study finds
(Penn State) Researchers found that in rats and human cells in vitro, LCCBs cause changes in blood vessels -- known as vascular remodeling -- that reduce blood flow and increase pressure. Examining epidemiological data, the team also found that LCCBs are associated with a greater risk for heart failure. The findings suggest that care should be taken when prescribing these drugs to patients, particularly older adults and those with advanced hypertension. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 23, 2020 Category: International Medicine & Public Health Source Type: news

Calcium imaging of left-right asymmetry
(Source: ScienceNOW)
Source: ScienceNOW - July 22, 2020 Category: Science Authors: Hadjantonakis, A.-K. Tags: twis Source Type: news

Jazz Pharmaceuticals Announces U.S. FDA Approval of Xywav(TM) (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy
Xywav is the first FDA approved new treatment option indicated for both cataplexy and excessive daytime sleepiness in people living with narcolepsy in more than 15 years Xywav contains 92 percent less sodium per nightly dose than sodium oxybate, a curre... Biopharmaceuticals, Neurology, FDA Jazz Pharmaceuticals, Xywav, Cataplexy, Narcolepsy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 22, 2020 Category: Pharmaceuticals Source Type: news

Calcium channel subunits play a major role in autistic disorders
(Johannes Gutenberg Universitaet Mainz) Neurobiologists at Johannes Gutenberg University Mainz (JGU) in Germany have found new evidence that specific calcium channel subunits play a crucial role in the development of excitatory and inhibitory synapses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 22, 2020 Category: International Medicine & Public Health Source Type: news

FDA Approves Xywav (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Cataplexy or Excessive Daytime Sleepiness Associated with Narcolepsy
DUBLIN, July 22, 2020 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the U.S. Food and Drug Administration (FDA) approved Xywav™ (calcium, magnesium, potassium, and sodium oxybates)... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 22, 2020 Category: Drugs & Pharmacology Source Type: news

Used Together, Troponin and Coronary Calcium Improve CV Risk Assessment Used Together, Troponin and Coronary Calcium Improve CV Risk Assessment
' If one ' s wish is to identify truly low-risk individuals, then it appears that it takes two negative ASCVD biomarkers to make that wish come true, ' observers say.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - July 21, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in Ca2+ signaling throughout the body. In the hippocampus, CaMKII is required for learning and memory. Vertebrate genomes encode four CaMKII homologs: CaMKIIα, CaMKIIβ, CaMKII, and CaMKII. All CaMKIIs consist of a kinase domain, a regulatory segment, a variable linker region, and a hub domain, which is responsible for oligomerization. The four proteins differ primarily in linker length and composition because of extensive alternative splicing. Here, we report the heterogeneity of CaMKII transcripts in three complex samples of human hipp...
Source: Signal Transduction Knowledge Environment - July 20, 2020 Category: Science Authors: Sloutsky, R., Dziedzic, N., Dunn, M. J., Bates, R. M., Torres-Ocampo, A. P., Boopathy, S., Page, B., Weeks, J. G., Chao, L. H., Stratton, M. M. Tags: STKE Research Articles Source Type: news

What Are Some Pediatric Oncological Emergencies?
Discussion Pediatric cancers in the US number about 12,000 per year. After injury, it is the second leading cause of death in children and adolescents. Cancer presentations vary widely, but often begin with non-specific symptoms that continue or progress depending on the location and tumor type. Patients can present with oncological emergencies especially if there are mechanical obstruction such as superior vena cava syndrome or cerebral herniation. More commonly are infections due to immunosuppression. Cancer treatment also causes its own myriad of problems that clinicians need to be aware of to diagnosis and treat, but a...
Source: PediatricEducation.org - July 20, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

New link between calcium and cardiolipin in heart defects
(Texas A&M AgriLife Communications) To function properly, the heart needs energy from cells' powerhouses, the mitochondria. In turn, mitochondria boost their energy output when calcium levels rise around them, a signal that more energy is needed. A new study shows that a shortage of cardiolipin, a type of fat, in the mitochondrial membrane, prevents calcium from entering mitochondria. The result helps explain heart and muscle weakness in the rare genetic disorder Barth syndrome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 7, 2020 Category: International Medicine & Public Health Source Type: news

Effects of desensitizing products on the reduction of pain sensitivity caused by in-office tooth bleaching: a 24-week follow-up
Conclusion Our results indicate that adding NF/S, NA/S, NF/AC, and NA/AC desensitizers to tooth bleaching protocols reduces pain sensitivity without affecting its effectiveness. (Source: Dental Technology Blog)
Source: Dental Technology Blog - July 2, 2020 Category: Dentistry Source Type: news

Rethink Food Security and Nutrition Following Covid-19 Pandemic
By Jomo Kwame Sundaram and Wan Manan MudaKUALA LUMPUR, Malaysia, Jul 2 2020 (IPS) The Covid-19 crisis has had several unexpected effects, including renewed attention to food security concerns. Earlier understandings of food security in terms of production self-sufficiency have given way to importing supplies since late 20th century promotion of trade liberalization. Jomo Kwame SundaramTransnational food business Disruption of transnational food supply chains and the devastation of many vulnerable livelihoods by policy responses to the Covid-19 pandemic have revived interest in earlier understandings of food self-sufficien...
Source: IPS Inter Press Service - Health - July 2, 2020 Category: International Medicine & Public Health Authors: Jomo Kwame Sundaram and Wan Manan Muda Tags: Development & Aid Economy & Trade Food Security and Nutrition Food Sustainability Global Headlines Health Humanitarian Emergencies Poverty & SDGs TerraViva United Nations Source Type: news

AHA News: A Healthier Frozen Treat for Hot Summer Days
TUESDAY, June 30, 2020 (American Heart Association News) -- Want to beat the heat with a cold treat this summer? Consider a healthy frozen yogurt pop with peaches. " It ' s a tasty low-calorie recipe that provides protein, potassium and calcium that... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 30, 2020 Category: General Medicine Source Type: news

What Causes Bradycardia?
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia ...
Source: PediatricEducation.org - June 22, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

A novel mechanism of mitochondrial dysfunctions-triggered the calcium signalling-dependent fungal multidrug resistance
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2020 Category: Respiratory Medicine Authors: MeganB Source Type: news

Calcium Scoring Pinpoints Stenoses in Asymptomatic Diabetes Calcium Scoring Pinpoints Stenoses in Asymptomatic Diabetes
Incorporating coronary calcium scoring into a silent myocardial ischemia screening algorithm may be an effective and cost-conscious strategy that avoids missed coronary stenoses suitable for revascularization.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 17, 2020 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news