Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 10:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and pre...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Ageing Res Rev. 2021 Jun 10:101391. doi: 10.1016/j.arr.2021.101391. Online ahead of print.ABSTRACTConformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands of people with alpha-1 antitrypsin deficiency (AATD) are underdiagnosed. Enemy-aggregating proteins may reside in these underdiagnosed AATD patients for many years before a pathology for AATD fully develops. In this perspective review, we hypothesize that the AAT protein could exert a new and pre...
Source: Ageing Research Reviews - June 13, 2021 Category: Genetics & Stem Cells Authors: Abdul-Hamid Emwas Mawadda Alghrably Manel Dhahri Abeer Sharfalddin Rawiah Alsiary Mariusz Jaremko Gavino Faa Marcello Campagna Terenzio Congiu Monica Piras Marco Piludu Giuseppina Pichiri Pierpaolo Coni Joanna Izabela Lachowicz Source Type: research

CircRNAs: Decrypting the novel targets of fibrosis and aging
Ageing Res Rev. 2021 Jun 9:101390. doi: 10.1016/j.arr.2021.101390. Online ahead of print.ABSTRACTFibrosis is a typical aging-related pathological process involving almost all organs. It is usually initiated by organic injury and leads to the gradual decline of organ function or even loss. Circular RNAs (circRNAs) are being hailed as a newly rediscovered class of covalently closed transcripts without a 5' cap or 3' tail which draw increasing attention. In particular, circRNAs have been identified to be involved in the multifaceted processes of fibrosis in various organs, including the heart, liver, lung, and kidney. As more...
Source: Ageing Research Reviews - June 12, 2021 Category: Genetics & Stem Cells Authors: Yang Yang Wangrui Lei Shuai Jiang Baoping Ding Changyu Wang Ying Chen Wenzhen Shi Zhen Wu Ye Tian Source Type: research

Age-related amyloidosis outside the brain: A state-of-the-art review
Ageing Res Rev. 2021 Jun 8:101388. doi: 10.1016/j.arr.2021.101388. Online ahead of print.ABSTRACTInside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid &b...
Source: Ageing Research Reviews - June 11, 2021 Category: Genetics & Stem Cells Authors: Masayoshi Tasaki Francesca Lavatelli Laura Obici Konen Obayashi Takeshi Miyamoto Giampaolo Merlini Giovanni Palladini Yukio Ando Mitsuharu Ueda Source Type: research

Age-related amyloidosis outside the brain: A state-of-the-art review
Ageing Res Rev. 2021 Jun 8:101388. doi: 10.1016/j.arr.2021.101388. Online ahead of print.ABSTRACTInside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid &b...
Source: Ageing Research Reviews - June 11, 2021 Category: Genetics & Stem Cells Authors: Masayoshi Tasaki Francesca Lavatelli Laura Obici Konen Obayashi Takeshi Miyamoto Giampaolo Merlini Giovanni Palladini Yukio Ando Mitsuharu Ueda Source Type: research

Novel insights into the relationship between cerebellum and dementia: a narrative review as a toolkit for clinicians
Ageing Res Rev. 2021 Jun 7:101389. doi: 10.1016/j.arr.2021.101389. Online ahead of print.ABSTRACTThe role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. This narrative review explores the possible factors explaining the involvement of the cerebellum in different kinds of dementia by providing more insights on how this structure can be relevant in clinical practice. It emerged that, despite overlapping in specifi...
Source: Ageing Research Reviews - June 10, 2021 Category: Genetics & Stem Cells Authors: Maria Devita Francesco Alberti Michela Fagnani Masina Fabio Enrica Ara Giuseppe Sergi Daniela Mapelli Alessandra Coin Source Type: research

