Identification of two novel subgroups in patients with diabetes mellitus and their association with clinical outcomes: a two ‐step cluster analysis
ConclusionsSeven subgroups of type 2 diabetes were identified in Chinese populations, with distinct characteristics and disparate clinical outcomes. This etiology ‐based stratification may contribute to the diagnosis and management of type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 7, 2021 Category: Endocrinology Authors: Xiao ‐fen Xiong, Yuan Yang, Ling Wei, Ying Xiao, Li Li, Lin Sun Tags: ORIGINAL ARTICLE Source Type: research

Sex differences in the association between fatty liver and type 2 diabetes incidence in non ‐obese Japanese: a retrospective cohort study
AbstractAims/IntroductionAsians develop type 2 diabetes (T2D) at a lower BMI compared to other races, which is partly because of Asian ‐specific fat depots. Sex plays a role in fat deposition, regardless of race. This retrospective cohort study aimed to investigate the association among fatty liver, sex and T2D in non‐obese Japanese.Materials and MethodsThe participants in this study (13,596 men and 6,037 women) were aged 30 –64 years and had undergone health check‐ups between 2013 and 2015, in Aichi, Japan. Baseline BMI was categorized as follows:
Source: Journal of Diabetes Investigation - January 7, 2021 Category: Endocrinology Authors: Akihiko Narisada, Eiji Shibata, Tomomi Hasegawa, Nobue Masamura, Chitose Taneda, Kohta Suzuki Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic value of dysregulated miRNAs in the placenta and circulating exosomes in gestational diabetes mellitus
ABSTRACTAims/Introduction: Differentially expressed microRNAs (miRNAs) in the placenta and circulating exosomes are of diagnostic value for gestational diabetes mellitus (GDM). In a cross ‐sectional study, we identified miRNAs expressed both in the placenta and circulating exosomes of pregnant women with GDM, and estimated their diagnostic value.Materials and MethodsNext ‐generation sequencing (NGS) was used to identify miRNAs in the placenta that were differentially expressed between GDM and normal glucose tolerant (NGT) pregnancies. Quantitative polymerase chain reaction (PCR) was used to validate the identified targ...
Source: Journal of Diabetes Investigation - January 7, 2021 Category: Endocrinology Authors: Lei Zhang, Ting Zhang, Daoxu Sun, Guanghui Cheng, Hanxiao Ren, Haijie Hong, Liyu Chen, Xue Jiao, Yijia Du, Yuqing Zou, Lina Wang Tags: ORIGINAL ARTICLE Source Type: research

Association of Protein Tyrosine Phosphatase 1B (PTPN1) Gene Polymorphism with the Effects of Weight Reduction Therapy on Body Weight and Glycolipid Profiles in Obese Patients
ConclusionsOur findings indicate that the SNP rs3787348 inPTPN1 was associated with the effects of weight reduction therapy on BMI and waist circumference among obese Japanese patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 5, 2021 Category: Endocrinology Authors: Hajime Yamakage, Yousuke Konishi, Kazuya Muranaka, Kikuko Hotta, Yoshihiro Miyamoto, Hiroko Morisaki, Takayuki Morisaki, Noriko Satoh ‐Asahara Tags: ORIGINAL ARTICLE Source Type: research

Response to ‘Focus on nerve fiber type: A diagnostic strategy for diabetic polyneuropathy’
Journal of Diabetes Investigation, EarlyView. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 4, 2021 Category: Endocrinology Authors: Hideyuki Sasaki, Shohei Kishimoto Tags: Letter To The Editor Source Type: research

Issue Information
Journal of Diabetes Investigation, Volume 12, Issue 1, Page 1-2, January 2021. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 3, 2021 Category: Endocrinology Tags: Issue Information Source Type: research

One ‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients
Primary end ‐point incidences and renal end‐point were much higher in rapid estimated glomerular filtration rate decliners compared with non‐decliners (P 
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Shu Meguro, Jun Inaishi, Yasunori Sato, Issei Komuro, Hiroshi Itoh Tags: Original Article Source Type: research

