Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
Ageing Res Rev. 2021 Sep 8:101459. doi: 10.1016/j.arr.2021.101459. Online ahead of print.ABSTRACTAlzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major risk factor. Since AD-related changes may emerge in midlife, intervention efforts are being redirected around this period. Midlife coincides with several endocrinological changes, such as the men...
Source: Ageing Research Reviews - September 11, 2021 Category: Genetics & Stem Cells Authors: Chinedu Udeh-Momoh Tam Watermeyer Female Brain health and Endocrine Research (FEMBER) consortium Source Type: research

Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
Ageing Res Rev. 2021 Sep 8:101459. doi: 10.1016/j.arr.2021.101459. Online ahead of print.ABSTRACTAlzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major risk factor. Since AD-related changes may emerge in midlife, intervention efforts are being redirected around this period. Midlife coincides with several endocrinological changes, such as the men...
Source: Ageing Research Reviews - September 11, 2021 Category: Genetics & Stem Cells Authors: Chinedu Udeh-Momoh Tam Watermeyer Female Brain health and Endocrine Research (FEMBER) consortium Source Type: research

Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
Ageing Res Rev. 2021 Sep 8:101459. doi: 10.1016/j.arr.2021.101459. Online ahead of print.ABSTRACTAlzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major risk factor. Since AD-related changes may emerge in midlife, intervention efforts are being redirected around this period. Midlife coincides with several endocrinological changes, such as the men...
Source: Ageing Research Reviews - September 11, 2021 Category: Genetics & Stem Cells Authors: Chinedu Udeh-Momoh Tam Watermeyer Female Brain health and Endocrine Research (FEMBER) consortium Source Type: research

Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
Ageing Res Rev. 2021 Sep 8:101459. doi: 10.1016/j.arr.2021.101459. Online ahead of print.ABSTRACTAlzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major risk factor. Since AD-related changes may emerge in midlife, intervention efforts are being redirected around this period. Midlife coincides with several endocrinological changes, such as the men...
Source: Ageing Research Reviews - September 11, 2021 Category: Genetics & Stem Cells Authors: Chinedu Udeh-Momoh Tam Watermeyer Female Brain health and Endocrine Research (FEMBER) consortium Source Type: research

Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
Ageing Res Rev. 2021 Sep 8:101459. doi: 10.1016/j.arr.2021.101459. Online ahead of print.ABSTRACTAlzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major risk factor. Since AD-related changes may emerge in midlife, intervention efforts are being redirected around this period. Midlife coincides with several endocrinological changes, such as the men...
Source: Ageing Research Reviews - September 11, 2021 Category: Genetics & Stem Cells Authors: Chinedu Udeh-Momoh Tam Watermeyer Female Brain health and Endocrine Research (FEMBER) consortium Source Type: research

A common signature of cellular senescence; does it exist?
Ageing Res Rev. 2021 Sep 6:101458. doi: 10.1016/j.arr.2021.101458. Online ahead of print.ABSTRACTCellular senescence is a stress response, which can be evoked in all type of somatic cells by different stimuli. Senescent cells accumulate in the body and participate in aging and aging-related diseases mainly by their secretory activity, commonly known as senescence-associated secretory phenotype-SASP. Senescence is typically described as cell cycle arrest. This definition stems from the original observation concerning limited cell division potential of human fibroblasts in vitro. At present, the process of cell senescence is...
Source: Ageing Research Reviews - September 9, 2021 Category: Genetics & Stem Cells Authors: Ewa Sikora Anna Bielak-Zmijewska Grazyna Mosieniak Source Type: research

A common signature of cellular senescence; does it exist?
Ageing Res Rev. 2021 Sep 6:101458. doi: 10.1016/j.arr.2021.101458. Online ahead of print.ABSTRACTCellular senescence is a stress response, which can be evoked in all type of somatic cells by different stimuli. Senescent cells accumulate in the body and participate in aging and aging-related diseases mainly by their secretory activity, commonly known as senescence-associated secretory phenotype-SASP. Senescence is typically described as cell cycle arrest. This definition stems from the original observation concerning limited cell division potential of human fibroblasts in vitro. At present, the process of cell senescence is...
Source: Ageing Research Reviews - September 9, 2021 Category: Genetics & Stem Cells Authors: Ewa Sikora Anna Bielak-Zmijewska Grazyna Mosieniak Source Type: research

