Metabolic associated fatty liver disease is a risk factor for chronic kidney disease
Metabolic associated fatty liver disease (MAFLD) was associated with the risk of chronic kidney disease (CKD). Fatty liver without metabolic dysfunction was not associated with the risk of CKD. MAFLD is an important treatment target for extra-hepatic disease. ABSTRACTBackground and AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD).MethodsThe participants were divided into four groups by the presence or absence of fatty liver disease (FLD) and metabolic dysfunction (MD). MAFLD was defined as having both FLD and MD, whereas CKD was defined as...
Source: Journal of Diabetes Investigation - October 13, 2021 Category: Endocrinology Authors: Yoshitaka Hashimoto, Masahide Hamaguchi, Takuro Okamura, Naoko Nakanishi, Akihiro Obora, Takao Kojima, Michiaki Fukui Tags: Original Article Source Type: research

The impact of flash glucose monitoring on glycemic control varies with the age and residual beta ‐cell function of patients with type 1 diabetes mellitus
AbstractAims/IntroductionWe aimed to explore clinical factors associated with glycemic variability (GV) assessed with flash glucose monitoring (FGM), and investigate the impact of FGM on glycemic control among Chinese type 1 diabetes mellitus (T1DM) patients in a real-life clinical setting.Materials and MethodsA total of 171 patients were included. GV was assessed from FGM data. One hundred ten patients wore FGM continuously for 6 months (longitudinal cohort). HbA1c, fasting and 2-hour postprandial C-peptide (FCP, 2hCP) and glucose profiles were collected. Changes in HbA1c and glycemic parameters were assessed during a 6-m...
Source: Journal of Diabetes Investigation - October 12, 2021 Category: Endocrinology Authors: Liyin Zhang, Yaling Xu, Xiaofang Jiang, Jieru Wu, Fang Liu, Li Fan, Xia Li, Guangming Yin, Lin Yang Tags: ORIGINAL ARTICLE Source Type: research

Comparisons of efficacy and safety in insulin glargine and lixisenatide plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type  2 diabetes
This study aimed to compare the efficacy (time in range of glucose level 70–180 mg/dL), safety (time below range level 1 of glucose
Source: Journal of Diabetes Investigation - October 11, 2021 Category: Endocrinology Authors: Yuji Kawaguchi, Shoko Miyamoto, Yuriko Hajika, Narumi Ashida, Koji Masumoto, Jun Sawa, Kenji Hamazaki, Yasuro Kumeda Tags: Original Article Source Type: research

Corrigendum
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 11, 2021 Category: Endocrinology Tags: Corrigendum Source Type: research

Fasting plasma glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 diabetes: Population ‐based Panasonic cohort study 2
ConclusionsThis study demonstrates that the risk of type 2 diabetes among the subjects having fasting plasma glucose concentration of 90-99 mg/dL, is progressively higher with the increasing level of fasting plasma glucose concentration in a Japanese people. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 8, 2021 Category: Endocrinology Authors: Chihiro Munekawa, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui Tags: ORIGINAL ARTICLE Source Type: research

Autonomic dysfunction, diabetes, and metabolic syndrome
AbstractAutonomic neuropathy is most often associated with advanced diabetes mellitus, either type 1 or type 2. The chronic diabetes complication can occur in various forms and affects the cardiovascular, gastrointestinal, endocrine, and genitourinary systems.One of the severe complications frequently under-recognized is cardiovascular autonomic neuropathy (CAN). The CAN Subcommittee of the Toronto Consensus Panel on Diabetic Neuropathy defined CAN as, “impairment of cardiovascular autonomic control in patients with established diabetes after excluding other causes.”1. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 8, 2021 Category: Endocrinology Authors: Tae Yang Yu, Moon ‐Kyu Lee Tags: EDITORIAL Source Type: research

Impact of vision and hearing impairments on risk of cardiovascular outcomes and mortality in patients with type 2 diabetes: a nationwide cohort study
ConclusionsVision and hearing impairments are independently important risk factors for adverse cardiovascular events and mortality in patients with type 2 diabetes. Vision and hearing impairments synergistically increased the risk of MI and all-cause deaths, but not stroke. In addition, in under 65 years of age, the HR of vision impairment was higher than those with vision and hearing impairments. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 8, 2021 Category: Endocrinology Authors: Younhea Jung, Kyungdo Han, Ji Min Lee, Hye Yeon Park, Jung Il Moon Tags: ORIGINAL ARTICLE Source Type: research

