Long non ‐coding ribonucleic acid ATP2B1‐AS1 modulates endothelial permeability through regulating the miR‐4729–IQGAP2 axis in diabetic retinopathy
ConclusionsThe present study showed that ATP2B1-AS1 acted as a miR-4729 sponge to regulate IQGAP2 reducing high-glucose-induced endothelial dysfunction in DR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2022 Category: Endocrinology Authors: Zengjin Ren, Xue Wang Tags: Original Article Source Type: research

Impact of newly diagnosed diabetes on COVID ‐19 severity and hyperglycemia
ConclusionsOur study suggests that the proportion of COVID-19 patients who are newly diagnosed with diabetes is high, and they have an increased risk of developing severe disease than those with pre-existing diabetes. It may be advisable that at the point of COVID-19 diagnosis, blood glucose and HbA1c levels be assessed in all patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2022 Category: Endocrinology Authors: Masaki Uchihara, Ryotaro Bouchi, Noriko Kodani, Sho Saito, Yusuke Miyazato, Kotaro Umamoto, Hirofumi Sugimoto, Michi Kobayashi, Sayaka Hikida, Yutaro Akiyama, Noriko Ihana ‐Sugiyama, Mitsuru Osugi, Akiyo Tanabe, Kojiro Ueki, Jin Takasaki, Tags: ORIGINAL ARTICLE Source Type: research

Repeated insulin injection without site rotation affect skin thickness ‐ultrasonographic and histological evaluation‐
AbstractAims/IntroductionThe influence of repeated insulin injection on subcutaneous tissue is known, but its impact on the skin is unclear. Therefore, we aimed to elucidate the impact of repeated insulin injections on the skin.Material and MethodsProperties of the skin and subcutaneous tissue were evaluated in fifty-two insulin-treated adult patients with diabetes with abnormal findings at the site of self-injection (36 with subcutaneous nodules, 16 with suspected subcutaneous tissue induration) by ultrasonography. In all subjects, both normal and abnormal areas were examined. In addition, skin biopsies were performed in ...
Source: Journal of Diabetes Investigation - January 21, 2022 Category: Endocrinology Authors: Satoshi Murao, Kazutoshi Murao, Tsuyoshi Nagata, Misato Shimizu, Yumi Miyai Tags: ORIGINAL ARTICLE Source Type: research

Sarcopenia in Elderly Diabetes
Abstract- (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2022 Category: Endocrinology Authors: Chen ‐Yu Wen, Angela Shin‐Yu Lien, Yi‐Der Jiang Tags: UPDATE Source Type: research

Current status of diabetes treatment in Miyazaki Prefecture, Japan: Results of a questionnaire survey conducted in 2016 and 2020
ConclusionsBecause SGLT2i became available in 2016 and a few years have passed, both diabetologists and non-diabetologists seemed to refrain from prescribing SGLT2i. However, with the emergence of various lines of firm evidence concerning the use of SGLT2i, physicians started to prescribe it. However, some diabetologists and non-diabetologists chose hypoglycemic agents inadequately: therefore, there is a need for novel and precise information. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 19, 2022 Category: Endocrinology Authors: Yudai Uehira, Hiroaki Ueno, Emi Ebihara, Taisuke Uchida, Hiroki Nabekura, Sakoda Hideyuki, Tadato Yonekawa, Yamaguchi Hideki, Masamitsu Nakazato Tags: ORIGINAL ARTICLE Source Type: research

Longitudinal effects of one ‐leg standing time on neuropathy outcomes in association with glycemic control in non‐elderly patients with type 2 diabetes
This study compared longitudinal changes in neuropathy outcomes relative to long-term glycemic control in patients aged 1 year after discharge were divided into OLST
Source: Journal of Diabetes Investigation - January 19, 2022 Category: Endocrinology Authors: Kazuhiro Sugimoto, Takashi Sozu, Takehiko Hoshino, Yuko Watanabe, Akira Tamura, Toshiro Yamazaki, Setsu Ohta, Susumu Suzuki, Takuro Shimbo Tags: ORIGINAL ARTICLE Source Type: research

Cardiovascular disease in patients with type  2 diabetes
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 19, 2022 Category: Endocrinology Authors: Ja Young Jeon, Dae Jung Kim Tags: JDI Update Source Type: research