Alterations of retinal thickness measured by optical coherence tomography correlate with neurophysiological measures in diabetic polyneuropathy
ConclusionsDepending on the progression of diabetic polyneuropathy, the ganglion cell complex and retinal pigment epithelium became thinner and the INL/OPL became thicker. These retinal changes might be noteworthy for pathological investigations and for the assessment of diabetic polyneuropathy and diabetic retinopathy. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada ‐Yamada, Yusuke Hayashi, Emi Asano‐Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hi Tags: Original Article Source Type: research

Forty ‐eight weeks of statin therapy for type 2 diabetes mellitus patients with lower extremity atherosclerotic disease: Comparison of the effects of pitavastatin and atorvastatin on lower femoral total plaque areas
This study compared the effects of pitavastatin and atorvastatin on femoral total plaque areas (FTPA), and lipids and glucose metabolism in type  2 diabetes mellitus patients with elevated LDL‐C level and LEAD. Type 2 diabetes mellitus patients with LDL‐C level>2.6  mmol/L and LEAD were randomly assigned to receive either pitavastatin 2 mg/day or atorvastatin 10 mg/day for 48 weeks. FTPA were measured at baseline and the end of the study. Levels of glucose and lipids profile were measured periodically. The efficacy was evaluated in 63 patients.ResultsThe percentage change in FTPA measur...
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Xieda Zhou, Liting Wu, Yan Chen, Huangmeng Xiao, Xiaoyu Huang, Yanbing Li, Haipeng Xiao, Xiaopei Cao Tags: Original Article Source Type: research

Reduced leukocyte telomere lengths and sirtuin  1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy
Individuals with long ‐term type 1 diabetes presented with significantly reduced leukocyte telomere lengths and sirtuin 1 expression, as compared with healthy controls. Additional lower levels were observed in diabetes patients with established coronary disease. Glycated hemoglobin and triglycerides seem to have an i mpact on telomere lengths and sirtuin 1, respectively. AbstractAims/IntroductionThe shortening of leukocyte telomere length with age has been associated with coronary disease, whereas the association with type  1 diabetes is unclear. We aimed to explore telomere lengths in diabetes patien...
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Trine Baur Opstad, Tore Julsrud Berg, Kristine Bech Holte, Harald Arnesen, Svein Solheim, Ingebj ørg Seljeflot Tags: Original Article Source Type: research

Sodium ‐glucose cotransporter 2 inhibitor‐induced reduction in the mean arterial pressure improved renal composite outcomes in type 2 diabetes mellitus patients with chronic kidney disease: A propensity score‐matched model analysis in Japan
ConclusionsThe degree of BP reduction after SGLT2 inhibitor treatment influenced renal composite outcomes in Japanese T2DM patients with CKD, confirming the importance of blood pressure management in T2DM patients with CKD, even when they are under SGLT2 inhibitor treatment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Kazuo Kobayashi, Masao Toyoda, Nobuo Hatori, Takayuki Furuki, Hiroyuki Sakai, Kazuyoshi Sato, Masaaki Miyakawa, Kouichi Tamura, Akira Kanamori Tags: ORIGINAL ARTICLE Source Type: research

Predictors of the maximal oxygen consumption in adult patients with type 1 diabetes treated with personal insulin pumps
ConclusionsIn our selected homogenous group of patients with T1DM treated with personal insulin pumps, higher CF was associated with lower percentage of body fat, male gender, higher lactate level after the CF test, and the PSS10 score. The proposed protocol in our cohort proved to be safe with regards to glycemic control. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 30, 2020 Category: Endocrinology Authors: Bart łomiej Matejko, Łukasz Tota, Sandra Mrozińska, Małgorzata Morawska, Tomasz Pałka, Beata Kieć‐Wilk, Tomasz Klupa, Maciej T. Malecki Tags: ORIGINAL ARTICLE Source Type: research

Association of Non ‐alcoholic Fatty Liver Disease with Diabetic Retinopathy in Type 2 Diabetic Patients: A Meta‐Analysis of Observational Studies
ConclusionOn the whole, there was no association between NAFLD and DR in T2DM individuals. However, subgroup analysis showed that the difference of country may have an influence on the result. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 29, 2020 Category: Endocrinology Authors: Dandan Song, Chengqian Li, Zhongchao Wang, Yuhang Zhao, Baoming Shen, Wenjuan Zhao Tags: ORIGINAL ARTICLE Source Type: research

