Effect of the use of passive body trunk exercise equipment on oxygen consumption and self ‐efficacy for performing exercise in patients with type 2 diabetes
ConclusionsExercise intensity using the PBTE is similar to low ‐intensity walking, and thus, it may be a useful therapeutic exercise device for patients with type 2 diabetes. Furthermore, it could be an effective exercise device for diabetic patients who do not have regular exercise habits, especially with reduced motor function or lower leg muscle strength. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 13, 2020 Category: Endocrinology Authors: Toshihiro Kawae, Daisuke Iwaki, Yuki Nakashima, Kenichi Fudeyasu, Tomoyasu Ishiguro, Hiroaki Kimura, Kiyokazu Sekikawa, Hironobu Hamada, Haruya Ohno, Masayasu Yoneda Tags: ORIGINAL ARTICLE Source Type: research

Safety and effectiveness of tofogliflozin in Japanese patients with type 2 diabetes mellitus: Results of 24 ‐month interim analysis of a long‐term post‐marketing study (J‐STEP/LT)
AbstractAims/IntroductionTofogliflozin is a potent and highly selective sodium glucose cotransporter 2 inhibitor and is currently used to treat patients with type 2 diabetes mellitus (T2DM). We designed a 3 ‐year study of tofogliflozin in patients with T2DM to evaluate the safety and effectiveness in routine clinical practice. The 3‐month and 12‐month interim analysis demonstrated tofogliflozin was well‐tolerated, safe, and clinically effective. Here we report the results of the 24‐month inte rim analysis.Materials and MethodsThis is a 3 ‐year prospective, observational, and multicenter post‐marketing study (...
Source: Journal of Diabetes Investigation - February 10, 2020 Category: Endocrinology Authors: Kazunori Utsunomiya, Seigo Kakiuchi, Masayuki Senda, Shoko Fujii, Yuji Kurihara, Ryoji Gunji, Ryusuke Koshida, Hiroyuki Kameda, Masahiro Tamura, Kohei Kaku Tags: ORIGINAL ARTICLE Source Type: research

Association of glucose tolerance status with pancreatic beta and alpha cell mass in community ‐based autopsy samples of Japanese: the Hisayama Study
AbstractAims/IntroductionChanges in histologically quantified beta and alpha cell mass during the development of glucose intolerance have not been fully elucidated. The aim of the present study was to explore differences in beta and alpha cell mass according to the glucose tolerance status.Materials and MethodsAutopsy samples from a total of 103 subjects (40 with normal glucose tolerance [NGT], 31 with prediabetes [PDM] and 32 with type 2 diabetes mellitus [T2DM] ) who underwent a 75 ‐g oral glucose tolerance test [OGTT] within 5 years before death were selected from 643 community‐based autopsy samples collected from 2...
Source: Journal of Diabetes Investigation - February 7, 2020 Category: Endocrinology Authors: Jun Inaishi, Yoshifumi Saisho, Yoichiro Hirakawa, Daigo Yoshida, Jun Hata, Naoko Mukai, Yuusuke Watanabe, Yoshinao Oda, Hiroshi Itoh, Toshiharu Ninomiya Tags: ORIGINAL ARTICLE Source Type: research

Failure to confirm a sodium –glucose cotransporter 2 inhibitor‐induced hematopoietic effect in non‐diabetic rats with renal anemia
ConclusionsThese data suggest that SGLT2 inhibitor fails to exert hematopoietic effects in non ‐diabetic conditions. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Daisuke Yamazaki, Yoshio Konishi, Takashi Morikawa, Hideki Kobara, Tsutomu Masaki, Hirofumhi Hitomi, Kenji Osafune, Daisuke Nakano, Wararat Kittikulsuth, Akira Nishiyama Tags: Original Article Source Type: research

Flash glucose monitoring in type 1 diabetes: A comparison with Self ‐monitoring blood glucose
ConclusionsThe results of this study provided evidence on the reliability of  FGM in Japanese patients with type 1 diabetes in home conditions. Based on the results, if abnormal glucose value is detected by FGM, SBMG should then be used to confirm the result. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Naru Babaya, Shinsuke Noso, Yoshihisa Hiromine, Yasunori Taketomo, Fumimaru Niwano, Sawa Yoshida, Sara Yasutake, Yumiko Kawabata, Hiroshi Ikegami Tags: ORIGINAL ARTICLE Source Type: research

