Fatty liver disease symptoms: Are you at risk? These four signs could lead to organ damage
FATTY liver disease is a condition with several types - non-alcoholic fatty liver disease is one of the main types. This is usually caused by being very overweight. But before being diagnosed, what are the symptoms to look out for, and are you at risk? (Source: Daily Express - Health)
Source: Daily Express - Health - June 21, 2018 Category: Consumer Health News Source Type: news

Liver Cancer Doubled in High-Income Countries Liver Cancer Doubled in High-Income Countries
Rates of liver cancer have doubled since the 1990s in high-income countries and are largely due to infection with hepatitis B and C, as well as nonalcoholic fatty liver disease.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 18, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Israeli Company Galmed Gets Positive Trial Results for Liver Drug Israeli Company Galmed Gets Positive Trial Results for Liver Drug
Galmed Pharmaceuticals said on Tuesday patients in a mid-stage trial for its treatment for non-alcoholic steatohepatitis (NASH), a fatty liver disease linked to obesity, showed a statistically significant reduction in liver fat.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 13, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Israeli company Galmed gets positive trial results for liver drug
TEL AVIV (Reuters) - Galmed Pharmaceuticals said on Tuesday patients in a mid-stage trial for its treatment for NASH, a fatty liver disease linked to obesity, showed a statistically significant reduction in liver fat. (Source: Reuters: Health)
Source: Reuters: Health - June 12, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

High Costs for Diagnosis, Care of Nonalcoholic Fatty Liver Disease
MONDAY, June 11, 2018 -- The health care costs associated with nonalcoholic fatty liver disease (NAFLD) are considerable, especially at first diagnosis, according to a study published online May 18 in Hepatology. Alina M. Allen, M.D., from the Mayo... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2018 Category: Pharmaceuticals Source Type: news

Too young for such an "old" condition: 8-year-olds now being diagnosed with nonalcoholic fatty liver disease
(Natural News) Adults who have an unhealthy lifestyle are often diagnosed with nonalcoholic fatty liver disease (NAFLD). But according to a study, there is an alarming link “between childhood obesity and juvenile liver health problems.” The study on children involved researchers from Harvard Medical School based on Project Viva of Massachusetts. It confirmed a connection between childhood obesity and... (Source: NaturalNews.com)
Source: NaturalNews.com - June 6, 2018 Category: Consumer Health News Source Type: news

Madrigal Pharma Shares Double After Successful Phase II Results For Fatty Liver Drug
Competition is tough for a drug to cure fatty liver disease. After today's 150% jump, is Madrigal Pharmaceuticals the next darling of the biotech sector? (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 31, 2018 Category: Pharmaceuticals Authors: Karl Kaufman, Contributor Tags: NASDAQ:MDGL NASDAQ:GILD NYSE:AGN NASDAQ:VKTX NASDAQ:ICPT Source Type: news

Madrigal Pharma more than doubles after liver drug study success
(Reuters) - Madrigal Pharmaceuticals Inc's shares more than doubled after mid-stage trial data showed its lead drug reduced liver fat in patients with fatty liver disease, placing it ahead of larger rivals to tap into a potential market worth $30 billion. (Source: Reuters: Health)
Source: Reuters: Health - May 31, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Madrigal Pharma's liver drug succeeds in study, shares soar
(Reuters) - Madrigal Pharmaceuticals Inc's lead experimental drug achieved the main goal of reducing liver fat in patients with fatty liver disease in a mid-stage study, sending its shares surging 66 percent in premarket trading on Thursday. (Source: Reuters: Health)
Source: Reuters: Health - May 31, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

We could reverse aging by removing wrinkles inside our cells, study suggests
(University of Virginia Health System) A new discovery about the effects of aging in our cells could allow doctors to cure or prevent diabetes, fatty liver disease and other metabolic diseases -- and possibly even turn back the clock on aging itself. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 29, 2018 Category: Biology Source Type: news

Steatosis complicates MR elastography for liver fibrosis
MR elastography is better at distinguishing between lower and higher stages...Read more on AuntMinnie.comRelated Reading: AIUM: Can deep learning classify liver fibrosis on US? Quantitative imaging biomarkers show promise for NASH Quantitative ultrasound CAD analyzes multiple conditions Quantitative ultrasound method stages fatty liver Panel says elastography has value for liver fibrosis (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - May 23, 2018 Category: Radiology Source Type: news

