Unusual case of recurrent hypoglycaemia in multiple bee sting envenomation - Pillur Tamilarasu K, Shankar T, Kabi A.
A bee sting can result in allergic and toxin-mediated local manifestations like pain, swelling, redness and itching to serious systemic effects like acute kidney injury (AKI), pancreatitis, Kounis syndrome and stroke. Melittin and phospholipase A2, which m... (Source: SafetyLit)
Source: SafetyLit - July 29, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

The venom of the scorpion Centruroides limpidus, which causes the highest number of stings in Mexico, is neutralized by two recombinant antibody fragments - Fern ández-Taboada G, Riaño-Umbarila L, Olvera-Rodríguez A, Gómez-Ramírez IV, Losoya-Uribe LF, Becerril B.
Phage display and directed evolution have made it possible to generate recombinant antibodies in the format of single chain variable fragments (scFvs) capable of neutralizing different toxins and venoms of Mexican scorpions. Despite having managed to neutr... (Source: SafetyLit)
Source: SafetyLit - July 26, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Relationship between scorpion stings events and environmental conditions in mainland France - Vaucel JA, Larr éché S, Paradis C, Labadie M, Courtois A, Grenet G, Langrand J, Tournoud C, Nisse P, Gallart JC, Schmitt C, Torrents R, Le Roux G, Gil-Jardiné C, Kallel H.
In the world, the impact of environmental conditions on the number of scorpion events was evaluated in North Africa,Middle East, and the Amazonian region but not in Europe. In mainland France, scorpion species described are Buthus occitanus (Amoreux, 1789)... (Source: SafetyLit)
Source: SafetyLit - July 8, 2021 Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news

Estimation of local incidence of jellyfish envenomation in developed marine coastal areas and large populated island on the western coast of Peninsular Malaysia using case surveillance of government health facilities in Manjung, Perak and Langkawi Island - Mubarak AI, Wan Mohd Shukri WNA, Ismail AK.
BACKGROUND: Jellyfish stings are one of the commonest causes of marine animal related injuries in human. Despite mostly being harmless, box jellyfish species can cause major stings with fatalities or systemic envenoming symptoms. There are 15-20 species id... (Source: SafetyLit)
Source: SafetyLit - July 5, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Chip and Joanna Gaines on Walking Away From ‘Fixer Upper,’ Launching Magnolia Network and the Criticism That Stings the Most
“Wish me luck,” says Joanna Gaines. Three men, outfitted with skeletal Steadicams, flank her as she places a raw chicken breast into a... (Source: Reuters: Health)
Source: Reuters: Health - June 30, 2021 Category: Consumer Health News Source Type: news

What NOT to use on insect bites - the four remedies to avoid
INSECT bites are a common occurrence in the summer months and can be extremely irritating. Here are four so-called remedies you should not be using on insect bites. (Source: Daily Express - Health)
Source: Daily Express - Health - June 24, 2021 Category: Consumer Health News Source Type: news

Dead 'murder hornet' found near Seattle is first in U.S. this year
While not particularly aggressive toward humans, their sting is extremely painful and repeated stings, though rare, can kill. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2021 Category: Consumer Health News Source Type: news

The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING
Many viral proteases mediate the evasion of antiviral innate immunity by cleaving adapter proteins in the interferon (IFN) induction pathway. Host proteases are also involved in innate immunity and inflammation. Here, we report that the transmembrane protease hepsin (also known as TMPRSS1), which is predominantly present in hepatocytes, inhibited the induction of type I IFN during viral infections. Knocking out hepsin in mouse embryonic fibroblasts (MEFs) increased the viral infection–induced expression of Ifnb1, an Ifnb1 promoter reporter, and an IFN-sensitive response element promoter reporter. Ectopic expression o...
Source: Signal Transduction Knowledge Environment - June 15, 2021 Category: Science Authors: Hsin, F., Hsu, Y.-C., Tsai, Y.-F., Lin, S.-W., Liu, H. M. Tags: STKE Research Articles Source Type: news

Epidemiological analysis of jellyfish stings in coastal bathing beaches in Qinhuangdao City from 2017 to 2019 - Zhang C, Lyu Z, Wu J, Cheng C, Wang Y, Liu Z, Du B, Yang Y, Li F, Chen Q.
OBJECTIVE: To analyze the distribution and composition characteristics of jellyfish stings in various coastal baths in Qinhuangdao City from 2017 to 2019, and to provide scientific basis for the prevention, control and early warning of jellyfish stings. ... (Source: SafetyLit)
Source: SafetyLit - June 14, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

