Eating whole fruits, not drinking fruits juice, may reduce the risk of type 2 diabetes mellitus
AbstractCarbohydrates, otherwise known as saccharides, are a macronutrient that is found in a wide variety of natural and processed foods. Carbohydrates include sugars, starch, and cellulose (insoluble dietary fiber), and can be categorized as monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Monosaccharides such as glucose and fructose, and disaccharides such as sucrose, are together referred to as sugars. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 28, 2021 Category: Endocrinology Authors: Yusuke Seino, Katsumi Iizuka, Atsushi Suzuki Tags: COMMENTARY Source Type: research

Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?
AbstractObesity, diabetes, and Alzheimer ’s disease (AD) are becoming increasingly common, especially in the aging population, and are adversely affecting quality of life for patients and their families. These conditions have been shown to be interrelated, and AD has recently been referred to as type 3 diabetes, because neuronal insulin resistance underlies the pathophysiology of AD. Based on the amyloid-beta hypothesis, BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is the most promising drug target for AD. BACE1 is a β-secretase that processes the amyloid precursor protein (APP) to generate am...
Source: Journal of Diabetes Investigation - July 28, 2021 Category: Endocrinology Authors: Hiraku Ono, Koutaro Yokote Tags: COMMENTARY Source Type: research

Long non ‐coding ribonucleic acid urothelial carcinoma‐associated 1 promotes high glucose‐induced human retinal endothelial cells angiogenesis through regulating micro‐ribonucleic acid‐624‐3p/vascular endothelial growth factor C
ConclusionsWe identified UCA1 as an important factor associated with DR, which could regulate the expression of VEGF-C by sponging miR-624-3p in human retinal endothelial cells. Our results pave the way for further studies on diagnostic and therapeutic studies related to UCA1 in DR patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 27, 2021 Category: Endocrinology Authors: Huang Yan, Panpan Yao, Ke Hu, Xueyao Li, Hong Li Tags: Original Article Source Type: research

Decline in renal function associated with cardiovascular autonomic neuropathy positively coordinated with proteinuria in patients with type  2 diabetes
ConclusionsCAN strongly increased the risk of a 40% eGFR decline from baseline, especially in type  2 diabetes patients with macroproteinuria. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 27, 2021 Category: Endocrinology Authors: Taichi Muramatsu, Masahiro Takahashi, Rena Kakinuma, Tomoyo Sato, Mitsuyo Yamamoto, Manabu Akazawa, Kentaro Tanaka, Takako Kikuchi, Akifumi Kushiyama Tags: Original Article Source Type: research

Delayed Heart Rate Recovery after Exercise Predicts Development of Metabolic Syndrome: A Retrospective Cohort Study
ConclusionThe slow phase of HRR, particularly HRR3, might be more sensitive at predicting the risk of MetS. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 27, 2021 Category: Endocrinology Authors: Tae Yang Yu, Won ‐Jung Hong, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Ji Cheol Bae, Jae Hyeon Kim, Moon‐Kyu Lee Tags: ORIGINAL ARTICLE Source Type: research

Prevalence and Clinical Characteristics of Fulminant Type 1 Diabetes Mellitus in Korean adults: A Multi ‐Institutional Joint Research
ConclusionsIn this study, the prevalence of T1DM was 1.2% among all patients with diabetes, and that of FT1DM was 3.2% among those newly diagnosed with T1DM. The HbA1c levels were lower in patients with FT1DM than in those with non-FT1DM at diagnosis and at the last follow-up examination. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 27, 2021 Category: Endocrinology Authors: Sun Ok Song, Jae ‐Seung Yun, Seung‐Hyun Ko, Yu‐Bae Ahn, Bo‐Yeon Kim, Chul‐Hee Kim, Ja Young Jeon, Dae Jung Kim, Da Hae Seo, So Hun Kim, Jung Hyun Noh, Da Young Lee, Kyung‐Soo Kim, Soo‐Kyung Kim, The Type 1 Diabetes Study Group Tags: ORIGINAL ARTICLE Source Type: research

A retrospective nationwide study on the trends in first ‐line antidiabetic medication for patients with type 2 diabetes in Japan
ConclusionsUnlike in the US/Europe, DPP4 inhibitor is the most prescribed first-line medication for type 2 diabetes in Japan, while there is a wide variation in the drug choice by facility-type and prefecture. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 26, 2021 Category: Endocrinology Authors: Ryotaro Bouchi, Takehiro Sugiyama, Atsushi Goto, Kenjiro Imai, Noriko Ihana ‐Sugiyama, Mitsuru Ohsugi, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki Tags: ORIGINAL ARTICLE Source Type: research