A case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetic patient and was associated with rapid body weight loss after sodium ‐glucose cotranspoter‐2 inhibitor administration
AbstractA 58 ‐year‐old female who was diagnosed with type 2 diabetes 20 years earlier had been treated with antidiabetic medicines since she was 40 years old. After sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) administration, her body weight (BW) rapidly decreased from 40 to 30 kg over 3 weeks. She had abdominal symptoms, including nausea, especially after a meal. On admission, physical examinations and laboratory data indicated euglycemic ketoacidosis, dehydration and low insulin secretion levels. Additionally, abdominal contrast computed tomography demonstrated the finding of superior mesen teric artery syn...
Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Taro Hirai, Munehiro Kitada, Yoshihiro Hayashi, Itaru Monno, Yuta Takagaki, Keiji Shimada, Yoshio Ogura, Mizue Fujii, Kazunori Konishi, Atsushi Nakagawa, Daisuke Koya Tags: CASE REPORT Source Type: research

Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for incidence of type 2 diabetes mellitus among middle ‐aged Japanese: Aichi Worker’s Cohort Study
ConclusionIFG represented a higher risk and PAF than MetS for T2DM incidence in middle ‐aged Japanese. Coexistence of MetS and IFG indicated the highest risk and PAF for T2DM incidence. The current Japanese MetS screening program should be reconsidered to follow up non‐MetS individuals with IFG. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of diabetes in Japanese patients with cancer
In conclusion, our study shows a large burden of diabetes in cancer patients in Japan, which warrants f urther attention by health practitioners and policy‐makers. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Eiko Saito, Atsushi Goto, Rieko Kanehara, Ken Ohashi, Mitsuhiko Noda, Tomohiro Matsuda, Kota Katanoda Tags: SHORT REPORT Source Type: research

The silent hemoglobin variant during capillary electrophoresis: a case report
AbstractHemoglobin (Hb) North Manchester [ β51(D2) Pro→His;HBB:c.155 C>A] is a rare Hb β‐globin gene variant that affects HbA1c measurement values such as ion‐exchange high‐performance liquid chromatography (ion‐exchange HPLC) in patients with diabetes. This variant was first detected in UK in 1998. Here, we describe the first case involving Hb North Manchester detected incid entally in a patient with type 2 diabetes in Northern China. The Hb variant was discovered by ion‐exchange HPLC, yet capillary electrophoresis of both HbA1c program and Hb program failed to detect it. Subsequently, Sanger s...
Source: Journal of Diabetes Investigation - February 5, 2020 Category: Endocrinology Authors: Yanping Yuan, Xianghai Zhou, Leili Gao, Qian Ren, Linong Ji Tags: CASE REPORT Source Type: research

Impact of baseline characteristics on glycemic effects of add ‐on saxagliptin or acarbose to metformin therapy: subgroup analysis of the SMART study in Chinese patients with type 2 diabetes mellitus
AbstractAimsThis secondary analysis of the 24 ‐week SMART study examined the efficacy of add‐on saxagliptin or acarbose to metformin across different patient subgroups with type 2 diabetes mellitus (T2DM), based on baseline characteristics.MethodsRandomized patients (N=481) were classified into subgroups based on their baseline age (
Source: Journal of Diabetes Investigation - February 5, 2020 Category: Endocrinology Authors: Hui Fang, Fengmei Xu, Jin Du, Li Liang, Wei Li, Liya Shen, Xueying Wang, Chun Xu, Fang Bian, Yiming Mu Tags: ORIGINAL ARTICLE Source Type: research

The Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test Is Associated with Insulin Clearance and Muscle Insulin Sensitivity in Healthy Nonobese Men
In conclusion, Healthy nonobese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 5, 2020 Category: Endocrinology Authors: Hideyoshi Kaga, Yoshifumi Tamura, Kageumi Takeno, Saori Kakehi, Yuki Someya, Takashi Funayama, Yasuhiko Furukawa, Ruriko Suzuki, Daisuke Sugimoto, Satoshi Kadowaki, Miho Nishitani ‐Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Tags: SHORT REPORT Source Type: research

