Growth Arrest ‐Specific 6 Modulates Adiponectin Expression and Insulin Resistance in Adipose Tissue
ConclusionsOur results suggest that Gas6 may modulate the expression of adiponectin and may therefore be associated with insulin resistance in adipose tissues. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 24, 2020 Category: Endocrinology Authors: Sheng ‐Chiang Su, Chi‐Fu Chiang, Chang‐Hsun Hsieh, Giieh‐Hua Lu, Jhih‐Syuan Liu, Yi‐Shing Shieh, Yi‐Jen Hung, Chien‐Hsing Lee Tags: ORIGINAL ARTICLE Source Type: research

In search of the optimal management strategy for non ‐alcoholic fatty liver disease in type 2 diabetes patients
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 24, 2020 Category: Endocrinology Authors: Chi ‐Ho Lee, David Tak‐Wai Lui, Karen Siu‐Ling Lam Tags: JDI Updates Source Type: research

Sodium ‐glucose Cotransporter 2 Inhibitors‐ a Drug with Anti‐diabetic and Cardioprotective Properties
AbstractRecently, two large double ‐blind randomized controlled trials testing the effect of sodium‐glucose cotransporter 2 (SGLT2) inhibitors in patients with heart failure with and without diabetes have led to a paradigm shift for the indication of this class of drugs. Key clinical features and main results in these two studies are summarized in Table 1 and 2. The dapagliflozin and prevention of adverse outcomes in heart failure (DAPA‐HF) trial included 4744 patients with heart failure and a reduced ejection fraction (HFrEF). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 23, 2020 Category: Endocrinology Authors: Hung ‐Yuan Li Tags: COMMENTARY Source Type: research

Serum vaspin levels are positively associated with diabetic retinopathy in patients with type  2 diabetes mellitus
This study showed that higher vaspin serum levels were associated with increased risk of diabetic retinopathy and vision ‐threatening diabetic retinopathy in patients with type 2 diabetes, which showed that vaspin is an important indicator factor for diabetic retinopathy. AbstractAims/IntroductionVaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision ‐threatening DR.Materials and MethodsThis was a cross ‐sectional singl...
Source: Journal of Diabetes Investigation - September 22, 2020 Category: Endocrinology Authors: Hong ‐Wei Yang, Yong‐gang Huang, Chun‐liu Gai, Guang‐rui Chai, Shufang Lee Tags: Original Article Source Type: research

Frequency of consumption of balanced meals, bodyweight gain and incident risk of glucose intolerance in Japanese men and women: A cohort study
ConclusionsA higher frequency of balanced meals, including grain, fish or meat and vegetable dishes – important components of healthy Japanese food – was associated with a lower risk of glucose intolerance in obese men, but not in non‐obese men and women. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2020 Category: Endocrinology Authors: Masaru Sakurai, Masao Ishizaki, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Yuki Nakashima, Chiaki Okamoto, Kazuhiro Nogawa, Yuuka Watanabe, Yasushi Suwazono, Atsushi Hozawa, Katsushi Yoshita, Hideaki Nakagawa Tags: Original Article Source Type: research

Prevalence and factors associated with non ‐alcoholic fatty liver disease in Indian women with a history of gestational diabetes mellitus
ConclusionsThe prevalence of NAFLD is high in women with prior GDM. Such women also have a high burden of cardiometabolic risk factors. Future studies should evaluate the intermediate and long ‐term hepatic and cardiovascular risk and the impact of lifestyle interventions in reducing morbidity in such women. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2020 Category: Endocrinology Authors: Suraj Kubihal, Yashdeep Gupta, Shalimar, Devasenathipathy Kandasamy, Alpesh Goyal, Kalaivani Mani, Ankur Goyal, Saurabh Kedia, Garima Kachhawa, Samita Ambekar, Divya Bhatia, Vineeta Garg, Nandita Gupta, Nikhil Tandon Tags: ORIGINAL ARTICLE Source Type: research

Phase  III, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of teneligliptin monotherapy in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise
This multicenter, randomized, double ‐blind, placebo‐controlled, parallel‐group study evaluated the efficacy and safety of teneligliptin monotherapy compared with a placebo in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise. To assess efficacy (primary efficacy end‐point: glycosyla ted hemoglobin from baseline to week 24) and safety (incidence of adverse events and adverse drug reactions), eligible type 2 diabetes patients were assigned in a 1:1 ratio to treatment with teneligliptin 20 mg or a placebo, administered orally once daily before breakfast ...
Source: Journal of Diabetes Investigation - September 20, 2020 Category: Endocrinology Authors: Linong Ji, Jianhua Ma, Weiping Lu, Jingdong Liu, Jiao ’e Zeng, Jialin Yang, Wei Li, Xiuzhen Zhang, Xinhua Xiao, Gen Takayanagi, Yi Wang Tags: Clinical Trial Source Type: research

