Calcium-sensing receptor of immune cells and diseases
(Compuscript Ltd) In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2021.0009, Wenxiu Liu, Yutong Guo, Yue Liu, Jiaxing Sun and Xinhua Yin from The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China consider calcium-sensing receptors of immune cells and diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 27, 2021 Category: International Medicine & Public Health Source Type: news

Low dietary calcium intake does not modify fracture risk but increases falls frequency: the results of GO Study - Pluskiewicz W, Adamczyk P, Drozdzowska B.
The aim of the study was to verify the thesis that dietary calcium intake influences the risk of osteoporotic fractures established by online available calculators. MATERIAL: The study was performed in 521 postmenopausal women aged over 55 years recruited ... (Source: SafetyLit)
Source: SafetyLit - March 26, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Photoinduced receptor confinement drives ligand-independent GPCR signaling
Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photoinstructive matrix with ultrasmall lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y2 receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After in situ confinement, changes ...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Sanchez, M. F., Els-Heindl, S., Beck-Sickinger, A. G., Wieneke, R., Tampe, R. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news

Erratum for the Report "PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release" by C. Giorgi, K. Ito, H.-K. Lin, C. Santangelo, M. R. Wieckowski, M. Lebiedzinska, A. Bononi, M. Bonora, J. Duszynski, R. Bernardi, R. Rizzuto, C. Tacchetti, P. Pinton, P. P. Pandolfi
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Tags: Errata Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

FAU researchers break bonds in molecular nitrogen with calcium
(University of Erlangen-Nuremberg) A research team at FAU has demonstrated that calcium, a metal commonly found in nature is able to break the highly-stable nitrogen bond and can do so at minus 60 ° C which is a significant discovery in terms of the bond-breaking capabilities of calcium, which had been largely disregarded in the past. But their findings could also form the basis for developing industrial processes in the future. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 17, 2021 Category: Biology Source Type: news

Dinitrogen complexation and reduction at low-valent calcium
Here we report that attempted preparation of low-valent CaI complexes in the form of LCa-CaL (where L is a bulky β-diketiminate ligand) under dinitrogen (N2) atmosphere led to isolation of LCa(N2)CaL, which was characterized crystallographically. The N22 anion in this complex reacted in most cases as a very potent two-electron donor. Therefore, LCa(N2)CaL acts as a synthon for the low-valent CaI complex LCa-CaL, which was the target of our studies. The N22 anion could also be protonated to diazene (N2H2) that disproportionated to hydrazine and N2. The role of Ca d orbitals for N2 activation is discussed. (Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Rösch, B., Gentner, T. X., Langer, J., Färber, C., Eyselein, J., Zhao, L., Ding, C., Frenking, G., Harder, S. Tags: Chemistry reports Source Type: news

Calcium catches dinitrogen
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Yeston, J. Tags: Chemistry twis Source Type: news

What Are the Causes of Secondary Amenorrhea?
Discussion The first sign of puberty in females is breast budding (Tanner stage II) which normally occurs from 8-13 years. Menarche usually occurs within 2 years of breast budding occurring usually at Tanner stage III-IV breast development. Menarche occurs for most girls from 10-15 years. Most cycles range between 21-45 days. Age > 13 years without acquisition of secondary sexual characteristics, > 15 years before menarche or 5 years after acquisition of secondary sexual characteristics or cycles longer than 45 days are indications for evaluation. After menarche is it not uncommon to have anovulatory cycles that are ...
Source: PediatricEducation.org - March 8, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Umbrella Review Reveals Links Between Diet, Colorectal Cancer
Review of meta - analyses of prospective observational studies reveals lower risk with higher intakes of dietary fiber, dietary calcium, yogurt (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 2, 2021 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Internal Medicine, Oncology, Journal, Source Type: news

Umbrella Review Reveals Links Between Diet, Colorectal Cancer
TUESDAY, March 2, 2021 -- Higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of red meat and alcohol are associated with a lower risk for colorectal cancer (CRC), according to a review published online Feb. 16 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 2, 2021 Category: Pharmaceuticals Source Type: news

Deep-learning algorithm can detect, quantify aortic valve calcium
Researchers from South Korea reported that their artificial intelligence (AI...Read more on AuntMinnie.comRelated Reading: Echo helps identify flossing-induced heart disease 3D printing enhances planning of TAVR procedures CT helps predict TAVR outcomes 4D CT sheds light on post-TAVR treatment strategies AR, 3D printing make waves in cardiac care (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 9, 2021 Category: Radiology Source Type: news

Vaithianathan receives $1.9 million grant for retinal research
(University of Tennessee Health Science Center) Thirumalini Vaithianathan, PhD, assistant professor in the Department of Pharmacology, Addiction Science, and Toxicology at the University of Tennessee Health Science Center, has spent a decade studying molecular signaling involved in vision. She has just received $1.9 million from the National Eye Institute for her project titled, " Dynamics of calcium signals control neurotransmitter release in retinal ribbon Synapses " . (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 4, 2021 Category: International Medicine & Public Health Source Type: news

Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU
February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said Craig Tendler, M...
Source: Johnson and Johnson - February 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Genetic approach to elucidate the role of cyclophilin D in traumatic brain injury pathology - Readnower RD, Hubbard WB, Kalimon OJ, Geddes JW, Sullivan PG.
Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade. Studies consistently demonstrate that mitochondrial dysfunction, including mitochondrial calcium... (Source: SafetyLit)
Source: SafetyLit - January 29, 2021 Category: International Medicine & Public Health Tags: TBI Source Type: news