Serum chromogranin  A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin‐like cell hyperplasia and autoimmune gastritis
A slight, but steady elevation in chromogranin  A (CgA) level was observed to co‐vary with the duration of type 1 diabetes. Approximately 20% of the patients had elevated serum CgA levels, which was associated with higher glycated hemoglobin levels. Enterochromaffin‐like cell hyperplasia and autoimmune gastritis was significantly more freq uent in the high CgA group. Detailed analyses on gastric tissue samples confirmed a progression of enterochromaffin‐like cell hyperplasia accompanied by CgA elevation. Therefore, the use of CgA could be considered as a novel auxiliary biomarker in the care of these type&n...
Source: Journal of Diabetes Investigation - February 4, 2020 Category: Endocrinology Authors: Zoltan Herold, Magdolna Herold, Peter Nagy, Attila Patocs, Marton Doleschall, Aniko Somogyi Tags: Original Article Source Type: research

Have pregnancy outcomes improved with the introduction of the International Association of Diabetes and Pregnancy Study Groups criteria in Japan?
This study aimed to investigate the effects of the introduction of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for diagnosing gestational diabetes mellitus (GDM) on maternal and neonatal outcomes in Japan.Materials and MethodsThis was a retrospective study performed at a tertiary center in Japan. Previously in Japan, GDM was diagnosed if two or more of the following Japan Society of Obstetrics and Gynecology (JSOG) criteria were met: fasting plasma glucose (FPG) ≥100 mg/dL, 1‐hour value ≥180 mg/dL, or 2‐hour value ≥150 mg/dL on the 75‐g OGTT. Since 2010, GDM has bee...
Source: Journal of Diabetes Investigation - February 4, 2020 Category: Endocrinology Authors: Sayuri Nakanishi, Shigeru Aoki, Junko Kasai, Ryosuke Shindo, Yusuke Saigusa, Etsuko Miyagi Tags: ORIGINAL ARTICLE Source Type: research

Vitamin D levels, Prediabetes Risk and HbA1c levels in Young Non ‐diabetic Saudi Women
ConclusionVitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels ’ effect on the risk of prediabetes may be small compared to other well‐established risk factors, such as obesity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 4, 2020 Category: Endocrinology Authors: Maha A. Al ‐Mohaissen, Terry Lee, Ali Faris Alamri Tags: ORIGINAL ARTICLE Source Type: research

Coping styles associated with glucose control in individuals with type 2 diabetes mellitus
ConclusionThese findings suggest that adaptive emotion ‐focused coping supports glycemic control in T2DM patients who do not use insulin. Additional studies using a longitudinal design are needed to further examine the relationships between psychological factors and glycemic control. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - February 4, 2020 Category: Endocrinology Authors: Hiroshi Murakami, Norio Yasui ‐Furukori, Hideyuki Otaka, Hirofumi Nakayama, Masaya Murabayashi, Satoru Mizushiri, Koki Matsumura, Jutaro Tanabe, Yuki Matsuhashi, Miyuki Yanagimachi, Norio Sugawara, Kazutaka Shimoda, Makoto Daimon Tags: ORIGINAL ARTICLE Source Type: research

Correlation between serum proinsulin levels and fatty liver: the DOSANCO Health Study
AbstractAims/IntroductionWe explored the association between fatty liver and pancreatic β‐cell dysfunction in a general population.Materials and MethodsThis cross ‐sectional study included 489 (53.8% women) community‐dwelling Japanese adults. The extent of fatty liver was estimated using the fatty liver index (FLI). After all participants were divided into three groups: low (FLI
Source: Journal of Diabetes Investigation - January 30, 2020 Category: Endocrinology Authors: Aika Miya, Akinobu Nakamura, Hideaki Miyoshi, Shigekazu Ukawa, Koshi Nakamura, Takafumi Nakagawa, Yasuo Terauchi, Akiko Tamakoshi, Tatsuya Atsumi Tags: ORIGINAL ARTICLE Source Type: research

Elevated serum glycated albumin and glycated albumin to hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study
AbstractAims/IntroductionTo investigate the association of alternative glycemic measures —namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c), and the GA/HbA1c ratio —with global brain and hippocampal atrophy in a general elderly Japanese population.Materials and Methods1,278 Japanese subjects aged ≥65 years in a community participated in brain magnetic resonance imaging (MRI) scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV), and intracranial volume (ICV) using the data from the MRI examination. The association of each glycemic...
Source: Journal of Diabetes Investigation - January 30, 2020 Category: Endocrinology Authors: Tomoyuki Ohara, Yoshihiko Furuta, Naoki Hirabayashi, Jun Hata, Yoichiro Hirakawa, Takanori Honda, Daigo Yoshida, Mao Shibata, Takanari Kitazono, Toshiharu Ninomiya Tags: ORIGINAL ARTICLE Source Type: research