Sodium –glucose cotransporter inhibitors as add‐on therapy in addition to insulin for type 1 diabetes mellitus: A meta‐analysis of randomized controlled trials
The present meta ‐analysis analyzed the efficacy and safety of sodium–glucose co‐transporter (SGLT) 2 inhibitors and dual SGLT1/2 inhibitors added to insulin for patients with type 1 diabetes, and carried out a subgroup analysis between SGLT2 inhibitors and dual SGLT1/2 inhibitors. Our results showed that SG LT inhibitors as add‐on therapy is associated with improved glycemic control, but increased risk for urinary tract infections and diabetic ketoacidosis, proving the potential benefits of SGLT inhibitors with careful use for type 1 diabetes patients. AbstractAims/IntroductionSeveral clinical t...
Source: Journal of Diabetes Investigation - September 19, 2020 Category: Endocrinology Authors: Hailan Zou, Lili Liu, Jia Guo, Hongjuan Wang, Siyun Liu, Yixuan Xing, Chao Deng, Yang Xiao, Zhiguang Zhou Tags: Original Article Source Type: research

Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type  2 diabetes patients
The association between fructosamine and glycated hemoglobin is significantly reduced in the most obese type  2 diabetes patients, and this is mostly driven by increased fat mass. AbstractObesity is increasing in patients with type  2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been s tudied. We studied 112 type 2 diabetes patients with assessment of fat mass, li...
Source: Journal of Diabetes Investigation - September 17, 2020 Category: Endocrinology Authors: Bruno Verg ès, Alexia Rouland, Sabine Baillot‐Rudoni, Marie‐Claude Brindisi, Laurence Duvillard, Isabelle Simoneau, Pauline Legris, Jean‐Michel Petit, Benjamin Bouillet Tags: Short Report Source Type: research

Efficacy of mesenchymal stem cells therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta ‐Analysis
ConclusionsThis meta ‐analysis of prospective studies showed associations between mesenchymal stem cell therapy and control of glucose level in patients with type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 14, 2020 Category: Endocrinology Authors: Hossein Ranjbaran, Bahareh Mohammadi ‐Joubani, Elham Amirfakhrian, Reza Alizadeh‐Navaei Tags: ORIGINAL ARTICLE Source Type: research

East Asian diet ‐mimicking diet plan based on the Mediterranean diet and the Dietary Approaches to Stop Hypertension diet in adults with type 2 diabetes: A randomized controlled trial
ConclusionWith the provision of ready meals, the glycemic benefits of the investigational diet plan were demonstrable over a self ‐prepared food exchange system‐based diet in Korean adults with established type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 14, 2020 Category: Endocrinology Authors: Sang ‐Man Jin, Jiyeon Ahn, Jiyun Park, Kyu Yeon Hur, Jae Hyeon Kim, Moon‐Kyu Lee Tags: Clinical Trial Source Type: research

Point ‐of‐care nerve conduction device predicts the severity of diabetic polyneuropathy: A quantitative, but easy‐to‐use, prediction model
ConclusionsNerve conduction parameters in the sural nerve acquired by the handheld device successfully predict the severity of DPN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 14, 2020 Category: Endocrinology Authors: Hideki Kamiya, Yuka Shibata, Tatsuhito Himeno, Hiroya Tani, Takayuki Nakayama, Kenta Murotani, Nobuhiro Hirai, Miyuka Kawai, Yuriko Asada ‐Yamada, Emi Asano‐Hayami, Hiromi Nakai‐Shimoda, Yuichiro Yamada, Takahiro Ishikawa, Yoshiaki Mori Tags: Original Article Source Type: research

Thresholds for postprandial hyperglycemia and hypertriglyceridemia associated with increased mortality risk in type two diabetes patients: A real ‐world longitudinal study
AbstractAims/IntroductionTo identify thresholds for postprandial hyperglycemia and hypertriglyceridemia predictive of all ‐cause mortality in patients with type 2 diabetes.Materials and MethodsA total of 1928 patients with type 2 diabetes visited our clinic for the first time from 1995 –1999 and were followed up for ≥1 year. During the first year, 2‐h post‐breakfast blood glucose (2h‐BG) levels were measured in 1122 patients (BG cohort) and postprandial serum triglyceride (ppTG) levels were measured in 1826 patients (TG cohort). Patients were retrospectively followed unt il 2017 and administered questionna...
Source: Journal of Diabetes Investigation - September 12, 2020 Category: Endocrinology Authors: Toshiko Takao, Machi Suka, Hiroyuki Yanagisawa, Masato Kasuga Tags: ORIGINAL ARTICLE Source Type: research