Novel insights into the relationship between cerebellum and dementia: a narrative review as a toolkit for clinicians
Ageing Res Rev. 2021 Jun 7:101389. doi: 10.1016/j.arr.2021.101389. Online ahead of print.ABSTRACTThe role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. This narrative review explores the possible factors explaining the involvement of the cerebellum in different kinds of dementia by providing more insights on how this structure can be relevant in clinical practice. It emerged that, despite overlapping in specifi...
Source: Ageing Research Reviews - June 10, 2021 Category: Genetics & Stem Cells Authors: Maria Devita Francesco Alberti Michela Fagnani Masina Fabio Enrica Ara Giuseppe Sergi Daniela Mapelli Alessandra Coin Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 5;70:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targetin...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 4:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targeting D...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Gene targeting techniques for Huntington's disease
Ageing Res Rev. 2021 Jun 4:101385. doi: 10.1016/j.arr.2021.101385. Online ahead of print.ABSTRACTHuntington's disease (HD) is an autosomal neurodegenerative disorder caused by extended trinucleotide CAG repetition in the HTT gene. Wild-type huntingtin protein (HTT) is essential, involved in a variety of crucial cellular functions such as vesicle transportation, cell division, transcription regulation, autophagy, and tissue maintenance. The mutant HTT (mHTT) proteins in the body interfere with HTT's normal cellular functions and cause additional detrimental effects. In this review, we discuss multiple approaches targeting D...
Source: Ageing Research Reviews - June 7, 2021 Category: Genetics & Stem Cells Authors: Eric Fields Erik Vaughan Deepika Tripu Isabelle Lim Katherine Shrout Jessica Conway Nicole Salib Yubin Lee Akash Dhamsania Michael Jacobsen Ashley Woo Huijing Xue Kan Cao Source Type: research

Mitochondria: their relevance during oocyte ageing
Ageing Res Rev. 2021 Jun 3:101378. doi: 10.1016/j.arr.2021.101378. Online ahead of print.ABSTRACTThe oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and mitochondrial architecture is different in oocytes than in somatic cells, characterised by its rounder appearance and fragmented network. Although the number of mitochondria per oocyte is higher than in any other mammalian cell, their number and activity decrease with advancing age. Mitochondria integrate numerous processes essential for cellular function, ...
Source: Ageing Research Reviews - June 6, 2021 Category: Genetics & Stem Cells Authors: Jiska van der Reest Gustavo Nardini Cecchino Marcia C Haigis Pawe ł Kordowitzki Source Type: research

Mitochondria: their relevance during oocyte ageing
Ageing Res Rev. 2021 Jun 3:101378. doi: 10.1016/j.arr.2021.101378. Online ahead of print.ABSTRACTThe oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and mitochondrial architecture is different in oocytes than in somatic cells, characterised by its rounder appearance and fragmented network. Although the number of mitochondria per oocyte is higher than in any other mammalian cell, their number and activity decrease with advancing age. Mitochondria integrate numerous processes essential for cellular function, ...
Source: Ageing Research Reviews - June 6, 2021 Category: Genetics & Stem Cells Authors: Jiska van der Reest Gustavo Nardini Cecchino Marcia C Haigis Pawe ł Kordowitzki Source Type: research

Transcranial Direct Current Stimulation Decreased Cognition-Related Reaction Time in Older Adults: A Systematic Review and Meta-Analysis
CONCLUSIONS: These findings suggest that providing online tDCS may effectively improve the ageing-induced reaction time related to specific cognitive functions of elderly people.PMID:34089900 | DOI:10.1016/j.arr.2021.101377 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - June 5, 2021 Category: Genetics & Stem Cells Authors: Joon Ho Lee Tae Lee Lee Nyeonju Kang Source Type: research

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging
Ageing Res Rev. 2021 Jun 2:101376. doi: 10.1016/j.arr.2021.101376. Online ahead of print.ABSTRACTAging can not only shorten a healthy lifespan, but can also lead to multi-organ dysfunction and failure. Anti-aging is a complex and worldwide conundrum for eliminating the various pathologies of senility. The past decade has seen great progress in the understanding of the aging-associated signaling pathways and their application for developing anti-aging approaches. Currently, some drugs can improve quality of life. The activation of mammalian target of rapamycin (mTOR) signaling is one of the core and detrimental mechanisms r...
Source: Ageing Research Reviews - June 5, 2021 Category: Genetics & Stem Cells Authors: Yan Zhang Jinjin Zhang Shixuan Wang Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases
Ageing Res Rev. 2021 May 31:101374. doi: 10.1016/j.arr.2021.101374. Online ahead of print.ABSTRACTThe first paper on "inflammaging" published in 2001 paved the way for a unifying theory on how and why aging turns out to be the main risk factor for the development of the most common age-related diseases (ARDs). The most exciting challenge on this topic was explaining how systemic inflammation steeps up with age and why it shows different rates among individuals of the same chronological age. The "epigenetic revolution" in the past twenty years conveyed that the assessment of the individual genetic make-u...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: Fabiola Olivieri Francesco Prattichizzo Angelica Giuliani Giulia Matacchione Maria Rita Rippo Jacopo Sabbatinelli Massimiliano Bonaf è Source Type: research