Insulin ‐GLP‐1 receptor agonist relay and GLP‐1 receptor agonist first regimens in individuals with type 2 diabetes: a randomized, open‐label trial study
AbstractAimGlucagon-like peptide-1 receptor agonists (GLP-1 RA) might be less effective in patients with severe hyperglycemia because hyperglycemia downregulates the GLP-1 receptor in an animal study. To examine this hypothesis clinically, we compared the glucose-lowering effects of GLP-1 receptor agonist liraglutide with and without prior glycemic control.MethodsIn an open-label, parallel trial, participants with poorly controlled type 2 diabetes were recruited and randomized to receive once-daily insulin therapy, degludec (Insulin-GLP-1 RA relay group, average 16.8 ± 11.4 IU/day), for 12 weeks and then liraglutide...
Source: Journal of Diabetes Investigation - January 17, 2022 Category: Endocrinology Authors: Yumie Takeshita, Yuki Kita, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Chisato Teramura, Yasufumi Enyama, Toshinari Takamura, , The Establishment of Rationale for Antiaging Diabetic Medicine (ERA ‐DM) Study Group Tags: CLINICAL TRIAL Source Type: research

East Asian Perspectives in Metabolic and Bariatric Surgery
AbstractThe prevalence of diabetes and obesity continues to rise in East Asia. As the risk of diabetes increases at a lower body mass index (BMI) in East Asians than in Europeans, the threshold of BMI values for metabolic and bariatric surgery (MBS) is lower in East Asians. MBS is considered upon reaching a BMI of 27.5 kg/m2 and is recommended at BMI ≥ 32.5 kg/m2, depending on the status of glucose homeostasis. The most commonly performed MBS in East Asia is sleeve gastrectomy, followed by Roux-en-Y gastric bypass (RYGB). Because the incidence of gastric cancer is higher in East Asia than in other regions, concerns rega...
Source: Journal of Diabetes Investigation - January 14, 2022 Category: Endocrinology Authors: Tae Jung Oh, Hyuk ‐Joon Lee, Young Min Cho Tags: MINI REVIEW Source Type: research

A New Era of Diabetic Kidney Disease Treatment with Sodium –Glucose Cotransporter‐2 Inhibitors
Abstract- (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 14, 2022 Category: Endocrinology Authors: Shinji Kume, Hiroshi Maegawa Tags: UPDATE Source Type: research

Acute kidney injury in Japanese type  2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort study
BLURB FOR ETOC: AKI risk associated with SGLT2 inhibitors AbstractThe present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type  2 diabetes treated with sodium–glucose cotransporter 2 inhibitors. We identified 171,622 patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors; among them, 476 (0.3%) patients developed acute kidney injury. The hazard ratio for acute kidney injury occurren ce risk was analyzed using a Cox proportional hazards model adjusted for patient characte...
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda Tags: Short Report Source Type: research

Diversity of pathophysiology in type  2 diabetes shown by islet pathology
Pathological findings of the islets can reflect the pathophysiologies of type  2 diabetes. Detailed pathological analysis enable to subclassify type 2 diabetes. ABSTRACTThe etiology of type  2 diabetes is multifactorial, in which environmental and genetic factors are involved to varying degrees. This suggests that its pathophysiology might vary depending on the individuals. Knowledge of the differences is critical, because these differences are directly linked to the care and treatme nt of the patients. Recent studies have attempted to carry out subclassifications of type 2 diabetes based on cli...
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Hiroki Mizukami, Kazuhiro Kudoh Tags: Review Article Source Type: research

Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Tags: Issue Information Source Type: research

Renal, cardiovascular and safety outcomes of canagliflozin in patients with type  2 diabetes and nephropathy in East and South‐East Asian countries: Results from the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation Trial
ConclusionsIn the CREDENCE trial, the risk of renal and cardiovascular events was safely reduced in participants from EA countries at high risk of renal events. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Takashi Wada, Kazumi Mori ‐Anai, Yutaka Kawaguchi, Hideyuki Katsumata, Hidetaka Tsuda, Mitsutaka Iida, Kenji Arakawa, Meg J Jardine Tags: Original Article Source Type: research