Current Concepts in the Management of Diabetic Polyneuropathy
In conclusion, multimodal treatment of DSPN should consider the individual risk profile, pathogenetic treatment, and pain management using pharmacotherapy (combinations, if needed) as well as non‐pharmacological options. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 12, 2020 Category: Endocrinology Authors: Dan Ziegler, Nikolaos Papanas, Oliver Schnell, Dao Thi Nguyen Bich, Khue Thy Nguyen, Kongkiat Kulkantrakorn, Chaicharn Deerochanawong Tags: REVIEW Source Type: research

Risk factors for abnormal postpartum glycemic states in women diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study Groups criteria
ConclusionsLess than one third of GDM women underwent PGST and nearly one third of these women had abnormal results. Future efforts should focus on reducing the barriers to PGST in women with GDM. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 11, 2020 Category: Endocrinology Authors: Tai ‐Ho Hung, Ya‐Chun Chuang, Fu‐Chieh Chu, Lulu Huang, Steven W. Shaw, T’sang‐T’ang Hsieh, Szu‐Fu Chen Tags: ORIGINAL ARTICLE Source Type: research

Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non ‐obese non‐diabetic men
AbstractAimsA low insulin secretion capacity has been implicated in the high prevalence of non ‐obese diabetes in East Asians. Since alcohol consumption alters insulin and glucose metabolism, we tested the hypothesis that alcohol consumption contributes to impaired insulin secretion and glucose intolerance in lean/normal‐weight non‐diabetic Japanese men.MethodsThis cross ‐sectional study was undertaken among the residents of Shika town, Japan between 2011 and 2017. A total of 402 non‐diabetic men, including participants with normal fasting plasma glucose (FPG) and impaired FPG (FPG 5.6 ‐ 6.9 mmol/l) and ag...
Source: Journal of Diabetes Investigation - September 10, 2020 Category: Endocrinology Authors: Sakae Miyagi, Toshinari Takamura, Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Akinori Hara, Haruki Nakamura, Keita Suzuki, Atsushi Tajima, Takayuki Kannon, Tadashi Toyama, Yasuhiro Kambayashi, Hiroyuki Nakamura Tags: ORIGINAL ARTICLE Source Type: research

Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
The role of dysregulated pyruvate dehydrogenase kinase in several diseases is herein reviewed. This review deals with the role of pyruvate dehydrogenase kinases in the muscle, liver and immune system, which contributes to the pathogenesis of a various spectrum of metabolic diseases. AbstractGood health depends on the maintenance of metabolic flexibility, which in turn is dependent on the maintenance of regulatory flexibility of a large number of regulatory enzymes, but especially the pyruvate dehydrogenase complex (PDC), because of its central role in carbohydrate metabolism. Flexibility in regulation of PDC is dependent o...
Source: Journal of Diabetes Investigation - September 10, 2020 Category: Endocrinology Authors: Jae ‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee Tags: Review Article Source Type: research

Mediation Effect of the Duration of Diabetes Mellitus on the Decrease in Bioimpedance Phase Angles in ethnically Korean People – a Multicenter Clinical Study
AbstractAimsWe performed a multicenter clinical study to investigate whether the decrease in segmental phase angles (PhA values) observed using bioelectrical impedance is useful in screening for diabetes mellitus and monitoring disease progression.Materials and MethodsThe segmental PhA values of the four limbs were acquired using multifrequency bioimpedance at 5, 50 and 250 kHz in three clinics. Differences in PhA values between the diabetes and control groups were analyzed using the two ‐sample t‐test and analysis of variance (ANOVA). Changes in PhA values with increasing durations of diabetes were analyzed using a mo...
Source: Journal of Diabetes Investigation - September 9, 2020 Category: Endocrinology Authors: Min ‐Ho Jun, Boncho Ku, Jihye Kim, Keun Ho Kim, Jaeuk U. Kim Tags: ORIGINAL ARTICLE Source Type: research

Relationships between gut microbiota, plasma glucose and gestational diabetes mellitus
ConclusionsOur results show the relationship between changed gut microbiota composition in the second trimester of pregnancy before the diagnosis of GDM and fasting serum levels of metabolites, which might inform the diagnosis, prevention and treatment of GDM. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 9, 2020 Category: Endocrinology Authors: Ting Chen, Yuqing Zhang, Yiyun Zhang, Chunjian Shan, Yingying Zhang, Kacey Fang, Yankai Xia, Zhonghua Shi Tags: Original Article Source Type: research

