The role of vascular adhesion protein ‐1 in diabetes and diabetic complications

Vascular adhesion protein-1 (VAP-1) has adhesive and enzymatic functions, aiding leukocyte migration to inflammation sites and producing by-products linked to diabetic complications. This review focuses on the impact of VAP-1 on diabetes and its complications, its association with related diseases, and the potential of soluble VAP-1 as a biomarker. ABSTRACTVascular adhesion protein-1 (VAP-1) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by-products, which are linked to diabetic complications. Present in various tissues, VAP-1 also circulates in a soluble form in the bloodstream. Diabetes is associated with several complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy, significantly contributing to disability and mortality. These complications arise from hyperglycemia-induced oxidative stress, inflammation, and the formation of advanced glycation end-products (AGEs). Earlier research, including our own from the 1990s and early 2000s, has underscored the critical role of VAP-1 in these pathological processes, prompting extensive investigation into its contribution to diabetic complications. In this review, we examine the involvement of VAP-1 in diabetes and its complications, alongside its link to other conditions related to diabetes, such as cancer and metabolic dysfunction-associated fatty liver disease. We also...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: REVIEW Source Type: research