Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need | Science
Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment ... (Source: Science: Current Issue)
Source: Science: Current Issue - April 18, 2024 Category: Science Source Type: research
Layered BaV6O16 ·3H2O@GO as a High Performance Cathode Material for Calcium Ion Batteries
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00988F, CommunicationLixiao Xiang, Wen-Hua Yang, Yuanhao Wang, Xiang Sun, Jie Xu, Derang Cao, Qiang Li, Hongsen Li, Xia Wang The lack of suitable cathode materials has hampered the further development of calcium-ion batteries (CIBs). A novel composite cathode material, namely BaV6O16 ·3H2O@GO was fabricated, which delivers a high specific capacity... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 18, 2024 Category: Chemistry Authors: Lixiao Xiang Source Type: research
Intramyocardial calcification in apical hypertrophic cardiomyopathy assessed using multimodality imaging: a case series
We report five cases of ApHCM, with evidence of intramyocardial calcification on echocardiogram. On cardiac magnetic imaging (MRI), a hypointense component at early gadolinium enhancement (EGE) sequences, compatible with calcium, and a deep layer, with hyperintensity at late gadolinium enhancement (LGE) sequences, referable to fibrosis, suggest an endomyocardial fibrosis (EMF) diagnosis. EMF pathologic hallmark is endocardium and myocardium scarring, evolving to dystrophic calcification. It is found only in few ApHCM patients. Our series is the largest one described until now. Analysing patients' history, coexistent inflam...
Source: ESC Heart Failure - April 18, 2024 Category: Cardiology Authors: Ilaria Radano,
Barbara Mabritto,
Stefania Luceri,
Sergio Bongioanni,
Francesco Maiellaro,
Luca Zappia,
Chiara Lario,
Annalisa Macera,
Stefano Cirillo,
Alfredo Pizzuti,
Rodolfo Citro,
Gennaro Galasso,
Giuseppe Musumeci Tags: Case Report Source Type: research
Enhanced cytotoxic activity of natural killer cells from increased calcium influx induced by electrical stimulation
This study suggests a promising immunotherapeutic approach without genetic modifications and elucidates the correlation between cytolytic effector function and intracellular Ca2+ levels in electrically stimulated NK cells. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Minseon Lee Source Type: research
A prospective cross-sectional study on hypocalcemia after total thyroidectomy in patients with Graves ’ disease: insights on secondary hyperparathyroidism
ConclusionsHyperfunctioning parathyroid glands in the SHPT state were more susceptible to postoperative PTH reduction, which, combined with low preoperative Ca levels, increased the risk of postoperative hypocalcemia in patients with Graves ’ disease. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Genes, Vol. 15, Pages 507: Assessment of the Effect of Leonurine Hydrochloride in a Mouse Model of PCOS by Gene Expression Profiling
ia Shang
Xinli Gu
Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays an important role in regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model of PCOS, and some mice were then treated with Leo by gavage. We found that Leo could improve the irregular oestros cycle of PCOS mice, reverse the significantly greater serum testosterone (T) and luteinising hormone (LH) levels, significa...
Source: Genes - April 18, 2024 Category: Genetics & Stem Cells Authors: Mengmeng Wang Li Yang Guojie Sun Yongbin Shao Yuran Liu Huiying Yang Yan Wang Mengyuan Zhang Yunxia Shang Xinli Gu Tags: Article Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Hand Surgery)
Source: Hand Surgery - April 17, 2024 Category: Surgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report
Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lym...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Zezhou Liu Zhigang Tang Jingping Yuan Ke Su Yonghong Jian Hongyan Liu Source Type: research
Synthesis and characterization of novel guar gum based waste material derived nanocomposite for effective removal of hexabromocyclododecane and lindane
Int J Biol Macromol. 2024 Apr 15:131535. doi: 10.1016/j.ijbiomac.2024.131535. Online ahead of print.ABSTRACTHerein, efficient degradation of hexabromocyclododecane (HBCD) and Lindane, a persistent organic pollutant using guar gum based calcium oxide doped silicon dioxide (GG-CaO@SiO2) has been reported. The nanocomposite was prepared by waste egg shell (CaO) and rice husk (SiO2) was well characterized. The maximum degradation of HBCD and Lindane were observed at 8 mg catalyst loading, basic pH, and 2 mg L-1 of pollutant amount. The photocatalytic performance of GG-CaO@SiO2 for HBCD and Lindane photodegradation was evaluate...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: None Keshu Manviri Rani Uma Shanker Source Type: research
Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Curr Biol. 2024 Apr 12:S0960-9822(24)00374-9. doi: 10.1016/j.cub.2024.03.034. Online ahead of print.ABSTRACTLearning to discriminate overlapping gustatory stimuli that predict distinct outcomes-a feat known as discrimination learning-can mean the difference between ingesting a poison or a nutritive meal. Despite the obvious importance of this process, very little is known about the neural basis of taste discrimination learning. In other sensory modalities, this form of learning can be mediated by either the sharpening of sensory representations or the enhanced ability of "decision-making" circuits to interpret sensory info...
Source: Current Biology - April 17, 2024 Category: Biology Authors: Joshua F Kogan Alfredo Fontanini Source Type: research
Materials analysis in three paintings of Thomas Gainsborough (1727-1788) by portable X-ray fluorescence
Appl Radiat Isot. 2024 Apr 16;209:111324. doi: 10.1016/j.apradiso.2024.111324. Online ahead of print.ABSTRACTThree paintings of Thomas Gainsborough (1727-1788), one of the most influential English portrait painters of the late 18th century, from the collection of the Museu de Arte de São Paulo (MASP) - "Francis Rawdon" (1783-1784), "Portrait of Mrs. John Bolton" (1770), and "Drinkstone Park" (1747) - were investigated using portable X-ray fluorescence (pXRF), employing a W tube anode and an XR-100CR detector. These artworks represent the only paintings by Thomas Gainsborough located in the southern hemisphere. Through an ...
Source: Applied Radiation and Isotopes - April 17, 2024 Category: Radiology Authors: Let ícia Martins Birelo Carlos Roberto Appoloni Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study
CONCLUSIONS: This study suggests that age is a potential barrier to the treatment of patients with CKD and highlights the need to establish individualized treatment strategies for cardiovascular protection in this population.PMID:38631869 | DOI:10.5551/jat.64798 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 17, 2024 Category: Cardiology Authors: Shigeru Tanaka Hiromasa Kitamura Kazuhiko Tsuruya Takanari Kitazono Toshiaki Nakano FKR Study Collaboration Group Source Type: research
Single-cell transcriptomics reveal metastatic CLDN4+ cancer cells underlying the recurrence of malignant pleural effusion in patients with advanced non-small-cell lung cancer
CONCLUSIONS: CLDN4 could be considered as a predictive marker of recurrent MPE among patients with advanced NSCLC. Further validation for its clinical value in cohorts with larger sample size and in-depth mechanism studies on its biological function are warranted.TRIAL REGISTRATION: Not applicable.PMID:38629624 | DOI:10.1002/ctm2.1649 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Xiaoshen Zhang Xuanhe Wang Yaokai Wen Shen Chen Caicun Zhou Fengying Wu Source Type: research