Effect of the FreeStyle Libre ™ flash glucose monitoring system on glycemic control in individuals with type 2 diabetes treated with basal–bolus insulin therapy: An open label, prospective, multicenter trial in Japan
Use of flash glucose monitoring technology in Japanese subjects with type 2 diabetes, treated with multiple daily insulin injections, resulted in increased time in range and decreased time in hyperglycemia without increasing hypoglycemia. AbstractAims/IntroductionWe investigated the effect of FreeStyle LibreTM on glycemic control in Japanese type  2 diabetes patients treated with basal–bolus insulin therapy.Materials and MethodsThis prospective, 90 ‐day single‐arm study enrolled 94 adults with type 2 diabetes treated with insulin. A 14‐day masked baseline phase was followed by an 11‐week treatment p...
Source: Journal of Diabetes Investigation - September 9, 2020 Category: Endocrinology Authors: Wataru Ogawa, Yushi Hirota, Takeshi Osonoi, Takahiro Tosaki, Yoshiro Kato, Kazunori Utsunomiya, Rimei Nishimura, Jiro Nakamura Tags: Clinical Trial Source Type: research

Recognition of maturity ‐onset diabetes of the young in China
Flow chart of the procedures for screening of MODY mutations. AbstractAims/IntroductionGiven that mutations related to maturity ‐onset diabetes of the young (MODY) are rarely found in Chinese populations, we aim to characterize the mutation spectrum of MODY pedigrees.Materials and MethodsMaturity ‐onset diabetes of the young candidate gene‐ or exome‐targeted capture sequencing was carried out in 76 probands from unrelated families fulfilling the clinical diagnostic criteria for MODY. MAF
Source: Journal of Diabetes Investigation - September 9, 2020 Category: Endocrinology Authors: Hua Liang, Yanan Zhang, Maixinyue Li, Jinhua Yan, Daizhi Yang, Sihui Luo, Xueying Zheng, Guoqing Yang, Zhuo Li, Wen Xu, Leif Groop, Jianping Weng Tags: Original Article Source Type: research

Issue Information
Journal of Diabetes Investigation, Volume 11, Issue 5, Page 1077-1078, September 2020. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 8, 2020 Category: Endocrinology Tags: Issue Information Source Type: research

Trends in the effects of pre ‐transplant diabetes on mortality and cardiovascular events after kidney transplantation
AbstractAimsIt is not clear whether survival in kidney transplant recipients with pre ‐transplant diabetes has improved over the past decades. We compared the rates of mortality and major adverse cardiovascular events (MACE) after renal transplantation in patients with and without pre‐transplant diabetes. Furthermore, we investigated whether transplant era and recipient age affec ted the association between diabetes status and adverse events.MethodsThis retrospective cohort study included 691 patients who underwent renal transplantation between 1994 and 2016 at a single tertiary center. We compared the incidences of po...
Source: Journal of Diabetes Investigation - September 7, 2020 Category: Endocrinology Authors: Ja Young Jeon, Soo Jung Kim, Kyoung Hwa Ha, Ji Hyun Park, Bumhee Park, Chang ‐Kwon Oh, Seung Jin Han Tags: ORIGINAL ARTICLE Source Type: research

Effect of hypertriglyceridemia in dyslipidemia ‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study
ConclusionsHypertriglyceridemia is a stronger risk factor for impaired glucose tolerance than increased LDL or decreased HDL. For dietary habits, increased daily alcohol energy intake in non ‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 7, 2020 Category: Endocrinology Authors: Yukiko Nonoyama, Mayumi Yamamoto, Shino Oba, Yukio Horikawa, Chisato Nagata, Daisuke Yabe, Jun Takeda, Gifu Diabetes Study Group Tags: ORIGINAL ARTICLE Source Type: research

Association between the triglyceride –glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross‐sectional study
The triglyceride –glucose index provides an affordable and easily interpreted biomarker for monitoring the degree of insulin resistance, and was independently associated with diabetic nephropathy in patients with type 2 diabetes. It was a better marker than homeostasis model assessment for insulin resistance for identification of diabetic nephropathy in type 2 diabetes patients. AbstractAims/IntroductionThe triglyceride –glucose (TyG) index has been proposed as a reliable and simple marker of insulin resistance. We investigated the association between TyG index and diabetic nephropathy (DN) in patient...
Source: Journal of Diabetes Investigation - September 7, 2020 Category: Endocrinology Authors: Li Liu, Rui Xia, Xiaoqing Song, Benping Zhang, Wentao He, Xinrong Zhou, Shengzhong Li, Gang Yuan Tags: Original Article Source Type: research

Association of time in range, as assessed by continuous glucose monitoring, with painful diabetic polyneuropathy
This study aimed to evaluate the association between time in range (TIR) obtained from continuous glucose monitoring and the prevalence and degree of painful diabetic neuropathy (PDN).Materials and methodsA total of 364 subjects with diabetic peripheral neuropathy (DPN) were enrolled in this study. Sensor ‐based flash glucose monitoring systems were used to monitor the subjects’ glucose levels, and the glycemic variability (GV) metrics were calculated, including the TIR, glucose coefficient of variation, standard deviation, and the mean amplitude of glycemic excursions. The participants were aske d to record any fo...
Source: Journal of Diabetes Investigation - September 3, 2020 Category: Endocrinology Authors: Junpeng Yang, Xueli Yang, Dongni Zhao, Xiaobing Wang, Wei Wei, Huijuan Yuan Tags: ORIGINAL ARTICLE Source Type: research