Underrepresentation of older adults in clinical trials on COVID-19 vaccines: a systematic review
In conclusion, our systematic review demonstrates that in published and ongoing phase II-III randomized clinical trials evaluating the efficacy of COVID-19 vaccines only a tiny fraction of the most vulnerable group of older people was included, although they clearly were the first population that had to be vaccinated.PMID:34487916 | PMC:PMC8413602 | DOI:10.1016/j.arr.2021.101455 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - September 6, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mirko Petrovic Athanase Benetos Michael Denkinger Adalsteinn Gudmundsson Wilma Knol Christine Marking George Soulis Stefania Maggi Antonio Cherubini special interest group in Systematic Reviews and Meta-analyses and the task force on Pharm Source Type: research

How good is the evidence that cellular senescence causes skin ageing?
Ageing Res Rev. 2021 Sep 3:101456. doi: 10.1016/j.arr.2021.101456. Online ahead of print.ABSTRACTSkin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. In case of skin, accumulation of senescence ...
Source: Ageing Research Reviews - September 6, 2021 Category: Genetics & Stem Cells Authors: Evon Low Ghazaleh Alimohammadiha Lucy A Smith Lydia F Costello Stefan A Przyborski Thomas von Zglinicki Satomi Miwa Source Type: research

Underrepresentation of older adults in clinical trials on COVID-19 vaccines: a systematic review
In conclusion, our systematic review demonstrates that in published and ongoing phase II-III randomized clinical trials evaluating the efficacy of COVID-19 vaccines only a tiny fraction of the most vulnerable group of older people was included, although they clearly were the first population that had to be vaccinated.PMID:34487916 | PMC:PMC8413602 | DOI:10.1016/j.arr.2021.101455 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - September 6, 2021 Category: Genetics & Stem Cells Authors: Nicola Veronese Mirko Petrovic Athanase Benetos Michael Denkinger Adalsteinn Gudmundsson Wilma Knol Christine Marking George Soulis Stefania Maggi Antonio Cherubini special interest group in Systematic Reviews and Meta-analyses and the task force on Pharm Source Type: research

How good is the evidence that cellular senescence causes skin ageing?
Ageing Res Rev. 2021 Sep 3:101456. doi: 10.1016/j.arr.2021.101456. Online ahead of print.ABSTRACTSkin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. In case of skin, accumulation of senescence ...
Source: Ageing Research Reviews - September 6, 2021 Category: Genetics & Stem Cells Authors: Evon Low Ghazaleh Alimohammadiha Lucy A Smith Lydia F Costello Stefan A Przyborski Thomas von Zglinicki Satomi Miwa Source Type: research

Bridging geriatric medicine, clinical pharmacology and ageing biology to understand and improve outcomes of medicines in old age and frailty
Ageing Res Rev. 2021 Sep 2:101457. doi: 10.1016/j.arr.2021.101457. Online ahead of print.NO ABSTRACTPMID:34481922 | DOI:10.1016/j.arr.2021.101457 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - September 5, 2021 Category: Genetics & Stem Cells Authors: Sarah N Hilmer Source Type: research

Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery
In conclusion, we need to obtain a full understanding of the dynamic roles of Aβ peptide at the molecular level in both the brain and periphery in relation to the pathology of AD. This will not only provide new information regarding the complex disease pathology, but also offer potential new clues to improve therapeutic strategies and diagnostic biomarkers for the successful treatment of AD.PMID:34450351 | DOI:10.1016/j.arr.2021.101451 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Rahat Ullah Tae Ju Park Xu Huang Myeong Ok Kim Source Type: research

Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis
CONCLUSIONS: In older people with cognitive impairment, fallers presented with balance deficits, poor mobility, slow gait speed and depressive symptoms. Reduced global cognition was not associated with falls. These findings suggest that interventions should target balance impairment and reveal that more high-quality research is needed.PMID:34450352 | DOI:10.1016/j.arr.2021.101452 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Thanwarat Chantanachai Daina L Sturnieks Stephen R Lord Narelle Payne Lyndell Webster Morag E Taylor Source Type: research

Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery
In conclusion, we need to obtain a full understanding of the dynamic roles of Aβ peptide at the molecular level in both the brain and periphery in relation to the pathology of AD. This will not only provide new information regarding the complex disease pathology, but also offer potential new clues to improve therapeutic strategies and diagnostic biomarkers for the successful treatment of AD.PMID:34450351 | DOI:10.1016/j.arr.2021.101451 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Rahat Ullah Tae Ju Park Xu Huang Myeong Ok Kim Source Type: research