Admission hyperglycemia as an independent predictor of long ‐term prognosis in acute myocardial infarction patients without diabetes: A retrospective study
The prognostic value of admission hyperglycemia on long ‐term prognosis remains elusive, especially in acute myocardial infarction patients with diabetes. Regarding acute myocardial infarction patients, there has been no accurate threshold of admission hyperglycemia to predict mortality. Therefore, in our study, we used different cut‐off values in pa tients with and without diabetes to discuss their predictive value in the long‐term prognosis of acute myocardial infarction patients. AbstractAims/IntroductionThe predictive value of admission hyperglycemia in the long ‐term prognosis of acute myocardial infarction pa...
Source: Journal of Diabetes Investigation - December 28, 2020 Category: Endocrinology Authors: Cai ‐yan Cui, Ming‐gang Zhou, Lian‐chao Cheng, Tao Ye, Yu‐mei Zhang, Feng Zhu, Si‐yi Li, Xing‐lin Jiang, Qiang Chen, Ling‐yao Qi, Xu Chen, Si‐qi Yang, Lin Cai Tags: Original Article Source Type: research

Impact of glucagon response on early ‐postprandial glucose excursions irrespective of residual β‐cell function in type 1 diabetes: A cross‐sectional study using a mixed‐meal tolerance test
AbstractAims/IntroductionControlling postprandial glucose levels in patients with type 1 diabetes (T1D) is challenging even under the adequate treatment of insulin injection. Recent studies revealed the dysregulated glucagon secretion exacerbates hyperglycemia in type 2 diabetes (T2D), but little is known in T1D. We investigated whether the glucagon response to a meal ingestion could influence the postprandial glucose excursion in patients with T1D.Materials and MethodsWe enrolled 34 patients with T1D and 23 patients with T2D as controls. All patients underwent a liquid mixed ‐meal tolerance test. We measured levels of p...
Source: Journal of Diabetes Investigation - December 25, 2020 Category: Endocrinology Authors: Ayako Ito, Ichiro Horie, Masaki Miwa, Ayaka Sako, Tetsuro Niri, Yomi Nakashima, Riyoko Shigeno, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Akie Kamada, Atsushi Kawakami, Norio Abiru Tags: ORIGINAL ARTICLE Source Type: research

Serum Growth Differentiation Factor 15 is closely associated with metabolic abnormalities in Chinese pregnant women
AbstractAimsTo explore the relationship between serum growth differentiation factor 15 (GDF ‐15) and metabolic abnormalities in Chinese pregnant women.Materails and MethodsWe recruited 200 patients with Gestational Diabetes Mellitus (GDM) and 211 matched normal control within 24 ‐28 weeks of pregnancy. Enzyme‐linked immunosorbent assay (ELISA) was used to determine the serum GDF15 levels of all participants. Then we grouped participants according to the number of metabolic abnormalities (including blood glucose, blood lipids and blood pressure), divided them into normal metabolic group, one metabolic abnormal group, ...
Source: Journal of Diabetes Investigation - December 23, 2020 Category: Endocrinology Authors: Enhao LI, Peihong Chen, Jun Lu, Jiarong Dai, Jufen Yi, Shan Zhang, Hua Jin, Meixinag Guo, Hongtao Wang, Xuemei Yu Tags: ORIGINAL ARTICLE Source Type: research

Incidence of adverse cardiovascular events in type 2 diabetes mellitus patients after initiation of the glucose ‐lowering agents: A population‐based community study from the Shizuoka Kokuho Database
ConclusionsThe incidence of HHF was similar to that of stroke. Significant portion of our cohort met the inclusion criteria for major randomized clinical trials for SGLT2i, and estimated reduction in the HHF events was substantial. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 21, 2020 Category: Endocrinology Authors: Shun Kohsaka, Hiraku Kumamaru, Shiori Nishimura, Satoshi Shoji, Eiji Nakatani, Nao Ichihara, Hiroyuki Yamamoto, Yoshiki Miyachi, Hiroaki Miyata Tags: ORIGINAL ARTICLE Source Type: research

All ‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan Cohort
AbstractWe aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death ‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (
Source: Journal of Diabetes Investigation - December 19, 2020 Category: Endocrinology Authors: Hiroshi Yokomichi, Mie Mochizuki, Makoto Hirata, Akiko Nagai, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Yuka Akiyama, Ryoji Shinohara, Kunio Miyake, Project BioBank Japan, Zentaro Yamagata Tags: SHORT REPORT Source Type: research

Decreased plasma n6  : n3 polyunsaturated fatty acids ratio interacting with high C‐peptide promotes non‐alcoholic fatty liver disease in type 2 diabetes patients
ConclusionDecreased n6  : n3 ratio was associated with increased NAFLD risk in type 2 diabetes patients, and the effect was only significant and amplified when there was the co‐presence of high C‐peptide. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 19, 2020 Category: Endocrinology Authors: Hui ‐Huan Luo, Meng‐Di Zhao, Xiao‐Fei Feng, Xiao‐Qian Gao, Mo Hong, Ming‐Li Liu, Yan‐Ping Li, Wan‐Qiu Liu, Yu‐Mo Liu, Cheng‐Cheng Yu, Yun‐Feng Cao, Xi‐Lin Yang, Zhong‐Ze Fang, Ping Zhang Tags: Original Article Source Type: research

All ‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan Cohort
AbstractWe aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death ‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (
Source: Journal of Diabetes Investigation - December 19, 2020 Category: Endocrinology Authors: Hiroshi Yokomichi, Mie Mochizuki, Makoto Hirata, Akiko Nagai, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Yuka Akiyama, Ryoji Shinohara, Kunio Miyake, Project BioBank Japan, Zentaro Yamagata Tags: SHORT REPORT Source Type: research

Decreased plasma n6  : n3 polyunsaturated fatty acids ratio interacting with high C‐peptide promotes non‐alcoholic fatty liver disease in type 2 diabetes patients
ConclusionDecreased n6  : n3 ratio was associated with increased NAFLD risk in type 2 diabetes patients, and the effect was only significant and amplified when there was the co‐presence of high C‐peptide. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 19, 2020 Category: Endocrinology Authors: Hui ‐Huan Luo, Meng‐Di Zhao, Xiao‐Fei Feng, Xiao‐Qian Gao, Mo Hong, Ming‐Li Liu, Yan‐Ping Li, Wan‐Qiu Liu, Yu‐Mo Liu, Cheng‐Cheng Yu, Yun‐Feng Cao, Xi‐Lin Yang, Zhong‐Ze Fang, Ping Zhang Tags: Original Article Source Type: research

Plasma xanthine oxidoreductase activity in Japanese patients with type  2 diabetes across hospitalized treatment
ConclusionsA close relationship was observed between plasma XOR activity and liver transaminases in patients with type  2 diabetes mellitus, cross‐sectionally, and also across treatment during hospitalization. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 18, 2020 Category: Endocrinology Authors: Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Hirofumi Nagao, Takashi Nakamura, Seigo Akari, Takayo Murase, Naohiro Taya, Kazuo Omori, Akimitsu Miyake, Shiro Fukuda, Mitsuyoshi Takahara, Shunbun Kita, Naoto Katakami, Norikazu Maeda, Ii Tags: Original Article Source Type: research

Neuroretinal dysfunction revealed by a flicker electroretinogram correlated with peripheral nerve dysfunction and parameters of atherosclerosis in patients with diabetes
ConclusionsElectroretinogram parameters obtained by the hand ‐held device successfully predict the severity of DPN. The device might be useful to evaluate DPN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 18, 2020 Category: Endocrinology Authors: Miyuka Kawai, Tatsuhito Himeno, Yuka Shibata, Nobuhiro Hirai, Yuriko Asada ‐Yamada, Emi Asano‐Hayami, Yohei Ejima, Rina Kasagi, Eriko Nagao, Yukako Sugiura‐Roth, Hiromi Nakai‐Shimoda, Takayuki Nakayama, Yuichiro Yamada, Takahiro Ishik Tags: Original Article Source Type: research