Prevalence and clinical characteristics of fulminant type  1 diabetes mellitus in Korean adults: A multi‐institutional joint research
ConclusionsIn this study, the prevalence of type  1 diabetes mellitus was 1.2% among all patients with diabetes, and that of fulminant type 1 diabetes mellitus was 3.2% among those newly diagnosed with type 1 diabetes mellitus. The glycated hemoglobin levels were lower in patients with fulminant type 1 diabetes mellitus than in those with non-fulminant type 1 diabetes mellitus at diagnosis and at the last follow-up examination. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Sun Ok Song, Jae ‐Seung Yun, Seung‐Hyun Ko, Yu‐Bae Ahn, Bo‐Yeon Kim, Chul‐Hee Kim, Ja Young Jeon, Dae Jung Kim, Da Hae Seo, So Hun Kim, Jung Hyun Noh, Da Young Lee, Kyung‐Soo Kim, Soo‐Kyung Kim, the Type 1 Diabetes Study Group Tags: Original Article Source Type: research

Bariatric surgery versus medical treatment in mildly obese patients with type  2 diabetes mellitus in Japan: Propensity score‐matched analysis on real‐world data
Mitochondrial haplogroups, but not nuclear genetic variants, have a better association with the insulin requirement in patients with type  2 diabetes mellitus. AbstractAims/IntroductionTo compare glycemic control 1  year after treatment in patients with mildly obese (body mass index 27.5–34.9 kg/m2) type  2 diabetes mellitus who underwent bariatric surgery (BS) to those who received medical treatment (MT) in Japan.Materials and MethodsA retrospective study using real-world data was carried out in electronic medical records from a tertiary care hospital and in the Japanese Medical Data Cent...
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Yosuke Seki, Kazunori Kasama, Renzo Yokoyama, Akihiro Maki, Hideharu Shimizu, Hyejin Park, Yoshimochi Kurokawa Tags: Original Article Source Type: research

Effect of Ramadan fasting in patients with type  2 diabetes mellitus treated with sodium–glucose cotransporter 2 inhibitors: A systematic review and meta‐analysis
This meta-analysis identifies an improvement in glycated hemoglobin, weight and diastolic blood pressure in patients treated with sodium –glucose cotransporter 2 inhibitors who fast during Ramadan. ABSTRACTAims/IntroductionSodium –glucose cotransporter 2 inhibitors (SGLT-2i) improve glycemic control and weight, but might be associated with dehydration, hypotension and ketoacidosis, especially in patients with type 2 diabetes mellitus who fast during Ramadan. This meta-analysis evaluates the effects of Ramadan fasting o n patients with type 2 diabetes mellitus treated with SGLT-2i.Mat...
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Hoda Gad, Noor Al ‐Nassr, Ibrahim Mohammed, Adnan Khan, Ross MacDonald, Paul Mussleman, Rayaz A. Malik Tags: Original Article Source Type: research

Hyperlipidemic Plasma Molecules Bind and Inhibit Adiponectin Activity
AbstractIntroductionAdiponectin is a potent vascular protective molecule. Recent findings suggested adiponectin resistance during early diabetes. However, responsible molecular mechanisms remain unidentified. Here, we took an unbiased approach to identify whether there exist hyperlipidemic plasma molecules that bind and inhibit adiponectin function, contributing to adiponectin resistance and diabetic vascular injury.MethodsAdult rats were randomly assigned to receive either normal or high-fat diet for 8 weeks. Plasma was coimmunoprecipitated with anti-APN antibody and analyzed by mass spectrometry. APN binding molecules an...
Source: Journal of Diabetes Investigation - January 13, 2022 Category: Endocrinology Authors: Yan ‐Qing Zhang, Sen Fan, Wen‐Qing Wang, Wayne Bond Lau, Jian‐Li Dai, Hai‐Feng Zhang, Xiao‐Ming Wang, Xiao‐Gang Liu, Rong Li Tags: ORIGINAL ARTICLE Source Type: research

Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology
ConclusionsComplement activation is involved in the development of DN, and activation of the classical complement pathway in glomeruli might accelerate disease progression. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 10, 2022 Category: Endocrinology Authors: Yuanyuan Jiao, Shimin Jiang, Ying Wang, Tianyu Yu, Guming Zou, Li Zhuo, Wenge Li Tags: Original Article Source Type: research

