Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Ageing Res Rev. 2024 Mar 15:102275. doi: 10.1016/j.arr.2024.102275. Online ahead of print.ABSTRACTOsteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated ...
Source: Ageing Research Reviews - March 17, 2024 Category: Genetics & Stem Cells Authors: Md Meraj Ansari Mrinmoy Ghosh Dong-Sun Lee Young-Ok Son Source Type: research

Sonic Hedgehog Signalling Pathway Contributes in Age-Related Disorders and Alzheimer's Disease
Ageing Res Rev. 2024 Mar 14:102271. doi: 10.1016/j.arr.2024.102271. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway ...
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Arun Parashar Dhruv Jha Vineet Mehta Bonney Chauhan Pappu Ghosh Prashanta Kumar Deb Mohit Jaiswal Santosh Kumar Prajapati Source Type: research

Improving Geriatric Outcomes through Nutritional and Immunonutritional Strategies: focus on Surgical Setting by a Comprehensive Evidence Review
This study reviews current literature on the impact of nutrition and immunonutrition on surgical outcomes in geriatrics, highlighting the potential benefits in terms of reduced complications, enhanced wound healing, and shortened hospital stays. Recognizing and addressing the specific nutritional needs of older persons undergoing surgery is essential for promoting successful surgical outcomes and improving overall quality of life in this vulnerable population.PMID:38492809 | DOI:10.1016/j.arr.2024.102272 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Virginia Boccardi Luigi Marano Source Type: research

Understanding the Intricacies of Cellular Senescence in Atherosclerosis: Mechanisms and Therapeutic Implications
Ageing Res Rev. 2024 Mar 14:102273. doi: 10.1016/j.arr.2024.102273. Online ahead of print.ABSTRACTCardiovascular disease is currently the largest cause of mortality and disability globally, surpassing communicable diseases, and atherosclerosis is the main contributor to this epidemic. Aging is intimately linked to atherosclerosis development and progression, however, the mechanism of aging in atherosclerosis is not well known. To emphasize the significant research on the involvement of senescent cells in atherosclerosis, we begin by outlining compelling evidence that indicates various types of senescent cells and SASP fact...
Source: Ageing Research Reviews - March 16, 2024 Category: Genetics & Stem Cells Authors: Ilyas Ali Hongliang Zhang Syed Aqib Ali Zaidi Guangqian Zhou Source Type: research

Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
Ageing Res Rev. 2024 Mar 13:102268. doi: 10.1016/j.arr.2024.102268. Online ahead of print.ABSTRACTThe accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed a gradual accumulation of mutations in most normal tissues with age as well as a substantial clonal expansion drive...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Kasit Chatsirisupachai Jo ão Pedro de Magalhães Source Type: research

Unveiling the Interplay of AMPK/SIRT1/PGC-1 α axis in Brain Health: Promising Targets Against Aging and NDDs
Ageing Res Rev. 2024 Mar 13:102255. doi: 10.1016/j.arr.2024.102255. Online ahead of print.ABSTRACTThe escalating prevalence of neurodegenerative diseases (NDDs) within an aging global population presents a pressing challenge. The multifaceted pathophysiological mechanisms underlying these disorders, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, remain complex and elusive. Among these, the AMPK/SIRT1/PGC-1α pathway emerges as a pivotal network implicated in neuroprotection against these destructive processes. This review sheds light on the potential therapeutic implications of targeting this...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Pratik Shankar Rakshe Bhaskar Jyoti Dutta Shivani Chib Niyogita Maurya Sanjiv Singh Source Type: research

Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
Ageing Res Rev. 2024 Mar 13:102268. doi: 10.1016/j.arr.2024.102268. Online ahead of print.ABSTRACTThe accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed a gradual accumulation of mutations in most normal tissues with age as well as a substantial clonal expansion drive...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Kasit Chatsirisupachai Jo ão Pedro de Magalhães Source Type: research