Effect of AMPK ‐p53‐klf2a Pathway in Hyperglycemia‐induced Cardiac Remodeling in Adult Zebrafish
AbstractIntroductionsDiabetic cardiomyopathy is a type of myocardial disease. It causes left ventricular hypertrophy, followed by diastolic and systolic dysfunction, eventually leading to congestive heart failure. However, the underlying mechanism still requires further elucidation.Materials and MethodsHigh glucose zebrafish model was constructed by administrating streptozocin intraperitoneally to enhance the development of cardiomyopathy, and then treated with AMPK activator. Cardiac structure and function, protein and gene expression were then analyzed. Cardiomyocytes culture in vitro using lentivirus were used for detec...
Source: Journal of Diabetes Investigation - September 3, 2020 Category: Endocrinology Authors: Quiyun Wang, Chen Luo, Guoping Lu, Zhenyue Chen Tags: ORIGINAL ARTICLE Source Type: research

Prediabetes and long ‐term outcomes in patients with three‐vessel coronary artery disease: A large single‐center cohort study
This study evaluated the relationship between different glycemic status and clinical outcomes in this specific population.Materials and MethodsThis study included 8,891 Chinese patients with three ‐vessel disease. Patients were categorized according to their glycemic status (normoglycemia [NG],n = 3,195; prediabetes,n = 1,978; diabetes mellitus,n = 3,718).ResultsThe median follow ‐up time was 7.5 years, during which 1,354 deaths and 2,340 major adverse cardiac and cerebrovascular events occurred. Compared with the NG group, patients in the prediabetes and diabetes mellitus groups had ...
Source: Journal of Diabetes Investigation - September 2, 2020 Category: Endocrinology Authors: Deshan Yuan, Ce Zhang, Sida Jia, Lin Jiang, Lianjun Xu, Yin Zhang, Jingjing Xu, Bo Xu, Rutai Hui, Runlin Gao, Zhan Gao, Lei Song, Jinqing Yuan Tags: Original Article Source Type: research

microRNA ‐23a‐3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of NLRP3 inflammatory bodies‐caused pyroptosis through negatively regulating NEK7
ConclusionsTargeting NEK7 by miR ‐23a‐3p could reduce NLRP3‐induced pyroptosis and assuage liver and kidney injuries in T2DM rats. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 2, 2020 Category: Endocrinology Authors: Hongye Chang, Hongjuan Chang, Tuanjie Cheng, Donghang Li, Xiaoping Chen, Kunqing Qi Tags: ORIGINAL ARTICLE Source Type: research

Anthropometry did not approach adequate predictive accuracies for detecting elevated FPG or HbA1c levels among 7 −9 years Chinese children
ConclusionsNone of the evaluated anthropometric indicators approached an adequate predictive accuracy for the detection of elevated FPG or HbA1c levels in Shenzhen children of 7 −9 years. The current study did not recommend anthropometry screening for pre‐diabetes in young children. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 2, 2020 Category: Endocrinology Authors: Ying ‐Bin You, Hua Zhou, Jing Han, Yan‐Hui Zhu, Ding Zan, Qing‐Ying Zhang Tags: ORIGINAL ARTICLE Source Type: research

Microencapsulation of cells and molecular therapy of type  1 diabetes mellitus: The actual state and future perspectives between promise and progress
AbstractThe history of microencapsulation of live cells started with an idea of Thomas MS Chang in 1964, thereafter applied to isolated pancreatic islets by Anthony M Sun in 1980. The original aim was to provide isolated cells with an immune ‐protective shield, to prevent physical contact between the transplanted cells and the host’s immune system, with retention of the microcapsules’ biocompatibility and physical–chemical properties over time. In particular, this revolutionary approach essentially applied to islet grafts, in di abetic recipients who are not immunosuppressed, at a preclinical (rodents) ...
Source: Journal of Diabetes Investigation - September 2, 2020 Category: Endocrinology Authors: Giuseppe Basta, Pia Montanucci, Riccardo Calafiore Tags: Review Article Source Type: research

Dietary fiber intake and risk of type  2 diabetes in a general Japanese population: The Hisayama Study
ConclusionsThe present study showed that higher dietary fiber intake was associated with a lower risk of type  2 diabetes in a general Japanese population. The intake of high dietary fiber foods might be useful for diabetes prevention. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2020 Category: Endocrinology Authors: Yasumi Kimura, Daigo Yoshida, Yoichiro Hirakawa, Jun Hata, Takanori Honda, Mao Shibata, Satoko Sakata, Kazuhiro Uchida, Takanari Kitazono, Toshiharu Ninomiya Tags: Original Article Source Type: research