Maturity ‐onset diabetes of the young type 5, presenting as diabetic ketoacidosis with alkalemia: A report of a case
Genetic mutations of hepatocyte nuclear factor  1 beta cause multiple organ disorders, as well as maturity-onset diabetes of the young type 5, collectively known as the hepatocyte nuclear factor 1 beta syndrome. It can lead to the development of diabetic ketoacidosis with alkalemia. AbstractA 34-year-old man visited our Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, because of dry mouth and weight loss. His plasma glucose level was 32.8  mmol/L and serum levels of ketone bodies were increased, but with metabolic alkalemia...
Source: Journal of Diabetes Investigation - January 10, 2022 Category: Endocrinology Authors: Akiko Hayakawa ‐Iwamoto, Daisuke Aotani, Yuki Shimizu, Shota Kakoi, Chie Hasegawa, Shunsuke Itoh, Asami Fujii, Katsushi Takeda, Takashi Yagi, Hiroyuki Koyama, Kenro Imaeda, Kandai Nozu, China Nagano, Hiromi Kataoka, Tomohiro Tanaka Tags: Case Report Source Type: research

Young ‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)
This is a diabetes registry comprising 31 hospitals in Thailand. Type  1 diabetes remains the most common type, and the prevalence of type 2 diabetes increases with age. The majority of patients did not achieve the glycemic target, especially type 1 diabetes patients. ABSTRACTAims/IntroductionThere is a lack of current information regarding young-onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young-onset diabetes.Materials and MethodsData...
Source: Journal of Diabetes Investigation - January 8, 2022 Category: Endocrinology Authors: Prapai Dejkhamron, Jeerunda Santiprabhob, Supawadee Likitmaskul, Chaicharn Deerochanawong, Petch Rawdaree, Thipaporn Tharavanij, Sirimon Reutrakul, Chawkaew Kongkanka, Chittiwat Suprasongsin, Nawaporn Numbenjapon, Taninee Sahakitrungruang, Rawe Tags: Original Article Source Type: research

Neuronal regulation of glucagon secretion and gluconeogenesis
AbstractHypoglycemia almost never develops in healthy individuals because multiple hypoglycemia sensing systems, located in the periphery and in the central nervous system trigger a coordinated counterregulatory hormonal response to restore normoglycemia. This involves not only the secretion of glucagon but also of epinephrine, norepinephrine, cortisol and growth hormone. Increased hepatic glucose production is also stimulated by direct autonomous nervous connections to the liver that stimulate glycogenolysis and gluconeogenesis. This counterregulatory response, however, becomes deregulated in a significant fraction of dia...
Source: Journal of Diabetes Investigation - January 6, 2022 Category: Endocrinology Authors: Bernard Thorens Tags: MINI REVIEW Source Type: research

Post –genome‐wide association study research focuses on the multifaceted nature of SKAP2 in type1 diabetes
Abstract- (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 6, 2022 Category: Endocrinology Authors: Hiroyuki Sano, Akihisa Imagawa Tags: COMMENTARY Source Type: research

Circulating level of fatty acid ‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals
Metabolic dysfunction-associated fatty liver disease, defined as hepatosteatosis with overweight/obesity, presence of type  2 diabetes mellitus or evidence of metabolic dysregulation, has been proposed as a new feature of chronic liver disease. Fatty acid-binding protein 4 concentration is independently associated with the fatty liver index and is an independent predictor of metabolic dysfunction-associated fatty li ver disease in a general population. ABSTRACTAims/IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD), defined as hepatosteatosis with type  2 diabetes mellitus, overwe...
Source: Journal of Diabetes Investigation - January 3, 2022 Category: Endocrinology Authors: Marenao Tanaka, Satoko Takahashi, Yukimura Higashiura, Akiko Sakai, Masayuki Koyama, Shigeyuki Saitoh, Kazuaki Shimamoto, Hirofumi Ohnishi, Masato Furuhashi Tags: Original Article Source Type: research

Association between fat mass index, fat ‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study
A higher fat mass index was related to higher hemoglobin A1c levels in men and women in all fat-free mass index subgroups. Although, the FFMI was not associated with higher HbA1c levels in most FMI subgroups among the whole population, when we excluded participants who were identified as having diabetes, the FFMI was still associated with higher HbA1c levels in most FMI subgroups. Reduction in the fat mass index and fat-free mass index; that is, weight loss, might be important for maintaining good control of blood glucose levels. AbstractAims/IntroductionFat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) lev...
Source: Journal of Diabetes Investigation - December 29, 2021 Category: Endocrinology Authors: Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Ku Tags: Original Article Source Type: research