The Utility of Using ECG Measures of Heart Rate Variability as a Measure of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes
AbstractAims/IntroductionCardiovascular autonomic neuropathy (CAN) is a predictor of cardiovascular disease and mortality. Cardiovascular reflex tests (CARTs) are the gold-standard for diagnosis of CAN, but may not be feasible in large research cohorts or in clinical care. We investigated whether measures of heart rate variability (HRV) obtained from standard ECG recordings provide a reliable measure of CAN.Materials and MethodsStandardized CARTs (R-R response to paced breathing, Valsalva, postural changes) and digitized 12-lead resting ECGs were obtained concomitantly in DCCT/EDIC participants (n=311). Standard deviation ...
Source: Journal of Diabetes Investigation - July 26, 2021 Category: Endocrinology Authors: Rodica Pop ‐Busui, Jye‐Yu C. Backlund, Ionut Bebu, Barbara H. Braffett, Gayle Lorenzi, Neil. H White, John M. Lachin, Elsayed Z. Soliman, The DCCT/EDIC Research Group Tags: ORIGINAL ARTICLE Source Type: research

A Low Fasting Glucose/Estimated Average Glucose Ratio was Associated with Superior Response to Insulin Degludec/Aspart Compared to Basal Insulin in Patients with Type 2 Diabetes
AbstractIntroductionBenefits of once-daily insulin degludec/aspart (IDegAsp) compared to basal insulin in type 2 diabetes has not been established.Materials and MethodsThis is a retrospective observational study. From a basal insulin cohort from 3 referral hospitals, patients were enrolled who initiated once-daily IDegAsp. A control group maintaining basal insulin was selected by Propensity-score matching. HbA1c changes over 6 months and associated clinical factors were evaluated.ResultsIDegAsp group and the control were comprised of 87 patients, respectively. Baseline HbA1c was comparable between the two groups (8.7 &plus...
Source: Journal of Diabetes Investigation - July 22, 2021 Category: Endocrinology Authors: Han Na Jang, Ye Seul Yang, Tae Jung Oh, Bo Kyung Koo, Seong Ok Lee, Kyong Soo Park, Hak Chul Jang, Hye Seung Jung Tags: ORIGINAL ARTICLE Source Type: research

Blood glucose control: where are we?
AbstractHyperglycemia is a hallmark of diabetes mellitus, however, the significance of blood glucose control in patients with diabetes has only been investigated relatively recently in the long history of diabetes. Through the well-known Diabetes Control and Complications Trial (DCCT), Kumamoto and United Kingdom Prospective Diabetes Study (UKPDS) studies, intensive blood glucose control indeed significantly prevented or delayed the development and/or progression of microangiopathies in both type 1 and type 2 diabetes, however, the effects on macroangiopathy were not certain in both populations. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 21, 2021 Category: Endocrinology Authors: Moon ‐Kyu Lee Tags: UPDATE Source Type: research

Association of leukocyte counts in the first trimester with glucose intolerance during pregnancy
AbstractAimsWe investigated the association between leukocyte counts and glucose challenge test (GCT) level during pregnancy.Methodswe collected prenatal information of women who had their first clinic visit in early pregnancy. Women underwent GCT at 24 to 28 gestational weeks, and a result of ≥7.8mmol/L was considered positive. Subjects were divided into quartiles of leukocyte counts, and association with GCT results and positive rate were analyzed by logistic regression.ResultsAmong 20707 pregnant women, the median of leukocyte counts was higher in positive group than normal group (8.5 ×109/L vs. 8.2 ×109/...
Source: Journal of Diabetes Investigation - July 20, 2021 Category: Endocrinology Authors: Leishen Wang, Weiqin Li, Shuang Zhang, Huikun Liu, Wei Li, Tongxin Hu, Junhong Leng Tags: ORIGINAL ARTICLE Source Type: research

Challenges of optimizing insulin therapy for patients with type  2 diabetes mellitus
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 19, 2021 Category: Endocrinology Authors: Fu ‐Shun Yen, Chii‐Min Hwu Tags: Editorial Source Type: research

