The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
The PLA < sub > 2 < /sub > inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA < sub > 2 < /sub > from honeybee venom
Toxicon. 2024 Apr 5;242:107711. doi: 10.1016/j.toxicon.2024.107711. Online ahead of print.ABSTRACTCrotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.PMID:38583578 | DOI:10...
Source: Toxicon - April 7, 2024 Category: Toxicology Authors: Paula Ladeira Ortolani Patr ícia Cota Campos Consuelo Latorre Fortes-Dias Source Type: research
STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity
Mol Biol Rep. 2024 Apr 5;51(1):487. doi: 10.1007/s11033-024-09418-4.ABSTRACTThe stimulator of the interferon genes (STING) signaling pathway plays a crucial role in innate immunity by detecting cytoplasmic DNA and initiating antiviral host defense mechanisms. The STING cascade is triggered when the enzyme cyclic GMP-AMP synthase (cGAS) binds cytosolic DNA and synthesizes the secondary messenger cGAMP. cGAMP activates the endoplasmic reticulum adaptor STING, leading to the activation of kinases TBK1 and IRF3 that induce interferon production. Secreted interferons establish an antiviral state in infected and adjacent cells. ...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Mohammad Mahdi Mokhtari Tabar Mahnaz Fathi Fatemeh Kazemi Ghazal Bazregari Abdolmajid Ghasemian Source Type: research
Potential Convergence of Olfactory Dysfunction in Parkinson's Disease and COVID-19: The Role of Neuroinflammation
Ageing Res Rev. 2024 Apr 3:102288. doi: 10.1016/j.arr.2024.102288. Online ahead of print.ABSTRACTParkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and more than 90% of PD patients suffer from OD. Recent studies have highlighted a high incidence of OD in patients with SARS-CoV-2 infection. This review investigates the potential convergence of OD in PD and COVID-19, particularly focusing on the mechanisms by which neuroinflammation contributes to OD and neurological events. Starting from our fundament...
Source: Ageing Research Reviews - April 5, 2024 Category: Genetics & Stem Cells Authors: Hui Li Junliang Qian Youcui Wang Juan Wang Xiaoqing Mi Le Qu Ning Song Junxia Xie Source Type: research
STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity
Mol Biol Rep. 2024 Apr 5;51(1):487. doi: 10.1007/s11033-024-09418-4.ABSTRACTThe stimulator of the interferon genes (STING) signaling pathway plays a crucial role in innate immunity by detecting cytoplasmic DNA and initiating antiviral host defense mechanisms. The STING cascade is triggered when the enzyme cyclic GMP-AMP synthase (cGAS) binds cytosolic DNA and synthesizes the secondary messenger cGAMP. cGAMP activates the endoplasmic reticulum adaptor STING, leading to the activation of kinases TBK1 and IRF3 that induce interferon production. Secreted interferons establish an antiviral state in infected and adjacent cells. ...
Source: Molecular Biology Reports - April 5, 2024 Category: Molecular Biology Authors: Mohammad Mahdi Mokhtari Tabar Mahnaz Fathi Fatemeh Kazemi Ghazal Bazregari Abdolmajid Ghasemian Source Type: research
High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway
In this study, adult C57BL/6 mice were fed either a chow or a high-fat diet for 18 weeks prior to 12-week 1-BP treatment. Subsequent neurobehavioral and neuropathological examinations were conducted to assess the effects of 1-BP exposure on parkinsonian pathology. The results demonstrated that 1-BP exposure produced obvious neurobehavioral abnormalities and dopaminergic degeneration in the nigral region of mice. Importantly, a high-fat diet further exacerbated the impact of 1-BP on motor and cognitive abnormalities in mice. Mechanistic investigation revealed that mitochondrial damage and mtDNA release induced by 1-BP and h...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Mingxue Song Yalong Qiang Shuai Wang Shan Shan Liwen Zhang Caipei Liu Fuyong Song Xiulan Zhao Source Type: research
High-fat diet exacerbates 1-Bromopropane-induced loss of dopaminergic neurons in the substantia nigra of mice through mitochondrial damage associated necroptotic pathway
In this study, adult C57BL/6 mice were fed either a chow or a high-fat diet for 18 weeks prior to 12-week 1-BP treatment. Subsequent neurobehavioral and neuropathological examinations were conducted to assess the effects of 1-BP exposure on parkinsonian pathology. The results demonstrated that 1-BP exposure produced obvious neurobehavioral abnormalities and dopaminergic degeneration in the nigral region of mice. Importantly, a high-fat diet further exacerbated the impact of 1-BP on motor and cognitive abnormalities in mice. Mechanistic investigation revealed that mitochondrial damage and mtDNA release induced by 1-BP and h...