Abdominal volume index trajectories and risk of diabetes mellitus: Results from the China Health and Nutrition Survey
Based on a 16-year large-scale cohort study, we identified three types of abdominal obesity trajectories with different incidences of diabetes mellitus in adults. Our research provides a new perspective on the management of abdominal obesity for the prevention of diabetes. AbstractAims/IntroductionAbdominal obesity is a risk factor for developing diabetes mellitus, but trajectories of abdominal obesity over time and incident diabetes mellitus have not been considered. We derived trajectories of abdominal volume index (AVI) over 16  years of follow up, and examined the associations between AVI trajectories and risk o...
Source: Journal of Diabetes Investigation - December 28, 2021 Category: Endocrinology Authors: Xiangming Hu, Allison A Appleton, Yanqiu Ou, Ying Zhang, Anping Cai, Yingling Zhou, Haojian Dong Tags: Original Article Source Type: research

HbA1c level may be a risk factor for oxygen therapy requirement in patients with coronavirus disease 2019
AbstractIntroductionMany clinical studies have identified significant predictors or risk factors for the severity or mortality of coronavirus disease 2019 (COVID-19) cases. However, there are very limited reports on the risk factors for requiring oxygen therapy during hospitalization. In particular, we sought to investigate whether plasma glucose and HbA1c levels could be risk factors for oxygen therapy requirement.Materials and MethodsWe conducted a single-center, retrospective study of 131 COVID-19 patients hospitalized at Saitama Medical University Hospital between March 2020 and November 2020. To identify the risk fact...
Source: Journal of Diabetes Investigation - December 27, 2021 Category: Endocrinology Authors: Shinnosuke Yanagisawa, Yoichi Oikawa, Sotaro Takagi, Yuta Horikoshi, Atsushi Satomura, Kazuo Imai, Jun Sakai, Noriomi Ishibashi, Norihito Tarumoto, Shinichiro Iida, Hideto Nakayama, Yoshiyuki Haga, Shigefumi Maesaki, Akira Shimada Tags: ORIGINAL ARTICLE Source Type: research

The effect of ramadan fasting in patients with type 2 diabetes mellitus treated with sglt ‐2 inhibitors: a systematic review and meta‐analysis
AbstractBackgroundSodium-glucose cotransporter-2 inhibitors (SGLT2-i) improve glycemic control and weight, but may be associated with dehydration, hypotension and ketoacidosis, especially in patients with type-2 diabetes mellitus (T2DM) who fast during Ramadan. This meta-analysis evaluates the effects of Ramadan fasting on T2DM patients treated with SGLT-2i.MethodsA literature search was done in PubMed, Embase, and the Cochrane Library. Quality assessment was done using the ROBINS-I and Cochrane tools for risk of bias and analyses were performed using RevMan version 5.3.ResultsA total of 5 studies were included in this met...
Source: Journal of Diabetes Investigation - December 25, 2021 Category: Endocrinology Authors: Hoda Gad, Noor AL ‐Nassr, Ibrahim Mohammed, Adnan Khan, Ross MacDonald, Paul Mussleman, Rayaz A. Malik Tags: ORIGINAL ARTICLE Source Type: research

Cardiovascular disease in patients with type 2 diabetes
Abstract- (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 25, 2021 Category: Endocrinology Authors: Ja Young Jeon, Dae Jung Kim Tags: UPDATE Source Type: research

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus ‐ A meta‐analysis
ConclusionsCurrent ML algorithms have sufficient ability to help clinicians determine whether individuals will develop T2DM in the future. However, persons should be cautious before changing their attitude toward future diabetes risk after learning the result of the diabetes prediction test using ML algorithms. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 24, 2021 Category: Endocrinology Authors: Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Masaru Kitazawa, Midori Iwanaga, Kiminori Kato, Kenichi Watanabe, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sones Tags: ORIGINAL ARTICLE Source Type: research

LncRNA ATP2B1 ‐AS1 modulates endothelial permeability via regulating miR‐4729/IQGAP2 axis in diabetic retinopathy
ConclusionsOur study indicates that ATP2B1-AS1 acts as a miR-4729 sponge to regulate IQGAP2 reduce high-glucose-induced endothelial dysfunction in DR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 22, 2021 Category: Endocrinology Authors: Zengjin Ren, Xue Wang Tags: ORIGINAL ARTICLE Source Type: research

