Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
We aimed to screen novel gene signatures for ovarian cancer (OC) and explore the role of biomarkers in OC via regulating pyroptosis using bioinformatics analysis. (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Wei Xie, Leiying Zhang, Junjing Shen, Fengdi Lai, Wenling Han and Xiaoyan Liu Tags: Research Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print.ABSTRACTEndothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nu...
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-Hua Zheng Jiao-Jiao Wang Jiu-Guo Lin Wei-le Ye Jia-Mi Zou Li-Yin Liang Ping-Lian Yang Wan-Lu Qiu Yuan-Yuan Li Si-Jia Yang Man Zhao Qing Zhou Cheng-Zhi Li Min Li Zhuo-Ming Li Dong-Mei Zhang Pei-Qing Liu Zhi-Ping Liu Source Type: research
Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy
This study provided a new paradigm for intensifying immune activation by constructing metal coordination nanotheranostics.PMID:38685387 | DOI:10.1016/j.jconrel.2024.04.042 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Lianyi Yang Yazhen Wang Yujun Song Zeya Li Lei Lei Hanmei Li Bin He Jun Cao Huile Gao Source Type: research
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization
CONCLUSION: These results suggest that sevoflurane can regulate microglial M1 polarization by activating the cGAS/STING signaling pathway and increasing immune factor release, thus accelerating the neuronal necroptosis induced by calcium overload.PMID:38688381 | DOI:10.1016/j.cellsig.2024.111195 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Qi Zhang Yanan Li Yanqin Liu Xin Wang Yonghui Yang Lei Shi Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print.ABSTRACTEndothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nu...
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-Hua Zheng Jiao-Jiao Wang Jiu-Guo Lin Wei-le Ye Jia-Mi Zou Li-Yin Liang Ping-Lian Yang Wan-Lu Qiu Yuan-Yuan Li Si-Jia Yang Man Zhao Qing Zhou Cheng-Zhi Li Min Li Zhuo-Ming Li Dong-Mei Zhang Pei-Qing Liu Zhi-Ping Liu Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print.ABSTRACTEndothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nu...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Zhi-Hua Zheng Jiao-Jiao Wang Jiu-Guo Lin Wei-le Ye Jia-Mi Zou Li-Yin Liang Ping-Lian Yang Wan-Lu Qiu Yuan-Yuan Li Si-Jia Yang Man Zhao Qing Zhou Cheng-Zhi Li Min Li Zhuo-Ming Li Dong-Mei Zhang Pei-Qing Liu Zhi-Ping Liu Source Type: research
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization
CONCLUSION: These results suggest that sevoflurane can regulate microglial M1 polarization by activating the cGAS/STING signaling pathway and increasing immune factor release, thus accelerating the neuronal necroptosis induced by calcium overload.PMID:38688381 | DOI:10.1016/j.cellsig.2024.111195 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Qi Zhang Yanan Li Yanqin Liu Xin Wang Yonghui Yang Lei Shi Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print.ABSTRACTEndothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of EC senescence has not been completely elucidated, and so far, there is no specific drug in the clinic to treat EC senescence and vascular aging. Here we show that various aging stimuli induce nu...