Clinical inertia in patients with type  2 diabetes treated with oral antidiabetic drugs: Results from a Japanese cohort study (JDDM53)
ConclusionsReal ‐world data here show clinical inertia in Japanese adults with type 2 diabetes from early diabetes stages when they are receiving OADs, and illustrate a need for earlier, more effective OADs or injectable treatment intensification and better communication around the existence of clinical inertia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2020 Category: Endocrinology Authors: Hiroshi Maegawa, Yasushi Ishigaki, Jakob Langer, Ai Saotome ‐Nakamura, Marc Andersen, on behalf of the Japan Diabetes Clinical Data Management (JDDM) Study Group Tags: Original Article Source Type: research

Frequency of consumption of balanced meals, body weight gain, and incident risk of glucose intolerance in Japanese men and women: a cohort study
ConclusionsA higher frequency of balanced meals, including grain, fish or meat, and vegetable dishes, important components of healthy Japanese food, was associated with a lower risk of glucose intolerance in obese men, but not in non ‐obese men and women. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 31, 2020 Category: Endocrinology Authors: Masaru Sakurai, Masao Ishizaki, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Yuki Nakashima, Chiaki Okamoto, Kazuhiro Nogawa, Yuuka Watanabe, Yasushi Suwazono, Atsushi Hozawa, Katsushi Yoshita, Hideaki Nakagawa Tags: ORIGINAL ARTICLE Source Type: research

Advancements in transplantation therapy for diabetes: Pancreas, islet and stem cell
This article summarizes recent developments in transplantation therapy for diabetes as well as research on the use of stem cells for complications of diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 27, 2020 Category: Endocrinology Authors: Toshihiro Nakamura, Junji Fujikura, Nobuya Inagaki Tags: Jdi Updates Source Type: research

Different interaction of onset age and duration of type  1 diabetes on the dynamics of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8
In the present study, we showed that there was a significant interaction between the onset age and duration of diabetes in patients diagnosed when aged ≤10 years regarding all of the autoantibodies to insulinoma‐associated antigen‐2, zinc transporter 8 and glutamic acid decarboxylase (P 
Source: Journal of Diabetes Investigation - August 26, 2020 Category: Endocrinology Authors: Eiji Kawasaki, Yoichi Oikawa, Akira Okada, Norio Kanatsuna, Tomoyuki Kawamura, Tadashi Kikuchi, Jungo Terasaki, Junnosuke Miura, Yoshihisa Itoh, Toshiaki Hanafusa Tags: Original Article Source Type: research

Angiotensin ‐converting enzyme 2 as a versatile player in the management of coronavirus disease 2019
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 25, 2020 Category: Endocrinology Authors: Tetsuya Amano Tags: Commentary Source Type: research

Safety and effectiveness of tofogliflozin in Japanese patients with type  2 diabetes mellitus treated in real‐world clinical practice: Results of a 36‐month post‐marketing surveillance study (J‐STEP/LT)
Japanese Study of Tofogliflozin with Type  2 Diabetes Mellitus Patients/Long Term was a 3‐year, prospective, observational and post‐marketing study of patients who received tofogliflozin, a sodium–glucose cotransporter 2 inhibitor, in usual clinical practice in Japan. There were no unprecedented adverse drug reactions. Reductions fr om baseline in HbA1c and bodyweight were maintained over the observation period. AbstractAims/IntroductionTofogliflozin is a sodium –glucose cotransporter 2 (SGLT2) inhibitor that lowers plasma glucose levels by enhancing urinary glucose excretion. After its appro...
Source: Journal of Diabetes Investigation - August 25, 2020 Category: Endocrinology Authors: Kazunori Utsunomiya, Ryusuke Koshida, Seigo Kakiuchi, Masayuki Senda, Shoko Fujii, Yuji Kurihara, Ryoji Gunji, Kohei Kaku Tags: Original Article Source Type: research

Rapid and dramatic glucose ‐lowering effect of bromocriptine in an inadequately controlled type 2 diabetes patient with prolactinoma
The areas of time above range (>180  mg/dL, shown in yellow) almost disappeared immediately after bromocriptine administration. AbstractDopamine receptor agonists are typically used to treat Parkinson ’s disease and certain pituitary tumors, such as prolactinoma or a growth hormone‐producing tumor. A 53‐year‐old woman with a history of prolactinoma was referred to Kumamoto University Hospital (Kumamoto, Japan) with poorly controlled type 2 diabetes. Her glycated hemoglobin and serum prol actin levels were increased (8.8% and 160.3 ng/mL, respectively). Bromocriptine, a dopamine D2 recepto...
Source: Journal of Diabetes Investigation - August 25, 2020 Category: Endocrinology Authors: Motoyuki Igata, Yoshitaka Yagi, Satoko Hanatani, Masaji Sakaguchi, Norio Ishii, Kayo Yoshinaga, Junji Kawashima, Hiroyuki Motoshima, Eiichi Araki Tags: Case Report Source Type: research

