Causes of Deaths and Estimated Life Expectancy among People with Diabetes: A Retrospective Cohort Study in a Diabetes Clinic
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 21, 2019 Category: Endocrinology Authors: Atsushi Goto, Toshiko Takao, Yoko Yoshida, Shoji Kawazu, Yasuhiko Iwamoto, Yasuo Terauchi Tags: Short Report Source Type: research

Impact of hip fracture on all ‐cause mortality in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
ConclusionsHip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 21, 2019 Category: Endocrinology Authors: Yuji Komorita, Masanori Iwase, Yasuhiro Idewaki, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai ‐Kitamura, Masahito Yoshinari, Ai Murao‐Kimura, Yutaro Oku, Udai Nakamura, Takanari Kitazono Tags: Original Article Source Type: research

Metformin exhibits anti ‐inflammatory effects in murine macrophages through Dicer/ miR‐34a‐5p and miR‐125b‐5p
ConclusionsMetformin may exhibit anti ‐inflammatory effects in macrophages via the induction of Dicer and the subsequent upregulation of miR‐34a‐5p and miR‐125b‐5p.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 18, 2019 Category: Endocrinology Authors: Xi Luo, Rong Hu, Ying Zheng, Shiping Liu, Zhiguang Zhou Tags: Original Article Source Type: research

Assessment of optimal insulin administration timing for standard carbohydrates ‐rich meals using continuous glucose monitoring in children with type 1 diabetes: A cross‐over randomized study
ConclusionsFor carbohydrates ‐rich meals, administration of a proper dose of a rapid‐acting insulin analog is crucial. The influence of rapid‐acting insulin analog administration timing seems to be of minor importance in comparison with correct insulin dose adjustment; however, a tendency to achieve more balanced glucose profiles was found in a group who administered insulin 20 min before a meal. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 18, 2019 Category: Endocrinology Authors: Krzysztof Tucholski, Magdalena Soko łowska, Dagmara Tucholska, Halla Kamińska, Przemysława Jarosz‐Chobot Tags: Original Article Source Type: research

Efficacy and safety of dulaglutide monotherapy compared with glimepiride in Chinese patients with type 2 diabetes: Post hoc analyses of a randomized, double ‐blind, phase 3 study
AbstractAims/IntroductionTo investigate the efficacy/safety of dulaglutide once ‐weekly monotherapy versus glimepiride in Chinese patients with type 2 diabetes.Materials and MethodsThis was a post hoc analysis of a Chinese randomized, double ‐blind, noninferiority, phase 3 study. Patients (N=572) with inadequate glycemic control received dulaglutide 1.5 (n=189) or 0.75 (n=194) mg once‐weekly or glimepiride (1 to 3 mg/day; n=189) for 26 weeks. Primary objective: noninferiority of dulaglutide 1.5 mg versus glimepiride for the change f rom baseline to Week 26 in glycated hemoglobin (HbA1c; noninferiority margin: 0.4%).R...
Source: Journal of Diabetes Investigation - May 18, 2019 Category: Endocrinology Authors: Li Xin Shi, Xiao Min Liu, Yong Quan Shi, Quan Min Li, Jian Hua Ma, Yan Bing Li, Li Ying Du, Feng Wang, Lu Lu Chen Tags: Original Article Source Type: research

Protective effect of sodium –glucose cotransporter 2 inhibitors in patients with rapid renal function decline, stage G3 or G4 chronic kidney disease and type 2 diabetes
Changes in estimated glomerular filtration arte in patients with or without sodium –glucose cotransporter 2 inhibitors administration. AbstractAims/IntroductionThe risk of end ‐stage kidney disease increases in proportion to the decline in the estimated glomerular filtration rate (eGFR). Although protective effects of sodium–glucose cotransporter 2 inhibitors (SGLT2i) on the eGFR decline were shown in several large‐scale clinical trials, there are no studies invest igating patients with a high risk of end‐stage kidney disease. We investigated the efficacy and safety of SGLT2i in advanced renal d...
Source: Journal of Diabetes Investigation - May 17, 2019 Category: Endocrinology Authors: Hideaki Miyoshi, Hiraku Kameda, Kumiko Yamashita, Akinobu Nakamura, Yoshio Kurihara Tags: Clinical Trial Source Type: research

Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type  2 diabetes
QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak ‐Tend/QT in a subgroup with Tpeak‐Tend/QT?0.25 (median). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 15, 2019 Category: Endocrinology Authors: Tatsuya Sato, Takayuki Miki, Shinya Furukawa, Bunzo Matsuura, Yoichi Hiasa, Hirofumi Ohnishi, Masaya Tanno, Tetsuji Miura Tags: Letter to the Editor Source Type: research

Clinical and Enzymatic Phenotypes in Congenital Hyperinsulinemic Hypoglycemia due to Glucokinase ‐activating Mutations: a report of two cases and a brief overview of literature
ConclusionThe clinical phenotypes of GCK ‐CHIs were highly heterogeneous. We have identified two novel GCK‐CHI mutations in young patients and investigated their pathogenicity by enzyme kinetic analysis, which expanded the spectrum of this rare disease.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 15, 2019 Category: Endocrinology Authors: Fan Ping, Zhixin Wang, Xinhua Xiao Tags: Original Article Source Type: research

Issue Information
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 1-4, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: Issue Information Source Type: research

Author Index
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 45-49, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: Author Index Source Type: research

Program
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 8-23, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: Program Source Type: research

Abstracts
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 24-44, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: Abstracts Source Type: research

The 11th Scientific Meeting of the Asian Association for the Study of Diabetes
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 5-5, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: The 11th Scientific Meeting of the Asian Association for the Study of Diabetes Source Type: research

Program at a Glance
Journal of Diabetes Investigation, Volume 10, Issue S1, Page 6-7, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Tags: Program at a Glance Source Type: research

Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population
ConclusionsIn Japan, ClinPNs and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS ’ components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Authors: Seigo Kurisu, Hideyuki Sasaki, Shohei Kishimoto, Kazuhiro Hirayasu, Kinichi Ogawa, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo, Takashi Akamizu Tags: Original Article Source Type: research

Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin ‐triggered type 1 diabetes
ConclusionsIn addition to type  1 diabetes high‐risk human leukocyte antigen class II and the class I allele of the insulin gene variable number tandem repeat genotype, the possibility that the risk variants ofBACH2 andCLEC16A could contribute to the development of insulin ‐triggered type 1 diabetes cannot be excluded. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2019 Category: Endocrinology Authors: Hiroshi Onuma, Ryoichi Kawamura, Yasuharu Tabara, Masakatsu Yamashita, Jun Ohashi, Eiji Kawasaki, Akihisa Imagawa, Yuya Yamada, Daisuke Chujo, Kenji Takahashi, Tadashi Suehiro, Yasunori Takata, Haruhiko Osawa, Hideichi Makino Tags: Original Article Source Type: research

The association between age at first childbirth and type 2 diabetes in Chinese women
ConclusionsThe study concluded that having the first child at an early age associated with an increased likelihood of developing T2D later in life; reproductive factors, overweight at 25 years old and status of hypotension could modify such an association.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 13, 2019 Category: Endocrinology Authors: Xueqi Qu, Hanyu Wang, Shiyuan Zhou, Zhe Fang, Jingyuan Li, Kun Tang Tags: Original Article Source Type: research

Inverse association of plasma leptin with cortical thickness at distal radius in patients with type 2 diabetes mellitus determined with quantitative ultrasound device
We examined the relationship of plasma leptin with cortical and trabecular bone components in patients with type 2 diabetes mellitus.Materials and MethodsThis cross ‐sectional study included 182 type 2 diabetes mellitus patients (93 males, 89 females). Cortical thickness and trabecular bone mineral density were determined at the 5.5% distal radius using an LD‐100 ultrasonic bone densitometry device. Plasma leptin along with physical and laboratory measureme nts were simultaneously determined.ResultsPlasma leptin, but not body mass index, was inversely correlated with cortical thickness ( ρ=‐0.487, p
Source: Journal of Diabetes Investigation - May 9, 2019 Category: Endocrinology Authors: Masafumi Kurajoh, Masaaki Inaba, Koka Motoyama, Nagato Kuriyama, Etsuko Ozaki, Teruhide Koyama, Shinsuke Yamada, Tomoaki Morioka, Yasuo Imanishi, Masanori Emoto Tags: Original Article Source Type: research

