Janssen Announces Unblinding of Phase 3 CARTITUDE-4 Study of CARVYKTI ® (cilta-cel) as Primary Endpoint Met in Treatment of Patients with Relapsed and Refractory Multiple Myeloma
RARITAN, New Jersey, January 27, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Phase 3 CARTITUDE-4 study evaluating CARVYKTI® (ciltacabtagene autoleucel; cilta-cel) versus pomalidomide, bortezomib, and dexamethasone (PVd) or daratumumab, pomalidomide, and dexamethasone (DPd) for the treatment of patients with relapsed and lenalidomide-refractory multiple myeloma met its primary endpoint of significant improvement in progression-free survival (PFS) at the first pre-specified interim analysis. As a result of meeting the primary endpoint, the Independent Data Monitoring Commi...
Source: Johnson and Johnson - January 27, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
4 essential food pairings for optimal nutrient absorption, from a vegan dietitian
We all seem to be looking for more ways to get the nutrients our bodies need, but nutrient intake is so much more than just the foods we eat. Even if you're eating foods that are high in the nutrients you're aiming to increase in your diet — like calcium, iron and antioxidants — depending on how…#catherineperez #dietitian #b12 #vegans (Source: Reuters: Health)
Source: Reuters: Health - January 20, 2023 Category: Consumer Health News Source Type: news
Scientists may have found magic ingredient behind ancient Rome ’s self-healing concrete
The ancient Roman Empire still makes its presence felt throughout Europe. Bathhouses, aqueducts, and seawalls built more than 2000 years ago are still standing—thanks to a special type of concrete that has proved far more durable than its modern counterpart. Now, researchers say they have figured out why Roman concrete remains so resilient: Quicklime used in the mix may have given the material self-healing properties.
The work could help engineers improve the performance of modern concrete, says Marie Jackson, a geologist who studies ancient Roman concrete at the University of Utah, but who was not involved with th...
Source: ScienceNOW - January 6, 2023 Category: Science Source Type: news
Good news about cheese — it’s much healthier than you thought
“Cheese is packed with nutrients like protein, calcium and phosphorus, and can serve a healthy purpose in the diet,” one nutrition expert says. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - January 2, 2023 Category: Consumer Health News Authors: Stephanie Clarke Source Type: news
Be Prepared For The Next Pandemic
Whether pro-vaccine or anti-vaccine, you’re not getting the complete Covid picture. That’s why it’s so important that you take steps to protect yourself.
When it comes to this virus, the truth is a moving target. This is partly because the virus is evolving but mostly because we just don’t have the data we need to make a truly informed decision.
And here’s one narrative no one is talking about…
Studies show that chemicals commonly found in food and consumer products weaken your immune system and make the symptoms of Covid worse — especially among those who are already vulnerable.1
You see, these toxins in...
Source: Al Sears, MD Natural Remedies - December 23, 2022 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news
Pollutants In Your Salt!?
Your doctor, the media, and the medical establishment continue to warn that flavoring your food with salt will kill you. They link sodium consumption to a higher risk of high blood pressure, stroke – and of course, heart disease.
As usual, the powers that be are missing the real picture…
You see, salt has been part of human life for thousands of years – long before these chronic diseases became as common as they are today.
Humans started adding salt to their food for more than 5,000 years. It was the most effective way to preserve food.
Some historians even go as far as to credit salt for the development of human civ...
Source: Al Sears, MD Natural Remedies - December 23, 2022 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news
Dark Chocolate Isn ’ t the Only Food With Heavy Metals. Here ’ s How to Protect Yourself
A recent Consumer Reports investigation struck fear into the hearts of chocolate lovers everywhere. After testing 28 dark chocolate bars, scientists detected the heavy metals lead and cadmium in all of them. For 23 of the chocolate bars, eating just an ounce would put an adult above the daily upper threshold recommended for heavy metals in food by public-health officials in California, which the authors said they chose because it is the most protective standard available.
Experts say, however, that this report offers just one small window into a larger problem. Heavy metals are detectable in many different foods, and limit...