Sex ‐specific differences in blood lipids and lipid ratios in type 2 diabetic foot patients
This study attempts to identify the contribution to sex-specific differences in blood lipids and lipid ratios in these patients.Materials and MethodsIn this case –control study, we explore 306 patients with T2DF as the study group and 306 patients with type 2 diabetes mellitus as the control group. Patients were diagnosed according to the Standards of Medical Care in Diabetes–2014 (American Diabetes Association). Blood lipid and lipid ratios were determ ined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.ResultsWe studied male patients with T2DF who were aged 68....
Source: Journal of Diabetes Investigation - July 18, 2021 Category: Endocrinology Authors: Shuming Yin, Puqing Zhao, Zisheng Ai, Bing Deng, Wei Jia, Huan Wang, Jiaqi Zheng Tags: ORIGINAL ARTICLE Source Type: research

Voxel ‐based specific regional analysis system for Alzheimer’s disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study
We evaluated the utility of the voxel-based specific regional analysis system of Alzheimer's disease, an automated brain morphometry system that includes the hippocampus, for screening unrecognized cognitive dysfunction in elderly patients with diabetes. This is the first report to assess the association between hippocampal atrophy and cognitive dysfunction by an automated voxel-based morphometry system in clinical diabetes practice. The results suggest that the voxel-based specific regional analysis system of Alzheimer's disease can be useful for early identification of cognitive dysfunction in the elderly with diabetes. ...
Source: Journal of Diabetes Investigation - July 17, 2021 Category: Endocrinology Authors: Yoko Ueba, Takaaki Murakami, Taizo Yamamoto, Akira Kuroe, Masahide Yamasaki, Daita Kaneda, Daisuke Otani, Sakura Kiyobayashi, Kaori Ikeda, Daisuke Yabe, Masahito Ogura, Nobuya Inagaki Tags: Original Article Source Type: research

Role of skeletal muscle lipids in the pathogenesis of insulin resistance of obesity and type  2 diabetes
In conclusion, reduced dietary lipid intake in association with physical exercise cou ld be a therapeutic option to improve insulin sensitivity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 17, 2021 Category: Endocrinology Authors: Marc Gilbert Tags: Mini Review Source Type: research

Bariatric surgery versus medical treatment in mildly obese patients with type 2 diabetes mellitus in Japan: propensity score ‐matched analysis on real‐world data
ABSTRACTAimsTo compare glycemic control one-year after treatment in patients with mildly obese (BMI 27.5-34.9 kg/m2) type 2 diabetes mellitus (T2DM) who underwent bariatric surgery (BS) to those who received medical treatment (MT) in Japan.Materials and MethodsA retrospective study using real world data was conducted in electronic medical records from a tertiary care hospital and in JMDC Inc. (JMDC) claim database from 2008 to 2019. Each patient was propensity score-matched between the BS and the MT group by age, gender, BMI, HbA1c, and T2DM duration and compared from the index date to the one-year post-index.ResultsThe st...
Source: Journal of Diabetes Investigation - July 16, 2021 Category: Endocrinology Authors: Yosuke Seki, Kazunori Kasama, Renzo Yokoyama, Akihiro Maki, Hideharu Shimizu, Hyejin Park, Yoshimochi Kurokawa Tags: ORIGINAL ARTICLE Source Type: research

Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals
ConclusionsMitochondrial haplogroups, but not nuclear genetic variants, have a better association with the insulin requirement. Our results highlight the role of mitochondria in the management of common metabolic diseases. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 14, 2021 Category: Endocrinology Authors: Feng ‐Chih Shen, Shao‐Wen Weng, Meng‐Han Tsai, Yu‐Jih Su, Sung‐Chou Li, Shun‐Jen Chang, Jung‐Fu Chen, Yen‐Hsiang Chang, Chia‐Wei Liou, Tsu‐Kung Lin, Jiin‐Haur Chuang, Ching‐Yi Lin, Pei‐Wen Wang Tags: ORIGINAL ARTICLE Source Type: research

Acute kidney injury in Japanese type 2 diabetes patients receiving sodium ‐glucose co‐transporter 2 inhibitors: A nationwide cohort study
AbstractThe present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors. We identified 171,622 patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors; among them, 476 (0.3%) patients developed acute kidney injury. Hazard ratio for acute kidney injury occurrence risk was analyzed using a Cox proportional hazards model adjusted for patient characteristics at baseline and use of concomitant agents. In the adjusted model, patients who developed acute...
Source: Journal of Diabetes Investigation - July 13, 2021 Category: Endocrinology Authors: Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda Tags: SHORT REPORT Source Type: research