Source: Ecotoxicology and Environmental Safety - April 4, 2024 Category: Environmental Health Authors: Mingxue Song Yalong Qiang Shuai Wang Shan Shan Liwen Zhang Caipei Liu Fuyong Song Xiulan Zhao Source Type: research
pH-responsive Manganese Sulfide Nanotheranostics Amplifying cGAS-STING Activation for MRI-Guided Immunotherapy
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4NJ00077C, PaperTingting Zhang, Mingya Tan, Mengke Fan, Zhenghuan Zhao, Zhiping Peng Manganese-based nanomaterials have attracted great interest in cancer nanotheranostics owing to their excellent physicochemical properties. Here we report -phase manganese sulfide nanotheranostics (MnSN) as MRI guided chemodynamic therapy agent and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 3, 2024 Category: Chemistry Authors: Tingting Zhang Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage
CONCLUSION: Neuritin alleviated EBI by restoring impaired autophagic flux after SAH through the regulation of the cGAS-STING pathway.PMID:38570154 | DOI:10.1016/j.brainres.2024.148909 (Source: Brain Research)
Source: Brain Research - April 3, 2024 Category: Neurology Authors: Hao Zhang Kunhao Ren Youjie Hu Bin Liu Yaowen He Hui Xu Ketao Ma Weidong Tian Linzhi Dai Dong Zhao Source Type: research
Immune response profiles from humans experimentally exposed to Phlebotomus duboscqi bites
DiscussionOur results demonstrate that humans mounted a local and systemic immune response against P. duboscqi salivary proteins. Specifically, PduM02/SP15-like and PduM73/adenosine deaminase recombinant salivary proteins triggered a Th1 type immune response that might be considered in future development of a potential Leishmania vaccine. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 3, 2024 Category: Allergy & Immunology Source Type: research
Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Suppresses macrophage capping protein beyond STING activation
In this study, we demonstrated that DMXAA binds to both human and mouse macrophage capping protein (CapG), with a KD of 5.839 μM for hCapG and a KD of 2.867 μM for mCapG, as determined by surface plasmon resonance (SPR) analysis. Homology modeling and molecular docking analysis of hCapG indicated that the critical residues involved in the hydrogen bond interaction of DMXAA with hCapG were Arg153, Thr151, and GLN141, Asn234. In addition, electrostatic pi-cation interaction occurred between DMXAA and hCapG. Further functional studies revealed that CapG protein plays a crucial role in the effects of DMXAA on human umbilical...
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Zhiyong Xiao Xia Cui Feng Liu Ying Wang Xiao Liu Wenxia Zhou Yongxiang Zhang Source Type: research
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway
Int Immunopharmacol. 2024 Apr 1;132:111971. doi: 10.1016/j.intimp.2024.111971. Online ahead of print.ABSTRACTDNA damage resulting from UV irradiation on the skin has been extensively documented in numerous studies. In our prior investigations, we demonstrated that UVB-induced DNA breakage from keratinocytes can activate the cGAS-STING pathway in macrophages. The cGAS-STING signaling pathway serves as the principal effector for detecting and responding to abnormal double-stranded DNA in the cytoplasm. Expanding on our previous findings, we have further validated that STING knockout significantly diminishes UVB-induced skin ...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Zhenqi Zuo Shengwei He Yinqi Qiu Runying Guo Yingxue He Chenyang Jiao Yugui Xia Wen Liu Chao Luan Wenjie Guo Source Type: research
IGF2 promotes alveolar bone regeneration in murine periodontitis via inhibiting cGAS/STING-mediated M1 macrophage polarization
This study evaluated the role of insulin-like growth factor 2 (IGF2) in periodontitis by inhibiting the polarization of M1 macrophages via the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. IGF2 was enriched in the gingival tissue of murine periodontitis model identified by RNA sequencing. IGF2 application alleviated the expression of pro-inflammatory factors and promoted osteogenesis and the expression of related genes and proteins in a dose-dependent manner in periodontitis. The result of micro-CT verified this finding. Both in vivo and in vitro results revealed that IGF2 decreased the pol...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Tairan Wang Yi Tang Yuxing Xia Qian Zhang Shaokang Cao Miaomiao Bie Feiwu Kang Source Type: research