N ‐acetyl‐seryl‐aspartyl‐lysyl‐proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: an update and translational aspects
AbstractN‐acetyl‐seryl‐aspartyl‐lysyl‐proline (AcSDKP) is the endogenous peptide which has been confirmed to display excellent organ protective effects. Even though originally discovered as modulator of hemotopoietic stem cells, during recent two decades AcSDKP has been recognized as valuable anti‐ fibrotic peptide. The anti‐fibrotic mechanism of AcSDKP is not clear yet, we have established that AcSDKP could target endothelial mesenchymal transition (EndMT) program via the induction of endothelial fibroblast‐growth factor receptor signaling pathway. Also recent reports suggested the clinic al significance o...
Source: Journal of Diabetes Investigation - January 29, 2020 Category: Endocrinology Authors: Keizo Kanasaki Tags: REVIEW ARTICLE Source Type: research

Adrenomedullin has a cytoprotective role against ER stress for pancreatic ß‐cells in autocrine and paracrine manners
ConclusionsER stress stimulates ADM production and secretion in islets. ADM signaling may protect ß‐cells from ER stress‐induced apoptosis, and might be one of self‐protective mechanisms. ß‐cell protection by pioglitazone is partly via induction of ADM. ADM‐based therapy could be a novel strategy for treating diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 27, 2020 Category: Endocrinology Authors: Risa Suetomi, Yasuharu Ohta, Masaru Akiyama, Takuro Matsumura, Akihiko Taguchi, Kaoru Yamamoto, Takashi Kamatani, Yukio Tanizawa Tags: ORIGINAL ARTICLE Source Type: research

Integrated 3 in 1 Siriraj Diabetes School Camp: Views, reflections and lessons learned by participating healthcare professionals
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 26, 2020 Category: Endocrinology Authors: Lukana Preechasuk, Jeerunda Santiprabhob, Apiradee Sriwijitkamol, Raweewan Lertwattanarak, Weerachai Srivanichakorn, Ornsuda Lertbannaphong, Chonpiti Siriwan, Pornsri Sriassadaporn, Wannee Nitiyanant, Supawadee Likitmaskul Tags: Letter to the Editor Source Type: research

Is visceral abdominal fat area a better indicator for hyperglycemic risk? Results from the Pinggu Metabolic Disease Study
ConclusionWHR and WC remains the best indicators for hyperglycemic risk among healthy Chinese population. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 25, 2020 Category: Endocrinology Authors: Fang Zhang, Yufeng Li, Yingxi Zhao, Xianghai Zhou, Linong Ji Tags: ORIGINAL ARTICLE Source Type: research

Relationship between metformin use and vitamin  B12 status in patients with type 2 diabetes in Japan
ConclusionsThe risk of VB12 deficiency during metformin treatment appears to be low in Japanese type  2 diabetes mellitus patients. However, high doses of metformin might result in a moderate decrease in the circulating VB12 level, as well as in anemia in elderly individuals. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 24, 2020 Category: Endocrinology Authors: Kenji Sugawara, Yuko Okada, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa Tags: Original Article Source Type: research

Iron Metabolism and Type 2 Diabetes Mellitus: A Meta ‐analysis and Systematic Review
ConclusionsThe elevated serum ferritin was one of the risk factors for type 2 diabetes, and soluble transferrin receptor to ferritin ratio was inversely related to the risk of type 2 diabetes. A systematic review showed that serum transferrin and hepcidin might be directly or indirectly related to the development of diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 23, 2020 Category: Endocrinology Authors: Jingfang Liu, Qingxiu Li, Yaxian Yang, Lihua Ma Tags: ORIGINAL ARTICLE Source Type: research

Characterization of the taste receptor ‐related G‐protein α‐gustducin in pancreatic β‐cells
Conclusionα‐Gustducin is involved in the regulation of cAMP, intracellular calcium levels and insulin secretion in pancreatic β‐cells in a manner independent of taste receptor signaling. α‐gustducin may play a novel role in β‐cell physiology and development of type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2020 Category: Endocrinology Authors: Authors: Haruhide Udagawa, Masaki Hiramoto, Miho Kawaguchi, Takashi Uebanso, Mica Ohara ‐Imaizumi, Takao Nammo, Wataru Nishimura, Kazuki Yasuda Tags: ORIGINAL ARTICLE Source Type: research

