Janssen ’s BCMA CAR-T Therapy JNJ-4528 Showed Early, Deep and Durable Responses in Heavily Pretreated Patients with Multiple Myeloma
RARITAN, NJ, May 13, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today updated results from the Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of JNJ-4528, an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy in the treatment of patients with relapsed or refractory multiple myeloma. Longer-term follow-up results from the Phase 1b portion of the study (n=29), to be shared in an oral presentation at the American Society of Clinical Oncology (ASCO) Virtual Scientific Program (Abstract #8505), show that ...
Source: Johnson and Johnson - May 14, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

CT CAC directs statin therapy in African Americans
CT coronary artery calcium (CAC) testing is a useful and cost-effective way...Read more on AuntMinnie.comRelated Reading: CT CAC predicts risk of death in smokers CT CAC linked to cardiovascular mortality in young adults Elevated CT CAC scores linked to future heart failure (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - May 13, 2020 Category: Radiology Source Type: news

A disease trigger for pancreatitis has been identified
(Technical University of Munich (TUM)) One factor contributing to the development of pancreatitis lies in mutations within a cell membrane ion channel that is characterized by its specific permeability for calcium ions. This groundbreaking discovery was made by a research team at Technical University of Munich (TUM), in cooperation with other groups from Germany, Japan and France. These insights could lead to the development of new therapeutic agents for treating and preventing chronic pancreatitis. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 13, 2020 Category: Biology Source Type: news

High calcium levels in mitochondria linked to neuronal death in Alzheimer's disease
(Massachusetts General Hospital) For the first time, using a mouse model of Alzheimer's disease, scientists at Massachusetts General Hospital have documented a link between raised levels of calcium in mitochondria and neuronal death in the living brain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 12, 2020 Category: International Medicine & Public Health Source Type: news

Dr MARTIN SCURR answers your health questions
DR MARTIN SCURR: Most people who take calcium supplements do so because they have osteoporosis, which weakens bones, making them more fragile and more likely to break. (Source: the Mail online | Health)
Source: the Mail online | Health - May 12, 2020 Category: Consumer Health News Source Type: news