NAFLD Is a Growing Problem NAFLD Is a Growing Problem
Recent guidance from the American Association for the Study of Liver Diseases for the evaluation and management of patients with nonalcoholic fatty liver disease is profiled.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 18, 2018 Category: Consumer Health News Tags: Gastroenterology Expert Column Source Type: news

Understanding vitamin D trends in children with non-alcoholic fatty liver disease
(University of Leeds) New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2018 Category: International Medicine & Public Health Source Type: news

IRE1{alpha} prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is caused by lipid accumulation in the liver. We found that IRE1α was critical to maintaining lipid homeostasis in the liver by repressing the biogenesis of microRNAs (miRNAs) that regulate lipid mobilization. In mice fed normal chow, the endoribonuclease function of IRE1α processed a subse...
Source: Signal Transduction Knowledge Environment - May 15, 2018 Category: Science Authors: Wang, J.-M., Qiu, Y., Yang, Z., Kim, H., Qian, Q., Sun, Q., Zhang, C., Yin, L., Fang, D., Back, S. H., Kaufman, R. J., Yang, L., Zhang, K. Tags: STKE Research Articles Source Type: news

Gut check: Metabolites shed by intestinal microbiota keep inflammation at bay
(Tufts University) Researchers have elucidated a mechanism by which 'good' bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 4, 2018 Category: International Medicine & Public Health Source Type: news

Newly discovered anti-inflammatory substances may potentially treat variety of diseases
(Bar-Ilan University) Researchers have discovered a new family of substances which has been found to display highly potent activity against the release of pro-inflammatory cytokines and the toxicity induced by reactive oxygen species (ROS). The novel compounds synthesized and evaluated belong to a family of low molecular weight substances named indolines. In early experiments, these compounds have shown promising activity in the treatment of acute pancreatic inflammation, acute fatty liver damage, and diabetes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 3, 2018 Category: International Medicine & Public Health Source Type: news

Dietary Improvements May Prevent NAFLD Dietary Improvements May Prevent NAFLD
People who make an effort to improve their diet may have a lower risk of non-alcoholic fatty liver disease (NAFDL) than individuals who stick to unhealthy eating habits, a U.S. study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 30, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Eating a lot of processed meat increases your risk of non-alcoholic fatty liver disease and insulin resistance
(Natural News) Researchers have found another reason why eating a lot of processed meat is bad: It increases the risk of non-alcoholic fatty liver disease (NAFLD) and insulin resistance, according to a study published in the Journal of Hepatology. These results add to the increasing amount of evidence on the harmful effects of eating red... (Source: NaturalNews.com)
Source: NaturalNews.com - April 30, 2018 Category: Consumer Health News Source Type: news

Factors ID'd to Predict Fatty Liver in Obese Teens
MONDAY, April 23, 2018 -- Ethnicity/race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver, according to a study published online April 17 in Hepatology. Domenico Tric ò, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 23, 2018 Category: Pharmaceuticals Source Type: news

Experimental Drug Takes on Injury From Fatty Liver Experimental Drug Takes on Injury From Fatty Liver
An investigative human fibroblast growth factor 19 analog is in development to reduce markers of liver damage in patients with nonalcoholic steatohepatitis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 20, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Unlocking the Potential of AI For Fatty Liver Treatments
ReviveMed, a Massachusetts Institute of Technology (MIT) spinout, is using artificial intelligence (AI) to unlock the power of metabolomics to discover new therapies to treat diseases. Metabolomics is the large-scale study of small molecules like glucose or cholesterol produced by cellular activity. ReviveMed’s platform could help pharmaceutical companies redesign existing drugs or develop new drugs to help patients suffering from disease. The Cambridge, MA-based company recently raised funding to help further develop its AI solution, closing an oversubscribed seed round of $1.5 million. Rivas Capital led the round, ...
Source: MDDI - April 19, 2018 Category: Medical Devices Authors: Omar Ford Tags: Software Source Type: news

Poverty Harms Patients With Diabetes, Fatty Liver Poverty Harms Patients With Diabetes, Fatty Liver
When patients with diabetes and nonalcoholic fatty liver disease cannot consistently afford a healthy diet, the risk for advanced hepatic fibrosis is elevated, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 17, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Gains from online lifestyle intervention similar to group program ’s for liver disease patients
In a cohort of patients with non-alcoholic fatty liver disease (NAFLD), an online lifestyle modification-focused intervention was similarly effective to a group-based program in achieving weight loss and liver enzyme normalization, according to data from an Italian study recently presented at The International Liver Congress in Paris. (Source: mobihealthnews)
Source: mobihealthnews - April 16, 2018 Category: Information Technology Source Type: news