Hyperglycemia in non ‐obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES‐DM study
AbstractAims/IntroductionHyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes.Materials and MethodsStudy participants consisted of patients with type 2 diabetes (n=746, the average age was 69.9 years old) and an older general population (n=2,067, the average age was 68.2 years old). Sarcopenia was defined as weak grip s...
Source: Journal of Diabetes Investigation - May 9, 2019 Category: Endocrinology Authors: Ken Sugimoto, Yasuharu Tabara, Hiroshi Ikegami, Yasunori Takata, Kei Kamide, Tome Ikezoe, Eri Kiyoshige, Yukako Makutani, Hiroshi Onuma, Yasuyuki Gondo, Kazunori Ikebe, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda, Katsuhiko Kohara, Tags: Original Article Source Type: research

Longitudinal examination of pancreatic β‐cell function in Japanese subjects
AbstractAims/IntroductionWe performed a retrospective, longitudinal analysis of β‐cell function between a diabetes mellitus (DM) group including those that progressed to DM during the follow‐up period and a diabetic type with HbA1c
Source: Journal of Diabetes Investigation - May 8, 2019 Category: Endocrinology Authors: Rumi Fujikawa, Chikako Ito, Sakurako Kira, Munechica Misumi Tags: Original Article Source Type: research

Circulating C1q Tumor Necrosis Factor A ‐related Protein Isoform 5 Levels are Low in Type 2 Diabetes Patients and Reduced by Dapagliflozin
AbstractAims/IntroductionAs a member of TNF α related protein family, CTRP5 has been found to be associated with obesity and IR. Previous studies in humans and animals have reported contradictory results related to the association between ctrp5 and insulin resistance. The purpose of our study is to explore the relationship between ctrp5 and IR through cross‐sectional study and drug intervention study on T2DM.Materials and MethodsA cross ‐sectional study was conducted in 118 newly diagnosed patients with T2DM (T2DM group) and 116 normal adults (NGT group). In an interventional study, 78 individuals with nT2DM rece...
Source: Journal of Diabetes Investigation - May 8, 2019 Category: Endocrinology Authors: Cheng Zhang, Yong Luo, Rui Liu, Xiaoqiang Li, Mengliu Yang, Yu Zhang, Ling Li, Huaming Mou, Lian Guo, Jing Li, Hua Liu, Gangyi Yang, Xianxiang Zhang Tags: Clinical Trial Source Type: research

Free fatty acid receptors, G  protein‐coupled receptor 120 and G protein‐coupled receptor 40, are essential for oil‐induced gastric inhibitory polypeptide secretion
ConclusionsOil ‐induced GIP secretion is triggered by the two major fatty acid receptors, GPR120 and GPR40, without changing K‐cell number or K‐cell characteristics. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 7, 2019 Category: Endocrinology Authors: Akiko Sankoda, Norio Harada, Tomoko Kato, Eri Ikeguchi, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Akira Hirasawa, Nobuya Inagaki Tags: Original Article Source Type: research

Diabetes attenuated age ‐related aortic root dilatation in end‐stage renal disease patients receiving peritoneal dialysis
ConclusionsThe present findings shown an inverse association between diabetes and age ‐related aortic root dilatation in ESRD patients. Diabetes remained to be independently correlated with aortic root dilatation even after adjustment for age, sex and other clinical confounders in ESRD patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 7, 2019 Category: Endocrinology Authors: Min Ye, Jingwei Zhang, Jianbo Li, Yanqiu Liu, Wei He, Hong Lin, Rui Fan, Cuiling Li, Wei Li, Donghong Liu, Fengjuan Yao Tags: Original Article Source Type: research

Interactive association of lipopolysaccharide and free fatty acid with the prevalence of type  2 diabetes: A community‐based cross‐sectional study
We, for the first time, showed that the interaction between lipopolysaccharide and free fatty acids is associated with higher systemic inflammation levels, insulin resistance levels and a higher prevalence of type 2 diabetes in the Chinese population. Further studies to validate our findings and clarify the mechanisms would provide a more effective alternative for improving inflammation and IR, and thereby the treatment and/or prevention of type  2 diabetes. AbstractAims/IntroductionIncreased blood lipopolysaccharide (LPS) or free fatty acid (FFA) levels correlate with an increased risk of type  2 diabetes. The p...
Source: Journal of Diabetes Investigation - May 3, 2019 Category: Endocrinology Authors: Xiuji Huang, Dan Yan, Mingtong Xu, Feng Li, Meng Ren, Jin Zhang, Muchao Wu Tags: Original Article Source Type: research

Issue Information
Journal of Diabetes Investigation, Volume 10, Issue 3, Page 555-556, May 2019. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 2, 2019 Category: Endocrinology Tags: Issue Information Source Type: research