Impact of daily glucose fluctuations on cardiovascular outcomes after percutaneous coronary intervention for patients with stable coronary artery disease undergoing lipid ‐lowering therapy
Mean amplitude glucose excursion (MAGE) was significantly higher in patients with CVE than in those without CVE. The cut ‐off value for the prediction of CVE by MAGE was 70.7 mg/dL. Higher MAGE was significantly associated with a high overall rate of CVE as well as of each component. AbstractAims/IntroductionGlucose fluctuation (GF) is a residual risk factor for coronary artery disease (CAD). We investigated whether GF influenced clinical outcomes and progression of coronary stenosis in stable CAD patients.Materials and MethodsIn this prospective study, 101 consecutive lipid ‐controlled stable CAD patients underwent pe...
Source: Journal of Diabetes Investigation - December 18, 2020 Category: Endocrinology Authors: Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Masaru Kuroda, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Ken ‐ichi Hirata Tags: Original Article Source Type: research

Plasma xanthine oxidoreductase activity in Japanese patients with type  2 diabetes across hospitalized treatment
ConclusionsA close relationship was observed between plasma XOR activity and liver transaminases in patients with type  2 diabetes mellitus, cross‐sectionally, and also across treatment during hospitalization. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 18, 2020 Category: Endocrinology Authors: Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Hirofumi Nagao, Takashi Nakamura, Seigo Akari, Takayo Murase, Naohiro Taya, Kazuo Omori, Akimitsu Miyake, Shiro Fukuda, Mitsuyoshi Takahara, Shunbun Kita, Naoto Katakami, Norikazu Maeda, Ii Tags: Original Article Source Type: research

Is metformin a miracle or a menace in COVID ‐19 patients with type 2 diabetes?
AbstractCoronavirus disease 2019 (COVID ‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a global pandemic since March 2020. Diabetes mellitus, especially type 2 diabetes, has been linked to worse COVID‐19‐related outcomes. It has been shown that glycemic control is important in COVID‐19 patients with diabetes. Individuals with well‐controlled blood glucose levels had lower mortality compared to those with poor control, and glucose management might potentially influence the prognosis and outcomes of COVID‐19 infection. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 17, 2020 Category: Endocrinology Authors: David Tak Wai Lui, Kathryn Choon Beng Tan Tags: COMMENTARY Source Type: research

Cardiovascular events and mortality in people with and without type  2 diabetes: An observational study in a contemporary multi‐ethnic population
ConclusionsDespite universal access to healthcare, there are large disparities in CVD outcomes in people with and without type  2 diabetes mellitus. Other non‐traditional risk factors might play a role in the higher CVD risk associated with type 2 diabetes mellitus in individuals of South Asian ethnicity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 16, 2020 Category: Endocrinology Authors: Briana Coles, Francesco Zaccardi, Suping Ling, Melanie J Davies, Nilesh J Samani, Kamlesh Khunti Tags: Original Article Source Type: research

Do Sodium ‐glucose Cotransporter 2 Inhibitors Lead to Fracture Risk? A Pharmacovigilance Real‐World Study
AbstractAims/IntroductionGiven the mechanism of action of Sodium ‐glucose cotransporter 2 inhibitors (SGLT2is), these drugs can also reduce bone density and increase fracture risk. We aimed to identify and characterize fracture‐related adverse events that are associated with SGLT2is.Materials and MethodsIn this observational, retrospective, pharmacovigilance, real ‐world study, we used disproportionality and Bayesian analyses to compare fracture‐related adverse event reporting in patients who received SGLT2is from the first quarter in 2004 to the fourth quarter in 2019 in the Food and Drug Administration (FDA) Adve...
Source: Journal of Diabetes Investigation - December 16, 2020 Category: Endocrinology Authors: Bin Zhao, Juan Shen, Jun Zhao, Hui Pan Tags: ORIGINAL ARTICLE Source Type: research