Risk factors for falls in older people with cognitive impairment living in the community: systematic review and meta-analysis
CONCLUSIONS: In older people with cognitive impairment, fallers presented with balance deficits, poor mobility, slow gait speed and depressive symptoms. Reduced global cognition was not associated with falls. These findings suggest that interventions should target balance impairment and reveal that more high-quality research is needed.PMID:34450352 | DOI:10.1016/j.arr.2021.101452 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Thanwarat Chantanachai Daina L Sturnieks Stephen R Lord Narelle Payne Lyndell Webster Morag E Taylor Source Type: research

Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery
In conclusion, we need to obtain a full understanding of the dynamic roles of Aβ peptide at the molecular level in both the brain and periphery in relation to the pathology of AD. This will not only provide new information regarding the complex disease pathology, but also offer potential new clues to improve therapeutic strategies and diagnostic biomarkers for the successful treatment of AD.PMID:34450351 | DOI:10.1016/j.arr.2021.101451 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Rahat Ullah Tae Ju Park Xu Huang Myeong Ok Kim Source Type: research

Risk factors for falls in older people with cognitive impairment living in the community: systematic review and meta-analysis
CONCLUSIONS: In older people with cognitive impairment, fallers presented with balance deficits, poor mobility, slow gait speed and depressive symptoms. Reduced global cognition was not associated with falls. These findings suggest that interventions should target balance impairment and reveal that more high-quality research is needed.PMID:34450352 | DOI:10.1016/j.arr.2021.101452 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 27, 2021 Category: Genetics & Stem Cells Authors: Thanwarat Chantanachai Daina L Sturnieks Stephen R Lord Narelle Payne Lyndell Webster Morag E Taylor Source Type: research

Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the spatial-temporal pattern of CBF decreased from the precuneus, posterior cingulate and temporal-parietal regions to broader areas with progression from HC to MCI to AD, supporting the incorporation of CBF into the AD research framework.PMID:34419673 | DOI:10.1016/j.arr.2021.101450 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 22, 2021 Category: Genetics & Stem Cells Authors: Heng Zhang Yan Wang Diyang Lyu Yan Li Wenwen Li Qi Wang Yan Li Qi Qin Xuechu Wang Min Gong Haishan Jiao Wenying Liu Jianping Jia Source Type: research

Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the spatial-temporal pattern of CBF decreased from the precuneus, posterior cingulate and temporal-parietal regions to broader areas with progression from HC to MCI to AD, supporting the incorporation of CBF into the AD research framework.PMID:34419673 | DOI:10.1016/j.arr.2021.101450 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 22, 2021 Category: Genetics & Stem Cells Authors: Heng Zhang Yan Wang Diyang Lyu Yan Li Wenwen Li Qi Wang Yan Li Qi Qin Xuechu Wang Min Gong Haishan Jiao Wenying Liu Jianping Jia Source Type: research

Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the spatial-temporal pattern of CBF decreased from the precuneus, posterior cingulate and temporal-parietal regions to broader areas with progression from HC to MCI to AD, supporting the incorporation of CBF into the AD research framework.PMID:34419673 | DOI:10.1016/j.arr.2021.101450 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 22, 2021 Category: Genetics & Stem Cells Authors: Heng Zhang Yan Wang Diyang Lyu Yan Li Wenwen Li Qi Wang Yan Li Qi Qin Xuechu Wang Min Gong Haishan Jiao Wenying Liu Jianping Jia Source Type: research

Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis
CONCLUSIONS: Our findings suggest that the spatial-temporal pattern of CBF decreased from the precuneus, posterior cingulate and temporal-parietal regions to broader areas with progression from HC to MCI to AD, supporting the incorporation of CBF into the AD research framework.PMID:34419673 | DOI:10.1016/j.arr.2021.101450 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 22, 2021 Category: Genetics & Stem Cells Authors: Heng Zhang Yan Wang Diyang Lyu Yan Li Wenwen Li Qi Wang Yan Li Qi Qin Xuechu Wang Min Gong Haishan Jiao Wenying Liu Jianping Jia Source Type: research

Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: an updated meta-analysis
Ageing Res Rev. 2021 Aug 17:101448. doi: 10.1016/j.arr.2021.101448. Online ahead of print.ABSTRACTBACKGROUND: The behavioural and psychological symptoms of dementia (BPSD) have significant negative effects on the health of both patients with dementia and their caregivers. However, the reported effectiveness of non-pharmacological interventions targeting caregivers of patients with dementia for BPSD is inconsistent.METHODS: We systematically searched the databases PubMed, PsycINFO, CINAHL, Embase, Cochrane Library and four Chinese databases from 2010 through April 2021. The Standardised mean difference (SMD) was calculated ...
Source: Ageing Research Reviews - August 20, 2021 Category: Genetics & Stem Cells Authors: Xiangfei Meng Jianping Su Huanhuan Li Dongfei Ma Yingnan Zhao Yijing Li Xu Zhang Zehui Li Jiao Sun Source Type: research

Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: an updated meta-analysis
Ageing Res Rev. 2021 Aug 17:101448. doi: 10.1016/j.arr.2021.101448. Online ahead of print.ABSTRACTBACKGROUND: The behavioural and psychological symptoms of dementia (BPSD) have significant negative effects on the health of both patients with dementia and their caregivers. However, the reported effectiveness of non-pharmacological interventions targeting caregivers of patients with dementia for BPSD is inconsistent.METHODS: We systematically searched the databases PubMed, PsycINFO, CINAHL, Embase, Cochrane Library and four Chinese databases from 2010 through April 2021. The Standardised mean difference (SMD) was calculated ...
Source: Ageing Research Reviews - August 20, 2021 Category: Genetics & Stem Cells Authors: Xiangfei Meng Jianping Su Huanhuan Li Dongfei Ma Yingnan Zhao Yijing Li Xu Zhang Zehui Li Jiao Sun Source Type: research

Cross-sectional Associations of Tau Protein Biomarkers with Semantic and Episodic Memory in Older Adults Without Dementia: A Systematic Review and Meta-analysis
Ageing Res Rev. 2021 Aug 13:101449. doi: 10.1016/j.arr.2021.101449. Online ahead of print.ABSTRACTPathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of Alzheimer's disease. We investigated cross-sectional associations of tau burden with episodic and semantic memory performance in older adults without dementia. A systematic search in MEDLINE (via PubMed), PsychINFO, and Embase resulted in 24 eligible studies for meta-analysis. Tau burden was assessed using CSF, PET, or histopathological measures. All studies evaluated associations of tau with episodic memory: weighted effect siz...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: Teuntje A D Pelgrim Magdalena Beran Emma L Twait Mirjam I Geerlings Jet M J Vonk Source Type: research

Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity
Ageing Res Rev. 2021 Aug 14:101447. doi: 10.1016/j.arr.2021.101447. Online ahead of print.ABSTRACTDeficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides proof of concept that adult neurogenesis is required to sustain complex and dynamic cognitive functions, such as learning and memory, mostly by providing a high degree of plasticity to neuronal circuits. In addition, adult neurogenesis is reactive to external stimuli and the environment making it particularly susceptible to impairment and consequently c...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: S ébastien Gillotin Vishal Sahni Tja ša Lepko Maya A Hanspal Jina E Swartz Zoi Alexopoulou Fiona H Marshall Source Type: research

Cross-sectional Associations of Tau Protein Biomarkers with Semantic and Episodic Memory in Older Adults Without Dementia: A Systematic Review and Meta-analysis
Ageing Res Rev. 2021 Aug 13:101449. doi: 10.1016/j.arr.2021.101449. Online ahead of print.ABSTRACTPathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of Alzheimer's disease. We investigated cross-sectional associations of tau burden with episodic and semantic memory performance in older adults without dementia. A systematic search in MEDLINE (via PubMed), PsychINFO, and Embase resulted in 24 eligible studies for meta-analysis. Tau burden was assessed using CSF, PET, or histopathological measures. All studies evaluated associations of tau with episodic memory: weighted effect siz...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: Teuntje A D Pelgrim Magdalena Beran Emma L Twait Mirjam I Geerlings Jet M J Vonk Source Type: research

Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity
Ageing Res Rev. 2021 Aug 14:101447. doi: 10.1016/j.arr.2021.101447. Online ahead of print.ABSTRACTDeficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides proof of concept that adult neurogenesis is required to sustain complex and dynamic cognitive functions, such as learning and memory, mostly by providing a high degree of plasticity to neuronal circuits. In addition, adult neurogenesis is reactive to external stimuli and the environment making it particularly susceptible to impairment and consequently c...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: S ébastien Gillotin Vishal Sahni Tja ša Lepko Maya A Hanspal Jina E Swartz Zoi Alexopoulou Fiona H Marshall Source Type: research

Cross-sectional Associations of Tau Protein Biomarkers with Semantic and Episodic Memory in Older Adults Without Dementia: A Systematic Review and Meta-analysis
Ageing Res Rev. 2021 Aug 13:101449. doi: 10.1016/j.arr.2021.101449. Online ahead of print.ABSTRACTPathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of Alzheimer's disease. We investigated cross-sectional associations of tau burden with episodic and semantic memory performance in older adults without dementia. A systematic search in MEDLINE (via PubMed), PsychINFO, and Embase resulted in 24 eligible studies for meta-analysis. Tau burden was assessed using CSF, PET, or histopathological measures. All studies evaluated associations of tau with episodic memory: weighted effect siz...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: Teuntje A D Pelgrim Magdalena Beran Emma L Twait Mirjam I Geerlings Jet M J Vonk Source Type: research

Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity
Ageing Res Rev. 2021 Aug 14:101447. doi: 10.1016/j.arr.2021.101447. Online ahead of print.ABSTRACTDeficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides proof of concept that adult neurogenesis is required to sustain complex and dynamic cognitive functions, such as learning and memory, mostly by providing a high degree of plasticity to neuronal circuits. In addition, adult neurogenesis is reactive to external stimuli and the environment making it particularly susceptible to impairment and consequently c...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: S ébastien Gillotin Vishal Sahni Tja ša Lepko Maya A Hanspal Jina E Swartz Zoi Alexopoulou Fiona H Marshall Source Type: research

Cross-sectional Associations of Tau Protein Biomarkers with Semantic and Episodic Memory in Older Adults Without Dementia: A Systematic Review and Meta-analysis
Ageing Res Rev. 2021 Aug 13:101449. doi: 10.1016/j.arr.2021.101449. Online ahead of print.ABSTRACTPathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of Alzheimer's disease. We investigated cross-sectional associations of tau burden with episodic and semantic memory performance in older adults without dementia. A systematic search in MEDLINE (via PubMed), PsychINFO, and Embase resulted in 24 eligible studies for meta-analysis. Tau burden was assessed using CSF, PET, or histopathological measures. All studies evaluated associations of tau with episodic memory: weighted effect siz...
Source: Ageing Research Reviews - August 17, 2021 Category: Genetics & Stem Cells Authors: Teuntje A D Pelgrim Magdalena Beran Emma L Twait Mirjam I Geerlings Jet M J Vonk Source Type: research

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Ageing Res Rev. 2021 Aug 12:101422. doi: 10.1016/j.arr.2021.101422. Online ahead of print.ABSTRACTDuring aging the immune system (IS) undergoes remarkable changes that collectively are known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays a critical role in most chronic diseases in older people. For a long time, immunosenescence has been considered detrimental because it may lead to a low-grade, sterile chronic inflammation we proposed to call "inflammaging" and a progressive reduction in the ability to trigger effective antibody and cel...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Aurelia Santoro Elisa Bientinesi Daniela Monti Source Type: research

Diagnostic Accuracy of Blood Biomarkers for Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
CONCLUSIONS: We suggest that blood-based biomarkers are minimally invasive and cost-effective tools for detecting AD; however, the evidence for detecting aMCI was still limited.PMID:34391944 | DOI:10.1016/j.arr.2021.101446 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Ying-Ren Chen Chih-Sung Liang Hsin Chu Joachim Voss Xiao Linda Kang Grant O'Connell Hsiu-Ju Jen Doresses Liu Shu-Tai H Shen Kuei-Ru Chou Source Type: research

The microglial lysosomal system in Alzheimer's disease: guardian against proteinopathy
Ageing Res Rev. 2021 Aug 12:101444. doi: 10.1016/j.arr.2021.101444. Online ahead of print.ABSTRACTMicroglia, the brain-resident immune cells, play an essential role in the upkeep of brain homeostasis. They actively adapt into specific activation states based on cues from the microenvironment. One of these encompasses the activated response microglia (ARMs) phenotype. It arises along a healthy aging process and in a range of neurodegenerative diseases, including Alzheimer's disease (AD). As the phenotype is characterized by an increased lipid metabolism, phagocytosis rate, lysosomal protease content and secretion of neuropr...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Zo ë P Van Acker Anika Perdok Marine Bretou Wim Annaert Source Type: research

