A thalamocortical top-down circuit for associative memory
The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are...
Source: ScienceNOW - November 12, 2020 Category: Science Authors: Pardi, M. B., Vogenstahl, J., Dalmay, T., Spano, T., Pu, D.-L., Naumann, L. B., Kretschmer, F., Sprekeler, H., Letzkus, J. J. Tags: Neuroscience reports Source Type: news
Astronomical context of Solar System formation from molybdenum isotopes in meteorite inclusions
Calcium-aluminum–rich inclusions (CAIs) in meteorites are the first solids to have formed in the Solar System, defining the epoch of its birth on an absolute time scale. This provides a link between astronomical observations of star formation and cosmochemical studies of Solar System formation. We show that the distinct molybdenum isotopic compositions of CAIs cover almost the entire compositional range of material that formed in the protoplanetary disk. We propose that CAIs formed while the Sun was in transition from the protostellar to pre–main sequence (T Tauri) phase of star formation, placing Solar System ...
Source: ScienceNOW - November 12, 2020 Category: Science Authors: Brennecka, G. A., Burkhardt, C., Budde, G., Kruijer, T. S., Nimmo, F., Kleine, T. Tags: Astronomy, Geochemistry, Geophysics, Planetary Science reports Source Type: news
Follow your Endocrine Networks on Twitter
Each of our eight Endocrine Networks now has its own Twitter account, run by the Convenors. Follow them to share news, events, resources, and to keep up to date with your Network colleagues. Get the conversation going in advance of the Network meetings atSfE BES online!The Endocrine Networks are a platform for collaboration between basic and clinical researchers, clinical endocrinologists and endocrine nurses.Go to theMembers' Area to select and update your preferred Networks.Adrenal and Cardiovascular -@adrenalnetwork Dr Scott MacKenzie& Dr Mick O'Reilly Bone& Cal...
Source: Society for Endocrinology - November 10, 2020 Category: Endocrinology Source Type: news
What is the best way to get your hit of Vitamin D?
Vitamin D also helps regulate the amount of calcium and phosphate in our bodies; keeping bones, teeth and muscles healthy. However, around half of the UK population is deficient in it. (Source: the Mail online | Health)
Source: the Mail online | Health - November 9, 2020 Category: Consumer Health News Source Type: news
What strength Vitamin D should I take?
VITAMIN D helps to regulate the amount of calcium and phosphate in the body, and a lack of it can cause deformities and pain. What strength Vitamin D should I take? (Source: Daily Express - Health)
Source: Daily Express - Health - November 3, 2020 Category: Consumer Health News Source Type: news
Zero Coronary Artery Calcium Score: Desirable, but Enough? Zero Coronary Artery Calcium Score: Desirable, but Enough?
In this essay, the author argues that while coronary artery calcium is important in stratifying cardiovascular risk, even a zero calcium score must be evaluated in clinical context.Circulation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2020 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Clinical and radiographic evaluation of platelet-rich fibrin for revascularization of necrotic immature permanent teeth: A controlled clinical trial
Conclusionsplatelet-rich fibrin revascularization and calcium hydroxide apexification were successful clinically. Radiographically, platelet-rich fibrin showed significant quantitative measurements than calcium hydroxide apexification regarding all parameters. (Source: Dental Technology Blog)
Source: Dental Technology Blog - October 27, 2020 Category: Dentistry Source Type: news
The 3p a day supplements to avoid high blood pressure - 'most effective natural remedy'
SUPPLEMENTS could be used to lower your risk, or even prevent some high blood pressure symptoms. This is useful and natural remedy to avoid the deadly signs and symptoms of hypertension. Should you consider adding calcium supplements to your diet, to prevent high blood pressure? (Source: Daily Express - Health)
Source: Daily Express - Health - October 17, 2020 Category: Consumer Health News Source Type: news
Phoslyra (calcium acetate)
Title: Phoslyra (calcium acetate)Category: MedicationsCreated: 10/16/2020 12:00:00 AMLast Editorial Review: 10/16/2020 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - October 16, 2020 Category: Drugs & Pharmacology Source Type: news
Calcium bursts kill drug-resistant tumor cells
(American Chemical Society) Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS'Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2020 Category: International Medicine & Public Health Source Type: news
CAC Helps ID CVD Risk in Women Receiving RT for Breast Cancer
THURSDAY, Oct. 15, 2020 -- For women with breast cancer, coronary artery calcium (CAC) detected on radiotherapy (RT)-planning computed tomography (CT) scan is associated with cardiovascular disease (CVD) risk, according to a study presented at the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 15, 2020 Category: Pharmaceuticals Source Type: news
The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway,...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Venturini, V., Pezzano, F., Catala Castro, F., Häkkinen, H.-M., Jimenez-Delgado, S., Colomer-Rosell, M., Marro, M., Tolosa-Ramon, Q., Paz-Lopez, S., Valverde, M. A., Weghuber, J., Loza-Alvarez, P., Krieg, M., Wieser, S., Ruprecht, V. Tags: Cell Biology, Online Only r-articles Source Type: news
Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles
Brains encode behaviors using neurons amenable to systematic classification by gene expression. The contribution of molecular identity to neural coding is not understood because of the challenges involved with measuring neural dynamics and molecular information from the same cells. We developed CaRMA (calcium and RNA multiplexed activity) imaging based on recording in vivo single-neuron calcium dynamics followed by gene expression analysis. We simultaneously monitored activity in hundreds of neurons in mouse paraventricular hypothalamus (PVH). Combinations of cell-type marker genes had predictive power for neuronal respons...
Source: ScienceNOW - October 15, 2020 Category: Science Authors: Xu, S., Yang, H., Menon, V., Lemire, A. L., Wang, L., Henry, F. E., Turaga, S. C., Sternson, S. M. Tags: Engineering, Neuroscience, Online Only r-articles Source Type: news
Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
Excitotoxicity induced by NMDA receptors (NMDARs) is thought to be intimately linked to high intracellular calcium load. Unexpectedly, NMDAR-mediated toxicity can be eliminated without affecting NMDAR-induced calcium signals. Instead, excitotoxicity requires physical coupling of NMDARs to TRPM4. This interaction is mediated by intracellular domains located in the near-membrane portions of the receptors. Structure-based computational drug screening using the interaction interface of TRPM4 in complex with NMDARs identified small molecules that spare NMDAR-induced calcium signaling but disrupt the NMDAR/TRPM4 complex. These i...
Source: ScienceNOW - October 8, 2020 Category: Science Authors: Yan, J., Bengtson, C. P., Buchthal, B., Hagenston, A. M., Bading, H. Tags: Neuroscience, Online Only r-articles Source Type: news
Allergan Aesthetics, an AbbVie Company, Acquires Innovative Luminera Dermal Filler Business
Acquisition Immediately Enhances Allergan Aesthetics' Leading International Dermal Filler Portfolio & Pipeline Adds HArmonyCa, a Dermal Filler Combining Hyaluronic Acid (HA) and Calcium Hydroxyapatite (CaHA) IRVINE, Calif., Oct. 7, 2020 -- (Healthcar... Devices, Dermatology, Acquisitions AbbVie, Allergan Aesthetics, Luminera , dermal filler (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 7, 2020 Category: Pharmaceuticals Source Type: news