When Amputation Is Not The End Of The Challenge: A Successful Therapy For Osteomyelitis And Soft Tissue Infection In A Patient With Type 1 Diabetes
ABSTRACTInfection is a common complication in patients with diabetic foot ulcer, leading to lower extremities amputation and healing failure. In this article, we report the case of a 39-year-old diabetic man who developed a severe soft tissues ’ infection and osteomyelitis after experiencing a major amputation for a wet gangrene of both the foot and the ankle. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 13, 2021 Category: Endocrinology Authors: Paola Caruso, Maurizio Gicchino, Miriam Longo, Lorenzo Scappaticcio, Ferdinando Campitiello, Katherine Esposito Tags: CASE REPORT Source Type: research

Application of weighted gene co ‐expression network analysis (WGCNA) to identify novel key genes in diabetic nephropathy
ConclusionWGCNA was applied to DN expression profiling in combination with Connectivity Map analysis. Several novel key genes and chemical compounds were screened out, providing new molecular targets for DN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 11, 2021 Category: Endocrinology Authors: Zheng Wang, Xiaolei Chen, Chao Li, Wanxin Tang Tags: ORIGINAL ARTICLE Source Type: research

Impact of extracellular ‐to‐intracellular fluid volume ratio on albuminuria in patients with type 2 diabetes: A cross‐sectional and longitudinal cohort study
ConclusionsThe ECW/ICW ratio is independently associated with the level of albuminuria in patients with type  2 diabetes mellitus without kidney failure. This reinforces the importance of monitoring fluid balance in patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Hanako Nakajima, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Fuyuko Takahashi, Yuta Yoshimura, Ryo Bamba, Takuro Okamura, Noriyuki Kitagawa, Saori Majima, Takufumi Senmaru, Hiroshi Okada, Naoko Nakanishi, Emi Ushigome, Mai Asano, Masahi Tags: Original Article Source Type: research

Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Tags: Issue Information Source Type: research

The COVID ‐19 world – Are we there yet?
The spreading of SARS-CoV-2 virus infection is still of great concern as well as clinical and social interest. The key to conquer this pandemic would be establishment of herd immunity by vaccination and of treatment, and I have discussed issues we are facing now. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Yoshiyuki Hamamoto Tags: Editorial Source Type: research

Pyogenic psoas abscess on the dorsal side, and bacterial meningitis and spinal epidural abscess on the ventral side, both of which were induced by spontaneous discitis in a patient with diabetes mellitus: A case report
Type  2 diabetes mellitus patients are immunocompromised, particularly under poorly controlled conditions, and thereby they could develop rare inflammatory diseases, such as spontaneous discitis, pyogenic psoas abscess, spinal epidural abscess and bacterial meningitis. Herein we report a pyogenic psoas abscess on the dorsal side, and bacterial meningitis and spinal epidural abscess on the ventral side, both of which were induced by spontaneous discitis in a patient with poorly controlled type 2 diabetes mellitus. This case was very rare and interesting, because we successfully treated various inf ections with ant...
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Megumi Horiya, Takatoshi Anno, Mayuko Kawada, Haruki Yamada, Kaiou Takahashi, Haruka Takenouchi, Hideyuki Iwamoto, Fumiko Kawasaki, Katsumi Kurokawa, Hideaki Kaneto, Kohei Kaku, Koichi Tomoda Tags: Case Report Source Type: research

Forecasting the type  2 diabetes mellitus epidemic and the role of key risk factors in Oman up to 2050: Mathematical modeling analyses
The prevalence of type  2 diabetes mellitus in Oman was projected to grow by 57% by 2050, whereas the incidence was projected to grow by 200% by 2050. By 2050, type 2 diabetes mellitus will consume 30% of Oman’s health expenditure. The type 2 diabetes mellitus epidemic in Oman is driven by the high obesity level. AbstractAims/IntroductionTo investigate and forecast type  2 diabetes mellitus epidemic, its related risk factors and cost in Oman by 2050.Materials and MethodsAn age-structured mathematical model was used to characterize type  2 diabetes mellitus epidemiology and trends in Oman betw...
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Susanne F Awad, Adhra Al ‐Mawali, Jawad A Al‐Lawati, Magdi Morsi, Julia A Critchley, Laith J Abu‐Raddad Tags: Original Article Source Type: research

Mean and visit ‐to‐visit variability of glycated hemoglobin, and the risk of non‐alcoholic fatty liver disease
ConclusionsIncreased mean HbA1c levels elevated the risk of incident NAFLD, even with NGT. Increases in visit-to-visit variability of HbA1c independently elevated the risk of incident NAFLD, but only in the diabetes group. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Jee Hee Yoo, Mira Kang, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Dong Hyun Sinn, Sang ‐Man Jin Tags: Original Article Source Type: research