Relationship Between Obesity and Structural Brain Abnormality: accumulated evidence from observational studies
Ageing Res Rev. 2021 Aug 12:101445. doi: 10.1016/j.arr.2021.101445. Online ahead of print.ABSTRACTWe aimed to evaluate the relationship between obesity and structural brain abnormalities assessed by magnetic resonance imaging using data from 45 observational epidemiological studies, where five articles reported prospective longitudinal results. In cross-sectional studies' analyses, the pooled weighted mean difference for total brain volume (TBV) and gray matter volume (GMV) in obese/overweight participants was -11.59 (95% CI: -23.17 to -0.02) and -10.98 (95% CI: -20.78 to -1.18), respectively. TBV was adversely associated ...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Yi-Peng Han Xingyao Tang Min Han Jinkui Yang Marly Augusto Cardoso Jianbo Zhou Rafael Sim ó Source Type: research

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Ageing Res Rev. 2021 Aug 12:101422. doi: 10.1016/j.arr.2021.101422. Online ahead of print.ABSTRACTDuring aging the immune system (IS) undergoes remarkable changes that collectively are known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays a critical role in most chronic diseases in older people. For a long time, immunosenescence has been considered detrimental because it may lead to a low-grade, sterile chronic inflammation we proposed to call "inflammaging" and a progressive reduction in the ability to trigger effective antibody and cel...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Aurelia Santoro Elisa Bientinesi Daniela Monti Source Type: research

Diagnostic Accuracy of Blood Biomarkers for Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
CONCLUSIONS: We suggest that blood-based biomarkers are minimally invasive and cost-effective tools for detecting AD; however, the evidence for detecting aMCI was still limited.PMID:34391944 | DOI:10.1016/j.arr.2021.101446 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Ying-Ren Chen Chih-Sung Liang Hsin Chu Joachim Voss Xiao Linda Kang Grant O'Connell Hsiu-Ju Jen Doresses Liu Shu-Tai H Shen Kuei-Ru Chou Source Type: research

The microglial lysosomal system in Alzheimer's disease: guardian against proteinopathy
Ageing Res Rev. 2021 Aug 12:101444. doi: 10.1016/j.arr.2021.101444. Online ahead of print.ABSTRACTMicroglia, the brain-resident immune cells, play an essential role in the upkeep of brain homeostasis. They actively adapt into specific activation states based on cues from the microenvironment. One of these encompasses the activated response microglia (ARMs) phenotype. It arises along a healthy aging process and in a range of neurodegenerative diseases, including Alzheimer's disease (AD). As the phenotype is characterized by an increased lipid metabolism, phagocytosis rate, lysosomal protease content and secretion of neuropr...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Zo ë P Van Acker Anika Perdok Marine Bretou Wim Annaert Source Type: research

Relationship Between Obesity and Structural Brain Abnormality: accumulated evidence from observational studies
Ageing Res Rev. 2021 Aug 12:101445. doi: 10.1016/j.arr.2021.101445. Online ahead of print.ABSTRACTWe aimed to evaluate the relationship between obesity and structural brain abnormalities assessed by magnetic resonance imaging using data from 45 observational epidemiological studies, where five articles reported prospective longitudinal results. In cross-sectional studies' analyses, the pooled weighted mean difference for total brain volume (TBV) and gray matter volume (GMV) in obese/overweight participants was -11.59 (95% CI: -23.17 to -0.02) and -10.98 (95% CI: -20.78 to -1.18), respectively. TBV was adversely associated ...
Source: Ageing Research Reviews - August 15, 2021 Category: Genetics & Stem Cells Authors: Yi-Peng Han Xingyao Tang Min Han Jinkui Yang Marly Augusto Cardoso Jianbo Zhou Rafael Sim ó Source Type: research