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-Hua Zheng Jiao-Jiao Wang Jiu-Guo Lin Wei-le Ye Jia-Mi Zou Li-Yin Liang Ping-Lian Yang Wan-Lu Qiu Yuan-Yuan Li Si-Jia Yang Man Zhao Qing Zhou Cheng-Zhi Li Min Li Zhuo-Ming Li Dong-Mei Zhang Pei-Qing Liu Zhi-Ping Liu Source Type: research
Glycemic variability is associated with sural nerve conduction velocity in outpatients with type 2 diabetes: Usefulness of a new point‐of‐care device for nerve conduction studies
ConclusionsIn outpatients with type 2 diabetes, multiple CGM-derived GV metrics were significantly associated with SCV obtained by DPNCheck ™. GV may have independent impacts on peripheral nerve function, particularly in patients with well-controlled HbA1c levels. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 30, 2024 Category: Endocrinology Authors: Machiko Morita,
Kentaro Sada,
Shuji Hidaka,
Miki Ogawa,
Hirotaka Shibata Tags: Original Article Source Type: research
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacologica Sinica, Published online: 30 April 2024; doi:10.1038/s41401-024-01281-0Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 30, 2024 Category: Drugs & Pharmacology Authors: Zhi-hua Zheng Jiao-jiao Wang Jiu-guo Lin Wei-le Ye Jia-mi Zou Li-yin Liang Ping-lian Yang Wan-lu Qiu Yuan-yuan Li Si-jia Yang Man Zhao Qing Zhou Cheng-zhi Li Min Li Zhuo-ming Li Dong-mei Zhang Pei-qing Liu Zhi-ping Liu Source Type: research
Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma
Cell Death & Disease, Published online: 29 April 2024; doi:10.1038/s41419-024-06685-8Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma (Source: Cell death and disease)
Source: Cell death and disease - April 29, 2024 Category: Internal Medicine Authors: Xin Li Yu-Fei Pan Yi-Bin Chen Qian-Qian Wan Yun-Kai Lin Tai-Yu Shang Meng-You Xu Tian-Yi Jiang Meng-Miao Pei Ye-Xiong Tan Li-Wei Dong Xu-Ying Wan Source Type: research
Poisoning by venomous animals
Poisoning by venomous creatures is common. Most is benign, causing only minor irritation or pain, but rarely significant morbidity and mortality can occur. Medically important venomous creatures include snakes, spiders, scorpions and marine creatures. For suspected cases of severe envenoming, seek early expert advice from a clinical toxicologist or poisons information centre. First aid measures include pressure bandaging of the affected limb with immobilization in suspected snakebite and funnel web spider bite, and hot water immersion therapy for many marin e stings. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Katherine Z. Isoardi, Geoffrey K. Isbister Tags: Poisonous substances Source Type: research
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Biochem Biophys Res Commun. 2024 Apr 23;715:149979. doi: 10.1016/j.bbrc.2024.149979. Online ahead of print.ABSTRACTEndothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS affects the initiation and progression of atherosclerosis remains to be explored. Here, we first reported that OSS can promote endothelial dysfunction and atherogenesis in vivo and in vitro by activating STING path...
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Mengdie Dong Minghong Chen Yunjia Zhang Xian He Jiao Min Yongkang Tan Huiyuan Wei Xinyu Li Xiang Chen Longbin Zheng Quanwen Yin Xuesong Li Hongshan Chen Hong Jiang Source Type: research
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Biochem Biophys Res Commun. 2024 Apr 23;715:149979. doi: 10.1016/j.bbrc.2024.149979. Online ahead of print.ABSTRACTEndothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS affects the initiation and progression of atherosclerosis remains to be explored. Here, we first reported that OSS can promote endothelial dysfunction and atherogenesis in vivo and in vitro by activating STING path...
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Mengdie Dong Minghong Chen Yunjia Zhang Xian He Jiao Min Yongkang Tan Huiyuan Wei Xinyu Li Xiang Chen Longbin Zheng Quanwen Yin Xuesong Li Hongshan Chen Hong Jiang Source Type: research
Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
Cell Rep Med. 2024 Apr 23:101528. doi: 10.1016/j.xcrm.2024.101528. Online ahead of print.ABSTRACTStimulator of interferon genes (STING)-dependent signaling is requisite for effective anti-microbial and anti-tumor activity. STING signaling is commonly defective in cancer cells, which enables tumor cells to evade the immunosurveillance system. We evaluate here whether intrinsic STING signaling in such tumor cells could be reconstituted by creating recombinant herpes simplex viruses (rHSVs) that express components of the STING signaling pathway. We observe that rHSVs expressing STING and/or cGAS replicate inefficiently yet re...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Tiphaine Delaunay Sehee Son Seongji Park Balveen Kaur Jeonghyun Ahn Glen N Barber Source Type: research