A juvenile case with the coexistence of MODY1 and later ‐onset latent autoimmune diabetes in youth (LADY)
We present the case of a 12 ‐year‐old Japanese girl, who was positive for markers of both, maturity onset diabetes of the young (MODY) and latent autoimmune diabetes in youth (LADY). She was initially diagnosed with MODY1 based on the molecular analysis, and she later developed an autoimmune response, leading to β‐cell associated antibody positive diabetes. She was treated with incretin‐associated drugs and maintained adequate glycemic control. Pathophysiologically, there was an overlap between the two different types of diabetes because the hyperglycemia and β‐cell stress seen in non‐autoimmune diabe...
Source: Journal of Diabetes Investigation - January 20, 2020 Category: Endocrinology Authors: Kei Yoshida, Tatsuhiko Urakami, Yusuke Mine, Remi Kuwabara, Ichiro Morioka Tags: CASE REPORT Source Type: research

Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type  2 diabetes patients
In this study, the relationship among the Geriatric Nutritional Risk Index (GNRI), bone mineral density (BMD) and osteoporosis in type  2 diabetes mellitus patients was explored, and the GNRI predictive value was evaluated.Materials and MethodsWe enrolled 225 men and 192 women with type  2 diabetes mellitus. Their general condition, and laboratory and BMD data were collected. Spearman’s partial correlation analysis adjusting for age, body mass index and albumin was used for exploring the association among the GNRI, BMD and bone metabolism markers. Statistical analyses, including multivariate regression anal...
Source: Journal of Diabetes Investigation - January 20, 2020 Category: Endocrinology Authors: Liang Wang, Die Zhang, Jing Xu Tags: Original Article Source Type: research

Dysglycemia risk score in Saudi Arabia: A tool to identify people at high future risk of developing type 2 diabetes
ConclusionSADRISC is a simple tool which can effectively distinguish Saudis at high risk of dysglycemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 19, 2020 Category: Endocrinology Authors: Suhad Bahijri, Rajaa Al ‐ Raddadi, Ghada Ajabnoor, Hanan Jambi, Jawaher Al Ahmadi, Anwar Borai, Noël C Barengo, Jaakko Tuomilehto Tags: ORIGINAL ARTICLE Source Type: research

How do you make new β‐cells in humans? An attempt to create human β‐cells from α‐cells of brain‐dead donors
Ex  vivo reprogramming of human α‐cells toward functional β‐cells by adenoviral transduction of key transcription factors. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 15, 2020 Category: Endocrinology Authors: Yoshio Fujitani Tags: Editorial Source Type: research

Association between mean platelet volume in the pathogenesis of type  2 diabetes mellitus and diabetic macrovascular complications in Japanese patients
ConclusionsThese findings suggest that MPV was significantly increased in the early stage of type  2 diabetes. We showed positive correlations between MPV and HbA1c levels, and between MPV and arterial stiffness in Japanese patients with type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 13, 2020 Category: Endocrinology Authors: Hiroyuki Inoue, Mayumi Saito, Kumiko Kouchi, Shun ‐ichiro Asahara, Fumihiko Nakamura, Yoshiaki Kido Tags: Original Article Source Type: research

Simultaneous Development of Graves ’ Disease and Type 1 Diabetes during Anti‐programmed Cell Death‐1 Therapy: A Case Report
We present the first case of simultaneous development of Graves ’ disease and type 1 diabetes during anti‐programmed cell death 1 (PD‐1) therapy. A 48‐year‐old man with parotid gland adenocarcinoma and lung metastasis had received 5 courses of nivolumab. Fourteen days after administration of the 6th course, his casual plasma glucose and hemoglobin A1c levels were 379  mg/dL and 7.2%, respectively. Moreover, thyrotoxicosis was detected with a blood test. Serum total ketone body and thyroid‐stimulating hormone receptor antibody levels increased, and serum C‐peptide level decreased to 0.01 ng/mL th...
Source: Journal of Diabetes Investigation - January 11, 2020 Category: Endocrinology Authors: Susumu Kurihara, Yoichi Oikawa, Ritsuko Nakajima, Atsushi Satomura, Ryuhei Tanaka, Hiroshi Kagamu, Akira Shimada Tags: CASE REPORT Source Type: research