Favorable effect of sodium –glucose cotransporter 2 inhibitor, dapagliflozin, on non‐alcoholic fatty liver disease compared with pioglitazone
AbstractAims/IntroductionSodium –glucose cotransporter 2 inhibitors, as well as thiazolidines, suppress nonalcoholic fatty liver disease (NAFLD); however, few comparative studies have been reported. Dapagliflozin has shown non-inferiority compared with pioglitazone for glycemic control, and superiority regarding weight reductio n in patients with type 2 diabetes. We carried out a secondary analysis for the favorable effects of sodium–glucose cotransporter inhibitors for NAFLD.Materials and MethodsIn this multicenter, open-label, prospective, randomized, parallel-group comparison trial, patients t...
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Kyu Yong Cho, Akinobu Nakamura, Kazuno Omori, Takahiro Takase, Aika Miya, Kohei Yamamoto, Hiroshi Nomoto, Hiraku Kameda, Shinji Taneda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi Tags: Original Article Source Type: research

New prospects for incretin ‐related drugs in the treatment of type 2 diabetes
This article is about new prospects for incretin-related drugs in the treatment of type  2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Tomohiko Kimura, Kohei Kaku Tags: JDI Updates Source Type: research

Normal parathyroid hormone and non ‐proliferative diabetic retinopathy in patients with type 2 diabetes
Low serum parathyroid hormone levels were significantly associated with complications of non-proliferative diabetic retinopathy in inpatients. Its causality remains to be further studied. AbstractAims/IntroductionTo investigate the associations between parathyroid hormone (PTH) and non-proliferative diabetic retinopathy (NPDR) in patients with type  2 diabetes mellitus.Materials and MethodsData were collected from 2,322 patients with type  2 diabetes mellitus in hospital between 2017 and 2019. The odds ratio (OR) and the corresponding 95% confidence interval related to the quartiles of PTH were obtained by logist...
Source: Journal of Diabetes Investigation - July 8, 2021 Category: Endocrinology Authors: Shengnan Sun, Yahao Wang, Wenru Ma, Bingfei Cheng, Bingzi Dong, Yuhang Zhao, Jianxia Hu, Yue Zhou, Yajing Huang, Fanxiang Wei, Yangang Wang Tags: Clinical Trial Source Type: research

Decline in the renal function associated with cardiovascular autonomic neuropathy positively coordinated with proteinuria in patients with type 2 diabetes
ConclusionsCAN strongly increased the risk of a 40% eGFR decline from baseline, especially in type 2 diabetic patients with macroproteinuria. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 6, 2021 Category: Endocrinology Authors: Taichi Muramatsu, Masahiro Takahashi, Rena Kakinuma, Tomoyo Sato, Mitsuyo Yamamoto, Akazawa Manabu, Kentaro Tanaka, Takako Kikuchi, Akifumi Kushiyama Tags: ORIGINAL ARTICLE Source Type: research

Lower Handgrip Strength levels probably precede Triglyceride Glucose Index and Associated with Diabetes in Men not in Women
ConclusionsOur results demonstrated that the HGS/W was inversely associated with TyG and DM, and lower HGS/W levels preceded TyG levels in the elderly population. However, the effect was inconsistent between males and females, and the possible mechanism would need further clarification. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 6, 2021 Category: Endocrinology Authors: Jia Zheng, Lu Zhang, Min Jiang Tags: ORIGINAL ARTICLE Source Type: research

Case of type  2 diabetes mellitus with edema resulting in subcutaneous insulin resistance syndrome
This article introduced a case of a woman with type 2 diabetes mellitus with heart failure edema. Her blood glucose control was significantly associated with the level of edema. Excluding other factors, it can be concluded that edema might lead to insulin subcutaneous malabsorption, even if the edema at the injection site is not obvious. AbstractSubcutaneous insulin resistance syndrome caused by obesity, induration at the injection site, skin temperature and other factors is common clinically, whereas resistance events caused by edema are relatively rare. This article introduced a case of a woman with type  2 diabetes...
Source: Journal of Diabetes Investigation - July 6, 2021 Category: Endocrinology Authors: Ying Hu, Qiongwen Zhu, Xiuli Yang, Jieping Yan, Jiana Shi Tags: Case Report Source Type: research

Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar
ConclusionsThis is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type  1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non-Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world.GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type  1B diabetes mell...
Source: Journal of Diabetes Investigation - July 4, 2021 Category: Endocrinology Authors: Basma Haris, Saras Saraswathi, Sara Al ‐Khawaga, Reem Hasnah, Amira Saeed, Shihab Mundekkadan, Noor Hamed, Houda Afyouni, Tasneem Abdel‐Karim, Shayma Mohammed, Amel Khalifa, Maryam Al‐Maadheed, Mahmoud Al‐Zyoud, Ahmed Shamekh, Ahmed Tags: Original Article Source Type: research

Inceptor intercepts insulin signaling in pancreatic β‐cells
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 4, 2021 Category: Endocrinology Authors: Hirotaka Watada Tags: Commentary Source Type: research

Onset of fulminant type  1 diabetes mellitus following hypophysitis after discontinuation of combined immunotherapy. A case report
We describe a case of immunotherapy-related type  1 diabetes developing after combined immunotherapy cessation. The patient developed fulminant type 1 diabetes>2  years after the first immunotherapy dose, and had previously developed immune-related hypophysitis. AbstractDiabetes is a rare, but potentially life-threatening, adverse event of immune checkpoint inhibitors that requires prompt recognition and treatment. It usually occurs in the first 3  months of treatment and is typically related to programmed cell death-1 antibodies, alone or in combined therapy. It has rarely been described developing ...
Source: Journal of Diabetes Investigation - July 4, 2021 Category: Endocrinology Authors: Laura Boswell, Gregori Casals, Jes ús Blanco, Amanda Jiménez, Francisco Aya, Ana Hollanda, Irene Halperin, Ana M Arance, Mireia Mora, Felicia A Hanzu Tags: Case Report Source Type: research

Renal, Cardiovascular and Safety Outcomes of Canagliflozin in Patients with Type 2 Diabetes and Nephropathy in East and Southeast Asian Countries: Results from the CREDENCE Trial
ConclusionIn the CREDENCE trial, the risk of renal and cardiovascular events was safely reduced in participants from EA countries at high risk of renal events. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 2, 2021 Category: Endocrinology Authors: Takashi Wada, Kazumi Mori ‐Anai, Yutaka Kawaguchi, Hideyuki Katsumata, Hidetaka Tsuda, Mitsutaka Iida, Kenji Arakawa, Meg J. Jardine Tags: ORIGINAL ARTICLE Source Type: research

N4BP2L1 interacts with dynactin and contributes to GLUT4 trafficking and glucose uptake in adipocytes
ConclusionsOur results suggest that N4BP2L1 is involved in adipocyte homeostasis by interacting with dynein –dynactin and affecting GLUT4-mediated glucose uptake and the insulin signaling pathway. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 1, 2021 Category: Endocrinology Authors: Kazuhisa Watanabe, Ayumi Matsumoto, Hidetoshi Tsuda, Sadahiko Iwamoto Tags: ORIGINAL ARTICLE Source Type: research

Islet microangiopathy and augmented β‐cell loss in Japanese non‐obese type 2 diabetes patients who died of acute myocardial infarction
ConclusionsIslet microangiopathy was associated with augmented β-cell loss and amyloid deposition in non-obese Japanese type 2 diabetes patients who died of AMI. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - July 1, 2021 Category: Endocrinology Authors: Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Kazuhiro Kudoh, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi Tags: ORIGINAL ARTICLE Source Type: research

VSRAD utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetic outpatient clinics: Multi ‐center retrospective exploratory study
AbstractAims/IntroductionAn efficient screening strategy for identification of cognitive dysfunction remains a clinical issue in management of elderly adults with diabetes. A magnetic resonance imaging (MRI) voxel-based specific regional analysis system for Alzheimer ’s disease (VSRAD) has been developed as an automated brain morphometry system that includes hippocampus. We conducted a multi-center retrospective study to evaluate the utility of VSRAD for screening cognitive dysfunction in diabetic outpatient clinics.Patients and MethodsWe enrolled patients with diabetes aged over 65 years who underwent brain MRI scan...
Source: Journal of Diabetes Investigation - June 30, 2021 Category: Endocrinology Authors: Yoko Ueba, Takaaki Murakami, Taizo Yamamoto, Akira Kuroe, Masahide Yamasaki, Daita Kaneda, Daisuke Otani, Sakura Kiyobayashi, Kaori Ikeda, Daisuke Yabe, Masahito Ogura, Nobuya Inagaki Tags: ORIGINAL ARTICLE Source Type: research