' Well Done' Red Meat Linked to Liver Disease, Insulin Resistance'Well Done' Red Meat Linked to Liver Disease, Insulin Resistance
People who eat lots of processed and red meat are at increased risk of developing non-alcoholic fatty liver disease and insulin resistance, especially if they like their steak well done, an Israeli study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 13, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Eating red meat boosts the risk of deadly liver disease
Israeli scientists have found the risk of non-alcoholic fatty liver disease is highest for those who enjoy their steak 'well done'. The conclusion was made based on a study of 789 adults. (Source: the Mail online | Health)
Source: the Mail online | Health - April 13, 2018 Category: Consumer Health News Source Type: news

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(European Association for the Study of the Liver) Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
(European Association for the Study of the Liver) A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

Ionis may get up to $300 million in licensing deal with AstraZeneca
(Reuters) - Ionis Pharmaceuticals Inc said on Monday a licensing deal for its fatty liver disease treatment with AstraZeneca Plc could fetch up to $300 million in milestone payments. (Source: Reuters: Health)
Source: Reuters: Health - April 9, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Ionis to get up to $300 million from licensing deal with AstraZeneca
(Reuters) - Ionis Pharmaceuticals said on Monday it signed a licensing deal for its fatty liver disease treatment with AstraZeneca Plc that could land the company up to $300 million in milestone payments and royalties. (Source: Reuters: Health)
Source: Reuters: Health - April 9, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

UCLA scientists discover that cells contain mitochondria specialized to build fats
Mitochondria, known to most people as the “powerhouses of the cell,” have been recognized for decades as the cellular organelle where sugars and fats are oxidized to generate energy. Now, new research by UCLA scientists has found that not all mitochondria fit this definition. Within each cell a group of specialized mitochondria can be f ound attached to fat droplets. Rather than burn fat to create energy, these specialized mitochondria are responsible for providing the energy to build and store fat molecules.“This is really a whole new view of mitochondria and what they can do,” said lead author Dr....
Source: UCLA Newsroom: Health Sciences - April 6, 2018 Category: Universities & Medical Training Source Type: news

PCOS linked to increased liver disease risk
According to a study, published inPLOS Medicine, women with PCOS have double the risk of developing nonalcoholic fatty liver disease.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 6, 2018 Category: Endocrinology Source Type: news

Liver Health Takes a Hit in Kids as Young as 8 Years Old Liver Health Takes a Hit in Kids as Young as 8 Years Old
Children who are obese or overweight in early childhood are at increased risk of developing signs of nonalcoholic fatty liver disease as early as age 8 years, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 5, 2018 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Liver Health Takes a Hit in Young Overweight Children Liver Health Takes a Hit in Young Overweight Children
Children who are obese or overweight in early childhood are at increased risk of developing signs of nonalcoholic fatty liver disease as early as age 8 years, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 5, 2018 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Fatty liver disease: Four ways to avoid the SILENT killer
NON-ALCOHOLIC fatty liver disease is one of the UK ’s biggest killers. But with diet and lifestyle changes, the condition is reversible. Here’s how to avoid the disease and try to beat it if you’ve already been diagnosed. (Source: Daily Express - Health)
Source: Daily Express - Health - April 5, 2018 Category: Consumer Health News Source Type: news

Toddlers' Girth Points to Later Risk of Fatty Liver Disease (CME/CE)
(MedPage Today) -- Waist at age 3 linked to elevated ALT levels by age 8 (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - April 4, 2018 Category: Psychiatry Source Type: news

Obesity Can Lead to Liver Damage by Age 8
A new study of 635 children in Massachusetts found that a bigger waist size at age 3 increases the odds that a child will have a marker for liver damage and nonalcoholic fatty liver disease by age 8. (Source: WebMD Health)
Source: WebMD Health - April 4, 2018 Category: Consumer Health News Source Type: news

Obese children are nearly twice as likely to show signs of a life-threatening liver disease
A Columbia University study revealed 35 percent of obese children showed signs of nonalcoholic fatty liver disease, a condition that causes damage similar to that of excessive alcohol consumption. (Source: the Mail online | Health)
Source: the Mail online | Health - April 4, 2018 Category: Consumer Health News Source Type: news