Impact of endogenous insulin secretion on the improvement of glucose variability in Japanese patients type 2 diabetes treated with canagliflozin plus teneligliptin
AbstractAims/IntroductionTo identify the effect of combination therapy with a dipeptidyl peptidase ‐4 (DPP‐4) inhibitor and a sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor compared with switching from a DPP‐4 inhibitor to a SGLT2 inhibitor on improving the glucose variability in patients with or without impaired endogenous insulin secretion.Materials and MethodsA secondary analysis regarding the relationship between endogenous insulin secretion and the change in mean amplitude of glycemic excursions ( ΔMAGE) was conducted in a multicenter, prospective, randomized, parallel‐group comparison trial tha...
Source: Journal of Diabetes Investigation - December 16, 2020 Category: Endocrinology Authors: Aika Miya, Akinobu Nakamura, Kyu Yong Cho, Shinichiro Kawata, Hiroshi Nomoto, So Nagai, Hajime Sugawara, Shinji Taneda, Kazuhisa Tsuchida, Kazuno Omori, Hiroki Yokoyama, Jun Takeuchi, Shin Aoki, Yoshio Kurihara, Tatsuya Atsumi, Hideaki Miyo Tags: CLINICAL TRIAL Source Type: research

Do Sodium ‐glucose Cotransporter 2 Inhibitors Lead to Fracture Risk? A Pharmacovigilance Real‐World Study
AbstractAims/IntroductionGiven the mechanism of action of Sodium ‐glucose cotransporter 2 inhibitors (SGLT2is), these drugs can also reduce bone density and increase fracture risk. We aimed to identify and characterize fracture‐related adverse events that are associated with SGLT2is.Materials and MethodsIn this observational, retrospective, pharmacovigilance, real ‐world study, we used disproportionality and Bayesian analyses to compare fracture‐related adverse event reporting in patients who received SGLT2is from the first quarter in 2004 to the fourth quarter in 2019 in the Food and Drug Administration (FDA) Adve...
Source: Journal of Diabetes Investigation - December 16, 2020 Category: Endocrinology Authors: Bin Zhao, Juan Shen, Jun Zhao, Hui Pan Tags: ORIGINAL ARTICLE Source Type: research

Impact of endogenous insulin secretion on the improvement of glucose variability in Japanese patients type 2 diabetes treated with canagliflozin plus teneligliptin
AbstractAims/IntroductionTo identify the effect of combination therapy with a dipeptidyl peptidase ‐4 (DPP‐4) inhibitor and a sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor compared with switching from a DPP‐4 inhibitor to a SGLT2 inhibitor on improving the glucose variability in patients with or without impaired endogenous insulin secretion.Materials and MethodsA secondary analysis regarding the relationship between endogenous insulin secretion and the change in mean amplitude of glycemic excursions ( ΔMAGE) was conducted in a multicenter, prospective, randomized, parallel‐group comparison trial tha...
Source: Journal of Diabetes Investigation - December 16, 2020 Category: Endocrinology Authors: Aika Miya, Akinobu Nakamura, Kyu Yong Cho, Shinichiro Kawata, Hiroshi Nomoto, So Nagai, Hajime Sugawara, Shinji Taneda, Kazuhisa Tsuchida, Kazuno Omori, Hiroki Yokoyama, Jun Takeuchi, Shin Aoki, Yoshio Kurihara, Tatsuya Atsumi, Hideaki Miyo Tags: CLINICAL TRIAL Source Type: research

Preoperative fundus examination in patients with diabetes scheduled for surgery
This study aimed to reveal the proportion of receiving fundus examination in patients with diabetes who were scheduled for surgery. We retrospectively analyzed 455 consecutive patients with diabetes admitted for surgery. Only 49% had fundus examination before hospitalization. The decision tree analysis demonstrated that the type of family doctor was the first split associated with fundus examination; patients treated by a diabetes specialist were more likely to receive the examination. In this subgroup, glycated hemoglobin (HbA1c) levels ≥8.0% and age ≥71 years were associated with a lower proportion of receiving the...
Source: Journal of Diabetes Investigation - December 15, 2020 Category: Endocrinology Authors: Hirotaka Watanabe, Mitsuyoshi Takahara, Naoto Katakami, Taka ‐aki Matsuoka, Iichiro Shimomura Tags: SHORT REPORT Source Type: research

Cardiovascular events and mortality in people with and without type  2 diabetes: An observational study in a contemporary multi‐ethnic population
ConclusionsDespite universal access to healthcare, there are large disparities in CVD outcomes in people with and without type  2 diabetes mellitus. Other non‐traditional risk factors might play a role in the higher CVD risk associated with type 2 diabetes mellitus in individuals of South Asian ethnicity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 15, 2020 Category: Endocrinology Authors: Briana Coles, Francesco Zaccardi, Suping Ling, Melanie J Davies, Nilesh J Samani, Kamlesh Khunti Tags: Original Article Source Type: research