Is it possible to predict the onset of nocturnal asymptomatic hypoglycemia in patients with type  1 diabetes receiving insulin degludec? Potential role of previous day and next morning glucose values
This study examined patients with type  1 diabetes who underwent continuous glucose monitoring assessments and received insulin degludec. NSH was defined as glucose level
Source: Journal of Diabetes Investigation - August 25, 2020 Category: Endocrinology Authors: Hiroshi Takahashi, Rimei Nishimura Tags: Original Article Source Type: research

Role of O ‐linked N‐acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications
This article briefly reviews recent studies related with role of O ‐linked N‐acetylglucosamine modification in specific organs in diabetes and its complications. AbstractRecent studies using genetically manipulated mouse models have shown the pivotal role of O ‐linked N‐acetylglucosamine modification (O‐GlcNAcylation) in the metabolism of multiple organs. The molecular mechanism involves the sensing of glucose flux by the hexosamine biosynthesis pathway, which leads to the adjustment of cellular metabolism to protect against changes in the environme nt of each organ through O‐GlcNAcylation. More recently, not o...
Source: Journal of Diabetes Investigation - August 25, 2020 Category: Endocrinology Authors: Katsutaro Morino, Hiroshi Maegawa Tags: Review Article Source Type: research

In search of the optimal management strategy for non ‐alcoholic fatty liver disease in type 2 diabetes
AbstractNon ‐alcoholic fatty liver disease (NAFLD) is present in over two‐thirds of individuals with type 2 diabetes. Diabetes increases the risk of NAFLD progression, especially the development of non‐alcoholic steatohepatitis (NASH), advanced fibrosis (AF; defined as fibrosis stage ≥3), and hepatocell ular carcinoma (HCC) (1). On the other hand, NAFLD also puts patients at a higher risk of cardiovascular diseases (CVD) (2). Driven by the rising prevalence of both obesity and type 2 diabetes, and increasing life‐expectancy of patients with type 2 diabetes consequent to the improved standard of c are, it is envi...
Source: Journal of Diabetes Investigation - August 19, 2020 Category: Endocrinology Authors: Chi ‐Ho Lee, David Tak‐Wai Lui, Karen Siu‐Ling Lam Tags: JDI UPDATES Source Type: research

Type 1 Diabetes management and outcomes: a multicenter study in Thailand
The objective of the registry was to evaluate glycemic control and complications of patients with type 1 diabetes (T1D).Materials and MethodsPatients ’ demographics, clinical data, frequencies of daily self‐monitoring of blood glucose (SMBG), glycemic control, and complications were collected.ResultsAmong the 1,907 T1D patients, the mean age was 21.2 ±11.3 years. The mean HbA1c level was 9.35 ±2.41%, with significant variations among age groups (p
Source: Journal of Diabetes Investigation - August 19, 2020 Category: Endocrinology Authors: Prapai Dejkhamron, Jeerunda Santiprabhob, Supawadee Likitmaskul, Chaicharn Deerochanawong, Petch Rawdaree, Thipaporn Tharavanij, Sirimon Reutrakul, Chawkaew Kongkanka, Jittiwat Suprasongsin, Nawaporn Numbenjapon, Taninee Sahakitrungruang, Rawee Tags: ORIGINAL ARTICLE Source Type: research

Phase 3, randomized, double ‐blind, placebo‐controlled study to evaluate the efficacy and safety of teneligliptin monotherapy in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise
AbstractIntroductionAlthough the efficacy of teneligliptin, a highly selective dipeptidyl peptidase ‐4 inhibitor, has been amply studied for the treatment of type 2 diabetes, no clinical trials of teneligliptin have been conducted in China. We evaluated the efficacy and safety of teneligliptin monotherapy compared with placebo in Chinese patients with type 2 diabetes mellitus inadequately contro lled with diet and exercise.Materials and methodsThis multicenter, randomized, double ‐blind, placebo‐controlled, parallel‐group study, conducted at 42 sites, enrolled type 2 diabetes patients with glycosylated hemoglobin (HbA1c) 7.0%−
Source: Journal of Diabetes Investigation - August 18, 2020 Category: Endocrinology Authors: Linong Ji, Jianhua Ma, Weiping Lu, Jingdong Liu, Jiao ’e Zeng, Jialin Yang, Wei Li, Xiuzhen Zhang, Xinhua Xiao, Gen Takayanagi, Yi Wang Tags: CLINICAL TRIAL Source Type: research