How to stop insect bites itching - 4 quick at-home remedies
INSECT BITES are common, and often do little more than cause a persistent itch while they heal - but can you stop the itch? Here's how to stop insect bites itching. (Source: Daily Express - Health)
Source: Daily Express - Health - June 14, 2021 Category: Consumer Health News Source Type: news

The FBI Secretly Ran the Anom Messaging Platform, Yielding Hundreds of Arrests in Global Sting
The FBI set up and monitored the encrypted communications platform Anom, yielding more than 800 arrests in 16 countries. (Source: Reuters: Health)
Source: Reuters: Health - June 8, 2021 Category: Consumer Health News Source Type: news

Trojan Shield: FBI Secure-Phone Sting Nets More than 800 Arrests Worldwide
(Source: Reuters: Health)
Source: Reuters: Health - June 8, 2021 Category: Consumer Health News Source Type: news

Australian Federal Police and FBI nab criminal underworld figures in worldwide sting using encrypted app
More than 200 members of Australia's mafia and bikie underworld have been arrested in the nation's biggest-ever crime sting, police say. (Source: Reuters: Health)
Source: Reuters: Health - June 7, 2021 Category: Consumer Health News Source Type: news

Malaria prevention guidelines for travellers from the UK: 2021, PHE (updated 2nd June 2021)
Due to the COVID-19 Pandemic, it was not possible to finalise a 2020 edition. Key changes in this update of the guidelines include changes to the section on insect bite avoidance, and addition of several new maps. 2 June 2021Updated with 2021 guidelines. 27 September 2019Updated Malaria guidance for travellers. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2021 Category: Consumer Health News Source Type: news

Kounis syndrome and multiorgan failure following multiple wasp stings - Navaradnam P, Suganthan N, Kumanan T, Sujanitha V, Mayorathan U.
Wasp and bee stings are common in Sri Lanka, and systemic envenomation causes a spectrum of clinical manifestations that includes simple local allergic reaction to life-threatening multiple organ injury or failure.  However, wasp toxin-induced acute myocar... (Source: SafetyLit)
Source: SafetyLit - May 29, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Penn researchers discover drug that blocks multiple SARS-CoV-2 variants in mice
(University of Pennsylvania School of Medicine) A small molecule STING agonist was highly protective against the virus that causes COVID-19 and likely other coronaviruses (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 28, 2021 Category: Infectious Diseases Source Type: news

Harris County constable leaders used 'bachelor party' stings to exploit female deputies, lawyer says
Three current and former deputy constables alleged a wide array of misconduct at the... (Source: Reuters: Health)
Source: Reuters: Health - May 24, 2021 Category: Consumer Health News Source Type: news

Current and former Texas constable's deputies file lawsuit alleging abuse from commanding officers
The lawsuit alleges that “prostitution stings soon grew into a booze-fueled playground for sexual exploitation." (Source: Reuters: Health)
Source: Reuters: Health - May 24, 2021 Category: Consumer Health News Source Type: news

What are Common Causes of Anaphylaxis?
Discussion Anaphylaxis is a potentially life-threatening hypersensitivity reaction of the body. Usually anaphylaxis is IgE mediated but complement-mediated immune complex reactions or IgG mediated reactions can cause anaphylaxis. Usually mucous membranes or skin are involved, but it is a systemic disease process with at least 2 systems involved (respiratory is second most common followed by gastrointestinal system). The epidemiology is difficult to discern but the estimated incidence is about 50-112 episodes per 100,000 person-years and estimated prevalence is 0.3-5.1%. There is data supporting an increased incidence. Over...
Source: PediatricEducation.org - May 17, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Toxic brain edema and brain death after scorpion envenomation - G ün E, Botan E, Bektaş, Kendirli T.
Scorpion sting is common in some global regions and mostly causes local envenoming of varying severity. Some estimates suggest that perhaps only 10% of those stung by even the most medically important species develop severe systemic envenomation; however, ... (Source: SafetyLit)
Source: SafetyLit - May 12, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