CircadiOmic medicine and aging
The objective of this review is to discuss the latest knowledge regarding the role of circadiomics in health and aging. The biological timekeepers are responsive to the environmental cues at microsecond to seasonal time-scales and act with precision of a clock machinery. The robustness of these rhythms is essential to normal daily function of cells, tissues and organs. Mis-alignment of circadian rhythms makes the individual prone to aging, sleep disorders, cancer, diabetes, and neuro-degenerative diseases. Circadian and CircadiOmic medicine are emerging fields that leverage our in-depth understanding of health issues, that...
Source: Ageing Research Reviews - August 14, 2021 Category: Genetics & Stem Cells Authors: Siamak Tabibzadeh Source Type: research

p21-Activated kinase 1 (PAK1) in aging and longevity: An overview
Ageing Res Rev. 2021 Aug 11:101443. doi: 10.1016/j.arr.2021.101443. Online ahead of print.ABSTRACTThe p21-activated kinases (PAKs) belong to serine/threonine kinases family, regulated by ∼21 kDa small signaling G proteins RAC1 and CDC42. The mammalian PAK family comprises six members (PAK1-6) that are classified into two groups (I and II) based on their domain architecture and regulatory mechanisms. PAKs are implicated in a wide range of cellular functions. PAK1 has recently attracted increasing attention owing to its involvement in oncogenesis, tumor progression, and metastasis as well as several life-limiting disease...
Source: Ageing Research Reviews - August 14, 2021 Category: Genetics & Stem Cells Authors: Mohankumar Amirthalingam Sundararaj Palanisamy Shinkichi Tawata Source Type: research

Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis
CONCLUSIONS: Affective symptoms in the form of anxiety, but not depressive symptoms, increase the risk of progression to objective cognitive impairment in individuals with SCD. Further research should focus on establishing whether psychological interventions aimed at reducing anxiety and worry also reduce the risk of clinical progression.PMID:34390850 | DOI:10.1016/j.arr.2021.101419 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 14, 2021 Category: Genetics & Stem Cells Authors: Roopal Desai Tim Whitfield Glorianne Said Amber John Rob Saunders Natalie L Marchant Joshua Stott Georgina Charlesworth Source Type: research

Adverse health outcomes in vitamin D supplementation trials for depression: a systematic review
CONCLUSIONS AND IMPLICATIONS: While depressed persons are at increased risk of vitamin D deficiency, supplementation trials hardly addressed the common negative health consequences of low vitamin D levels as secondary outcome measures. Well-designed trials of the effects of vitamin D supplementation in late-life depression should explore whether adverse health outcomes can be prevented or stabilised, and whether depression benefits from this improvement.PMID:34390851 | DOI:10.1016/j.arr.2021.101442 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - August 14, 2021 Category: Genetics & Stem Cells Authors: Karen S van den Berg Radboud M Marijnissen Rob H S van den Brink Richard C Oude Voshaar Johanna M Hegeman Source Type: research

The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: Pathways, mechanisms and translational opportunities
Ageing Res Rev. 2021 Aug 9;71:101425. doi: 10.1016/j.arr.2021.101425. Online ahead of print.ABSTRACTIn the past two decades, advances in sequencing technology and analysis of the human and mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) including: microRNA, small-interfering RNAs, piwi-associated small RNAs, transfer RNA-derived small RNAs, long-non-coding RNAs and circular RNAs. Compared with healthy controls, levels of some ncRNAs are significantly altered in the central nervous system and blood of patients affected by neurodegenerative disorders like Alzheimer's disease (AD). Although the...
Source: Ageing Research Reviews - August 13, 2021 Category: Genetics & Stem Cells Authors: Elisabetta Lauretti Konrad Dabrowski Domenico Pratic ò Source Type: research

Diabetes mellitus and hearing loss: A review
Ageing Res Rev. 2021 Aug 9;71:101423. doi: 10.1016/j.arr.2021.101423. Online ahead of print.ABSTRACTDiabetes (type 2) and sensorineural hearing loss are common health problems manifested with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss, a causal link has been difficult to establish. Individuals with diabetes have twice the incidence of hearing loss compared to those without diabetes and those with prediabetes have a 30% higher rate of hearing loss. Whether hearing loss is associated with diabetes independent of glycemic control remains to be determined. Hearing loss has its own set ...
Source: Ageing Research Reviews - August 13, 2021 Category: Genetics & Stem Cells Authors: Dorit Samocha-Bonet Buffy Wu David K Ryugo Source Type: research

