Working too hard or not hard enough? The interaction of effort and value on regret.
Social Psychology, Vol 55(1), 2024, 1-11; doi:10.1027/1864-9335/a000534Does working hard take the sting out of regret following failure or does working hard increase feelings of regret? The present research finds that neither of these views is correct. Rather, the results of both experiments found that regret was an interactive function of instrumental effort and goal value. In support of the consistency-fit model, large versus small amounts of effort produced more regret on a low-valued task, whereas small amounts of effort produced more regret on a high-valued task. Furthermore, supporting the consistency-fit model, rece...
Source: Social Psychology - March 21, 2024 Category: Psychiatry & Psychology Source Type: research
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway
CONCLUSION: These findings suggest that pretreated MSCs with IronQ demonstrate a synergistic effect in alleviating neuroinflammation, thereby improving neurological function, which is achieved through the inhibition of the cGAS-STING signaling pathway.PMID:38504697 | PMC:PMC10949311 | DOI:10.2147/JIR.S449579 (Source: Cell Research)
Source: Cell Research - March 20, 2024 Category: Cytology Authors: Guoqiang Yang Jiraporn Kantapan Maryam Mazhar Qiongdan Hu Xue Bai Yuanxia Zou Honglian Wang Sijin Yang Li Wang Nathupakorn Dechsupa Source Type: research
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy
Mol Oncol. 2024 Mar 20. doi: 10.1002/1878-0261.13619. Online ahead of print.ABSTRACTAn immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase in the autophagy/endosomal trafficking pathway, decreases tumor growth in several cancer models, increases infiltration of immune cells and sensitizes tumors to anti-programmed cell death protein 1/programmed cell death 1 ligand 1 therapy by upregulation of C-C motif chemokine 5 (CCL5) and C-X-...
Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Yasmin Yu Madhumita Bogdan Muhammad Zaeem Noman Santiago Parpal Elisabetta Bartolini Kris Van Moer Simone Caroline Kleinendorst Kristine Bilgrav Saether Lionel Tr ésaugues Camilla Silvander Johan Lindstr öm Jodi Simeon Mary Jane Timson Hikmat Al-Hashimi Source Type: research
STING is significantly increased in high-grade glioma with high risk of recurrence
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - March 20, 2024 Category: Cancer & Oncology Authors: Meishi ZhongManmei LongChenjie HanSaiyan JiQingyuan YangDepartment of Pathology, Shanghai Ninth People ’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Source Type: research
Natto (fermented soybeans)-induced anaphylaxis in a surfer with the possibility of sensitization to poly( γ-glutamic acid) from cutaneous exposure to jellyfish sting: a case report
ConclusionsThe major allergen that induces natto allergy is poly( γ-glutamic acid) (PGA), which is present in its mucilage. Given that PGA is also produced by jellyfish tentacles, it can be inferred that the PGA sensitization occurred via dermal exposure to jellyfish PGA. This is an example of a food allergy induced by animal stings. As PGA is a high-molecular-we ight polymer, natto allergy, despite being IgE-mediated, often presents with late-onset anaphylaxis, which typically develops half a day after digestion. PGA has a wide range of applications in pharmaceuticals, cosmetics, and foods. Patients may develop allergic ...
Source: International Journal of Emergency Medicine - March 18, 2024 Category: Emergency Medicine Source Type: research
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages
HBV infection can result in severe liver diseases and is one of the primary causes of liver cell carcinoma-related mortality. Liuwei Wuling tablet (LWWL) is a traditional Chinese medicine formula, with a prote... (Source: Chinese Medicine)
Source: Chinese Medicine - March 18, 2024 Category: Complementary Medicine Authors: Zhixin Wu, Xiaomei Zhao, Ruisheng Li, Xinru Wen, Ye Xiu, Minjuan Long, Junjie Li, Xiuqin Huang, Jincai Wen, Xu Dong, Yingjie Xu, Zhaofang Bai, Xiaoyan Zhan and Xiaohe Xiao Tags: Research Source Type: research
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
Free Radic Biol Med. 2024 Mar 15:S0891-5849(24)00137-0. doi: 10.1016/j.freeradbiomed.2024.03.012. Online ahead of print.ABSTRACTIn various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated that hypoxia plays a role in the development of adenomyosis (AM) by inducing mitochondrial dysfunction. However, the precise involvement of the cGAS-STING signaling pathway and mtDNA in AM remains unclear. Therefore, this study aims to investigate the relationship ...
Source: Free Radical Biology and Medicine - March 17, 2024 Category: Biology Authors: Kun Wang Yi Wen Xianyun Fu Shaobin Wei Shidan Liu Minmin Chen Source Type: research
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
Free Radic Biol Med. 2024 Mar 15:S0891-5849(24)00137-0. doi: 10.1016/j.freeradbiomed.2024.03.012. Online ahead of print.ABSTRACTIn various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated that hypoxia plays a role in the development of adenomyosis (AM) by inducing mitochondrial dysfunction. However, the precise involvement of the cGAS-STING signaling pathway and mtDNA in AM remains unclear. Therefore, this study aims to investigate the relationship ...
