U.S. FDA Approves CARVYKTI ™ (ciltacabtagene autoleucel), Janssen’s First Cell Therapy, a BCMA-Directed CAR-T Immunotherapy for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., February 28, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) has approved CARVYKTI™ (ciltacabtagene autoleucel; cilta-cel) for the treatment of adults with relapsed or refractory multiple myeloma (RRMM) after four or more prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.1 The approval is based on data from the pivotal CARTITUDE-1 study, which included patients who had received a median of six prior treatment regimens (range, 3-18), and had previously rec...
Source: Johnson and Johnson - March 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

CAC Scores, Lp(a) Together May Inform CV Risk Assessment CAC Scores, Lp(a) Together May Inform CV Risk Assessment
Calcium scores and Lp(a) levels predict 10-year risk independent of each other, and together could swing shared decision-making about whether to start statins, researchers say.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - February 28, 2022 Category: Neurology Tags: Cardiology News Source Type: news

A case of paralytic intestinal obstruction caused by nifedipine poisoning - Mu YH, Li XL, Pang L.
This article retrospectively analyzed the clinical data of a patient with nifedipine poisoning complicated with paralytic intestinal obstruction admi... (Source: SafetyLit)
Source: SafetyLit - February 18, 2022 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

CAC Tied to Cardiovascular Risk During Radiation Therapy for NSCLC
MONDAY, Feb. 14, 2022 -- The burden of coronary artery calcium (CAC) may help predict the risk for major adverse cardiovascular events (MACE) during radiation treatment for non-small cell lung cancer (NSCLC), according to a study presented at the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 14, 2022 Category: Pharmaceuticals Source Type: news

Radiation therapy increases heart attack risk in lung cancer patients
Thoracic radiation therapy increases the risk of heart disease, heart attack...Read more on AuntMinnie.comRelated Reading: Higher coronary artery calcium scores increase COVID-19 mortality risk New studies show how CT reveals 'silent' atherosclerosis How has the COVID-19 pandemic affected CT CAC testing? CT CAC helps determine which patients benefit from statin therapy JAMA Internal Medicine stirs debate on coronary CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 14, 2022 Category: Radiology Source Type: news

Vitamin D deficiency: The 'constant' feeling which may indicate a deficiency
VITAMIN D helps regulate the amount of calcium and phosphate in the body, so a lack of it can lead to a number of issues. Some signs of deficiency can be somewhat vague, while others may only occur if you have been lacking the vitamin for some time. (Source: Daily Express - Health)
Source: Daily Express - Health - February 12, 2022 Category: Consumer Health News Source Type: news

CAC scores predict cardiac risk in patients with high cholesterol
Patients with elevated LDL-C levels but with low coronary artery calcium score...Read more on AuntMinnie.comRelated Reading: CCTA plaque data improve heart disease risk assessment in diabetics Are radiologists regaining control of cardiac imaging? CTA shows how statin treatment changes coronary plaque CTA shows the effect of job stress on the heart Use of CTA, CT perfusion up -- but for the right reasons (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 11, 2022 Category: Radiology Source Type: news

Dr Reddy's inks exclusive sales pact with Novartis India
Under the arrangement, Dr Reddy's will have exclusive rights to promote and distribute the well-established Voveran range, the Calcium range and Methergine in India. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 11, 2022 Category: Pharmaceuticals Source Type: news

Vitamin D deficiency: The sign when you wake up which is 'an early' indicator
VITAMIN D is crucial for your health, because it helps regulate the amount of calcium and phosphate in the body. This is necessary for keeping bones and teeth healthy. (Source: Daily Express - Health)
Source: Daily Express - Health - February 8, 2022 Category: Consumer Health News Source Type: news

Clinimix E (Amino Acids with Electrolytes in Dextrose with Calcium Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 31, 2022 Category: Drugs & Pharmacology Source Type: news

Evaluation of the ability of adhesives with antibacterial and remineralization functions to prevent secondary caries in vivo
ConclusionsThe NACP-DMAHDM-containing adhesive exhibited good performance in preventing secondary caries in vivo.Clinical relevanceAdhesives containing NACP and DMAHDM have great potential for use in clinical dentistry to prevent secondary caries by inhibiting bacterial growth and promoting remineralization. (Source: Dental Technology Blog)
Source: Dental Technology Blog - January 29, 2022 Category: Dentistry Source Type: news

Vitamin deficiency: ‘One in five are lacking an essential’ nutrient – symptoms
"ONE in five" Britons suffer from vitamin D deficiency, which is "essential" for various functions in the body. For example, it helps to regulate the amount of calcium and phosphate. This in return helps to keep your bones, teeth and muscles healthy. New research shared that many Britons are "unclear" about vitamin D's benefits and deficiency symptoms. Here are the warning signs to spot. (Source: Daily Express - Health)
Source: Daily Express - Health - January 19, 2022 Category: Consumer Health News Source Type: news

Janssen Submits Biologics License Application to U.S. FDA Seeking Approval of Teclistamab for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
RARITAN, N.J., December 29, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) seeking approval of teclistamab for the treatment of patients with relapsed or refractory (R/R) multiple myeloma. Teclistamab is an investigational, off-the-shelf, T-cell redirecting, bispecific antibody targeting both B-cell maturation antigen (BCMA) and CD3.“Despite all the gains that have been made in treating multiple myeloma, the unmet need still remains very high. Our relentless pursuit of treatments ...
Source: Johnson and Johnson - December 29, 2021 Category: Pharmaceuticals Tags: Latest News Source Type: news

The effect of various fluoride products on dentine lesions during pH-cycling
In conclusion, all topical fluoride products protected the dentine lesions against lesion progression, but at different degrees. SDF showed a superior effect in protection against further demineralization and enhancement of remineralization. This was probably attributed to its fluoride concentration that was the highest among the fluoride products.  (Source: Dental Technology Blog)
Source: Dental Technology Blog - December 28, 2021 Category: Dentistry Source Type: news

Coronary Calcium Better Predictor of Need for Statin Than Equations Coronary Calcium Better Predictor of Need for Statin Than Equations
A feasibility study shows coronary artery calcium scanning has the potential to better target patients who require statin therapy than the current standard of pooled cohort equations.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - December 21, 2021 Category: Cardiology Tags: Cardiology News Source Type: news