Role of the adaptive immune system in diabetic kidney disease
Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Here, we review the role of the T and B  cells of the adaptive immune system, and associated cytokines, in the development of diabetic kidney disease. AbstractDiabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subseque...
Source: Journal of Diabetes Investigation - December 22, 2021 Category: Endocrinology Authors: Lingyun Kong, Sofianos Andrikopoulos, Richard J MacIsaac, Laura K Mackay, David J Nikolic ‐Paterson, Niloufar Torkamani, Neda Zafari, Evelyn C S Marin, Elif I Ekinci Tags: Review Article Source Type: research

Heart rate ‐corrected QT interval: a novel diagnostic biomarker for diabetic peripheral neuropathy
AbstractAimsTo explored the relationship between heart rate-corrected QT (QTc) interval and diabetic peripheral neuropathy (DPN) and whether QTc interval has diagnostic utility for DPN beyond nerve conduction velocity.Materials and MethodsA total of 965 patients with diabetes, including 473 patients with DPN, and 492 patients without DPN, underwent standard 12-lead electrocardiography and detailed assessments of peripheral neuropathy.ResultsPatients with DPN had longer QTc interval than those without. Among participants, from the first to fourth quartile of QTc interval, the proportion of patients with DPN appreciably incr...
Source: Journal of Diabetes Investigation - December 21, 2021 Category: Endocrinology Authors: Ai ‐jun Jiang, Heng Gu, Zhan‐rong Feng, Ying Ding, Xiao‐hua Xu, Guo‐ping Yin, Wen‐li Zhang, Zi‐yang Shen, Qian Li Tags: ORIGINAL ARTICLE Source Type: research

The activation of complement C1q and C3 in glomeruli may accelerate the progression of diabetic nephropathy: evidence from transcriptomic data and renal histopathology
ConclusionsComplement activation is involved in the development of DN, and activation of the classical complement pathway in glomeruli may accelerate disease progression. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 21, 2021 Category: Endocrinology Authors: Yuanyuan Jiao, Shimin Jiang, Ying Wang, Tianyu Yu, Guming Zou, Li Zhuo, Wenge Li Tags: ORIGINAL ARTICLE Source Type: research

Maturity ‐onset diabetes of the young (MODY) type 5, presenting as diabetic ketoacidosis with alkalemia – A report of a case.
AbstractA 34-year-old man visited our hospital because of dry mouth and weight loss. His plasma glucose level was 32.8 mmol/L and serum levels of ketone bodies were increased, but with metabolic alkalemia. He was also suffering from renal tubular hypomagnesemia and hypokalemia. Abdominal CT revealed bilateral renal cysts. These findings were suggestive of maturity-onset diabetes of the young (MODY) type5. Genetic testing revealed heterozygous hepatocyte nuclear factor 1 beta (HNF1B) gene deletion. In the present case, it seemed reasonable to viewHNF1B gene deletion as the common cause of MODY5-associated diabetic ketoacido...
Source: Journal of Diabetes Investigation - December 21, 2021 Category: Endocrinology Authors: Akiko Hayakawa ‐Iwamoto, Daisuke Aotani, Yuki Shimizu, Shota Kakoi, Chie Hasegawa, Shunsuke Itoh, Asami Fujii, Katsushi Takeda, Takashi Yagi, Hiroyuki Koyama, Kenro Imaeda, Kandai Nozu, China Nagano, Hiromi Kataoka, Tomohiro Tanaka Tags: CASE REPORT Source Type: research

Reviewers
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 17, 2021 Category: Endocrinology Tags: Reviewers Source Type: research

Use of automated insulin delivery systems in people with type  1 diabetes fasting during Ramadan: An observational study
In well-managed people with type  1 diabetes, Ramadan fasting while using commercial and open-source automated insulin delivery systems can be achieved with no compromise on safety and efficacy when compared with time outside Ramadan (Time in range before Ramadan-blue, during Ramadan-green and after Ramadan-purple). AbstractFasting among people with type  1 diabetes imposes the risk of metabolic decompensation. Automated insulin dosing systems can allow better glycemic control without safety concerns. The utility in prolonged and repetitive fasting has not been studied. In this observational study, validated ...
Source: Journal of Diabetes Investigation - December 15, 2021 Category: Endocrinology Authors: Ali Aldibbiat, Ahmed Alqashami, Sufyan Hussain Tags: Short Report Source Type: research