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy
AbstractDiabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and is the leading cause of visual loss in the elderly. Hyperglycemia and altered metabolic pathways, leading to oxidative stress and development of neurodegeneration in the initial stage of diabetic retinopathy1. Vascular endothelial damage, development of microaneurysms and dot intraretinal hemorrhage were early hallmarks of non ‐proliferative diabetic retinopathy (NPDR). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 14, 2020 Category: Endocrinology Authors: Kuan ‐Yu Lin, Wen‐Hui Hsih, Yen‐Bo Lin, Chen‐Yu Wen, Tien‐Jyun Chang Tags: JDI UPDATES Source Type: research

Serum progesterone and retinopathy in male patients with type  2 diabetes: A cross‐sectional study
High levels of serum progesterone are significantly associated with diabetic retinopathy complications in male hospitalized patients. This could mean that a higher progesterone level in men is a predictor of diabetic retinopathy, and the causality remains to be further explored. AbstractAims/IntroductionThe aim of this study was to investigate the relationship between serum progesterone (P) and retinopathy in male patients with type  2 diabetes mellitus, and to investigate whether P is associated with its progression.Materials and methodsA total of 1,376 male participants with type  2 diabetes mellitus were recru...
Source: Journal of Diabetes Investigation - December 14, 2020 Category: Endocrinology Authors: Shengnan Sun, Yahao Wang, Yue Zhou, Wenru Ma, Yajing Huang, Jianxia Hu, Yangang Wang Tags: Clinical Trial Source Type: research

Association of mean corpuscular volume with sarcopenia and visceral obesity in individuals without anemia
ConclusionsIn individuals without anemia and with normal MCV levels, a lower MCV was associated with unfavorable body composition, including lower muscle quality, lower muscle quantity, sarcopenia and visceral obesity. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 14, 2020 Category: Endocrinology Authors: Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui Tags: Original Article Source Type: research

Serum progesterone and retinopathy in male patients with type  2 diabetes: A cross‐sectional study
High levels of serum progesterone are significantly associated with diabetic retinopathy complications in male hospitalized patients. This could mean that a higher progesterone level in men is a predictor of diabetic retinopathy, and the causality remains to be further explored. AbstractAims/IntroductionThe aim of this study was to investigate the relationship between serum progesterone (P) and retinopathy in male patients with type  2 diabetes mellitus, and to investigate whether P is associated with its progression.Materials and methodsA total of 1,376 male participants with type  2 diabetes mellitus were recru...
Source: Journal of Diabetes Investigation - December 14, 2020 Category: Endocrinology Authors: Shengnan Sun, Yahao Wang, Yue Zhou, Wenru Ma, Yajing Huang, Jianxia Hu, Yangang Wang Tags: Clinical Trial Source Type: research

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy
AbstractDiabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and is the leading cause of visual loss in the elderly. Hyperglycemia and altered metabolic pathways, leading to oxidative stress and development of neurodegeneration in the initial stage of diabetic retinopathy1. Vascular endothelial damage, development of microaneurysms and dot intraretinal hemorrhage were early hallmarks of non ‐proliferative diabetic retinopathy (NPDR). (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 14, 2020 Category: Endocrinology Authors: Kuan ‐Yu Lin, Wen‐Hui Hsih, Yen‐Bo Lin, Chen‐Yu Wen, Tien‐Jyun Chang Tags: JDI UPDATES Source Type: research

Beneficial effects of switching to denosumab from bisphosphonates or selective estrogen receptor modulators in postmenopausal women with type  2 diabetes and osteopenia/osteoporosis
In this study, we investigated the effects of switching to Dmab fro m bisphosphonates (BP) or a selective estrogen receptor modulator (SERM) in postmenopausal type 2 diabetes mellitus patients.Materials and MethodsThis was a three medical institutions, prospective, observational study for postmenopausal patients with type  2 diabetes mellitus whose T‐score of femoral neck or lumbar spine bone mineral density was under −1.0 standard deviation, even after>6  months of BP or SERM administration. After obtaining consent, participants were treated for osteopenia/osteoporosis by either continuing BP (BP...
Source: Journal of Diabetes Investigation - December 13, 2020 Category: Endocrinology Authors: Arina Miyoshi, Hiraku Kameda, So Nagai, Akinobu Nakamura, Aika Miya, Takahiro Takase, Tatsuya Atsumi, Hideaki Miyoshi Tags: Original Article Source Type: research

