GSE244205 TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
Contributors : Lingzhen Kong ; Shan Li ; Chen Cheng ; Abigael Cheruiyot ; Jiayi Yuan ; Yichan Yang ; Sydney Hwang ; Daniel Foust ; Ning Tsao ; Emily Wilkerson ; Nima Mosammaparast ; M B Major ; David W Piston ; Zhongsheng YouSeries Type : OtherOrganism : Homo sapiensThe protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered after the generation of cytosolic DNA and the activation of cGAS/STING. The resulting CaMKK2/AMPK activati...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE249852 A Single-atom Manganese Nanozyme Mn-N/C Promotes Anti-tumor Immune Response via Eliciting Type I Interferon Signaling
Contributors : Wen Qiao ; Jingqi Chen ; Huayuan Zhou ; Cegui Hu ; Sumiya Dalangood ; Hanjun Li ; Dandan Yang ; Yu Yang ; Gui JunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are a new type of nanozyme with incredible catalytic efficiency. Here we construct a single-atom manganese (Mn)-N/C nanozyme. Mn-N/C catalyzes the conversion of cellular H2O2 to ∙OH through a Fenton-like ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice
AbstractMyeloid neoplasms are a group of bone marrow diseases distinguished by disruptions in the molecular pathways that regulate the balance between hematopoietic stem cell (HSC) self-renewal and the generation of specialized cells. Cytokines and chemokines, two important components of the inflammatory process, also influence hematological differentiation. In this scenario, immunological dysregulation plays a pivotal role in the pathogenesis of bone marrow neoplasms. The STING pathway recognizes DNA fragments in the cell cytoplasm and triggers an immune response by type I interferons. The role of STING in cancer has not ...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
We report that infection with multiple human viruses depletes some of these cGAMP conduits. This includes herpes simplex virus 1 (HSV-1) that targets SLC46A2, P2X7, and the VRAC subunits LRRC8A and LRRC8C for degradation. The HSV-1 protein UL56 is necessary and sufficient for these effects that are mediated at least partially by proteasomal turnover. UL56 thereby inhibits cGAMP uptake via VRAC, SLC46A2, and P2X7. Taken together, HSV-1 antagonizes intercellular cGAMP transfer. We propose that this limits innate immunity by reducing cell-to-cell communication via the immunotransmitter cGAMP.PMID:38652659 | DOI:10.1016/j.celr...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Henry T W Blest Alexander Redmond Jed Avissar Jake Barker Anne Bridgeman Gerissa Fowler Lise Chauveau Jonny Hertzog Iolanda Vendrell Roman Fischer Marie B Iversen Lichen Jing David M Koelle S øren R Paludan Benedikt M Kessler Colin M Crump Jan Rehwinkel Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway
This article aims to explore the role of the mtDNA-triggered cGAS-STING pathway and its mechanisms in SLE, with the goal of providing novel insights for clinical interventions.PMID:38652968 | DOI:10.1016/j.intimp.2024.112114 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Xiaotian Gu Yong Chen Kunyu Cao Miao Tu Wan Liu Jiyu Ju Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
We report that infection with multiple human viruses depletes some of these cGAMP conduits. This includes herpes simplex virus 1 (HSV-1) that targets SLC46A2, P2X7, and the VRAC subunits LRRC8A and LRRC8C for degradation. The HSV-1 protein UL56 is necessary and sufficient for these effects that are mediated at least partially by proteasomal turnover. UL56 thereby inhibits cGAMP uptake via VRAC, SLC46A2, and P2X7. Taken together, HSV-1 antagonizes intercellular cGAMP transfer. We propose that this limits innate immunity by reducing cell-to-cell communication via the immunotransmitter cGAMP.PMID:38652659 | DOI:10.1016/j.celr...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Henry T W Blest Alexander Redmond Jed Avissar Jake Barker Anne Bridgeman Gerissa Fowler Lise Chauveau Jonny Hertzog Iolanda Vendrell Roman Fischer Marie B Iversen Lichen Jing David M Koelle S øren R Paludan Benedikt M Kessler Colin M Crump Jan Rehwinkel Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Electroacupuncture alleviates the symptom of depression in mice by regulating the cGAS-STING-NLRP3 signaling
CONCLUSIONS: EA significantly mitigated the symptom of depression in mice, which was closely associated with the repressed neuroinflammation, increased monoamine concentration, inactivated microglia, and inhibited cGAS-STING-NLRP3 signaling.PMID:38643466 | DOI:10.18632/aging.205596 (Source: Aging)
Source: Aging - April 21, 2024 Category: Biomedical Science Authors: Shiyun Chen Jingjing Li Luda Yan Xianhao Zhang Jiesi Huang Peng Zhou Source Type: research
The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