B.1.617 can duck antibodies, but vax blunts sting: Study
Covid-19 ’s so-called ‘Indian variant’ has a “modest” ability to “escape” the antibodies developed by vaccines, but it can, at best, cause moderate illness among those who have got the shots, scientists from India and the UK have found, establishing that “vaccination is still protective for t he majority of people”. (Source: The Economic Times)
Source: The Economic Times - May 12, 2021 Category: Consumer Health News Source Type: news

Clinical effects and factors associated with adverse clinical outcomes of hymenopteran stings treated in a Thai Poison Centre: a retrospective cross-sectional study - Srisuwarn P, Srisuma S, Sriapha C, Tongpoo A, Rittilert P, Pradoo A, Tanpudsa Y, Wananukul W.
OBJECTIVE: To describe clinical effects and outcomes of hymenopteran stings and to explore the non-laboratory factors associated with adverse clinical outcomes, a composite outcome including death, respiratory failure requiring intubation, acute kidney inj... (Source: SafetyLit)
Source: SafetyLit - May 11, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Moffitt researchers discover regulatory pathway that blocks immune response against cancer
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 11, 2021 Category: Cancer & Oncology Source Type: news

Cloaked by mutant p53
Mutant p53 takes the STING out of antitumor immunity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 11, 2021 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

Free COVID-19 Vaccines Are Luring Visitors to Dracula ’s Castle in Transylvania
Residents of Romania who find themselves in central Transylvania this May now have the option of getting vaccinated at a legendary location from horror history: Bran Castle. Every weekend this month, the fortress that’s believed to be the inspiration behind Count Dracula’s lair in Bram Stoker’s 19th-century gothic novel Dracula will be home to a free COVID-19 vaccination center where Romanians can get a Pfizer-BioNTech shot without making an appointment—or, as a Facebook post announcing the event put it, “another kind of sting.” Daniel Mihailescu—AFP/Getty ImagesA banner reading &l...
Source: TIME: Health - May 10, 2021 Category: Consumer Health News Authors: Megan McCluskey Tags: Uncategorized Brief Vaccines Source Type: news

Former Oregon House speaker arrested in sex trafficking sting
David Hunt, 53, has denied allegations that he responded to online ads to arrange payment for sexual acts. (Source: Reuters: Health)
Source: Reuters: Health - May 5, 2021 Category: Consumer Health News Source Type: news

Mets hand Phillies crushing loss and move into first-place tie in NL East
The Phillies will be feeling the sting of their Sunday defeat for a while (Source: Reuters: Health)
Source: Reuters: Health - May 3, 2021 Category: Consumer Health News Source Type: news

Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING
Protein function is regulated by posttranslational modifications (PTMs), among which reversible oxidation of cysteine residues has emerged as a key regulatory mechanism of cellular responses. Given the redox regulation of virus-host interactions, the identification of oxidized cysteine sites in cells is essential to understand the underlying mechanisms involved. Here, we present a proteome-wide identification of reversibly oxidized cysteine sites in oxidant-treated cells using a maleimide-based bioswitch method coupled to mass spectrometry analysis. We identified 2720 unique oxidized cysteine sites within 1473 proteins wit...
Source: Signal Transduction Knowledge Environment - April 27, 2021 Category: Science Authors: Zamorano Cuervo, N., Fortin, A., Caron, E., Chartier, S., Grandvaux, N. Tags: STKE Research Articles Source Type: news

NIH Awards BellBrook Labs Phase II Grant to Develop Drugs Targeting the cGAS-STING Pathway for Lupus and Related Autoimmune Diseases
The National Institute of Allergy and Infectious Diseases (NIAID) recently awarded BellBrook Labs a $1.8 million Phase II Small Business Innovative Research (SBIR) grant to develop small molecule... (Source: The Scientist)
Source: The Scientist - April 22, 2021 Category: Science Tags: The Scientist The Marketplace Source Type: news

Trillions of ‘Brood X’ Cicadas Are About to Emerge Across the U.S. to Sing, Mate and Die. Here’s What to Expect
This coming May, millions of people around the United States will have front-row seats to an extraordinary entomological event: Trillions of Brood X cicadas across 15 states will emerge almost synchronously after having spent the last 17 years underground. The males will take up elevated positions, each buzzing as loud as a lawnmower to attract females. After mating, the adult cicadas will die off en masse just about as quickly as they arrived—likely sometime in late June or July—while their offspring tunnel underground, not to emerge until 2038, when the dance will begin anew. Annual, or “dog day,”...
Source: TIME: Science - April 14, 2021 Category: Science Authors: Rebecca Katzman Tags: Uncategorized animals Environment News Source Type: news