Long ‐term safety and efficacy of the sodium glucose cotransporter 2 inhibitor tofogliflozin added on glucagon‐like peptide‐1 receptor agonist in Japanese patients with type 2 diabetes mellitus (J‐STEP/GLP): a 52‐week open‐label, multicenter, post‐marketing clinical study
AbstractAims/IntroductionTofogliflozin is a potent and highly selective sodium glucose cotransporter 2 inhibitor and is currently used to treat patients with type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the safety and efficacy of tofogliflozin add ‐on to glucagon‐like peptide‐1 (GLP‐1) receptor agonist monotherapy.Materials and MethodsIn this 52 ‐week, prospective, multicenter, single arm, post‐marketing clinical study, Japanese patients who had already been receiving GLP‐1 receptor agonist monotherapy for ≥8 weeks, glycated hemoglobin (HbA1c) ≥7.0% and
Source: Journal of Diabetes Investigation - April 29, 2019 Category: Endocrinology Authors: Yasuo Terauchi, Hisataka Fujiwara, Yuji Kurihara, Hideki Suganami, Masahiro Tamura, Masayuki Senda, Ryoji Gunji, Kohei Kaku Tags: Clinical Trial Source Type: research

Fat ‐specific protein 27α inhibits autophagy‐dependent lipid droplet breakdown in white adipocytes
ConclusionsThe present results thus showed that FSP27 α inhibits autophagy and might thereby contribute to the energy‐storage function of WAT. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 26, 2019 Category: Endocrinology Authors: Shinsuke Nakajima, Yuki Nishimoto, Sanshiro Tateya, Yasuyuki Iwahashi, Yuko Okamatsu ‐Ogura, Masayuki Saito, Wataru Ogawa, Yoshikazu Tamori Tags: Original Article Source Type: research

Safety of Ramadan fasting in young patients with type  1 diabetes: A systematic review and meta‐analysis
ConclusionsThe CSII regimen had lower rates of severe hypoglycemia and hyperglycemia/ketosis, but a higher rate of non ‐severe hyperglycemia than premixed/MDI regimens. These suggest that appropriate patient selection with regular, supervised fine‐tuning of the basal insulin rate with intensive glucose monitoring might mitigate the residual hypoglycemia risk during Ramadan. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 26, 2019 Category: Endocrinology Authors: Huai Heng Loh, Lee ‐Ling Lim, Huai Seng Loh, Anne Yee Tags: Original Article Source Type: research

The protective effect of sodium ‐glucose cotransporter 2 inhibitors in patients with rapid renal function decline, stage G3 or G4 chronic kidney disease, and type 2 diabetes
AbstractIntroductionThe risk of end ‐stage kidney disease (ESKD) increases in proportion to the decline in the estimated glomerular filtration rate (eGFR). Although protective effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) on the eGFR decline were demonstrated in several large‐scale clinical trials, there are no s tudies investigating patients with a high risk of ESKD. We investigated the efficacy and safety of SGLT2i in advanced renal dysfunction patients (stage G3 or G4 of chronic kidney disease) with a rapid decline in eGFR.Materials and MethodsThis retrospective, longitudinal study enrolled patient...
Source: Journal of Diabetes Investigation - April 26, 2019 Category: Endocrinology Authors: Hideaki Miyoshi, Hiraku Kameda, Kumiko Yamashita, Akinobu Nakamura, Yoshio Kurihara Tags: Clinical Trial Source Type: research

Recommended configuration for personal health records by standardized data item sets for diabetes mellitus and associated chronic diseases: A report from Collaborative Initiative by six Japanese Associations
AbstractIt is expected that a large amount of data related to diabetes and other chronic diseases will be generated. However, databases constructed without standardized data item sets can be limited in their usefulness. To address this, the Collaborative Committee of Clinical Informatization in Diabetes Mellitus was established in 2011 by the Japan Diabetes Society and Japan Association for Medical Informatics. The committee has developed core item sets and self ‐management item sets for diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease in collaboration with the Japanese Society of Hypertension, J...
Source: Journal of Diabetes Investigation - April 25, 2019 Category: Endocrinology Authors: Naoki Nakashima, Mitsuhiko Noda, Kohjiro Ueki, Tatsuhiko Koga, Michio Hayashi, Katsuya Yamazaki, Tomoko Nakagami, Makoto Ohara, Akira Gochi, Yasushi Matsumura, Michio Kimura, Kazuhiko Ohe, Dongchon Kang, Yoshiyuki Toya, Kunihiro Yamagata, K Tags: Special Report Source Type: research