Diet ‐induced prediabetes: Effects on the activity of the renin‐angiotensin‐aldosterone system (RAAS) in selected organs
ConclusionDue to these observed changes, we suggest that local RAAS activity in the prediabetic state in selected organs elicits the derangements noted in T2D. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 7, 2021 Category: Endocrinology Authors: Bongeka Cassandra Mkhize, Palesa Mosili, Phikelelani Sethu Ngubane, Ntethelelo Hopewell Sibiya, Andile Khathi Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: Issue Information Source Type: research

Author Index
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: AUTHOR INDEX Source Type: research

Oral Abstracts
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: Abstracts Source Type: research

Poster Abstracts
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: Abstracts Source Type: research

Overview
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: Overview Source Type: research

Program at a Glance
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 6, 2021 Category: Endocrinology Tags: Program at a Glance Source Type: research

Effectiveness and safety of ertugliflozin for type 2 diabetes: a meta ‐analysis data from randomized controlled trials
ConclusionErtugliflozin effectively reduces HbA1c levels and provides extra clinical benefits including body weight and FPG. Common adverse effects including genital mycotic infectious and so on were reviewed. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 5, 2021 Category: Endocrinology Authors: Fudan Zhang, Wenting Wang, Xu Hou Tags: ORIGINAL ARTICLE Source Type: research

The early diagnostic value of ankle ‐brachial index combined with feet electrochemical skin conductance for peripheral artery disease in type 2 diabetes
ConclusionsABI in combination with FESC can accurately be used in early diagnosis of PAD. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 5, 2021 Category: Endocrinology Authors: Yun Zhao, Liji Huang, Xiqiao Zhou, Jingshun Liu, Jiangyi Yu Tags: ORIGINAL ARTICLE Source Type: research

Obituary of Dr. Susumu Seno
AbstractI am deeply saddened to report that my esteemed mentor Susumu Seino passed away on April 14, 2021. Susumu left a remarkable scientific legacy to his colleagues, former students, and physicians who benefitted from his many academic accomplishments in diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 4, 2021 Category: Endocrinology Authors: Nobuya Inagaki Tags: EDITORIAL Source Type: research

Factors associated with the degree of glycemic deterioration among patients with type 2 diabetes who dropped out of diabetes care: a longitudinal analysis using medical claims and health checkup data in Japan
ConclusionOverall in this study, glycemic control worsened mainly in male employees during treatment interruptions. However, changes in HbA1c greatly varied based on baseline HbA1c and antidiabetic medication type. Caring for patients at risk of worsening glycemic control due to treatment dropout, especially those using sulfonylurea and insulin, is imperative. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 3, 2021 Category: Endocrinology Authors: Noriko Ihana ‐Sugiyama, Takehiro Sugiyama, Kenjiro Imai, Ayako Yanagisawa‐Sugita, Hirokazu Tanaka, Mitsuru Ohsugi, Kohjiro Ueki, Nanako Tamiya, Yasuki Kobayashi Tags: ORIGINAL ARTICLE Source Type: research

Association between visceral adiposity index and risk of prediabetes: a meta ‐analysis of observational studies
ConclusionsIntegrated epidemiological evidence supports the hypothesis that VAI is a lipid combined anthropometric indices and may be a risk factor for prediabetes. VAI may be related to the high risk of prediabetes. However, it should be noted that the included studies have published bais and significant heterogeneity between our pooled estimate. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 2, 2021 Category: Endocrinology Authors: Dan Wang, Rui Fang, Haicheng Han, Jidong Zhang, Kaifei Chen, Xiaoqing Fu, Qinghu He, Yong Yang Tags: ORIGINAL ARTICLE Source Type: research