Interspecific interactions that affect ageing: age-distorters manipulate host ageing to their own evolutionary benefits
Ageing Res Rev. 2021 May 31:101375. doi: 10.1016/j.arr.2021.101375. Online ahead of print.ABSTRACTGenetic causes for ageing are traditionally investigated within a species. Yet, the lifecycles of many organisms intersect. Additional evolutionary and genetic causes of ageing, external to a focal species/organism, may thus be overlooked. Here, we introduce the phrase and concept of age-distorters and its evidence. Age-distorters carry ageing interfering genes, used to manipulate the biological age of other entities upon which the reproduction of age-distorters relies, e.g. age-distorters bias the reproduction/maintenance tra...
Source: Ageing Research Reviews - June 3, 2021 Category: Genetics & Stem Cells Authors: J érôme Teulière Charles Bernard Eric Bapteste Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26;69:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is relevant in older people. Attention was given to the nursing homes in which frailer people are usually admitted. In this review, we discuss the approaches for daily problems found in nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anot...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Specific approaches to patients affected by dementia and covid-19 in nursing homes: the role of the geriatrician
Ageing Res Rev. 2021 May 26:101373. doi: 10.1016/j.arr.2021.101373. Online ahead of print.ABSTRACTThe coronavirus disease 19 (COVID-19) is increasing in older people. Attention was given to the nursing homes in which frail people are usually admitted. In this work, we discuss the approaches for daily problems found in our nursing home as geriatricians and potentially new research directions. We start with the problem of the older people affected by dementia and Behavioral and Psychological Symptoms of Dementia for which also the execution of a simple diagnostic test (such as nasopharyngeal swab) could be problematic. Anoth...
Source: Ageing Research Reviews - May 29, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mario Barbagallo Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

Neuronal Excitation/Inhibition imbalance: a core element of a translational perspective on Alzheimer pathophysiology
Ageing Res Rev. 2021 May 21:101372. doi: 10.1016/j.arr.2021.101372. Online ahead of print.ABSTRACTOur incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfun...
Source: Ageing Research Reviews - May 24, 2021 Category: Genetics & Stem Cells Authors: Fernando Maest ú Willem de Haan Marc Aurel Busche Javier DeFelipe Source Type: research

The role of senescence in the pathogenesis of atrial fibrillation: a target process for health improvement and drug development
Ageing Res Rev. 2021 May 20:101363. doi: 10.1016/j.arr.2021.101363. Online ahead of print.ABSTRACTCellular senescence is a state of growth arrest that occurs after cells encounter various stresses. Senescence contributes to tumour suppression, embryonic development, and wound healing. It impacts on the pathology of various diseases by secreting inflammatory chemokines, immune modulators and other bioactive factors. These secretory biosignatures ultimately cause inflammation, tissue fibrosis, immunosenescence and many ageing-related diseases such as atrial fibrillation (AF). Because the molecular mechanisms underpinning AF ...
Source: Ageing Research Reviews - May 23, 2021 Category: Genetics & Stem Cells Authors: Guangran Guo Steven Watterson Shu-Dong Zhang Anthony Bjourson Victoria McGilligan Aaron Peace Taranjit Singh Rai Source Type: research

Cellular functions regulated by deubiquitinating enzymes in neurodegenerative diseases
Ageing Res Rev. 2021 May 20:101367. doi: 10.1016/j.arr.2021.101367. Online ahead of print.ABSTRACTNeurodegenerative diseases are one of the most common diseases in mankind. Although there are reports of several candidates that cause neurodegenerative diseases, the exact mechanism of pathogenesis is poorly understood. The ubiquitin-proteasome system (UPS) is an important posttranslational modification for protein degradation and control of homeostasis. Enzymes such as E1, E2, E3 ligases, and deubiquitinating enzymes (DUBs) participating in UPS, regulate disease-inducing proteins by controlling the degree of ubiquitination. ...
Source: Ageing Research Reviews - May 23, 2021 Category: Genetics & Stem Cells Authors: Hyeon-Ah Do Kwang-Hyun Baek Source Type: research

Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials
Ageing Res Rev. 2021 May 19:101368. doi: 10.1016/j.arr.2021.101368. Online ahead of print.ABSTRACTBACKGROUND: We aimed to summarize evidence on the safety, adherence and effectiveness of home-based resistance training (UHBRT) for improving health-related endpoints in community-dwelling older adults.METHODS: Randomized controlled trials of UHBRT in older adults (≥60yrs) were included after a systematic search (PubMed, CINAHL, PsycInfo, SPORTDiscus, Web of Science, MEDLINE, Cochrane Central Register of Controlled Trials) until 02/19/2021. Adverse events and adherence rates were assessed as indicators of feasibility. Other...
Source: Ageing Research Reviews - May 22, 2021 Category: Genetics & Stem Cells Authors: Asier Ma ñas Paola G ómez-Redondo Pedro L Valenzuela Javier S Morales Alejandro Luc ía Ignacio Ara Source Type: research

Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials
Ageing Res Rev. 2021 May 19:101368. doi: 10.1016/j.arr.2021.101368. Online ahead of print.ABSTRACTBACKGROUND: We aimed to summarize evidence on the safety, adherence and effectiveness of home-based resistance training (UHBRT) for improving health-related endpoints in community-dwelling older adults.METHODS: Randomized controlled trials of UHBRT in older adults (≥60yrs) were included after a systematic search (PubMed, CINAHL, PsycInfo, SPORTDiscus, Web of Science, MEDLINE, Cochrane Central Register of Controlled Trials) until 02/19/2021. Adverse events and adherence rates were assessed as indicators of feasibility. Other...
Source: Ageing Research Reviews - May 22, 2021 Category: Genetics & Stem Cells Authors: Asier Ma ñas Paola G ómez-Redondo Pedro L Valenzuela Javier S Morales Alejandro Luc ía Ignacio Ara Source Type: research

A conversation with Judith Campisi: Leader in the field of aging research
Ageing Res Rev. 2021 May 17:101366. doi: 10.1016/j.arr.2021.101366. Online ahead of print.NO ABSTRACTPMID:34015525 | DOI:10.1016/j.arr.2021.101366 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 20, 2021 Category: Genetics & Stem Cells Authors: Marissa J Schafer Judith Campisi Laura J Niedernhofer Source Type: research

A conversation with Judith Campisi: Leader in the field of aging research
Ageing Res Rev. 2021 May 17:101366. doi: 10.1016/j.arr.2021.101366. Online ahead of print.NO ABSTRACTPMID:34015525 | DOI:10.1016/j.arr.2021.101366 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 20, 2021 Category: Genetics & Stem Cells Authors: Marissa J Schafer Judith Campisi Laura J Niedernhofer Source Type: research

Socioeconomic position and healthy ageing: a systematic review of cross-sectional and longitudinal studies
CONCLUSIONS: There is evidence that socioeconomic inequalities, as assessed by educational level and income/wealth, are associated with healthy ageing. These findings, and the broader evidence base on SEP and healthy ageing, highlight the importance of addressing inequality through integrated health and social policies and strategies.PMID:34004378 | DOI:10.1016/j.arr.2021.101365 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 18, 2021 Category: Genetics & Stem Cells Authors: Emma Wagg Fiona M Blyth Robert G Cumming Saman Khalatbari-Soltani Source Type: research

Socioeconomic position and healthy ageing: a systematic review of cross-sectional and longitudinal studies
CONCLUSIONS: There is evidence that socioeconomic inequalities, as assessed by educational level and income/wealth, are associated with healthy ageing. These findings, and the broader evidence base on SEP and healthy ageing, highlight the importance of addressing inequality through integrated health and social policies and strategies.PMID:34004378 | DOI:10.1016/j.arr.2021.101365 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 18, 2021 Category: Genetics & Stem Cells Authors: Emma Wagg Fiona M Blyth Robert G Cumming Saman Khalatbari-Soltani Source Type: research

Socioeconomic position and healthy ageing: a systematic review of cross-sectional and longitudinal studies
CONCLUSIONS: There is evidence that socioeconomic inequalities, as assessed by educational level and income/wealth, are associated with healthy ageing. These findings, and the broader evidence base on SEP and healthy ageing, highlight the importance of addressing inequality through integrated health and social policies and strategies.PMID:34004378 | DOI:10.1016/j.arr.2021.101365 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 18, 2021 Category: Genetics & Stem Cells Authors: Emma Wagg Fiona M Blyth Robert G Cumming Saman Khalatbari-Soltani Source Type: research

Curcumin Nanoformulations to Combat Aging-related Diseases
We describe current barriers for the routine use of curcumin nanoformulations in the clinic. Our review highlights outstanding questions and future work that is needed to ensure nano-curcumin is efficient and safe to lessen the burden of aging-related health problems.PMID:34000462 | DOI:10.1016/j.arr.2021.101364 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - May 17, 2021 Category: Genetics & Stem Cells Authors: Maryam Mahjoob Ursula Stochaj Source Type: research

Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis
Ageing Res Rev. 2021 May 14:101361. doi: 10.1016/j.arr.2021.101361. Online ahead of print.ABSTRACTBACKGROUND: Retinal changes may reflect the pathophysiological processes in the central nervous system and can be assessed by imaging modalities non-invasively. We aim to localize candidate retinal biomarkers in Alzheimer's disease (AD), mild cognitive impairment (MCI), and preclinical AD.METHODS: We systematically searched PubMed, EMBASE, Scopus, and Web of Science from inception to January 2021 for observational studies that investigated retinal imaging and electrophysiological markers in AD, MCI, and preclinical AD. Between...
Source: Ageing Research Reviews - May 17, 2021 Category: Genetics & Stem Cells Authors: Yi-Jun Ge Wei Xu Ya-Nan Ou Yi Qu Ya-Hui Ma Yu-Yuan Huang Xue-Ning Shen Shi-Dong Chen Lan Tan Qian-Hua Zhao Jin-Tai Yu Source Type: research

Efficacy of Serotonergic Antidepressant Treatment for the Neuropsychiatric Symptoms and Agitation in Dementia: A Systematic Review and Meta-analysis
Ageing Res Rev. 2021 May 14:101362. doi: 10.1016/j.arr.2021.101362. Online ahead of print.ABSTRACTOBJECTIVE: Serotonergic dysfunction may be involved in the etiology of overall neuropsychiatric symptoms (NPS) and agitation in patients with dementia; therefore, we aim to perform a systematic review and meta-analysis to investigate the efficacy of serotonergic antidepressants in such populations.METHODS: We systematically searched PubMed, Medline, Embase, and Cochrane Library to obtain randomized controlled trials (RCTs) from the date of their inception until December 11, 2020 to examine the effect of serotonergic antidepres...
Source: Ageing Research Reviews - May 17, 2021 Category: Genetics & Stem Cells Authors: Tien-Wei Hsu Brendon Stubbs Chih-Sung Liang Tien-Yu Chen Ta-Chuan Yeh Chih-Chuan Pan Che-Sheng Chu Source Type: research

Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies
Ageing Res Rev. 2021 May 12:101360. doi: 10.1016/j.arr.2021.101360. Online ahead of print.ABSTRACTThe high prevalence of unhealthy dietary patterns and related brain disorders, such as dementia, emphasizes the importance of research that examines the effect of dietary factors on brain health. Identifying markers of brain health, such as volume and connectivity, that relate to diet is an important first step towards understanding the lifestyle determinants of healthy brain ageing. We conducted a systematic review of 52 studies (total n = 21,221 healthy participants aged 26-80 years, 55% female) that assessed with a range of...
Source: Ageing Research Reviews - May 15, 2021 Category: Genetics & Stem Cells Authors: Daria E A Jensen Virginia Leoni Miriam C Klein-Fl ügge Klaus P Ebmeier Sana Suri Source Type: research

Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies
Ageing Res Rev. 2021 May 12:101360. doi: 10.1016/j.arr.2021.101360. Online ahead of print.ABSTRACTThe high prevalence of unhealthy dietary patterns and related brain disorders, such as dementia, emphasizes the importance of research that examines the effect of dietary factors on brain health. Identifying markers of brain health, such as volume and connectivity, that relate to diet is an important first step towards understanding the lifestyle determinants of healthy brain ageing. We conducted a systematic review of 52 studies (total n = 21,221 healthy participants aged 26-80 years, 55% female) that assessed with a range of...
Source: Ageing Research Reviews - May 15, 2021 Category: Genetics & Stem Cells Authors: Daria E A Jensen Virginia Leoni Miriam C Klein-Fl ügge Klaus P Ebmeier Sana Suri Source Type: research

Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies
Ageing Res Rev. 2021 May 12:101360. doi: 10.1016/j.arr.2021.101360. Online ahead of print.ABSTRACTThe high prevalence of unhealthy dietary patterns and related brain disorders, such as dementia, emphasizes the importance of research that examines the effect of dietary factors on brain health. Identifying markers of brain health, such as volume and connectivity, that relate to diet is an important first step towards understanding the lifestyle determinants of healthy brain ageing. We conducted a systematic review of 52 studies (total n = 21,221 healthy participants aged 26-80 years, 55% female) that assessed with a range of...
Source: Ageing Research Reviews - May 15, 2021 Category: Genetics & Stem Cells Authors: Daria E A Jensen Virginia Leoni Miriam C Klein-Fl ügge Klaus P Ebmeier Sana Suri Source Type: research

