Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Formononetin Restrains Tumorigenesis of Breast Tumor by Restraining STING-NF- κB and Interfering with the Activation of PD-L1
CONCLUSION: Formononetin can restrain the proliferation of BC cells, which may be mediated through the interference of PD-L1 and suppression of the activation of the STING-NF-κB pathway.PMID:38531802 | DOI:10.24976/Discov.Med.202436182.58 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Hongmei Liu Zhipeng Wang Zhigang Liu Source Type: research