Changing epidemiology of chronic kidney disease as a result of type  2 diabetes mellitus from 1990 to 2017: Estimates from Global Burden of Disease 2017
ConclusionsCKD as a result of type  2 diabetes mellitus has been the main contributor to the increasing burden of CKD over the past several decades. We suggest a more pragmatic approach focusing on early diagnosis, primary care and adequate follow up to reduce mortality and the long‐term burden in low‐to‐middle Sociodemographi c Index regions. Interventions should address high systolic blood pressure, as well as overweight and obesity problems, especially in high‐income regions. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 17, 2020 Category: Endocrinology Authors: Huixian Li, Wanhong Lu, Ani Wang, Hongli Jiang, Jun Lyu Tags: Original Article Source Type: research

Bilateral atrophy of the extensor digitorum brevis muscle might be a useful sign for diagnosing diabetic polyneuropathy in Japanese men who do not sit in the traditional “seiza” style
ConclusionsEDBA detection might be a useful method to screen for distal symmetric polyneuropathy, such as DSPN in men, although the exclusion of individuals withseiza habit is necessary to improve accuracy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 16, 2020 Category: Endocrinology Authors: Shohei Kishimoto, Hideyuki Sasaki, Seigo Kurisu, Kenichi Ogawa, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo, Takashi Akamizu Tags: Original Article Source Type: research

Maternal and paternal histories differentially influence risks for diabetes, insulin secretion and insulin resistance in a Chinese population
Impaired glucose metabolism was significantly more prevalent among participants with a maternal history of diabetes than among those with a paternal history. Maternal history had significantly greater influences on the elevated disease risk for impaired glucose metabolism than paternal history. Maternal history could contribute to the diseases through its impact on both insulin secretion impairment and insulin resistance, whereas the contribution of paternal history could rely on its specific impact on insulin resistance. AbstractAims/IntroductionTo investigate the differential effects of maternal versus paternal history o...
Source: Journal of Diabetes Investigation - August 16, 2020 Category: Endocrinology Authors: Xiaomu Kong, Zhaojun Yang, Bo Zhang, Xiaoping Chen, Liping Yu, Haiqing Zhu, Xiaoyan Xing, Wenying Yang Tags: Original Article Source Type: research

The Asian Association for the Study of Diabetes: The first 10  years and the next 10 years
The Asian Association for the Study of Diabetes (AASD) was established in 2009 as an international academic organization corresponding to the American Diabetes Association and the European Association for the Study of Diabetes. The AASD is committed to promoting diabetes research activities across the region by organizing annual scientific meetings and publishingJournal of Diabetes Investigation to strengthen academic collaborations with international societies/associations, including the European Association for the Study of Diabetes and the American Diabetes Association by organizing joint sessions in scientific meetings...
Source: Journal of Diabetes Investigation - August 16, 2020 Category: Endocrinology Authors: Yutaka Seino, Yuji Yamazaki, Daisuke Yabe Tags: Editorial Source Type: research

Prevalence and risk factors for diabetic neuropathy and painful diabetic neuropathy in primary and secondary health care in Qatar
This study determined the prevalence and risk factors for DPN and pDPN in patients with type 2 diabetes (T2D) in primary health care (PHC) and secondary health care (SHC) in Qatar.Materials and MethodsThis is a cross ‐sectional multi‐center study. Adults with T2D were randomly enrolled from four PHC centres and two Diabetes Centres in SHC in Qatar. Subjects underwent assessment of clinical and metabolic parameters, DPN and pDPN.Results1,386 subjects with T2D (297 from PHC and 1,089 from SHC) were recruited. The prevalence of DPN (14.8% vs 23.9%, P=0.001) and pDPN (18.1% vs 37.5%, P
Source: Journal of Diabetes Investigation - August 16, 2020 Category: Endocrinology Authors: Georgios Ponirakis, Tarik Elhadd, Subitha Chinnaiyan, Abdul H. Hamza, Sanaulla Sheik, Mohamed A. Kalathingal, Mohamed S. Anodiyil, Zeinab Dabbous, MashhoodA. Siddique, Hamad Almuhannadi, Ioannis Petropoulos, Adnan Khan, Khaled A.E. Ashawesh, Tags: ORIGINAL ARTICLE Source Type: research

A point ‐of‐care nerve conduction device predicts the severity of diabetic polyneuropathy: a quantitative but easy‐to‐use prediction model.
ConclusionsNerve conduction parameters in the sural nerve acquired by the handheld device successfully predict the severity of DPN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - August 16, 2020 Category: Endocrinology Authors: Hideki Kamiya, Yukauka Shibata, Tatsuhito Himeno, Hiroya Tani, Takayuki Nakayama, Kenta Murotani, Nobuhiro Hirai, Miyuka Kawai, Yuriko Asada ‐Yamada, Emi Asano‐Hayami, Hiromi Nakai‐Shimoda, Yuichiro Yamada, Takahiro Ishikawa, Yoshiaki M Tags: ORIGINAL ARTICLE Source Type: research