Revisiting the strategies for the pharmacological management of type 2 diabetes – From glycemic control, organ protection, safety to weight reduction
With the development of several new classes of anti-diabetic drugs in the past decade, the concept for the pharmacological management of type 2 diabetes is evolving from ‘glycemic control’ to ‘organ protection’. Besides, the increase in the prevalence of an aging population urges a strategy focusing on safety and de-intensification. In the coming years, with the development of several novel and potent anti-obesity drugs, the ‘weight-centric’ strategy is expected to gain more and more attention in the treatment of diabetes, since it can both prevent diabetic complications and optimize the...
Source: Journal of Diabetes Investigation - December 15, 2021 Category: Endocrinology Authors: Hung ‐Yuan Li Tags: Editorial Source Type: research

Subject Index
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Tags: Subject Index Source Type: research

Commentary on Intraglumerular dysfunction predicts kidney failure in the type  2 diabetes
The key physiological parameters that determine glomerular filtration rate levels are renal plasma flow, filtration fraction, intraglomerular pressure, and balance between afferent and efferent glomerular arteriolar resistance. The evaluation of the balance between afferent and efferent glomerular arteriolar resistance might be useful for the classification of diabetic kidney disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Jun Wada Tags: Commentary Source Type: research

Onset of fulminant type  1 diabetes mellitus following hypophysitis after discontinuation of combined immunotherapy. A case report
We describe a case of immunotherapy-related type  1 diabetes developing after combined immunotherapy cessation. The patient developed fulminant type 1 diabetes>2  years after the first immunotherapy dose, and had previously developed immune-related hypophysitis. AbstractDiabetes is a rare, but potentially life-threatening, adverse event of immune checkpoint inhibitors that requires prompt recognition and treatment. It usually occurs in the first 3  months of treatment and is typically related to programmed cell death-1 antibodies, alone or in combined therapy. It has rarely been described dev...
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Laura Boswell, Gregori Casals, Jes ús Blanco, Amanda Jiménez, Francisco Aya, Ana Hollanda, Irene Halperin, Ana M Arance, Mireia Mora, Felicia A Hanzu Tags: Case Report Source Type: research

Case of type  2 diabetes mellitus with edema resulting in subcutaneous insulin resistance syndrome
This article introduced a case of a woman with type 2 diabetes mellitus with heart failure edema. Her blood glucose control was significantly associated with the level of edema. Excluding other factors, it can be concluded that edema might lead to insulin subcutaneous malabsorption, even if the edema at the injection site is not obvious. AbstractSubcutaneous insulin resistance syndrome caused by obesity, induration at the injection site, skin temperature and other factors is common clinically, whereas resistance events caused by edema are relatively rare. This article introduced a case of a woman with type  2 diabet...
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Ying Hu, Qiongwen Zhu, Xiuli Yang, Jieping Yan, Jiana Shi Tags: Case Report Source Type: research

Islet microangiopathy and augmented β‐cell loss in Japanese non‐obese type 2 diabetes patients who died of acute myocardial infarction
ConclusionsIslet microangiopathy was associated with augmented β-cell loss and amyloid deposition in non-obese Japanese type 2 diabetes patients who died of AMI. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Kazuhiro Kudoh, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi Tags: ORIGINAL ARTICLE Source Type: research

Sex ‐specific differences in blood lipids and lipid ratios in type 2 diabetic foot patients
This study attempts to identify the contribution to sex-specific differences in blood lipids and lipid ratios in these patients.Materials and MethodsIn this case –control study, we explore 306 patients with T2DF as the study group and 306 patients with type 2 diabetes mellitus as the control group. Patients were diagnosed according to the Standards of Medical Care in Diabetes–2014 (American Diabetes Association). Blood lipid and lipid ratios were deter mined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.ResultsWe studied male patients with T2DF who were a...
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Shuming Yin, Puqing Zhao, Zisheng Ai, Bing Deng, Wei Jia, Huan Wang, Jiaqi Zheng Tags: ORIGINAL ARTICLE Source Type: research