Conditioned media from dental pulp stem cells improved diabetic polyneuropathy through anti ‐inflammatory, neuroprotective and angiogenic actions: Cell‐free regenerative medicine for diabetic polyneuropathy
ConclusionsWe showed that DPSC ‐CM injection into hindlimb skeletal muscles has a therapeutic effect on diabetic polyneuropathy through neuroprotective, angiogenic and anti‐inflammatory actions. DPSC‐CM could be a novel cell‐free regenerative medicine treatment for diabetic polyneuropathy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 23, 2019 Category: Endocrinology Authors: Eriko Makino, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Saki Kanada, Masaki Hata, Tomokazu Saiki, Kazunori Sango, Hideki Kamiya, Jiro Nakamura, Ken Miyazawa, Shigemi Goto, Tatsuaki Matsubara, Keiko Naruse Tags: Original Article Source Type: research

Pregnancy outcome of Japanese patients with glucokinase –maturity‐onset diabetes of the young
ConclusionsIn Japanese GCK ‐MODY families, unaffected offspring born to affected women were heavier than affected offspring. However, insulin treatment of affected women might not be advisable because of the lower risk of macrosomic birth injury, and an increased risk of perinatal complications in affected offspring. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 23, 2019 Category: Endocrinology Authors: Yuki Hosokawa, Shinji Higuchi, Rie Kawakita, Ikue Hata, Tatsuhiko Urakami, Tsuyoshi Isojima, Kei Takasawa, Yohei Matsubara, Haruo Mizuno, Yoshihiro Maruo, Katsuyuki Matsui, Katsuya Aizu, Kazuhiko Jinno, Shunsuke Araki, Yasuko Fujisawa, Koji Tags: Original Article Source Type: research

Inverse association between physical activity and blood glucose is independent of sex, menopause status, and first ‐degree family history of diabetes
AbstractAimsExercise training is a recognized strategy central to the prevention, treatment and management of diabetes and prediabetes. The present study was to investigate the association between physical activity and blood glucose, as well as the influence of sex, menopause status, and family history of diabetes.Materials and MethodsParticipants with normal weight were selected from REACTION study, and divided into inactive (moderate ‐to‐vigorous‐intensity physical activity [MVPA] 420 min/week) active groups.ResultsA total of 2601 individuals with an average age of 57.85 ± 8.39 years were enrolled. Multivari...
Source: Journal of Diabetes Investigation - April 23, 2019 Category: Endocrinology Authors: Xiang Hu, Weihui Yu, Lijuan Yang, Wei Pan, Qiya Si, Xueqin Chen, Qianqian Li, Xuejiang Gu Tags: Original Article Source Type: research

Free fatty acid receptor GPR120 and GPR40 are essential for oil ‐induced GIP secretion
ConclusionsOil ‐induced GIP secretion is triggered by the two major fatty acid receptors, GPR120 and GPR40, without changing K cell number or K cell characteristics.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 19, 2019 Category: Endocrinology Authors: Akiko Sankoda, Norio Harada, Tomoko Kato, Eri Ikeguchi, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Akira Hirasawa, Nobuya Inagaki Tags: Original Article Source Type: research

Rho ‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis
Rho ‐associated, coiled‐coil‐containing protein kinase 1 might have applications as a potential therapeutic target for the treatment of non‐alcoholic fatty liver disease. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 19, 2019 Category: Endocrinology Authors: Takafumi Miyamoto, Takashi Matsuzaka, Hitoshi Shimano Tags: Commentary Source Type: research

Clinical utility of carotid ultrasonography: Application for the management of patients with diabetes
This article reviews related articles, summarizes the rationale for the application of carotid ultrasonography in clinical practice, and addresses the features and the limitations of carotid ultrasonography in cardio vascular risk prediction. AbstractCarotid ultrasonography is a non ‐invasive, simple and inexpensive modality to assess the severity of atherosclerosis. This article reviews related articles, summarizes the rationale for the application of carotid ultrasonography in clinical practice, and addresses the features and the limitations of carotid ultrasonography in ca rdiovascular risk prediction. Numerous large ...
Source: Journal of Diabetes Investigation - April 15, 2019 Category: Endocrinology Authors: Naoto Katakami, Taka ‐aki Matsuoka, Iichiro Shimomura Tags: Review Article Source Type: research

Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes
AbstractThe relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595 ±683 vs 3596±1203 pg/mL, p
Source: Journal of Diabetes Investigation - April 15, 2019 Category: Endocrinology Authors: Richard J MacIsaac, Matthew Farag, Varuni Obeyesekere, Michele Clarke, Ray Boston, Glenn M Ward, George Jerums, Elif Ekinci Tags: Short Report Source Type: research

Bullous Pemphigoid with Dipeptidyl Peptidase ‐4 Inhibitors: Clinical Features and Pathophysiology
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 15, 2019 Category: Endocrinology Authors: Takaaki Murakami, Daisuke Yabe, Nobuya Inagaki Tags: Commentary Source Type: research

Clinical polyneuropathy does not increase by pre ‐diabetes or metabolic syndrome in Japanese general population
ConclusionsIn Japan, ClinPNs and NCA increased in known diabetic patients, but did not increase in participants with pre ‐diabetes, MetS and MetS components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 12, 2019 Category: Endocrinology Authors: Seigo Kurisu, Hideyuki Sasaki, Shohei Kishimoto, Masahiro Hirayasu, Kinichi Ogawa, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo, Takashi Akamizu Tags: Original Article Source Type: research

High, but stable, trend in the prevalence of gestational diabetes mellitus: A population ‐based study in Xiamen, China
ConclusionsGDM affects 17.6% of all pregnant women in Xiamen. Age and maternal obesity were major contributors to GDM. The trend of GDM risk remained stable during the study. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 11, 2019 Category: Endocrinology Authors: Bing Yan, Yaxin Yu, Mingzhu Lin, Zhibin Li, Liying Wang, Peiying Huang, Haiqu Song, Xiulin Shi, Shuyu Yang, Xiaoying Li, Xuejun Li Tags: Original Article Source Type: research

Glucagon secretions are impaired in patients with fulminant type  1 diabetes
Arginine ‐challenge test in various types of diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 11, 2019 Category: Endocrinology Authors: Hisako Komada, Yushi Hirota, Wataru Ogawa Tags: Letter to the Editor Source Type: research

Macrophage ‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice
ConclusionsThe activation of macrophage HIF ‐1α might play important roles in the development of liver cancer associated with diet‐induced obesity and diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 11, 2019 Category: Endocrinology Authors: Akiko Takikawa, Isao Usui, Shiho Fujisaka, Koichi Tsuneyama, Keisuke Okabe, Takashi Nakagawa, Allah Nawaz, Tomonobu Kado, Teruo Jojima, Yoshimasa Aso, Yoshihiro Hayakawa, Kunikimi Yagi, Kazuyuki Tobe Tags: Original Article Source Type: research

Variants in the BACH2 and CLEC16A gene may be associated with susceptibility to insulin ‐triggered type 1 diabetes
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 10, 2019 Category: Endocrinology Authors: Hiroshi Onuma, Ryoichi Kawamura, Yasuharu Tabara, Masakatsu Yamashita, Jun Ohashi, Eiji Kawasaki, Akihisa Imagawa, Yuya Yamada, Daisuke Chujo, Kenji Takahashi, Tadashi Suehiro, Yasunori Takata, Haruhiko Osawa, Hideichi Makino Tags: Original Article Source Type: research

Interactive Association of Lipopolysaccharide and Free Fatty Acid with the Prevalence of Type 2 Diabetes: A  Community‐Based Cross‐Sectional Study
AbstractAims/IntroductionIncreased blood lipopolysaccharide (LPS) or free fatty acid (FFA) levels correlate with an increased risk of type 2 diabetes (T2D). The purpose of the present  study was to evaluate the interactive effect of serum LPS and FFA levels on the prevalence of T2D.Materials and MethodsThis cross ‐sectional study included 2553 community‐dwelling Chinese adults. Fasting serum LPS levels were determined using the Limulus Amebocyte Lysate Chromogenic Endpoint assay, and FFA levels were determined using an enzymatic method. The subjects were divided into three groups according to the tertil es of...
Source: Journal of Diabetes Investigation - April 5, 2019 Category: Endocrinology Authors: Xiuji Huang, Dan Yan, Mingtong Xu, Feng Li, Meng Ren, Jin Zhang, Muchao Wu Tags: Original Article Source Type: research