Epigenetic Regulation of Melanogenesis
Ageing Res Rev. 2021 May 10:101349. doi: 10.1016/j.arr.2021.101349. Online ahead of print.ABSTRACTMelanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides. DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT) and microphthalmia-associated transcription factor (MITF), as we...
Source: Ageing Research Reviews - May 13, 2021 Category: Genetics & Stem Cells Authors: Shihang Zhou Hongliang Zeng Jinhua Huang Li Lei Xiaoliang Tong Si Li Ying Zhou Haoran Guo Manal Khan Liping Luo Rong Xiao Jing Chen Qinghai Zeng Source Type: research

5-Lipoxygenase as an emerging target against age-related brain disorders
Ageing Res Rev. 2021 May 10:101359. doi: 10.1016/j.arr.2021.101359. Online ahead of print.ABSTRACTNeuroinflammation is a common feature of age-related brain disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and cerebral ischemia. 5-lipoxygenase (5-LOX), a proinflammatory enzyme, modulates inflammation by generating leukotrienes. Abnormal activation of 5-LOX and excessive production of leukotrienes have been detected in the development of age-related brain pathology. In this review, we provide an update on the current understanding of 5-LOX activation and several groups of functionally related inhibitor...
Source: Ageing Research Reviews - May 13, 2021 Category: Genetics & Stem Cells Authors: Mengdie Yan Siran Zhang Chengtan Li Yanyan Liu Jianbo Zhao Yanfang Wang Yi Yang Lihui Zhang Source Type: research

Epigenetic Regulation of Melanogenesis
Ageing Res Rev. 2021 May 10:101349. doi: 10.1016/j.arr.2021.101349. Online ahead of print.ABSTRACTMelanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides. DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT) and microphthalmia-associated transcription factor (MITF), as we...
Source: Ageing Research Reviews - May 13, 2021 Category: Genetics & Stem Cells Authors: Shihang Zhou Hongliang Zeng Jinhua Huang Li Lei Xiaoliang Tong Si Li Ying Zhou Haoran Guo Manal Khan Liping Luo Rong Xiao Jing Chen Qinghai Zeng Source Type: research

5-Lipoxygenase as an emerging target against age-related brain disorders
Ageing Res Rev. 2021 May 10:101359. doi: 10.1016/j.arr.2021.101359. Online ahead of print.ABSTRACTNeuroinflammation is a common feature of age-related brain disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and cerebral ischemia. 5-lipoxygenase (5-LOX), a proinflammatory enzyme, modulates inflammation by generating leukotrienes. Abnormal activation of 5-LOX and excessive production of leukotrienes have been detected in the development of age-related brain pathology. In this review, we provide an update on the current understanding of 5-LOX activation and several groups of functionally related inhibitor...
Source: Ageing Research Reviews - May 13, 2021 Category: Genetics & Stem Cells Authors: Mengdie Yan Siran Zhang Chengtan Li Yanyan Liu Jianbo Zhao Yanfang Wang Yi Yang Lihui Zhang Source Type: research

Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis
Ageing Res Rev. 2021 May 9;69:101358. doi: 10.1016/j.arr.2021.101358. Online ahead of print.ABSTRACTHuntington disease (HD) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene, which leads to a toxic, aggregation-prone, mutant HTT-polyQ protein. Beyond the well-established mechanisms of HD progression in the central nervous system, growing evidence indicates that also peripheral tissues are affected in HD and that systemic signaling originating from peripheral tissues can influence the progression of HD in the brain. Herein, we re...
Source: Ageing Research Reviews - May 12, 2021 Category: Genetics & Stem Cells Authors: Chia-Lung Chuang Fabio Demontis Source Type: research

Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis
Ageing Res Rev. 2021 May 9:101358. doi: 10.1016/j.arr.2021.101358. Online ahead of print.ABSTRACTHuntington disease (HD) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene, which leads to a toxic, aggregation-prone, mutant HTT-polyQ protein. Beyond the well-established mechanisms of HD progression in the central nervous system, growing evidence indicates that also peripheral tissues are affected in HD and that systemic signaling originating from peripheral tissues can influence the progression of HD in the brain. Herein, we revie...
Source: Ageing Research Reviews - May 12, 2021 Category: Genetics & Stem Cells Authors: Chia-Lung Chuang Fabio Demontis Source Type: research