Current status of oral antidiabetic drug prescribing patterns based on the body mass index for Japanese type 2 diabetes mellitus patients and yearly changes in diabetologists ’ prescribing patterns from 2002 to 2019 (JDDMXX)
ABSTRACTAims/IntroductionType 2 diabetes mellitus (T2DM) is caused by a relative imbalance between insulin secretion and sensitivity related to the body mass index (BMI). Seven categories of oral antidiabetic drugs (OADs) are available in Japan. It is important to assess the OAD utilization patterns based on patients ’ BMI levels.Materials and methodsOAD prescribing patterns from 2002 to 2019 were analyzed using the data collected in the computerized diabetes care (CoDiC) database provided by the Japan Diabetes Clinical Data Management Study Group (JDDM); OAD utilization patterns in 25,751 OAD-treated T2DM patients r...
Source: Journal of Diabetes Investigation - June 30, 2021 Category: Endocrinology Authors: Noriharu Yagi, Ichiro Komiya, Keiko Arai, Mariko Oishi, Yoshihide Fukumoto, Shinichirou Shirabe, Hiroki Yokoyama, Katsuya Yamazaki, Hidekatsu Sugimoto, Hiroshi Maegawa, Japan Diabetes Clinical Data Management Study Group (JDDM study group) Tags: ORIGINAL ARTICLE Source Type: research

Effects of intermittent very ‐low calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitus: a randomized controlled trial
ConclusionIntermittent VLCD was highly effective in achieving optimal glycemic control. The effects of 2 days/week and 4 days/week of intermittent VLCD on diabetes remission were relatively similar. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 28, 2021 Category: Endocrinology Authors: Mongkontida Umphonsathien, Peedaporn Rattanasian, Siriporn Lokattachatiya, Wanlapa Suansawang, Kunwadee Boonyasuppayakorn, Weerapan Khovidhunkit Tags: CLINICAL TRIAL Source Type: research

Effect of depression on progression to end ‐stage renal disease or pre‐end‐stage renal disease death in advanced diabetic nephropathy: A prospective cohort study of the Diabetes Study from the Center of Tokyo Women’s Medical University
ConclusionDepression potentially has a weak impact on progression to ESRD, however, the presence of comorbidities may have the possibility to reduce the effect of depression on the renal outcome in patients with advanced diabetic nephropathy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 27, 2021 Category: Endocrinology Authors: Yu Horiba, Kaya Ishizawa, Keiko Takasaki, Junnosuke Miura, Tetsuya Babazono Tags: ORIGINAL ARTICLE Source Type: research

Islet β‐cells physiological difference study of old and young mice based on single‐cell transcriptomics
This study could serve as new therapies that attenuate aging and alleviate aging-related diseases with further research. AbstractAims/IntroductionBody aging is a universal biological process. With aging, cells undergo a series of physiological changes. The main feature is cell proliferation decline, although the cells still have normal functions. Pancreatic β-cells are no exception. However, the physiological senescence of β-cells, and the resulting function and transcriptome changes have rarely attracted attention. The specific senescence phenotype of β-cells remains unknown.Materials and MethodsPancreatic ...
Source: Journal of Diabetes Investigation - June 26, 2021 Category: Endocrinology Authors: Zeyu Zheng, Qiufeng Zhan, Ayun Chen, Zhen Yu, Gang Chen Tags: Original Article Source Type: research

Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta ‐analyses and network meta‐analysis
ConclusionsThis review study of available literature shows that metformin can be a superior option in most neonatal and maternal adverse pregnancy outcomes in women with gestational diabetes mellitus; the results need to be further updated by including future more qualified studies. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 24, 2021 Category: Endocrinology Authors: Razieh Bidhendi Yarandi, Mina Amiri, Fahimeh Ramezani Tehrani, Samira Behboudi ‐Gandevani Tags: Original Article Source Type: research

Association between Grit Scales and adherence to regular hospital visits among Japanese patients with type  2 diabetes: Prospective observational study
In conclusion, it is likely that the Grit Scale is closely associated with adherence to regular hospital visits among Japanese type 2 diabetes patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - June 19, 2021 Category: Endocrinology Authors: Shuhei Nakanishi, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Junpei Sanada, Yoshiro Fushimi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto Tags: Short Report Source Type: research