Gaetz's glare stings House GOP
The restraint from party leadership suggests it’s unlikely the Florida congressman will suffer any intra-party consequences until the... (Source: Reuters: Health)
Source: Reuters: Health - April 14, 2021 Category: Consumer Health News Source Type: news

Experts' medicine cabinet essentials: The shopping list to keep your family healthy
Whatever health problem you face -from cuts and stings to a thumping headache or even mild symptoms of Covid, such as fever - it is vital to have the correct, up-to-date products to hand. (Source: the Mail online | Health)
Source: the Mail online | Health - April 12, 2021 Category: Consumer Health News Source Type: news

Rwanda: How Wedding Entourage Ended Up at Stadium in Sting Operation
[New Times] The arrests sparked public outrage, especially on social media platforms. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - April 9, 2021 Category: African Health Source Type: news

Moffitt investigators identify STING gene methylation allows melanoma to evade the immune system
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in Proceedings of the National Academy of Sciences of the United States of America, Moffitt Cancer Center researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 8, 2021 Category: Cancer & Oncology Source Type: news

'Bee' prepared for insect stings
You may not be aware of an allergy until you're stung. Summer's the season for gardening, playing outside, backyard picnics and just enjoying the outdoors. It's also the season of bee and other insect stings. According to the American College of Allergy, Asthma& Immunology, about 5% of the population is allergic to insect stings. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 5, 2021 Category: Databases & Libraries Source Type: news

A clue to how some fast-growing tumors hide in plain sight
(La Jolla Institute for Immunology) Viruses churn out genetic material in parts of the cell where it's not supposed to be. Cancer cells do too. A new study shows that a tumor-suppressor enzyme called DAPK3 is an essential component of a multi-protein system that senses misplaced genetic material in tumor cells, and slows tumor growth by activating the fierce-sounding STING pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 25, 2021 Category: Cancer & Oncology Source Type: news

Lung damage shows coronavirus hasn ’t lost sting: Doctors
Doctors at SevenHills Hospital in Andheri have treated a 40-year-old who went from mildly symptomatic to high oxygen dependence in four days. Intensivist Dr Rahul Sawalia said she subsequently needed a non-invasive ventilator despite having been detected on the second day of symptoms. (Source: The Economic Times)
Source: The Economic Times - March 23, 2021 Category: Consumer Health News Source Type: news

Coronavirus: Brits claim yawning, screaming and losing teeth are possible vaccine side effects
EXCLUSIVE: Weird events after vaccination, reported by the public to the UK's medicines watchdog, include retirement, starting smoking and insect bites - the regulator insists none are proven side effects. (Source: the Mail online | Health)
Source: the Mail online | Health - March 22, 2021 Category: Consumer Health News Source Type: news

Scorpion stings and antivenom use in Arizona - Klotz SA, Yates S, Smith SL, Dudley SJ, Schmidt JO, Shirazi FM.
BACKGROUND: Arizona's rugged desert landscape harbors many venomous animals including a small nocturnal scorpion, Centruroides sculpturatus, whose venom can cause severe neuromotor disturbance. An effective antivenom is available at selected health care fa... (Source: SafetyLit)
Source: SafetyLit - March 4, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Teenage boy dies from box jellyfish sting in Cape York
A 17-year-old boy dies after being stung by a box jellyfish near Bamaga — the same place the last person was killed by the animal in 2006. (Source: Reuters: Health)
Source: Reuters: Health - March 4, 2021 Category: Consumer Health News Source Type: news

What Is the Best Treatment for a Jellyfish Sting?
Title: What Is the Best Treatment for a Jellyfish Sting?Category: Diseases and ConditionsCreated: 2/25/2021 12:00:00 AMLast Editorial Review: 2/25/2021 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - February 25, 2021 Category: Dermatology Source Type: news

Epidemiology of scorpionism in France: nationwide scorpion exposure - Vaucel JA, Gil-Jardin é C, Labadie M, Larréché S, Paradis C, Nardon A, Courtois A, Langrand J, Kallel H.
INTRODUCTION: In France, 57 species of scorpions are described with a limited number of clinical studies. In this article, we report the epidemiology of scorpion sting events in mainland France and its overseas territories based on cases reported to the Fr... (Source: SafetyLit)
Source: SafetyLit - February 22, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