Source: Free Radical Biology and Medicine - March 17, 2024 Category: Biology Authors: Kun Wang Yi Wen Xianyun Fu Shaobin Wei Shidan Liu Minmin Chen Source Type: research
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
Free Radic Biol Med. 2024 Mar 15:S0891-5849(24)00137-0. doi: 10.1016/j.freeradbiomed.2024.03.012. Online ahead of print.ABSTRACTIn various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated that hypoxia plays a role in the development of adenomyosis (AM) by inducing mitochondrial dysfunction. However, the precise involvement of the cGAS-STING signaling pathway and mtDNA in AM remains unclear. Therefore, this study aims to investigate the relationship ...
Source: Free Radical Biology and Medicine - March 17, 2024 Category: Biology Authors: Kun Wang Yi Wen Xianyun Fu Shaobin Wei Shidan Liu Minmin Chen Source Type: research
Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery
ConclusionsOur findings demonstrate the ability of ACE-27 to predict grade III + perioperative complications or unintended ICU admission and survival in elderly patients with AEOC. This highlights the possibility for ACE-27 to play an instrumental role in identifying AEOC patients who are more susceptible to adverse surgical outcomes and have a poor survival rate and assi sting in decisions regarding treatment. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 17, 2024 Category: Research Source Type: research
STING-activating cyclic dinucleotide-manganese nanoparticles evoke robust immunity against acute myeloid leukemia
J Control Release. 2024 Mar 14:S0168-3659(24)00174-3. doi: 10.1016/j.jconrel.2024.03.022. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) is one of the most common types of leukemia in adults with a 5-year survival rate of 30.5%. These poor patient outcomes are attributed to tumor relapse, stemming from ineffective innate immune activation, T cell tolerance, and a lack of immunological memory. Thus, new strategies are needed to activate innate and effector immune cells and evoke long-term immunity against AML. One approach to address these issues is through Stimulator of Interferon Genes (STING) pathway activati...
Source: Cancer Control - March 16, 2024 Category: Cancer & Oncology Authors: Marisa E Aikins Xiaoqi Sun Hannah Dobson Xingwu Zhou Yao Xu Yu Leo Lei James J Moon Source Type: research
Membrane Palmitoylated Protein 2 Serves as a Potential Biomarker for Colon Adenocarcinoma through Promoting CGAS-STING Pathway
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - March 16, 2024 Category: Nanotechnology Authors: Pan, Chenchen Ma, Jiheng Cui, Ying Zhang, Qiyang Sun, Siyuan Luo, Di Nie, Mengjun Huo, Jiege Hu, Canhong Tags: research-article Source Type: research
Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis–dependent intervertebral disc inflammatory degeneration
In this study, we reveal a mechanism of IVDD progression in which aberrant genomic DNA damage promoted NP cell inflammatory senescence via activation of the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) axis but not of absent in melanoma 2 (AIM2) inflammasome assembly. Ataxia-telangiectasia–mutated and Rad3-related protein (ATR) deficiency destroyed genomic integrity and led to cytosolic mislocalization of genomic DNA, which acted as a powerful driver of cGAS/STING axis–dependent inflammatory phenotype acquisition during NP cell senescence. Mechanistically, disassembly of the ATR–tripartite motif–con...
Source: Journal of Clinical Investigation - March 16, 2024 Category: Biomedical Science Authors: Weifeng Zhang, Gaocai Li, Xingyu Zhou, Huaizhen Liang, Bide Tong, Di Wu, Kevin Yang, Yu Song, Bingjin Wang, Zhiwei Liao, Liang Ma, Wencan Ke, Xiaoguang Zhang, Jie Lei, Chunchi Lei, Xiaobo Feng, Kun Wang, Kangcheng Zhao, Cao Yang Source Type: research
The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
Cancer Immunol Res. 2024 Mar 18. doi: 10.1158/2326-6066.CIR-23-1078. Online ahead of print.ABSTRACTThe DNA exonuclease TREX1 (Three-prime repair exonuclease 1) is critical for preventing autoimmunity in mice and humans by degrading endogenous cytosolic DNA, which otherwise triggers activation of the innate cGAS/STING pathway leading to the production of type I IFNs. Since tumor cells are prone to aberrant cytosolic DNA accumulation, we hypothesized that they are critically dependent on TREX1 activity to limit their immunogenicity. Here we show, that in tumor cells TREX1 indeed restricts the spontaneous activation of the cG...
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Junghyun Lim Ryan Rodriguez Katherine Williams John Silva Alan G Gutierrez Paul Tyler Faezzah Baharom Tao Sun Eva Lin Scott Martin Brandon D Kayser Robert J Johnston Ira Mellman L élia Delamarre Nathaniel R West S ören Müller Yan Qu Klaus Heger Source Type: research
Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice
Prostatitis is a highly prevalent condition that seriously affects men ’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep a... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 15, 2024 Category: Molecular Biology Authors: Jia Chen, Wenming Ma, Shaoyu Yue, Dongsheng Li, Lei Chen, Cheng Zhang, Yu Guan, Chun Li, Changqin Jiang, Guiyi Liao, Chaozhao Liang, Hui Wang and Sheng Tai Tags: Research Source Type: research
