O-GlcNAc of STING mediates antiviral innate immunity
O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response. Stimulator of interferon genes (S... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 1, 2024 Category: Molecular Biology Authors: Yujia Li, Wang An, Liyuan Lu, Jiali Yuan, Danhui Wu, Qi Yang, Jinrong Guo, Jingyu Yang, Mengjie Liu, Kaiyue He, Xinyuan Lei and Zhi-Xiang Xu Tags: Research Source Type: research
HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
Cell Rep. 2024 Feb 28;43(3):113870. doi: 10.1016/j.celrep.2024.113870. Online ahead of print.ABSTRACTThe cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity. Here, we report that cGAS is responsible for the DNA-induced ISG15 conjugation system. The E3 HERC5 catalyzes the ISGylation of cytoplasmic cGAS at lysine 21, 187, 219, and 458, whereas Ubl carboxy-terminal hydrolase 18 removes the ISGylation of cGAS. The interaction of cGAS and HERC5 depends on the cGAS C-terminal dom...
Source: Herpes - February 29, 2024 Category: Infectious Diseases Authors: Lei Chu Li Qian Yu Chen Shengnan Duan Ming Ding Wu Sun Wei Meng Juanjuan Zhu Quanyi Wang Haiping Hao Chen Wang Shufang Cui Source Type: research
Fatal Africanized bee attack in captive non-human primates (Saimiri ustus and Sapajus libidinosus)
We describe the clinical, pathological, and ultrastructural findings of a massive lethal bee attack in two non-human primates (NHPs). Both animals showed BS scattered throughout the skin, surrounded by a local reaction, diffuse pulmonary congestion, edema, hemorrhage, and remarkable degeneration and necrosis of renal epithelial cells from the proximal and distal tubules, characterizing a systemic bee envenomation reaction.PMID:38423220 | DOI:10.1016/j.toxicon.2024.107666 (Source: Toxicon)
Source: Toxicon - February 29, 2024 Category: Toxicology Authors: Isabel Luana de Mac êdo Davi Emanuel Ribeiro de Sousa Antonizete Dos Reis Souza An íbal G Armién Mizael Machado M árcio Botelho de Castro Source Type: research
ER: a critical hub for STING signaling regulation
Trends Cell Biol. 2024 Feb 28:S0962-8924(24)00029-1. doi: 10.1016/j.tcb.2024.02.006. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING) has a crucial role in mediating the immune response against cytosolic double-stranded DNA (dsDNA) and its activation is critically involved in various diseases. STING is synthesized, modified, and resides in the endoplasmic reticulum (ER), and its ER exit is intimately connected with its signaling. The ER, primarily known for its roles in protein folding, lipid synthesis, and calcium storage, has been identified as a pivotal platform for the regulation of a wide range...
Source: Trends in Cell Biology - February 29, 2024 Category: Cytology Authors: Yuan Luo Lei Chang Yewei Ji Tingbo Liang Source Type: research
HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
Cell Rep. 2024 Feb 28;43(3):113870. doi: 10.1016/j.celrep.2024.113870. Online ahead of print.ABSTRACTThe cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity. Here, we report that cGAS is responsible for the DNA-induced ISG15 conjugation system. The E3 HERC5 catalyzes the ISGylation of cytoplasmic cGAS at lysine 21, 187, 219, and 458, whereas Ubl carboxy-terminal hydrolase 18 removes the ISGylation of cGAS. The interaction of cGAS and HERC5 depends on the cGAS C-terminal dom...
Source: Herpes - February 29, 2024 Category: Infectious Diseases Authors: Lei Chu Li Qian Yu Chen Shengnan Duan Ming Ding Wu Sun Wei Meng Juanjuan Zhu Quanyi Wang Haiping Hao Chen Wang Shufang Cui Source Type: research
Fatal Africanized bee attack in captive non-human primates (Saimiri ustus and Sapajus libidinosus)
We describe the clinical, pathological, and ultrastructural findings of a massive lethal bee attack in two non-human primates (NHPs). Both animals showed BS scattered throughout the skin, surrounded by a local reaction, diffuse pulmonary congestion, edema, hemorrhage, and remarkable degeneration and necrosis of renal epithelial cells from the proximal and distal tubules, characterizing a systemic bee envenomation reaction.PMID:38423220 | DOI:10.1016/j.toxicon.2024.107666 (Source: Toxicon)
Source: Toxicon - February 29, 2024 Category: Toxicology Authors: Isabel Luana de Mac êdo Davi Emanuel Ribeiro de Sousa Antonizete Dos Reis Souza An íbal G Armién Mizael Machado M árcio Botelho de Castro Source Type: research
ER: a critical hub for STING signaling regulation
Trends Cell Biol. 2024 Feb 28:S0962-8924(24)00029-1. doi: 10.1016/j.tcb.2024.02.006. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING) has a crucial role in mediating the immune response against cytosolic double-stranded DNA (dsDNA) and its activation is critically involved in various diseases. STING is synthesized, modified, and resides in the endoplasmic reticulum (ER), and its ER exit is intimately connected with its signaling. The ER, primarily known for its roles in protein folding, lipid synthesis, and calcium storage, has been identified as a pivotal platform for the regulation of a wide range...
Source: Trends in Cell Biology - February 29, 2024 Category: Cytology Authors: Yuan Luo Lei Chang Yewei Ji Tingbo Liang Source Type: research
Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production
Biochem Biophys Res Commun. 2024 Feb 15;704:149661. doi: 10.1016/j.bbrc.2024.149661. Online ahead of print.ABSTRACTTo date only four recombinant growth factors, including Filgrastim (rhG-CSF), have been approved by FDA as radiomitigators to ameliorate hematopoietic acute radiation syndrome (H-ARS). These approved agents are not stable under room-temperature, needing to be stored at 2-8 °C, and would not be feasible in a mass casualty scenario where rapid and cost-effective intervention is crucial. Delta-tocotrienol (δ-T3H), the most potent G-CSF-inducing agent among vitamin E isoforms, exhibited efficiency and selectivit...