Diabetes attenuated age ‐related aortic root dilation in end‐stage renal disease patients receiving peritoneal dialysis
ConclusionOur findings demonstrated an inverse association between diabetes and age ‐related aortic root dilation in ESRD patients. Diabetes remained to be independently correlated with aortic root dilation even after adjustment for age, gender and other clinical confounders in ESRD patients.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 3, 2019 Category: Endocrinology Authors: Min Ye, Jingwei Zhang, Jianbo Li, Yanqiu Liu, Wei He, Hong Lin, Rui Fan, Cuiling Li, Wei Li, Donghong Liu, Fengjuan Yao Tags: Original Article Source Type: research

Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar
This was a large cross ‐sectional study of patients with type 2 diabetes mellitus (n = 1,095), and the first study to establish the prevalence and risk factors for painful diabetic peripheral neuropathy in Qatar. It shows that one‐third of patients with type 2 diabetes mellitus had painful diabetic peripheral neuropathy, but ~80% of patients had not been diagnosed or treated f or this condition. We further identify that diabetic peripheral neuropathy, obesity and smoking are major modifiable risk factors for painful diabetic peripheral neuropathy in this population. AbstractAims/IntroductionPainful ...
Source: Journal of Diabetes Investigation - April 2, 2019 Category: Endocrinology Authors: Georgios Ponirakis, Tarik Elhadd, Subitha Chinnaiyan, Zeinab Dabbous, Mashhood Siddiqui, Hamad Al ‐muhannadi, Ioannis Petropoulos, Adnan Khan, Khaled AE Ashawesh, Khaled MO Dukhan, Ziyad R Mahfoud, Christopher Murgatroyd, Mark Slevin, Rayaz Tags: Original Article Source Type: research

Cutaneous microangiopathy in patients with type  2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy
ConclusionsThe present study is the first report to show that cutaneous microangiopathy, as indicated by subepidermal microvascular proliferation and impaired VEGF expression, appears to occur before the development of overt clinical neuropathy, retinopathy or nephropathy in patients with type  2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 2, 2019 Category: Endocrinology Authors: Kazuhiro Sugimoto, Hiroshi Murakami, Takahisa Deguchi, Aiko Arimura, Makoto Daimon, Susumu Suzuki, Takuro Shimbo, Soroku Yagihashi Tags: Original Article Source Type: research

Maturity ‐onset diabetes of the young type 5 uncovered during pregnancy with a long‐term diagnosis of type 1 diabetes
We report a case of missed diagnosis of maturity ‐onset diabetes of the young type 5 uncovered during pregnancy with a previous diagnosis of type 1 diabetes. Maturity‐onset diabetes of the young type 5 cannot be excluded in early‐onset diabetes with positive islet‐related autoantibodies and type 1 diabetes‐prone human leukocyte antig en subtypes. Abdominal ultrasound should be used in all patients with pre‐gestational diabetes, and maturity‐onset diabetes of the young type 5 should be considered when renal abnormality is presented. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 2, 2019 Category: Endocrinology Authors: Mingqun Deng, Xiaojing Wang, Xinhua Xiao, Fan Ping Tags: Case Report Source Type: research

Safety of Ramadan Fasting in Young Patients with Type 1 Diabetes: A Systematic Review and Meta ‐analysis
ConclusionCSII regimen had lower rates of severe hypoglycemia and hyperglycemia/ketosis, but a higher rate of non ‐severe hyperglycemia than premixed/MDI regimens. These suggest that appropriate patient selection with regular, supervised fine‐tuning of basal insulin rate with intensive glucose monitoring may mitigate the residual hypoglycemia risk during Ramadan.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 2, 2019 Category: Endocrinology Authors: Huai Heng Loh, Lee Ling Lim, Huai Seng Loh, Anne Yee Tags: Original Article Source Type: research

FSP27 α inhibits autophagy‐dependent lipid droplet breakdown in white adipocytes
ConclusionsOur results thus indicate that FSP27 α inhibits autophagy and may thereby contribute to the energy‐storage function of WAT.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - March 30, 2019 Category: Endocrinology Authors: Shinsuke Nakajima, Yuki Nishimoto, Sanshiro Tateya, Yasuyuki Iwahashi, Yuko Okamatsu ‐Ogura, Masayuki Saito, Wataru Ogawa, Yoshikazu Tamori Tags: Original Article Source Type: research