The PKM2 activator TEPP ‐46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF‐1α accumulation
ConclusionPKM2 activation could restore the tubular phenotype via suppression of the EMT program and aberrant glycolysis, providing an alternative target to mitigate fibrosis in the diabetic kidneys. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 12, 2020 Category: Endocrinology Authors: Haijie Liu, Yuta Takagaki, Asako Kumagai, Keizo Kanasaki, Daisuke Koya Tags: ORIGINAL ARTICLE Source Type: research

Imaging the eye and its relevance to diabetes care
Investigating ocular imaging techniques for analyzing diabetic retinopathy and its complications. AbstractDiabetes is a major cause of vision loss globally, yet this devastating complication is largely preventable. Early detection and treatment of diabetic retinopathy necessitates screening. Ocular imaging is widely used clinically, both for the screening and management of diabetic retinopathy. Common eye conditions, such as glaucoma, cataracts and retinal vessel thrombosis, and signs of systemic conditions, such as hypertension, are frequently revealed. As well as imaging by a skilled clinician during an eye examination, ...
Source: Journal of Diabetes Investigation - December 11, 2020 Category: Endocrinology Authors: Nicola Quinn, Alicia Jenkins, Chris Ryan, Andrzej Januszewski, Tunde Peto, Laima Brazionis Tags: Review Source Type: research

Alterations of retinal thickness measured by optic coherence tomography correlate with neurophysiological measures in diabetic polyneuropathy
ConclusionsDepending on the progress of DPN, GCC and RPE became thinner and INL/OPL became thicker. These retinal changes might be noteworthy for pathological investigations and assessment of DPN and DR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 10, 2020 Category: Endocrinology Authors: Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada ‐Yamada, Yusuke Hayashi, Emi Asano‐Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hi Tags: ORIGINAL ARTICLE Source Type: research

Epigenetic changes caused by diabetes and their potential role in the development of periodontitis
ConclusionsDiabetes mellitus induces morphological and epigenetic changes in periodontal tissue, which may contribute to the increased susceptibility of periodontal diseases in patients with diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 10, 2020 Category: Endocrinology Authors: Yanfen Li, Zhibin Du, Xiaoting Xie, Yangheng Zhang, Huifen Liu, Ziqian Zhou, Jing Zhao, Ryan SB Lee, Yin Xiao, Saso Ivanoviski, Fuhua Yan Tags: ORIGINAL ARTICLE Source Type: research

Young people with type 1 diabetes on insulin pump therapy could fast safely during COVID –19 pandemic Ramadan: A telemonitoring experience in Bangladesh
AbstractOur aim was to report our telemedicine experience with type  1 diabetes patients using insulin pumps who fasted for Ramadan 2020 during the COVID‐19 pandemic. The routine diabetes outpatient care in our Changing Diabetes in Children (CDiC) Pediatric Diabetes Center at the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metab olic Disorders hospital was closed, as there was a lockdown from 26 March in Bangladesh. The diabetes team in our center started telemedicine care for routine follow up of patients. Nine patients who wished to fast for Ramadan contacted our diabetes team ov...
Source: Journal of Diabetes Investigation - December 10, 2020 Category: Endocrinology Authors: Bedowra Zabeen, Bulbul Ahmed, Jebun Nahar Tags: Short Report Source Type: research

Alterations of retinal thickness measured by optic coherence tomography correlate with neurophysiological measures in diabetic polyneuropathy
ConclusionsDepending on the progress of DPN, GCC and RPE became thinner and INL/OPL became thicker. These retinal changes might be noteworthy for pathological investigations and assessment of DPN and DR. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - December 10, 2020 Category: Endocrinology Authors: Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada ‐Yamada, Yusuke Hayashi, Emi Asano‐Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hi Tags: ORIGINAL ARTICLE Source Type: research