Insulin resistance limits corneal nerve regeneration in patients with type  2 diabetes undergoing intensive glycemic control
This study shows that patients with type  2 diabetes and insulin resistance undergoing intensive glycemic control with pioglitazone plus exenatide or basal–bolus insulin show blunted small nerve fiber regeneration. Therefore, interventions, such as physical activity and weight reduction, to improve insulin resistance might benefit diabe tic neuropathy, and insulin resistance should be considered when assessing the benefits of disease-modifying therapies for diabetic neuropathy. AbstractAims/IntroductionThis study aimed to investigate whether insulin resistance (IR) in individuals with type  2 diabetes under...
Source: Journal of Diabetes Investigation - June 19, 2021 Category: Endocrinology Authors: Georgios Ponirakis, Muhammad A Abdul ‐Ghani, Amin Jayyousi, Mahmoud A Zirie, Salma Al‐Mohannadi, Hamad Almuhannadi, Ioannis N Petropoulos, Adnan Khan, Hoda Gad, Osama Migahid, Ayman Megahed, Murtaza Qazi, Fatema AlMarri, Fatima Al‐Khaya Tags: Clinical Trial Source Type: research

Frequent scanning using flash glucose monitoring contributes to better glycemic control in children and adolescents with type 1 diabetes
We examined the impact of scanning frequency with flash glucose monitoring (FGM) on glycemic control in children and adolescents with type 1 diabetes.Materials and MethodsThe study included 85 patients, aged 14.0 ±0.5 years, with type 1 diabetes. The median time in the target glucose range (TIR) and glycosylated hemoglobin (HbA1c) values were 50.0±1.4% and 7.5±0.1%, respectively.ResultsThe median scanning frequency using FGM was 12.0 ±0.4 times/ day. Scanning frequency showed a significant positive correlation with TIR and an inverse correlation with HbA1c. Scanning frequency was identified to b...
Source: Journal of Diabetes Investigation - June 18, 2021 Category: Endocrinology Authors: Tatsuhiko Urakami, Kei Yoshida, Remi Kuwabara, Yusuke Mine, Masako Aoki, Junichi Suzuki, Ichiro Morioka Tags: ORIGINAL ARTICLE Source Type: research

Long noncoding RNA UCA1 promotes high glucose ‐induced human retinal endothelial cells angiogenesis via regulating miR‐624‐3p/VEGF‐C
ABSTRACTAims/IntroductionEmerging evidences have indicated that lncRNAs play important roles in the development and progression of Diabetic retinopathy (DR). It is reported that UCA1 was highly expressed in diabetic lymphoendothelial cells and influences glucose metabolism in rats with DR. The aim of the present study was to explore the role of UCA1 in the mechanism of DR.MethodsGene expression analyses in fibrovascular membranes excised from patients with DR using public microarray datasets (GSE60436). RT-PCR was performed to detect UCA1, miR-624-3p and VEGF-C expressions in blood of patients and human retinal endothelial...
Source: Journal of Diabetes Investigation - June 17, 2021 Category: Endocrinology Authors: Huang Yan, Panpan Yao, Ke Hu, Li Xueyao, Li Hong Tags: ORIGINAL ARTICLE Source Type: research

Corneal Confocal Microscopy: A Useful Tool for Diagnosis of Small Fiber Neuropathy in Type 2 Diabetes
ABSTRACTAimTo investigate the diagnostic utility of corneal confocal microscopy (CCM) for small fiber neuropathy in type 2 diabetes.Materials and MethodsThere were altogether 186 participants with type 2 diabetes enrolled in this cross-sectional research. We defined pure small fiber neuropathy and mixed fiber neuropathy using clinical examination, electromyography, and quantitative sensory testing. Demographics and clinical data, CCM parameters, and other neuropathy measures were compared among groups. The diagnosability of CCM for small fiber neuropathy was assessed by the receiver operating curve.ResultsOf the 186 patien...
Source: Journal of Diabetes Investigation - June 16, 2021 Category: Endocrinology Authors: Yu Jin, Weimin Wang, Wei Chen, Simin Guo, Chenxi Li, Dalong Zhu, Yan Bi Tags: ORIGINAL ARTICLE Source Type: research

β‐Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes
Despite distinct etiologies and pathogenesis of type  1, type 2 and other types of diabetes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β-cell failure among different types of diabetes. Understanding these susceptibilities and mechanisms can help in the development of therapeutic strategies rega rdless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future prospects as well. Abst...
Source: Journal of Diabetes Investigation - June 16, 2021 Category: Endocrinology Authors: Hiroshi Ikegami, Naru Babaya, Shinsuke Noso Tags: Review Source Type: research