Women with polycystic ovary syndrome at double risk of liver disease
Women with polycystic ovaries having a two-fold increased risk of developing non-alcoholic fatty liver disease, according to UK researchers. (Source: Nursing Times)
Source: Nursing Times - March 29, 2018 Category: Nursing Source Type: news

e-Cigarettes Linked to Fatty Liver Disease in Mice e-Cigarettes Linked to Fatty Liver Disease in Mice
Use of electronic cigarettes combined with a Western diet may raise the risk of fatty liver disease, suggests new research in mice.Reuters Health Information (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - March 26, 2018 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes Empagliflozin Eyed for Fatty Liver Disease in Type 2 Diabetes
The first trial of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes and nonalcoholic fatty liver disease indicates the drug might reduce liver fat, but the results of the small study need replication.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 22, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Fermented tea protects the liver from oxidative stress with antioxidant properties that regulate glucose levels
(Natural News) A lot of diseases, such as fatty liver disease, are caused by oxidative stress. Fortunately, there are natural treatments that help fight it. One of these is a fermented tea called Pu-erh that contains antioxidant properties and glucose-regulating extracts and can protect the liver from impairment. A team of researchers from China examined the oxidative... (Source: NaturalNews.com)
Source: NaturalNews.com - March 22, 2018 Category: Consumer Health News Source Type: news

High consumption of red and processed meat linked to non-alcoholic fatty liver disease and insulin resistance
(Elsevier) World meat consumption has increased during the last decades, and evidence is mounting that high consumption of red and mainly processed meat is unhealthy to humans and is related to chronic diseases such as cancer, type 2 diabetes, and cardiovascular disease. A new study published in the Journal of Hepatology adds non-alcoholic fatty liver disease (NAFLD) to the list. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 20, 2018 Category: Biology Source Type: news

NIH study to test treatment for fatty liver disease in children
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gut Microbes Transmit Susceptibility to Nonalcoholic Fatty Liver Disease Progression
Studies have expanded understanding of the role of gut microbes in nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Cell Signaling Pathways Point to Top Notch Solution for Fatty Liver Disease
Notch, a type of cell receptor, may be responsible for fat build up in individuals with nonalcoholic fatty liver disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Gastrointestinal hormone can decrease liver fat levels
According to a clinical study, published inThe Lancet, a variant of hormone FGF19 can reduce the liver fat levels of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - March 13, 2018 Category: Endocrinology Source Type: news

Post-Transplant Fatty Liver Disease on the Rise (CME/CE)
(MedPage Today) -- Over 25% of liver-transplanted patients had new-onset NAFLD (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 10, 2018 Category: Gastroenterology Source Type: news

Gastrointestinal hormone measurably improved symptoms of non-alcoholic fatty liver disease
(University of California - San Diego) Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings represent an important proof-of-concept for the compound as there are currently no Food and Drug Administration-approved treatments for NAFLD and NASH. (Source: EurekAle...
Source: EurekAlert! - Medicine and Health - March 8, 2018 Category: International Medicine & Public Health Source Type: news

Combating childhood obesity by preventing 'fatty liver' in fetus
(The Physiological Society) New research published in The Journal of Physiology indicates that an obese pregnant mother and exposure to a high fat, high sugar diet during pregnancy produces a 'fatty liver' in the fetus, potentially predisposing children to obesity, metabolic and cardiovascular disorders later in life. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 7, 2018 Category: Cancer & Oncology Source Type: news

Zebra Medical wins CE Mark for brain-bleed detection algorithm
Israeli machine-learning radiology firm Zebra Medical Vision said today it won CE Mark approval in the European Union for an algorithm for detecting intracranial hemorrhages as part of its deep learning imaging analytics platform. Zebra Medical said that its algorithm is designed to identify brain bleeds to provide extra support for physicians in acute care settings, and that it plans to use the algorithm for point-of-care detection to identify bleeds accurately and with reduced delay. “This new algorithm is an important addition to Zebra’s Analytics Engine. The ability to alert radiologists and surgeons t...
Source: Mass Device - March 6, 2018 Category: Medical Devices Authors: Fink Densford Tags: Neurological Regulatory/Compliance Software / IT Zebra Medical Vision Source Type: news