Abdominal ‐Volume Index Trajectories and Risk of Diabetes Mellitus: Results from the China Health and Nutrition Survey
AbstractAims/IntroductionAbdominal obesity is a risk factor for developing diabetes mellitus (DM), but trajectories of abdominal obesity over time and incident DM have not been considered. We derived trajectories of abdominal volume index (AVI) over 16 years of follow up, and examined the associations between AVI trajectories and risk of DM.Materials and MethodsData were used from the China Health and Nutrition Survey (CHNS) and 5,267 participants were enrolled to fit the trajectory of AVI by using latent class growth models. Multivariate logistic regression models explored the relationship between different AVI trajectori...
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Xiangming Hu, Allison A Appleton, Yanqiu Ou, Ying Zhang, Anping Cai, Yingling Zhou, Haojian Dong Tags: ORIGINAL ARTICLE Source Type: research

Trained immunity: a key player of “metabolic memory” in diabetes
Abstract- (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 13, 2021 Category: Endocrinology Authors: Keiko Naruse Tags: COMMENTARY Source Type: research

Young ‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)
AbstractAims/IntroductionThere are lack of current information regarding young-onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens, and achievement of glycemic control in Thai patients with young-onset diabetes.Materials and MethodsData of 2,844 patients with diabetes onset before 30 years of age were retrospectively  reviewed from a diabetes registry comprising 31 hospitals in Thailand. Gestational diabetes was excluded.ResultsBased on clinical criteria, type 1 diabetes (T1D) was identified in 62.6%, type 2 diabete...
Source: Journal of Diabetes Investigation - December 10, 2021 Category: Endocrinology Authors: Prapai Dejkhamron, Jeerunda Santiprabhob, Supawadee Likitmaskul, Chaicharn Deerochanawong, Petch Rawdaree, Thipaporn Tharavanij, Sirimon Reutrakul, Chawkaew Kongkanka, Chittiwat Suprasongsin, Nawaporn Numbenjapon, Taninee Sahakitrungruang, Rawe Tags: ORIGINAL ARTICLE Source Type: research

Circulating level of FABP4 is an independent predictor of metabolic dysfunction ‐associated fatty liver disease in middle‐aged and elderly individuals
AbstractAims/IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD), defined as hepatosteatosis with type 2 diabetes mellitus, overweight/obesity or metabolic dysregulation, has been proposed as a new feature of chronic liver disease. Fatty acid-binding protein 4 (FABP4) is expressed in adipose tissue, and secreted FABP4 is associated with the development of insulin resistance and atherosclerosis. However, the relationship between MAFLD and FABP4 has not been fully addressed.Materials and MethodsAssociations of MAFLD with metabolic markers including FABP4, fibroblast growth factor 21 (FGF21) and adiponect...
Source: Journal of Diabetes Investigation - December 10, 2021 Category: Endocrinology Authors: Marenao Tanaka, Satoko Takahashi, Yukimura Higashiura, Akiko Sakai, Masayuki Koyama, Shigeyuki Saitoh, Kazuaki Shimamoto, Hirofumi Ohnishi, Masato Furuhashi Tags: ORIGINAL ARTICLE Source Type: research

Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type  1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus
ConclusionsOur study provides a new polyclonal antiserum against CVB1-2Apro, which might be useful for IHC of EV-infected human tissues stored as archive of formaldehyde-fixed and paraffin-embedded tissue samples. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 9, 2021 Category: Endocrinology Authors: Erika Jimbo, Tetsuro Kobayashi, Akira Takeshita, Keiichiro Mine, Seiho Nagafuchi, Tomoyasu Fukui, Soroku Yagihashi Tags: Original Article Source Type: research

Usefulness of subclassification of adult diabetes mellitus among inpatients in Japan
We applied a novel data-driven clustering method previously proposed to patients with diabetes in educational admission. As a result, we obtained clustering results quite similar to those in the original paper, indicating that clinical information at onset might not be essential for the clustering. Furthermore, we found a trend toward a greater educational effect in a specific cluster, suggesting clinical usefulness of the clustering. AbstractAims/IntroductionWe aimed to replicate a new diabetes subclassification based on objective clinical information at admission in a diabetes educational inpatient program. We also asses...
Source: Journal of Diabetes Investigation - December 8, 2021 Category: Endocrinology Authors: Kohei Saito, Tatsuhide Inoue, Hiroyuki Ariyasu, Toshio Shimada, Hiroshi Itoh, Issei Tanaka, Chikashi Terao Tags: Original Article Source Type: research