The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: pathways, mechanisms and translational opportunities
Ageing Res Rev. 2021 Aug 9:101425. doi: 10.1016/j.arr.2021.101425. Online ahead of print.ABSTRACTIn the past two decades, advances in sequencing technology and analysis of the human and mouse genome have led to the discovery of many non-protein-coding RNAs (ncRNAs) including: microRNA, small-interfering RNAs, piwi-associated small RNAs, transfer RNA-derived small RNAs, long-non-coding RNAs and circular RNAs. Compared with healthy controls, levels of some ncRNAs are significantly altered in the central nervous system and blood of patients affected by neurodegenerative disorders like Alzheimer's disease (AD). Although the me...
Source: Ageing Research Reviews - August 13, 2021 Category: Genetics & Stem Cells Authors: Elisabetta Lauretti Konrad Dabrowski Domenico Pratic ò Source Type: research

Diabetes Mellitus and Hearing Loss: A Review
Ageing Res Rev. 2021 Aug 9:101423. doi: 10.1016/j.arr.2021.101423. Online ahead of print.ABSTRACTDiabetes (type 2) and sensorineural hearing loss are common health problems manifested with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss, a causal link has been difficult to establish. Individuals with diabetes have twice the incidence of hearing loss compared to those without diabetes and those with prediabetes have a 30% higher rate of hearing loss. Whether hearing loss is associated with diabetes independent of glycemic control remains to be determined. Hearing loss has its own set of ...
Source: Ageing Research Reviews - August 13, 2021 Category: Genetics & Stem Cells Authors: Dorit Samocha-Bonet Buffy Wu David K Ryugo Source Type: research

Can platelet activation result in increased plasma A β levels and contribute to the pathogenesis of Alzheimer's disease?
Ageing Res Rev. 2021 Aug 6:101420. doi: 10.1016/j.arr.2021.101420. Online ahead of print.ABSTRACTOne of the central lesions in the brain of subjects with Alzheimer's disease (AD) is represented by aggregates of β-amyloid (Aβ), a peptide of 40-42 amino acids derived from the amyloid precursor protein (APP). The reasons why Aβ accumulates in the brain of individuals with sporadic forms of AD are unknown. Platelets are the primary source of circulating APP and, upon activation, can secrete significant amounts of Aβ into the blood which can be actively transported to the brain across the blood-brain barrier...
Source: Ageing Research Reviews - August 9, 2021 Category: Genetics & Stem Cells Authors: Manuel Glauco Carbone Giovanni Pagni Claudia Tagliarini Bruno Pietro Imbimbo Nunzio Pomara Source Type: research

Untangling huge literature to disinter genetic underpinnings of Alzheimer's Disease: A Systematic review and Meta-analysis
Ageing Res Rev. 2021 Aug 6:101421. doi: 10.1016/j.arr.2021.101421. Online ahead of print.ABSTRACTDrug discovery for Alzheimer's Disease (AD) is channeled towards unravelling key disease specific drug targets/genes to predict promising therapeutic candidates. Though enormous literature on AD genetics is available, there exists dearth in data pertinent to drug targets and crucial pathological pathways intertwined in disease progression. Further, the research findings revealing genetic associations failed to demonstrate consistency across different studies. This scenario prompted us to initiate a systematic review and meta-an...
Source: Ageing Research Reviews - August 9, 2021 Category: Genetics & Stem Cells Authors: Hema Sree G N S V Lakshmi Prasanna Marise Kshreeraja S Satish Abhijna Vithal Yergolkar Mamatha Krishnamurthy Saraswathy Ganesan Rajalekshmi K Radhika Raghunadha R Burri Source Type: research

Can platelet activation result in increased plasma A β levels and contribute to the pathogenesis of Alzheimer's disease?
Ageing Res Rev. 2021 Aug 6:101420. doi: 10.1016/j.arr.2021.101420. Online ahead of print.ABSTRACTOne of the central lesions in the brain of subjects with Alzheimer's disease (AD) is represented by aggregates of β-amyloid (Aβ), a peptide of 40-42 amino acids derived from the amyloid precursor protein (APP). The reasons why Aβ accumulates in the brain of individuals with sporadic forms of AD are unknown. Platelets are the primary source of circulating APP and, upon activation, can secrete significant amounts of Aβ into the blood which can be actively transported to the brain across the blood-brain barrier...
Source: Ageing Research Reviews - August 9, 2021 Category: Genetics & Stem Cells Authors: Manuel Glauco Carbone Giovanni Pagni Claudia Tagliarini Bruno Pietro Imbimbo Nunzio Pomara Source Type: research