The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
The Role of SHP2 in Advancing COPD: Insights into Oxidative Stress, Endoplasmic Reticulum Stress, and Pyroptosis
CONCLUSIONS: SHP2 promotes COPD progression by inducing oxidative stress, endoplasmic reticulum stress, and pyroptosis.PMID:38639622 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Haidong Ding Rina Wu Source Type: research
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research
Unusual presentation of disseminated gonococcal infection
A 30-year-old homosexual man living with HIV and receiving virologically suppressive antiretroviral treatment presented to the emergency department with a 3-day history of pain in his left wrist accompanied by fever and chills. On examination, the left wrist showed redness, swelling, tenderness and decreased range of movement. The patient had no history of trauma, insect bites or scratches. Four weeks earlier, he had engaged in unprotected oral sex with a casual partner. Nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoea (Ng) were performed from oropharyngeal, anal and urine samples...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: AlHammadi, M., Schembri, A., Calleja, L., Padovese, V. Tags: PostScript Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | PMC:PMC11023972 | DOI:10.1007/s00018-024-05214-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
GSE244062 Tissue-specific inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
Contributors : Rayk Behrendt ; Hella Luksch ; Angela R ösen-WolffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConstitutive activation of STING by gain-of-function mutations triggers manifestation of the systemic autoinflammatory disease STING-associated vasculopathy with onset in infancy (SAVI) in humans and in mice. Murine SAVI is characterized by T cell lymphopenia, severe inflammatory interstitial lung disease, neuroinflammation and neurodegeneration with only limited contribution of type I interferon signaling. Here, we show that pharmacologic inhibition of TNF signaling in...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
AbstractClostridium perfringens (C. perfringens) infection is recognized as one of the most challenging issues threatening food safety and perplexing agricultural development. To date, the molecular mechanisms of the interactions betweenC. perfringens and the host remain poorly understood. Here, we show that stimulator of interferon genes (STING)-dependent trained immunity protected againstC. perfringens infection through mTOR signaling. Heat-killedCandida albicans (HKCA) training elicited elevated TNF- α and IL-6 production after LPS restimulation in mouse peritoneal macrophages (PM). Although HKCA-trained PM produced de...
Source: Veterinary Research - April 15, 2024 Category: Veterinary Research Source Type: research
STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells
Cell Death & Disease, Published online: 13 April 2024; doi:10.1038/s41419-024-06638-1STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells (Source: Cell death and disease)
Source: Cell death and disease - April 13, 2024 Category: Internal Medicine Authors: Ling Wang Zhaoduan Liang Yunzhuo Guo Jean de Dieu Habimana Yuefei Ren Obed Boadi Amissah Omar Mukama Siqi Peng Xuanyan Ding Linshuang Lv Junyi Li Min Chen Zhaoming Liu Rongqi Huang Yinchao Zhang Yi Li Zhiyuan Li Yirong Sun Source Type: research
PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibit... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu & hellip; Tags: Research article Source Type: research
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
AbstractThe accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly present in many age-related diseases and in the cancer microenvironment. The escape of abnormal cells from immune surveillance indicates that there is some defect in the function of cytotoxic immune cells, e.g., CD8+ T cells and natural killer (NK) cells. Recent studies have revealed that the expression of programmed death-ligand 1 (PD-L1) protein is abundantly increased in senescent cells. An increase in the amount of PD-L1 protein protects senescent cells from clearance by the PD-1 checkpoint r...
Source: Journal of Molecular Medicine - April 11, 2024 Category: Molecular Biology Source Type: research