Case of subcutaneous insulin resistance syndrome treated with ultra ‐rapid insulin lispro
We reported a case of subcutaneous insulin resistance syndrome that achieved good glycemic control with ultra-rapid insulin lispro, novel insulin formulation. Although it has been reported that the combination of insulin lispro and heparin is effective for subcutaneous insulin resistance syndrome, it is suggested that ultra-rapid insulin lispro might provide good glycemic control without heparin. AbstractSubcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40-year-old woman with type...
Source: Journal of Diabetes Investigation - September 28, 2021 Category: Endocrinology Authors: Takahiro Ishii, Akihiro Katayama, Mihiro Sue, Remi Kuribayashi, Masafumi Tenta, Yuichi Matsushita, Masaya Takeda, Izumi Iseda, Satomi Tani, Kazuyuki Hida Tags: Case Report Source Type: research

A novel mechanism of imeglimin ‐mediated insulin secretion via the cADPR‐TRP channel pathway
ConclusionsImeglimin may activate TRPM2 channels in β-cells via the production of NAD+/cADPR, leading to the potentiation of GSIS. Developing approaches to stimulate cADPR-TRPM2 signaling provides a potential therapeutic tool to treat type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 28, 2021 Category: Endocrinology Authors: Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki Tags: Original Article Source Type: research

Efficacy of acceptance and commitment therapy for people with type  2 diabetes: Systematic review and meta‐analysis
ConclusionsACT might reduce glycated hemoglobin, and increase self-care ability and acceptance among people with type  2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 28, 2021 Category: Endocrinology Authors: Ryo Sakamoto, Yoichi Ohtake, Yuki Kataoka, Yoshinobu Matsuda, Tomokazu Hata, Jun Otonari, Akira Yamane, Hiromichi Matsuoka, Kazuhiro Yoshiuchi Tags: Original Article Source Type: research

Validity and reliability of the Japanese version of the Diabetes Knowledge Test among in ‐patients with type 2 diabetes
ConclusionsThe validity and reliability of the J-DKT after the diabetes education programme were acceptable in this study. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 26, 2021 Category: Endocrinology Authors: Taichi Minami, Jun Shirakawa, Hiroko Hiiragi, Taku Yamada, Youichi Suzuki, Shinitiro Shirabe, Hajime Maeda, Yasuo Terauchi Tags: ORIGINAL ARTICLE Source Type: research

Werner syndrome presented as early ‐onset diabetes: a case report
ABSTRACTWerner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. It is characterized by early onset of age-related diseases, such as cataracts, atherosclerosis, diabetes mellitus, osteoporosis, and malignancies, in which diabetes often onset at the 30s-40s. Herein we report a Chinese patient of Werner syndrome with uncommon early-onset diabetes at 18 years old, who had low BMI, insulin resistance, negative antibodies of diabetes, and early onset of cataracts. Genome sequencing and RT-PCR confirm the diagnosis. A novel heterozygous splice-site mutation in theWRN gene (c...
Source: Journal of Diabetes Investigation - September 26, 2021 Category: Endocrinology Authors: Xiaoli Wang, Siruo Liu, Fengye Tan, Qian Liu, Qiuyue Wang Tags: CASE REPORT Source Type: research

Diversity of Pathophysiology in Type 2 Diabetes Revealed by Islet Pathology
AbstractThe etiology of type 2 diabetes is multifactorial, in which environmental and genetic factors are involved to varying degrees. This suggests that its pathophysiology may vary depending on the subjects. Knowledge of the differences is critical because these differences are directly linked to the care and treatment of the patients. Recent studies have attempted to conduct subclassifications of type 2 diabetes based on clinical and genetic differences. However, there is no pathological evidence to support these subclassifications. The pathophysiology of type 2 diabetes is generally divided into insulin resistance in p...
Source: Journal of Diabetes Investigation - September 25, 2021 Category: Endocrinology Authors: Hiroki Mizukami, Kazuhiro Kudoh Tags: REVIEW ARTICLE Source Type: research

