Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes
Conclusions/interpretationHere we use our large-scale, multi-condition, single-cell dataset to show that human islets have cell-type-specific Ca2+-regulated gene expression profiles, some of them specific to subpopulations. In our dataset, we identifyPCDH7 as a novel marker of beta cells having an increased number of Ca2+-regulated genes and enhanced insulin secretory function.Data availabilityA searchable and user-friendly format of the data in this study, specifically designed for rapid mining of single-cell RNA sequencing data, is available athttps://lynnlab.shinyapps.io/Human_Islet_Atlas/. The raw data files are availa...
Source: Diabetologia - August 11, 2022 Category: Endocrinology Source Type: research

Simultaneous removal of cationic and anionic dyes from simulated industrial effluents using a nature-inspired adsorbent
Environ Res. 2022 Aug 8:113966. doi: 10.1016/j.envres.2022.113966. Online ahead of print.ABSTRACTAlginate-grafted polyaniline (Alg-g-PANI) microparticles were synthesized through the grafting of aniline onto functionalized Alg followed by double crosslinking by glutaraldehyde and calcium chloride. The performance of the developed microparticles as adsorbent in simultaneous removal of malachite green (MG) and congo red (CR) dyes were examined by the batch method. Experimental parameters, including adsorbent amount, pH, initial dyes concentrations, and contact time were optimized. Langmuir and Freundlich adsorption models we...
Source: Environmental Research - August 11, 2022 Category: Environmental Health Authors: Rahim Mohammad-Rezaei Balal Khalilzadeh Fatemeh Rahimi Sajad Moradi Mohsen Shahlaei Hossein Derakhshankhah Mehdi Jaymand Source Type: research

Mavacamten, a First-in-Class Cardiac Myosin Inhibitor for Obstructive Hypertrophic Cardiomyopathy
CONCLUSIONS: Mavacamten is a new option for patients with refractory obstructive hypertrophic cardiomyopathy and an ejection fraction ≥55% but its pricing makes therapy not cost-effective. Final health outcomes are not fully elucidated and additional studies are needed to determine long-term effects.PMID:35950315 | DOI:10.1177/10600280221117812 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 11, 2022 Category: Drugs & Pharmacology Authors: Joseph D Dalo Nissen D Weisman C Michael White Source Type: research

Effect of Calcium-Sensitive Receptor Agonist R568 on Gastric Motility and the Underlying Mechanism
Conclusion: Activation of the gastrointestinal CaSR inhibited gastric motility in vivo and ex vitro. Transmitting nutrients signals to the brain through the vagal afferent nerve, modulating the cholinergic and nitrergic system in the enteric nervous system, and inhibiting activity of pacemaker ICCs in the myenteric plexus are involved in the mechanism of CaSR in gastric motility suppression. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 11, 2022 Category: Endocrinology Source Type: research

[ASAP] Effect of Calcium on the Atomic and Electronic Structures of CdSe QD-Embedded Soda –Lime–Silica Glasses
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.2c03917 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - August 11, 2022 Category: Chemistry Authors: Wenke Li, Xiujian Zhao, Franc ̧ois-Xavier Coudert, and Chao Liu Source Type: research

Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis
Conclusions Acute CPP crystal arthritis was significantly associated with elevated short and long-term risk for non-fatal CV event. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - August 11, 2022 Category: Rheumatology Authors: Tedeschi, S. K., Huang, W., Yoshida, K., Solomon, D. H. Tags: ARD, Crystal arthropathies Source Type: research

Outcomes in patients with a first episode of chest pain undergoing early coronary CT imaging
Conclusions In a real-world regular care database, a CT-first strategy in patients suspected of angina pectoris was associated with a lowering of all-cause mortality. (Source: Heart)
Source: Heart - August 11, 2022 Category: Cardiology Authors: Siegersma, K. R., Onland-Moret, N. C., Appelman, Y., van der Harst, P., Tulevski, I. I., Somsen, G. A., Narula, J., den Ruijter, H. M., Hofstra, L. Tags: Open access Coronary artery disease Source Type: research

Response to: Rapid response by Diehl on 'Supplemental calcium and vitamin D and long-term mortality in aortic stenosis'
We appreciate the critical review of our study1 by Dr Diehl (https://heart.bmj.com/content/108/12/964.responses%23physician). The concern surrounding our caution towards unrestricted oral calcium supplementation is a reasonable one, certainly when considering the public reception of our claims and the effects that such reactions may have on those who are vulnerable to underlying bone disease. We agree that physicians and patients alike are prone to these impressions. We further acknowledge, as we note in the Limitations section, that the absence of specific dosages in our study serves as a pitfall in identifying any theore...
Source: Heart - August 11, 2022 Category: Cardiology Authors: Kassis, N., Hariri, E., Kapadia, S. Tags: Correspondence Source Type: research