STING activation reduces graft-versus-host disease in a mouse model
(Medical University of South Carolina) MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 11, 2021 Category: Biology Source Type: news

Catalytic asymmetric and stereodivergent oligonucleotide synthesis
We report the catalytic stereocontrolled synthesis of dinucleotides. We have demonstrated, for the first time to our knowledge, that chiral phosphoric acid (CPA) catalysts control the formation of stereogenic phosphorous centers during phosphoramidite transfer. Unprecedented levels of diastereodivergence have also been demonstrated, enabling access to either phosphite diastereomer. Two different CPA scaffolds have proven to be essential for achieving stereodivergence: peptide-embedded phosphothreonine-derived CPAs, which reinforce and amplify the inherent substrate preference, and C2-symmetric BINOL-derived CPAs, which com...
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Featherston, A. L., Kwon, Y., Pompeo, M. M., Engl, O. D., Leahy, D. K., Miller, S. J. Tags: Chemistry r-articles Source Type: news

STINGing tumors with nanoparticles
(UT Southwestern Medical Center) DALLAS - Feb. 8, 2021 - A new nanoparticle-based drug can boost the body's innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published inNature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 8, 2021 Category: International Medicine & Public Health Source Type: news

Analgesic culture: can reframing pain make it go away?
The way we think about pain could change how much we actually sufferWe ’ve all got a story about pain. Maybe it’s that time you broke your arm skating, or the time you finished the game on a twisted ankle, or the 10 hours of labour without an epidural. Maybe your story of pain is a story of violence, the injury and trauma of an assault. Maybe it’s a story of terr or. Or it’s heartbreak, the seemingly endless depths of grief and despair after a loss. Whatever it is, (almost) all of us have experienced what we call pain and we’re not in a hurry to experience it again.But have you ever tried to d...
Source: Guardian Unlimited Science - January 23, 2021 Category: Science Authors: Margee Kerr and Linda Rodriguez McRobbie Tags: Life and style Psychology Science Health & wellbeing Source Type: news

UK stars from Ed Sheeran to Elton John raise alarm over post-Brexit music tours
More than 100 British musicians, from Ed Sheeran, Sting and Pink Floyd's Roger Waters to classical stars like conductor Simon Rattle,... (Source: Reuters: Health)
Source: Reuters: Health - January 20, 2021 Category: Consumer Health News Source Type: news

For true herd immunity, we must vaccinate immigrants as a priority | Laura Spinney
The US hasn ’t learned from past pandemics. The health of naturalized Americans is intertwined with that of immigrantsThe Trump administration ’s colossal mismanagement of the Covid-19 pandemic isn’t over, and won’t be for a long time after the current president’s departure. There’s a sting in that administration’s tail, whose poison is already spreading through the US population. It has been invisible until now, at least in th e higher echelons of power, but as the mass vaccination campaign moves into its next phase its effects are becoming painfully and tragically obvious. The st...
Source: Guardian Unlimited Science - January 14, 2021 Category: Science Authors: Laura Spinney Tags: Coronavirus Health policy Infectious diseases Politics Public services policy Science Source Type: news

The epidemiological study of clinical signs and outcomes of patients with scorpion stings referred to emergency department of Rafsanjan Ali-Ibn-Abitaleb Hospital in 2017-2018: a descriptive study - Shahrabadi E, Moradi MS, Rezaeian M, Salimabadi Y, Esmaeili Ranjbar A, Moinaddini5 S, Sanji Rafsanjani M.
Background and Objectives: Scorpion bite is one of the public health problems, which sometimes causes human death. The aim of this study was to determine various epidemiological aspects, clinical signs and outcomes of patients with scorpion bite referred t... (Source: SafetyLit)
Source: SafetyLit - January 4, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

Scorpions and scorpion sting envenoming (scorpionism) in the Arab Countries of the Middle East - Amr ZS, Abu Baker MA, Al-Saraireh M, Warrell DA.
The twelve Arab countries of the Middle East are inhabited by 117 species of scorpions of varying medical importance within six families. Scorpion stings are a very common occurrence throughout the region. Twenty-two scorpion species are considered to be... (Source: SafetyLit)
Source: SafetyLit - January 4, 2021 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news