Metabolic associated fatty liver disease is the risk factor for chronic kidney disease
AbstractBackground& AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD).MethodsThe participants were divided into four groups by the presence or absence of fatty liver disease (FLD) and metabolic dysfunction (MD). MAFLD was defined as having both FLD and MD, whereas CKD was defined as estimated glomerular filtration rate of
Source: Journal of Diabetes Investigation - September 25, 2021 Category: Endocrinology Authors: Yoshitaka Hashimoto, Masahide Hamaguchi, Takuro Okamura, Naoko Nakanishi, Akihiro Obora, Takao Kojima, Michiaki Fukui Tags: ORIGINAL ARTICLE Source Type: research

Association between dipeptidyl peptidase ‐4 inhibitors and increased risk for bullous pemphigoid within 3 months from first use: A 5‐year Population‐Based Cohort Study Using the Japanese National Database
ConclusionsAlthough DPP-4i were associated with increased risk for BP, the risk was particularly significant within 3 months from first use. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 24, 2021 Category: Endocrinology Authors: Hirohito Kuwata, Yuichi Nishioka, Tatsuya Noda, Shinichiro Kubo, Tomoya Myojin, Tsuneyuki Higashino, Yutaka Takahashi, Hitoshi Ishii, Tomoaki Imamura Tags: ORIGINAL ARTICLE Source Type: research

Placental expression of glucose transporters GLUT ‐1, GLUT‐3, GLUT‐8 and GLUT‐12 in pregnancies complicated by gestational and type 1 diabetes mellitus.
AbstractAimThe aim of the present study was to evaluate the placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in term pregnancies complicated by well-controlled gestational (GDM) and type 1 pregestational diabetes mellitus (PGDM).Materials and MethodsA total of 103 placental samples were obtained from patients diagnosed with GDM (n=60), PGDM (n=20) and a non-diabetic control group (n=23). Computer-assisted quantitative morphometry of stained placental sections was performed to determine the expression of selected GLUT proteins.ResultsImmunohistochemical techniques used for the identification o...
Source: Journal of Diabetes Investigation - September 23, 2021 Category: Endocrinology Authors: Pawe ł Jan Stanirowski, Dariusz Szukiewicz, Agata Majewska, Mateusz Wątroba, Michał Pyzlak, Dorota Bomba‐Opoń, Mirosław Wielgoś Tags: ORIGINAL ARTICLE Source Type: research

Commentary on Intraglumerular dysfunction predicts kidney failure in the type  2 diabetes
The key physiological parameters that determine glomerular filtration rate levels are renal plasma flow, filtration fraction, intraglomerular pressure, and balance between afferent and efferent glomerular arteriolar resistance. The evaluation of the balance between afferent and efferent glomerular arteriolar resistance might be useful for the classification of diabetic kidney disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 23, 2021 Category: Endocrinology Authors: Jun Wada Tags: Commentary Source Type: research

Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation ‐associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report
In conclusion, genetic testing is helpful in identifying rare and interesting cases when clinicians suspect inheritable diseases. Additionally, when one fibrate drug is ineffective in treating hyperlipidemia, it might be worthwhile trying another fibrate. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2021 Category: Endocrinology Authors: Xiaojuan Zhang, Yongyong Chen, Nanwei Tong, Qing Shao, Yueyang Zhou, Tong Mu, Xiaoling Yang, Yuwei Zhang Tags: Case Report Source Type: research

Comparisons of efficacy and safety in insulin glargine and lixisenatide (iGlarLixi) plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type 2 diabetes
This study aimed to compare the efficacy (time in range of glucose level 70 –180 mg/dL), safety (time below range level 1 of glucose
Source: Journal of Diabetes Investigation - September 22, 2021 Category: Endocrinology Authors: Yuji Kawaguchi, Shoko Miyamoto, Yuriko Hajika, Narumi Ashida, Koji Masumoto, Jun Sawa, Kenji Hamazaki, Yasuro Kumeda Tags: ORIGINAL ARTICLE Source Type: research

Dipeptidyl peptidase ‐4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: a meta‐analysis
ConclusionsThis study demonstrated the effectiveness and safety of DPP-4 inhibitors bonded with insulin in patients with T2D and CKD, but the protective actions of this cure on kidney and cardiovascular outcomes, as well as the functions of other DPP-4 inhibitors, need to be affirmed by more good-quality RCTs. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2021 Category: Endocrinology Authors: Xianling Zhou, Heng Shi, Shiping Zhu, Haixia Wang, Shengyun Sun Tags: ORIGINAL ARTICLE Source Type: research

Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study
AbstractAims/IntroductionWe aimed to study the relationships among the copper (Cu)/zinc (Zn) ratio, inflammatory biomarkers, and the prevalence of diabetic kidney disease (DKD) in patients with type 2 diabetes.Materials and MethodsWe performed a cross-sectional study on 651 patients with type 2 diabetes. DKD was defined as a urinary albumin-to-creatinine ratio ≥30 mg/g creatinine and/or an estimated glomerular filtration rate using cystatin C
Source: Journal of Diabetes Investigation - September 18, 2021 Category: Endocrinology Authors: Toshiko Takao, Hiroyuki Yanagisawa, Machi Suka, Yoko Yoshida, Yukiko Onishi, Tazu Tahara, Takako Kikuchi, Akifumi Kushiyama, Motonobu Anai, Kazuyuki Takahashi, Sayaka Wakabayashi Sugawa, Hiroki Yamazaki, Shoji Kawazu, Yasuhiko Iwamoto, Mitsu Tags: ORIGINAL ARTICLE Source Type: research

Pancreatic β‐cell fate in subjects with COVID‐19
AbstractSubjects with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are still increasing worldwide as of August 2021. The association of COVID-19 with diabetes has been reported in the context of severity, complications such as diabetic ketoacidosis, and new onset of diabetes. Impairment of insulin-producing pancreatic β-cells is a key contributing factor to the abovementioned diabetic pathogenesis by COVID-19. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 16, 2021 Category: Endocrinology Authors: Jun Shirakawa Tags: COMMENTARY Source Type: research

Epidemiological characteristics of diabetic kidney disease in Taiwan
AbstractDiabetic kidney disease (DKD) is a critical microvascular complication of diabetes. With the continuous increase in diabetes prevalence since 2000, the prevalence of DKD has also been increasing in the past years. The prevalence of DKD among individuals with type 2 diabetes (T2D) in Taiwan increased from 13.32% in 2000 to 17.92% in 2014. The cumulative incidence of DKD among individuals with type 1 diabetes in Taiwan was higher than 30% during 1999 –2012. DKD is the leading cause of end-stage renal disease (ESRD), with a prevalence of approximately 45% in the population on chronic dialysis in Taiwan. Among in...
Source: Journal of Diabetes Investigation - September 16, 2021 Category: Endocrinology Authors: Jun ‐Sing Wang, Fu‐Shun Yen, Kun‐Der Lin, Shyi‐Jang Shin, Yueh‐Han Hsu, Chih‐Cheng Hsu, Diabetes Kidney Disease Research Committee of the Diabetes Association of the Republic of China (Taiwan) Tags: REVIEW ARTICLE Source Type: research

Recent updates and future perspectives on gestational diabetes mellitus: An important public health challenge
AbstractGestational diabetes mellitus (GDM) is the most common form of dysglycaemia during pregnancy. GDM is defined as hyperglycemia diagnosed for the first time during pregnancy, most commonly during the second or third trimester. GDM can be harmful to both the mother and the offspring. Complications to fetuses include excessive birthweight and preterm birth, while women with GDM are more susceptible to gestational hypertension, pre-eclampsia, and postpartum abnormal glucose intolerance (pAGT). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 16, 2021 Category: Endocrinology Authors: Leo Check Hei Chu, Takashi Sugiyama, Ronald Ching Wan Ma Tags: UPDATE Source Type: research

A novel mechanism of Imeglimin ‐mediated insulin secretion via the cADPR ‐ TRP channel pathway
ConclusionsImeglimin may activate TRPM2 channels in β-cells via the production of NAD+/cADPR, leading to the potentiation of GSIS. Developing approaches to stimulate cADPR-TRPM2 signaling provides a potential therapeutic tool to treat type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 15, 2021 Category: Endocrinology Authors: Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki Tags: ORIGINAL ARTICLE Source Type: research