Unveiling the Interplay of AMPK/SIRT1/PGC-1 α axis in Brain Health: Promising Targets Against Aging and NDDs
Ageing Res Rev. 2024 Mar 13:102255. doi: 10.1016/j.arr.2024.102255. Online ahead of print.ABSTRACTThe escalating prevalence of neurodegenerative diseases (NDDs) within an aging global population presents a pressing challenge. The multifaceted pathophysiological mechanisms underlying these disorders, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, remain complex and elusive. Among these, the AMPK/SIRT1/PGC-1α pathway emerges as a pivotal network implicated in neuroprotection against these destructive processes. This review sheds light on the potential therapeutic implications of targeting this...
Source: Ageing Research Reviews - March 15, 2024 Category: Genetics & Stem Cells Authors: Pratik Shankar Rakshe Bhaskar Jyoti Dutta Shivani Chib Niyogita Maurya Sanjiv Singh Source Type: research

Somatostatin and the pathophysiology of Alzheimer's disease
Ageing Res Rev. 2024 Mar 12:102270. doi: 10.1016/j.arr.2024.102270. Online ahead of print.ABSTRACTAmong the central features of Alzheimer's disease (AD) progression are altered levels of the neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a molecular model for the pathogenesis of AD based on SST-IN hypofunction and hyperactivity. Namely, hypofunctional and hyperactive SST-INs struggle to control hyperactivity in mid-temporal regions in early stages, leading to axonal Aβ production through ex...
Source: Ageing Research Reviews - March 14, 2024 Category: Genetics & Stem Cells Authors: Victor N Almeida Source Type: research

Somatostatin and the pathophysiology of Alzheimer's disease
Ageing Res Rev. 2024 Mar 12:102270. doi: 10.1016/j.arr.2024.102270. Online ahead of print.ABSTRACTAmong the central features of Alzheimer's disease (AD) progression are altered levels of the neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a molecular model for the pathogenesis of AD based on SST-IN hypofunction and hyperactivity. Namely, hypofunctional and hyperactive SST-INs struggle to control hyperactivity in mid-temporal regions in early stages, leading to axonal Aβ production through ex...
Source: Ageing Research Reviews - March 14, 2024 Category: Genetics & Stem Cells Authors: Victor N Almeida Source Type: research

Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits
Ageing Res Rev. 2024 Mar 11:102269. doi: 10.1016/j.arr.2024.102269. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite extensive research and efforts of the multidisciplinary scientific community, to date, there is no cure for this debilitating disease. Moreover, the existing pharmacotherapy for AD only provides symptomatic support and does not modify the course of the illness or halt the disease progression. This is a significant limitation as the underlying pathology of the disease con...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Raj A Katariya Shivkumar S Sammeta Mayur B Kale Nandkishor R Kotagale Milind J Umekar Brijesh G Taksande Source Type: research

The underlying roles and neurobiological mechanisms of Music-Based Intervention in Alzheimer's disease: A comprehensive review
Ageing Res Rev. 2024 Mar 11:102265. doi: 10.1016/j.arr.2024.102265. Online ahead of print.ABSTRACTNon-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognit...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Liyang Sun Qin Wang Jing Ai Source Type: research

The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis
This article is an update of a review of dyadic interventions up to 2012 (Van't Leven et al., 2013). Twenty-two randomized controlled trials published between January 2012 and March 2023 met eligibility criteria, representing 3857 dyads. Results of a meta-analysis showed no overall intervention effect. Thirteen studies reported positive intervention effects, 9 studies reported no intervention effects. Intervention content and participant characteristics and knowledge of the disease varied widely between the studies reviewed. Effective interventions were those that matched activities for the person with dementia to their in...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Sanne C E Balvert Giovanna C Del Sordo Maarten V Milders Source Type: research

Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits
Ageing Res Rev. 2024 Mar 11:102269. doi: 10.1016/j.arr.2024.102269. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite extensive research and efforts of the multidisciplinary scientific community, to date, there is no cure for this debilitating disease. Moreover, the existing pharmacotherapy for AD only provides symptomatic support and does not modify the course of the illness or halt the disease progression. This is a significant limitation as the underlying pathology of the disease con...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Raj A Katariya Shivkumar S Sammeta Mayur B Kale Nandkishor R Kotagale Milind J Umekar Brijesh G Taksande Source Type: research

The underlying roles and neurobiological mechanisms of Music-Based Intervention in Alzheimer's disease: A comprehensive review
Ageing Res Rev. 2024 Mar 11:102265. doi: 10.1016/j.arr.2024.102265. Online ahead of print.ABSTRACTNon-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognit...
Source: Ageing Research Reviews - March 13, 2024 Category: Genetics & Stem Cells Authors: Liyang Sun Qin Wang Jing Ai Source Type: research