Towards Prolonging Ovarian Reproductive Life: Insights into Trace Elements Homeostasis
Ageing Res Rev. 2024 Apr 16:102311. doi: 10.1016/j.arr.2024.102311. Online ahead of print.ABSTRACTOvarian aging is marked by a reduction in the quantity and quality of ovarian follicles, leading to a decline in female fertility and ovarian endocrine function. While the biological characteristics of ovarian aging are well-established, the exact mechanisms underlying this process remain elusive. Recent studies underscore the vital role of trace elements (TEs) in maintaining ovarian function. Imbalances in TEs can lead to ovarian aging, characterized by reduced enzyme activity, hormonal imbalances, ovulatory disorders, and de...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Weicheng Tang Xiaoran Zhu Ying Chen Shuhong Yang Chuqing Wu Dan Chen Liru Xue Yican Guo Yun Dai Simin Wei Mingfu Wu Meng Wu Shixuan Wang Source Type: research
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Ageing Res Rev. 2024 Apr 16:102310. doi: 10.1016/j.arr.2024.102310. Online ahead of print.ABSTRACTMaintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular...
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: L éo Pio-Lopez Michael Levin Source Type: research
Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol
CONCLUSIONS: CST as delivered in adherence to the original 14-session protocol is an efficacious treatment for mild to moderate dementia with improvements in cognition, affective symptoms and quality of life demonstrated from global trials.PMID:38636561 | DOI:10.1016/j.arr.2024.102312 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - April 18, 2024 Category: Genetics & Stem Cells Authors: Roopal Desai Wing Gi Leung Caroline Fearn Amber John Joshua Stott Aimee Spector Source Type: research
The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?
Ageing Res Rev. 2024 Apr 12;97:102308. doi: 10.1016/j.arr.2024.102308. Online ahead of print.ABSTRACTAging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a considerable economic burden on individuals and society. The development of age-related ocular disease is predominantly triggered by oxidative stress and chronic inflammatory reaction. Heme oxygenase-1 (HO-1) is a crucial antioxidant t...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Dong Wei Chengkang Qu Na Zhao Siyu Li Ning Pu Zongming Song Ye Tao Source Type: research
Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease
Ageing Res Rev. 2024 Apr 12:102309. doi: 10.1016/j.arr.2024.102309. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a multi-factorial neurodegenerative disorder has affected over 30 million individuals globally and these numbers are expected to increase in the coming decades. Current therapeutic interventions are largely ineffective as they focus on a single target. Development of an effective drug therapy requires a deep understanding of the various factors influencing the onset and progression of the disease. Aging and genetic factors exert a major influence on the development of AD. Other factors like post-viral...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Kayalvizhi Rajendran Uma Maheswari Krishnan Source Type: research
The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?
Ageing Res Rev. 2024 Apr 12:102308. doi: 10.1016/j.arr.2024.102308. Online ahead of print.ABSTRACTAging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a considerable economic burden on individuals and society. The development of age-related ocular disease is predominantly triggered by oxidative stress and chronic inflammatory reaction. Heme oxygenase-1 (HO-1) is a crucial antioxidant that...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Dong Wei ChengKang Qu Na Zhao SiYu Li Ning Pu Ye Tao ZongMing Song Source Type: research
Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease
Ageing Res Rev. 2024 Apr 12:102309. doi: 10.1016/j.arr.2024.102309. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a multi-factorial neurodegenerative disorder has affected over 30 million individuals globally and these numbers are expected to increase in the coming decades. Current therapeutic interventions are largely ineffective as they focus on a single target. Development of an effective drug therapy requires a deep understanding of the various factors influencing the onset and progression of the disease. Aging and genetic factors exert a major influence on the development of AD. Other factors like post-viral...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Kayalvizhi Rajendran Uma Maheswari Krishnan Source Type: research
The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?