Incidence and risk factors of severe non ‐proliferative/proliferative diabetic retinopathy: More than a decade follow up in the Tehran Lipids and Glucose Study
The present study showed that each year, approximately 1% of Iranian patients with type  2 diabetes mellitus suffered from severe non-proliferative and proliferative diabetic retinopathy. Poor control of diabetes, current smoking, prehypertension, newly diagnosed hypertension and normal bodyweight were associated with a higher risk of severe non-proliferative and proliferative diabeti c retinopathy. AbstractAims/IntroductionTo examine the incidence rate of severe non-proliferative and proliferative diabetic retinopathy (severe-NPDR/PDR) and determine its potential risk factors.Materials and MethodsThe study consisted ...
Source: Journal of Diabetes Investigation - September 13, 2021 Category: Endocrinology Authors: Mahsa Sardarinia, Samaneh Asgari, Reyhane Hizomi Arani, Fatemeh Eskandari, Fereidoun Azizi, Davood Khalili, Farzad Hadaegh Tags: Original Article Source Type: research

Pregestational Diabetes Mediates the Association between Maternal Obesity and the Risk of Congenital Heart Defects
AbstractObjectiveWe aimed to explore whether the association between obesity and congenital heart defects(CHDs) can be mediated by maternal pregestational diabetes(PGDM).MethodsWe involved 53708 mother-infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen (BiCoS). Mothers were categorized into four groups: the underweight group (Body mass index, BMI
Source: Journal of Diabetes Investigation - September 13, 2021 Category: Endocrinology Authors: Xiao ‐Xia Wu, Ru‐Xiu Ge, Le Huang, Fu‐Ying Tian, Yi‐Xuan Chen, Lin‐Lin Wu, Jian‐Min Niu Tags: ORIGINAL ARTICLE Source Type: research

A case of subcutaneous insulin resistance syndrome treated with ultra ‐rapid insulin lispro
AbstractSubcutaneous insulin resistance (SIR) syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40-year-old woman with type 2 diabetes mellitus who had been diagnosed with SIR syndrome since the age of 29 and had been persistently treated with continuous subcutaneous insulin infusion using a mixture of insulin lispro and heparin. The patient was switched from insulin lispro plus heparin to ultra-rapid insulin lispro (URLi); given that it contains treprostinil and citrate, it is expected to have similar effects a...
Source: Journal of Diabetes Investigation - September 12, 2021 Category: Endocrinology Authors: Takahiro Ishii, Akihiro Katayama, Mihiro Sue, Remi Kuribayashi, Masafumi Tenta, Yuichi Matsushita, Masaya Takeda, Izumi Iseda, Satomi Tani, Kazuyuki Hida Tags: CASE REPORT Source Type: research

Eating whole fruit, not drinking fruit juice, may reduce the risk of type 2 diabetes mellitus
Fruit intake may reduce the risk of type 2 diabetes by probably four factors: dietary fiber, phytochemicals (flavonoids), fructose, and chewing. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 10, 2021 Category: Endocrinology Authors: Yusuke Seino, Katsumi Iizuka, Atsushi Suzuki Tags: COMMENTARY Source Type: research

Association of Insulin treatment with gastric residue during an esophagogastroduodenoscopy
AbstractThe purpose of this study was investigating the association of glycemic control and diabetic treatment to gastric residue observed during an esophagogastroduodenoscopy. Among 6,592 subjects who had esophagogastroduodenoscopy at our clinic between 2003 and 2019, we retrospectively and longitudinally identified those who had gastric residue during an esophagogastroduodenoscopy. Other data collected were age, sex, diagnosis of diabetes, glycated hemoglobin (HbA1c) and diabetic medication. Cox proportional hazard models were used to assess the association of these data with occurrence of gastric residue. To the best of...
Source: Journal of Diabetes Investigation - September 9, 2021 Category: Endocrinology Authors: Toshiko Kobori, Yukiko Onishi, Masahiko Iwamoto, Tetsuya Kubota, Takako Kikuchi, Tazu Tahara, Toshiko Takao, Hiroaki Fujiwara, Yoko Yoshida, Masato Kasuga Tags: SHORT REPORT Source Type: research