Source: TIME: Health - December 22, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized Diet & Nutrition healthscienceclimate Wellbeing Source Type: news
GP warns against taking calcium and iron supplements together - especially at meal time
Calcium can "inhibit" the absorption of iron, risking a potentially dangerous deficiency, she said. (Source: Daily Express - Health)
Source: Daily Express - Health - December 22, 2022 Category: Consumer Health News Source Type: news
Ocean geoengineering scheme aces its first field test
The balmy, shallow waters of Apalachicola Bay, off Florida’s panhandle, supply about 10% of U.S. oysters. But the industry has declined in recent years, in part because the bay is warming and its waters are acidifying because of rising carbon dioxide (CO
2
) levels. Things got so bad that in 2020, the state banned oyster harvesting for 5 years. Soon afterward, state officials encouraged climate scientists to perform an unusual experiment to see whether they could reverse the changes in the water.
In May, at an Apalachicola estuary, the researchers injected some 2000 liters of seawater enriched with lime, ...
Source: ScienceNOW - December 16, 2022 Category: Science Source Type: news
No Blaming Common Antihypertensives for Pancreatic Cancer, Study Suggests
(MedPage Today) -- Long-time users of dihydropyridine calcium channel blockers (CCBs) were not at disproportionately high risk of pancreatic cancer, according to a large observational cohort study.
Based on primary care records from the U.K. in... (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - December 15, 2022 Category: Urology & Nephrology Source Type: news
Janssen Presents Efficacy and Subgroup Analyses from MAIA Study Showing Long-Term Results of DARZALEX ® (daratumumab)-based Regimen in Newly Diagnosed, Transplant-Ineligible Multiple Myeloma
NEW ORLEANS, December 12, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new analyses from the Phase 3 MAIA study of DARZALEX® (daratumumab) in combination with lenalidomide and dexamethasone (D-Rd), evaluating progression-free survival (PFS), minimal residual disease (MRD) negativity and overall response rate (ORR) at a median follow-up of 64.5 months, and overall survival (OS) at a median follow-up of 73.6 months in newly diagnosed, transplant-ineligible (TIE) patients with multiple myeloma, regardless of patients’ age and across clinically important subgroups, as well as health...
Source: Johnson and Johnson - December 12, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news
Janssen Presents First Data from MajesTEC-2 Trial of TECVAYLI ™ (teclistamab-cqyv) in Combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) and Lenalidomide in Relapsed or Refractory Multiple Myeloma
NEW ORLEANS, December 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today new results from a cohort of the Phase 1b MajesTEC-2 study of TECVAYLI™ (teclistamab-cqyv), a first-in-class, BCMAxCD3 bispecific T-cell engager antibody, in combination with DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj) and lenalidomide. According to the results, the immune-based triplet therapy regimen had a manageable safety profile with no unexpected safety signals observed. A very good partial response (VGPR) or better was achieved by 90.3 percent of patients with relapsed or refractory multiple ...
Source: Johnson and Johnson - December 10, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news
Janssen Presents New Data for Talquetamab, a First-in-Class GPRC5DxCD3 Bispecific Antibody, Suggesting Durable Responses in Patients with Heavily Pretreated Multiple Myeloma
NEW ORLEANS, December 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today updated results from the Phase 1/2 MonumenTAL-1 study of talquetamab, an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody. Talquetamab targets both GPRC5D, a novel target on multiple myeloma cells, and CD3 on T cells, activating the body’s immune system to fight this blood cancer.[1] Results from the study suggest patients with relapsed or refractory multiple myeloma who received a median of five prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agen...
Source: Johnson and Johnson - December 10, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news
Janssen Submits Biologics License Application to U.S. FDA for Talquetamab for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
RARITAN, N.J., December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for talquetamab for the treatment of patients with relapsed or refractory multiple myeloma. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody targeting both GPRC5D, a novel drug target that is on some normal cells but overexpressed on myeloma cells, and separately targets CD3 on T cells.[1]“Despite the therapies that have been developed for the treatment of m...
Source: Johnson and Johnson - December 9, 2022 Category: Pharmaceuticals Tags: Latest News Source Type: news
Yes, You Can Actually Die of a Broken Heart
On May 26, 2022, Joe Garcia died suddenly of a heart attack just two days after his wife, Irma, was killed in the Uvalde, Texas school shooting. The papers reported a Garcia’s family member saying, “I truly believe Joe died of a broken heart.”
As a cardiac scientist working in this field, I am regularly asked to comment on tragic cases like these. Sometimes they are celebrities such as Debbie Reynolds, who died soon after her daughter, Carrie Fisher. But often, they are long-married couples who pass away on the same day or soon after.
These events can be rare and sporadic, so it is hard to find a pattern....
Source: TIME: Health - December 1, 2022 Category: Consumer Health News Authors: Dr. Sian Harding Tags: Uncategorized freelance health Source Type: news