Case report: Biochemical and clinical phenotypes caused by cysteine substitutions in the epidermal growth factor-like domains of fibrillin-1
In this study, we report a cysteine to tyrosine substitution in two different domains of fibrillin-1, both of which cause Marfan syndrome with ocular abnormalities, in two families. Using protease degradation and liquid chromatography-tandem mass spectrometry analyses, we explored the different effects of substitution of cysteine by tyrosine in an EGF-like and a calcium-binding (cb) EGF-like domain on protein stability. The results showed that cysteine mutations in the EGF domain are more likely to result in altered proteolytic sensitivity and thermostability than those in the cbEGF domain. Furthermore, cysteine mutations ...
Source: Frontiers in Genetics - August 11, 2022 Category: Genetics & Stem Cells Source Type: research

IJERPH, Vol. 19, Pages 9907: Water Quality Assessment Bias Associated with Long-Screened Wells Screened across Aquifers with High Nitrate and Arsenic Concentrations
The objectives of this study were to estimate the rate of ambient flow in seven production wells utilizing an end-member mixing model that is constrained by the observed transient chemical composition of produced water. The end-member chemical composition of the upper and lower layers of an urban aquifer that overlies geothermal heat is estimated to anticipate the future quality of this sole source of water for a rapidly growing urban area. The comprehensive water chemistry produced by seven continuously perforated municipal production wells, spanning three geologically unique zones across the city of San Miguel de Allende...
Source: International Journal of Environmental Research and Public Health - August 11, 2022 Category: Environmental Health Authors: Yibin Huang Yanmei Li Peter S. K. Knappett Daniel Montiel Jianjun Wang Manuel Aviles Horacio Hernandez Itza Mendoza-Sanchez Isidro Loza-Aguirre Tags: Article Source Type: research

Deep-learning image reconstruction for image quality evaluation and accurate bone mineral density measurement on quantitative CT: A phantom-patient study
ConclusionImage quality with DLIR was high-qualified without affecting the accuracy of BMD measurement. It has a potential clinical utility in osteoporosis screening. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - August 11, 2022 Category: Endocrinology Source Type: research

The study of the relevance of macro- and microelements in the hair of young wrestlers depending on the style of wrestling
While participating in an intensive training process, the athlete’s body requires not only energy, but also specific macro- and microelements. The purpose of this study was to show the meaning of monitoring the level of mineral trace elements in athletes-wrestlers during physical activity. As an experimental group, 66 male wrestlers aged 18-20 years with at least 3 years of intensive wrestling experience were examined. The control group consisted of 92 young cadets of military school aged 18-20 years, who had previous sports training, but were not engaged in wrestling. To determine the quantitative content of trace eleme...
Source: Frontiers in Endocrinology - August 11, 2022 Category: Endocrinology Source Type: research

Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
Immune responses can severely perturb endoplasmic reticulum (ER) function. As a protein-folding factory and dynamic calcium storage compartment, the ER plays a pivotal role in resisting pathogens and in the development of autoimmune diseases and various other diseases, including cancer, cardiovascular, neurological, orthopedic, and liver-related diseases, metabolic disorders, etc. In recent years, an increasing number of studies have shown that extracellular vesicles (EVs) play important roles in these conditions, suggesting that cells carry out some physiological functions through EVs. The formation of EVs is dependent on...
Source: Frontiers in Immunology - August 11, 2022 Category: Allergy & Immunology Source Type: research

Do the diverse environments of Baltic coastal zone affect hematological and biochemical alterations in the blood of mute swan Cygnus olor?
Environ Res. 2022 Aug 7:114014. doi: 10.1016/j.envres.2022.114014. Online ahead of print.ABSTRACTBased on studies of the wintering population of mute swans in large urban agglomerations, it is possible to identify and infer the impact of environmental pollution in coastal regions near Baltic Sea on the physiological and biochemical changes in the blood of waterfowls. Hematological and biochemical changes in the blood in relation to chemical elements in their feathers are a useful tool for general ecophysiological conclusions. Hematological changes and blood chemistry in Mute Swan Cygnus olor is particularly environmentally...
Source: Environmental Research - August 10, 2022 Category: Environmental Health Authors: Natalia Kurhaluk Halyna Tkachenko Piotr Kami ński Source Type: research

Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease
We report the efficacy and safety of cinacalcet for treatment of refractory secondary hyperparathyroidism (SHPT) in children with ESKD. After 6 months of cinacalcet treatment, the mean level of iPTH serum level decreased by 56% from 202 pmol/L [95% confidence interval (CI): 150-253] to 88 pmol/L (95% CI: 41-136), compared to the change observed in the control group (P <0.001). None of our patients reported serious adverse effects or developed hypocalcemia. Cinacalcet could be an effective and safe alternative to treat severe SHPT in children with ESKD. Further long-term and large-scale studies are necessary to confirm i...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Areej Adel Sheerah Rafif Ali Al-Ahmed Sherif M El-Desoky Khalid Abdulaziz Alhasan Amr S Albanna Mohamed A Shalaby Jameela Abdulaziz Kari Source Type: research