nAChR signaling regulates IRE1 α activation to protect β cells against terminal unfolded protein response under irremediable ER stress
ConclusionsOur findings suggest that nAChR signaling regulates IRE1 α activation to protect β cells from the T‐UPR and apoptosis under ER stress partly through α7 nAChR. Targeting nAChR signaling to inhibit the T‐UPR cascade may therefore hold therapeutic promise by thwarting β cell death in diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 10, 2020 Category: Endocrinology Authors: Tatsuya Ishibashi, Shuhei Morita, Shohei Kishimoto, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hidefumi Inaba, Hiroyuki Ariyasu, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Feroz R. Papa, Takashi Akamizu Tags: ORIGINAL ARTICLE Source Type: research

Differential regulation of hypoxanthine and xanthine by obesity in a general population
ConclusionsThe concentration of hypoxanthine, but not that of xanthine, is independently associated with obesity and smoking habit, indicating differential regulation of hypoxanthine and xanthine in a general population. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 8, 2020 Category: Endocrinology Authors: Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term maternal cardiometabolic outcomes 22 years following gestational diabetes mellitus
AbstractAims/IntroductionWomen with gestational diabetes mellitus are at increased risk for type 2 diabetes. We characterized the association between maternal glycaemia during pregnancy with long ‐term outcomes.Methods and MethodsIn this prospective nested case ‐cohort study, subjects were recalled for follow up with detailed evaluation including oral glucose tolerance test at 8, 15 and 22 years. Logistic regression was used to estimate the risk of developing impaired glucose tolerance/type 2 diabetes and metabolic syndrome at follow up. Association betw een maternal glycaemia at pregnancy and follow up was evaluated b...
Source: Journal of Diabetes Investigation - January 8, 2020 Category: Endocrinology Authors: Greg E. Tutino, Claudia H.T. Tam, Riza Ozaki, Lai Yuk Yuen, Wing Yee So, Michael H.M. Chan, Gary T.C. Ko, Xilin Yang, Juliana C.N. Chan, Wing Hung Tam, Ronald C.W. Ma Tags: ORIGINAL ARTICLE Source Type: research

Intra ‐individual association between C‐reactive protein and insulin administration in postoperative lumbar spinal canal stenosis patients: a retrospective cohort study
AbstractThe association of intra ‐individual variability in insulin requirements with C‐reactive protein (CRP) levels among acute phase patients remains unclear. This retrospective cohort study aimed to evaluate this association. Patients with type 2 diabetes undergoing surgery for lumbar spinal canal stenosis were included in the study. We analyzed 286 records of 49 patients using the linear mixed‐effect model. The model showed CRP levels to be significantly associated with insulin requirements, with an effect size of 0.60 U/day for an elevation of 1 mg/dL. The effect size was increased in patients with higher hemog...
Source: Journal of Diabetes Investigation - January 7, 2020 Category: Endocrinology Authors: Ken Kurisu, Yuya Tsurutani, Kosuke Inoue, Yoshitomo Hoshino, Fumiko Saiki, Kazuhiro Yoshiuchi Tags: SHORT REPORT Source Type: research

Incidence of severe urinary tract infections not increased by initiating sodium –glucose cotransporter 2 inhibitors
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 7, 2020 Category: Endocrinology Authors: Hiroki Yokoyama Tags: Commentary Source Type: research

Potential linkage between dipeptidyl peptidase ‐4 inhibitor use and the risk of pancreatitis/pancreatic cancer
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 7, 2020 Category: Endocrinology Authors: Jun Shirakawa, Yasuo Terauchi Tags: Commentary Source Type: research

Association between Pro12Ala Polymorphism and Albuminuria in Type ‐2 Diabetic Nephropathy
ConclusionsOur results suggest that the PPAR ‐γ2 Ala12 variant has significant protective effects against albuminuria and DN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 7, 2020 Category: Endocrinology Authors: Yung ‐Nien Chen, Pei‐Wen Wang, Shih‐Chen Tung, Ming‐Chun Kuo, Shao‐Wen Weng, Chen‐Kai Chou, Chih‐Min Chang, Chia‐Jen Tsa, Cheng‐Feng Taso, Feng‐Chih Shen, Jung‐Fu Chen Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Journal of Diabetes Investigation, Volume 11, Issue 1, Page 1-2, January 2020. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 6, 2020 Category: Endocrinology Tags: Issue Information Source Type: research