Ageing Res Rev. 2024 Apr 12:102308. doi: 10.1016/j.arr.2024.102308. Online ahead of print.ABSTRACTAging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a considerable economic burden on individuals and society. The development of age-related ocular disease is predominantly triggered by oxidative stress and chronic inflammatory reaction. Heme oxygenase-1 (HO-1) is a crucial antioxidant that...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Dong Wei ChengKang Qu Na Zhao SiYu Li Ning Pu Ye Tao ZongMing Song Source Type: research
Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease
Ageing Res Rev. 2024 Apr 12:102309. doi: 10.1016/j.arr.2024.102309. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a multi-factorial neurodegenerative disorder has affected over 30 million individuals globally and these numbers are expected to increase in the coming decades. Current therapeutic interventions are largely ineffective as they focus on a single target. Development of an effective drug therapy requires a deep understanding of the various factors influencing the onset and progression of the disease. Aging and genetic factors exert a major influence on the development of AD. Other factors like post-viral...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Kayalvizhi Rajendran Uma Maheswari Krishnan Source Type: research
Treating Alzheimer's disease using nanoparticle-mediated drug delivery strategies/systems
Ageing Res Rev. 2024 Apr 12;97:102291. doi: 10.1016/j.arr.2024.102291. Online ahead of print.ABSTRACTThe administration of promising medications for the treatment of neurodegenerative disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) is significantly hampered by the blood-brain barrier (BBB). Nanotechnology has recently come to light as a viable strategy for overcoming this obstacle and improving drug delivery to the brain. With a focus on current developments and prospects, this review article examines the use of nanoparticles t...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Aryan Kia Roghani Ricardo Isaiah Garcia Ali Roghani Aananya Reddy Sachi Khemka Ruhananhad P Reddy Vasanthkumar Pattoor Michael Jacob P Hemachandra Reddy Ujala Sehar Source Type: research
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases
Ageing Res Rev. 2024 Apr 11:102307. doi: 10.1016/j.arr.2024.102307. Online ahead of print.ABSTRACTSleep is a highly intricate biological phenomenon, and its disorders play a pivotal role in numerous diseases. However, the specific regulatory mechanisms remain elusive. In recent years, the role of mitochondria in sleep disorders has gained considerable attention. Sleep deprivation not only impairs mitochondrial morphology but also decreases the number of mitochondria and triggers mitochondrial dysfunction. Furthermore, mitochondrial dysfunction has been implicated in the onset and progression of various sleep disorder-relat...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Wentao Zhang Dan Liu Mei Yuan Ling-Qiang Zhu Source Type: research
Treating Alzheimer's Disease Using Nanoparticle-Mediated Drug Delivery Strategies/Systems
Ageing Res Rev. 2024 Apr 11:102291. doi: 10.1016/j.arr.2024.102291. Online ahead of print.ABSTRACTThe administration of promising medications for the treatment of neurodegenerative disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) is significantly hampered by the blood-brain barrier (BBB). Nanotechnology has recently come to light as a viable strategy for overcoming this obstacle and improving drug delivery to the brain. With a focus on current developments and prospects, this review article examines the use of nanoparticles to o...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Aryan Kia Roghani Ricardo Isaiah Garcia Ali Roghani Aananya Reddy Sachi Khemka Ruhananhad P Reddy Vasanthkumar Pattoor Michael Jacobs P Hemachandra Reddy Ujala Sehar Source Type: research
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases
Ageing Res Rev. 2024 Apr 11:102307. doi: 10.1016/j.arr.2024.102307. Online ahead of print.ABSTRACTSleep is a highly intricate biological phenomenon, and its disorders play a pivotal role in numerous diseases. However, the specific regulatory mechanisms remain elusive. In recent years, the role of mitochondria in sleep disorders has gained considerable attention. Sleep deprivation not only impairs mitochondrial morphology but also decreases the number of mitochondria and triggers mitochondrial dysfunction. Furthermore, mitochondrial dysfunction has been implicated in the onset and progression of various sleep disorder-relat...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Wentao Zhang Dan Liu Mei Yuan Ling-Qiang Zhu Source Type: research
The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review
Ageing Res Rev. 2024 Apr 9;97:102299. doi: 10.1016/j.arr.2024.102299. Online ahead of print.ABSTRACTParkinson's disease is predominantly caused by dopaminergic neuron loss in the substantia nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general consensus is that several factors, such as aging, environmental factors, mitochondrial dysfunction, accumulations of neurotoxic alpha-synuclein, malfunctions of the lysosomal and proteasomal protein degradation systems, oxidative stress, and neuroinflammation, are involved in the neurodegeneration process of Parkinson's disease, the precise mechanism...
Source: Ageing Research Reviews - April 11, 2024 Category: Genetics & Stem Cells Authors: Samira Hassani Abolghasem Esmaeili Source Type: research
Innovative Approaches to Alzheimer's Therapy: Harnessing the Power of Heterocycles, Oxidative Stress Management, and Nanomaterial Drug Delivery System
Ageing Res Rev. 2024 Apr 9:102298. doi: 10.1016/j.arr.2024.102298. Online ahead of print.ABSTRACTAlzheimer's disease (AD) presents a complex pathology involving amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, and cholinergic deficits. Oxidative stress exacerbates AD progression through pathways like macromolecular peroxidation, mitochondrial dysfunction, and metal ion redox potential alteration linked to amyloid-beta (Aβ). Despite limited approved medications, heterocyclic compounds have emerged as promising candidates in AD drug discovery. This review highlights recent advancements in synthetic h...
Source: Ageing Research Reviews - April 11, 2024 Category: Genetics & Stem Cells Authors: Mohammad Umar Yasir Rehman Subiya Ambreen Sayed Md Mumtaz Mohd Shaququzzaman Mohammad Mumtaz Alam Ruhi Ali Source Type: research