Source: Biochemical and Biophysical Research communications - February 28, 2024 Category: Biochemistry Authors: Shaozheng Wang Zongchao Zuo Zhangyi Ouyang Xinyu Liu Junke Wang Yajun Shan Ruoxi Meng Zhenhu Zhao Xiaolan Liu Xiaoyan Liu Yiguang Jin Zhongtang Li Hong Zhang Limei Wang Yuwen Cong Source Type: research
Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production
Biochem Biophys Res Commun. 2024 Feb 15;704:149661. doi: 10.1016/j.bbrc.2024.149661. Online ahead of print.ABSTRACTTo date only four recombinant growth factors, including Filgrastim (rhG-CSF), have been approved by FDA as radiomitigators to ameliorate hematopoietic acute radiation syndrome (H-ARS). These approved agents are not stable under room-temperature, needing to be stored at 2-8 °C, and would not be feasible in a mass casualty scenario where rapid and cost-effective intervention is crucial. Delta-tocotrienol (δ-T3H), the most potent G-CSF-inducing agent among vitamin E isoforms, exhibited efficiency and selectivit...
Source: Biochemical and Biophysical Research communications - February 28, 2024 Category: Biochemistry Authors: Shaozheng Wang Zongchao Zuo Zhangyi Ouyang Xinyu Liu Junke Wang Yajun Shan Ruoxi Meng Zhenhu Zhao Xiaolan Liu Xiaoyan Liu Yiguang Jin Zhongtang Li Hong Zhang Limei Wang Yuwen Cong Source Type: research
The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia –reperfusion injury by inhibiting the STING pathway
Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and Salvia miltiorrhiza Bunge, respectively, both of which hav... (Source: Chinese Medicine)
Source: Chinese Medicine - February 28, 2024 Category: Complementary Medicine Authors: Pan Zhai, Qianyun Chen, Xunxun Wang, Xiaohu Ouyang, Mengling Yang, Yalan Dong, Junyi Li, Yiming Li, Shanshan Luo, Yue Liu, Xiang Cheng, Rui Zhu and Desheng Hu Tags: Research Source Type: research
Aging STINGs: mitophagy at the crossroads of neuroinflammation
Autophagy. 2024 Feb 27. doi: 10.1080/15548627.2024.2322421. Online ahead of print.ABSTRACTLoss of proteostasis and dysregulated mitochondrial function are part of the traditional hallmarks of aging, and in their last revision impaired macroautophagy and chronic inflammation are also included. Mitophagy is at the intersection of all these processes but whether it undergoes age-associated perturbations was not known. In our recent work, we performed a systematic and systemic analysis of mitolysosome levels in mice and found that, despite the already-known decrease in non-selective macroautophagy, mitophagy remains stable or ...
Source: Autophagy - February 27, 2024 Category: Cytology Authors: Juan Ignacio Jim énez-Loygorri Patricia Boya Source Type: research
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice
CONCLUSIONS: SS-31 conferred neuroprotection against POCD by promoting PHB2-mediated mitophagy activation to inhibit mtDNA release, which in turn suppressed the cGAS-STING pathway and M1 microglial polarization.PMID:38411634 | DOI:10.1007/s00011-024-01860-1 (Source: Cell Research)
Source: Cell Research - February 27, 2024 Category: Cytology Authors: Yelong Ji Yuanyuan Ma Yimei Ma Ying Wang Xining Zhao Danfeng Jin Li Xu Shengjin Ge Source Type: research
Aging STINGs: mitophagy at the crossroads of neuroinflammation
Autophagy. 2024 Feb 27. doi: 10.1080/15548627.2024.2322421. Online ahead of print.ABSTRACTLoss of proteostasis and dysregulated mitochondrial function are part of the traditional hallmarks of aging, and in their last revision impaired macroautophagy and chronic inflammation are also included. Mitophagy is at the intersection of all these processes but whether it undergoes age-associated perturbations was not known. In our recent work, we performed a systematic and systemic analysis of mitolysosome levels in mice and found that, despite the already-known decrease in non-selective macroautophagy, mitophagy remains stable or ...
Source: Autophagy - February 27, 2024 Category: Cytology Authors: Juan Ignacio Jim énez-Loygorri Patricia Boya Source Type: research
Aging STINGs: mitophagy at the crossroads of neuroinflammation
Autophagy. 2024 Feb 27. doi: 10.1080/15548627.2024.2322421. Online ahead of print.ABSTRACTLoss of proteostasis and dysregulated mitochondrial function are part of the traditional hallmarks of aging, and in their last revision impaired macroautophagy and chronic inflammation are also included. Mitophagy is at the intersection of all these processes but whether it undergoes age-associated perturbations was not known. In our recent work, we performed a systematic and systemic analysis of mitolysosome levels in mice and found that, despite the already-known decrease in non-selective macroautophagy, mitophagy remains stable or ...
Source: Autophagy - February 27, 2024 Category: Cytology Authors: Juan Ignacio Jim énez-Loygorri Patricia Boya Source Type: research
SS-31 inhibits mtDNA –cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
ConclusionsSS-31 conferred neuroprotection against POCD by promoting PHB2-mediated mitophagy activation to inhibit mtDNA release, which in turn suppressed the cGAS –STING pathway and M1 microglial polarization. (Source: Inflammation Research)
Source: Inflammation Research - February 27, 2024 Category: Research Source Type: research