Achieving the composite end ‐point of glycated hemoglobin < 7.0% without weight gain or hypoglycemia with once ‐weekly dulaglutide in Chinese patients with type 2 diabetes: A post‐hoc analysis
The present post ‐hoc analysis was carried out using data from two randomized, multinational, parallel‐arm and non‐inferiority phase III trials (AWARD‐CHN1 study [NCT01644500] and AWARD‐CHN2 study [NCT01648582] of dulaglutide in patients with type 2 diabetes. AbstractAims/IntroductionTo assess the effect of dulaglutide (DU) 1.5/0.75  mg in comparison with glimepiride (GLIM) or insulin glargine (GLAR) on the composite end‐point in Chinese type 2 diabetes patients.Materials and MethodsPost ‐hoc analyses of two randomized phase III trials (NCT01644500 and NCT01648582) were carried out us...
Source: Journal of Diabetes Investigation - January 3, 2020 Category: Endocrinology Authors: Xinhua Xiao, Changjiang Wang, Xiaoyang Lai, Bin Zhang, Liqun Gu, Jianing Hou, Zhiguang Zhou Tags: Clinical Trial Source Type: research

Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin ‐like cell hyperplasia and autoimmune gastritis
AbstractAimsThe relationship of Chromogranin A (CgA) levels above the normal range with various outcomes such as glycated hemoglobin (HbA1C) levels, enterochromaffin ‐like cell hyperplasia and autoimmune gastritis was investigated in type 1 diabetes patients with special regard to the progression of comorbidities.MethodsA cohort study on 153 type 1 diabetes patients was performed with a prospective branch on clinical and laboratory data and a retrospective branch on histological data obtained by gastroscopy.ResultsPatients with CgA levels above the upper limit of the normal range (N = 28) had significantly higher HbA1C l...
Source: Journal of Diabetes Investigation - December 28, 2019 Category: Endocrinology Authors: Zoltan Herold, Magdolna Herold, Peter Nagy, Attila Patocs, Marton Doleschall, Aniko Somogyi Tags: ORIGINAL ARTICLE Source Type: research

Dawn of a New Era of Diabeto ‐Oncology
AbstractDiabetes mellitus and cancer have several risk factors in common (Figure 1). Besides these shared factors, they might directly trigger each other. Compelling evidence has been accumulated over the past decades that shows the increased risk of cancer in relation to diabetes in Western and Asian countries1. It is postulated that hyperglycemia and compensatory hyperinsulinemia in type 2 diabetes mellitus are the prevailing mechanisms through which diabetes directly raises cancer risk (Figure 1). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 28, 2019 Category: Endocrinology Authors: Hiroshi Noto Tags: EDITORIAL Source Type: research

Failure to confirm an SGLT2 inhibitor ‐induced hematopoietic effect in non‐diabetic rats with renal anemia
ConclusionThese data suggest that SGLT2 inhibitor fails to exert hematopoietic effects in non ‐diabetic conditions. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 27, 2019 Category: Endocrinology Authors: Daisuke Yamazaki, Yoshio Konishi, Takashi Morikawa, Hideki Kobara, Tsutomu Masaki, Hirofumi Hitomi, Kenji Osafune, Daisuke Nakano, Wararat Kittikulsuth, Akira Nishiyama Tags: ORIGINAL ARTICLE Source Type: research

Increased diagnosis of autoimmune childhood ‐onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme‐linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit
ConclusionsThe diagnosis of autoimmune childhood ‐onset Japanese type 1 diabetes increased when GADAb results were obtained using a new ELISA method, compared with a previously utilized RIA method. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 24, 2019 Category: Endocrinology Authors: Shigetaka Sugihara, Ichiro Yokota, Tokuo Mukai, Takahiro Mochizuki, Masashi Nakayama, Emiko Tachikawa, Yasumasa Kawada, Kinship Minamitani, Nobuyuki Kikuchi, Tatsuhiko Urakami, Tomoyuki Kawamura, Eiji Kawasaki, Toru Kikuchi, Shin Amemiya, Th Tags: Original Article Source Type: research

Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017 –2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)
ConclusionsThe first nationwide, all age group survey of EHH showed the current status of each type of EHH disorder and the unmet needs of the patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 24, 2019 Category: Endocrinology Authors: Yuki Yamada, Kana Kitayama, Maki Oyachi, Shinji Higuchi, Rie Kawakita, Yutaka Kanamori, Tohru Yorifuji Tags: Original Article Source Type: research

Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic β‐cell mass and function
AbstractThere are numerous  lines of clinical evidence that inhibition of the renin‐angiotensin system (RAS) can prevent and delay the development of diabetes. Also, the role of RAS in the pathogenesis of diabetes, including insulin resistance and β‐cell dysfunction, has been extensively investigated. Nonetheless, t his role is not yet fully revealed. A variety of possible protective mechanisms for RAS blockers in the regulation of glucose homeostasis have been suggested. However, the direct effect on pancreatic islet fibrosis has only recently been spotlighted. Various degrees o...
Source: Journal of Diabetes Investigation - December 24, 2019 Category: Endocrinology Authors: Yeoree Yang, Ji ‐Won Kim, Heon‐Seok Park, Eun‐Young Lee, Kun‐Ho Yoon Tags: REVIEW Source Type: research

Relation between metformin use and vitamin B12 status in patients with type 2 diabetes in Japan
ConclusionsThe risk of VB12 deficiency during metformin treatment appears to be low in Japanese T2DM patients. However, high doses of metformin might result in a moderate decrease in the circulating VB12 level as well as in anemia in elderly individuals. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 23, 2019 Category: Endocrinology Authors: Kenji Sugawara, Yuko Okada, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa Tags: ORIGINAL ARTICLE Source Type: research

Whole genome bisulfite sequencing of human spermatozoa reveals differentially methylated patterns from type 2 diabetic patients
ConclusionsOur study provides the first evidence for DNA methylation reprogramming in spermatozoa of T2DM patients and provides a new basis for explaining the complex mechanism of T2DM susceptibility in offspring. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 23, 2019 Category: Endocrinology Authors: Xiongfeng Chen, Qinghua Lin, Junping Wen, Wei Lin, Jixing Liang, Huibin Huang, Liantao Li, Jianxin Huang, Falin Chen, Deli Liu, Gang Chen Tags: ORIGINAL ARTICLE Source Type: research

Insulin ‐derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases
This report presents two cases of insulin‐derived amyloidosis without palpable masses at insulin injection sites. In both cases, blood glucose concentrations improved, and the insulin dose could be reduced by an average of 45% after changing the insulin injection sites. The insulin absorption at the site was reduced to at most 40% of that at a normal site in one case. Magnetic resonance imaging and ultrasonography were useful to screen and differentiate insulin‐derived amyloido sis without a palpable mass. This report showed that insulin‐derived amyloidosis without a palpable mass can be present at the insulin inject...
Source: Journal of Diabetes Investigation - December 22, 2019 Category: Endocrinology Authors: Terumasa Nagase, Keiichi Iwaya, Koichiro Kogure, Tamotsu Zako, Yohei Misumi, Minoru Kikuchi, Koichi Matsumoto, Masayuki Noritake, Yasuhiro Kawachi, Masaki Kobayashi, Yukio Ando, Yoshiya Katsura Tags: CASE REPORT Source Type: research

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross ‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes
ConclusionsThese results imply that the combination of avoiding sedentary behavior and increasing PA might be important in the prevention bodyweight gain and in the avoidance of central obesity, respectively, in Japanese type  2 diabetes patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 20, 2019 Category: Endocrinology Authors: Shuhei Nakanishi, Hidenori Hirukawa, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Seizo Okauchi, Yukino Katakura, Junpei Sanada, Yoshiro Fushimi, Momoyo Nishioka, Yuki Kan, Akiko Tomita ‐Mizoguchi, Hayato Isobe, Hideyuki Tags: Original Article Source Type: research

Opportunistic invasive fungal disease in patients with type  2 diabetes mellitus from Southern China: Clinical features and associated factors
We investigated the characteristics and associated factors of invasive fungal disease in patients with type  2 diabetes mellitus from Southern China for the first time. We found thatCandida albicans,Cryptococcus neoformans andAspergillus fumigatus were the leading agents. Prolonged hyperglycemia results in unfavorable outcomes. Correction of anemia and hypoalbuminemia might improve prognosis. AbstractAims/IntroductionA retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type  2 diabetes mellitus.Materials and MethodsDe...
Source: Journal of Diabetes Investigation - December 20, 2019 Category: Endocrinology Authors: Minxi Lao, Chen Li, Jin Li, Dubo Chen, Meilin Ding, Yingying Gong Tags: Original Article Source Type: research