VX ‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation
ConclusionsThis work revealed that caspase-1-mediated pyroptosis drives renal inflammation and fibrosis in diabetes. Our results are the first demonstration of VX-765 representing a promising therapeutic opportunity for alleviating the progression of DN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 8, 2021 Category: Endocrinology Authors: Si Wen, Fei Deng, Lulu Li, Li Xu, Xin Li, Qiuling Fan Tags: ORIGINAL ARTICLE Source Type: research

The efficacy of acceptance and commitment therapy for people with type 2 diabetes: Systematic review and meta ‐analysis
ConclusionsACT may reduce HbA1c and increase self-care ability and acceptance among people with type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 6, 2021 Category: Endocrinology Authors: Ryo Sakamoto, Yoichi Ohtake, Yuki Kataoka, Yoshinobu Matsuda, Tomokazu Hata, Jun Otonari, Akira Yamane, Hiromichi Matsuoka, Kazuhiro Yoshiuchi Tags: ORIGINAL ARTICLE Source Type: research

Comparison of the effects of frequent versus conventional nutritional interventions in patients with type 2 diabetes mellitus: a randomized, controlled trial
ConclusionIntensive nutritional education is useful for alleviating the risk factors associated with the onset and progression of diabetic kidney disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 4, 2021 Category: Endocrinology Authors: Nao Kawabata, Kenta Okada, Akihiko Ando, Tomoyuki Kurashina, Manabu Takahashi, Tetsuji Wakabayashi, Daisuke Nagata, Eiji Kusano, Satsuki Mogi, Toshiko Sato, Shizukiyo Ishikawa, Shun Ishibashi Tags: CLINICAL TRIAL Source Type: research

Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2021 Category: Endocrinology Tags: Issue Information Source Type: research

Commentary on Intraglumerular dysfunction predicts kidney failure in the type 2 diabetes
AbstractThe substantial renoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors in diabetic kidney disease (DKD) has been reported and many researchers focus on the glomerular hemodynamic dysfunction for the progression mechanism of DKD. In type 1 diabetes, Cherneyet al. measured the inulin (glomerular filtration; GFR) and para-aminohippurate (effective renal plasma flow; RPF) clearances and reported that empagliflozin ameliorated renal glomerular hyperfiltration by affecting tubular-glomerular feedback mechanisms. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2021 Category: Endocrinology Authors: Jun Wada Tags: COMMENTARY Source Type: research

New mediators in diabetes pathogenesis: exosomes and metabolites
AbstractType 2 diabetes is a systemic disorder characterized by metabolic impairment in multiple organs1. Various factors trigger insulin resistance in muscle, liver and adipose tissue resulting in increased insulin demand and de-repression of hepatic gluconeogenesis. When pancreatic β cells fail to compensate their mass and function to the increased insulin demand, β cell apoptosis and dedifferentiation occurs which leads to hyperglycemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2021 Category: Endocrinology Authors: Joonyub Lee, Seung ‐Hwan Lee Tags: EDITORIAL Source Type: research

Precision medicine in diabetes: A non ‐invasive prenatal diagnostic test for the determination of fetal glucokinase mutations
AbstractHyperglycemia caused by mutations in the glucokinase gene,  GCK, is the most common form of monogenic diabetes. Prenatal diagnosis is important, as it impacts on treatment. Here we report a monogenic non-invasive prenatal diagnostic (NIPD-M) test on cell-free DNA in maternal plasma using relative haplotype dosage. In three pregnancies of two families with known maternalGCK mutations, we unambiguously determined the fetal genotype already at 12 weeks of gestation. In summary, we provide proof of feasibility for NIPD-M in  GCK diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2021 Category: Endocrinology Authors: Thierry Nouspikel, Jean ‐Louis Blouin, Jardena Puder, Bettina Köhler Ballan, Valerie M. Schwitzgebel Tags: SHORT REPORT Source Type: research

Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus
ConclusionsIncreased cortisol levels may increase the risk of developing LVDD in DM patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 1, 2021 Category: Endocrinology Authors: Rikako Sagara, Tomoaki Inoue, Noriyuki Sonoda, Chieko Yano, Misato Motoya, Hironobu Umakoshi, Ryuichi Sakamoto, Yoshihiro Ogawa Tags: ORIGINAL ARTICLE Source Type: research