Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis
As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The bur...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Reversal of Atherosclerosis at Repair Biotechnologies
As some of you know, Repair Biotechnologies is the company I co-founded with Bill Cherman back in 2018. We've been working on an approach to reverse atherosclerosis for much of that time, and matters have progressed through the stage of great data in mice to present preparations for a pre-IND meeting with the FDA. While excess cholesterol has long been understood to be important to the development of atherosclerosis, it turns out that circulating cholesterol bound to LDL particles is less important than the amount of localized excess cholesterol in the liver and blood vessel walls.
Any localized excess of cholestero...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Twin Health Secures $50M to Expand its Groundbreaking Whole Body Digital Twin Technology and Service to Reverse Chronic Metabolic Disease
Investment Fuels Twin Health’s Mission to Revolutionize Chronic Metabolic Disease Prevention and Reversal with Cutting-Edge Science, Precision Guidance, and Licensed Clinical Care Team
Twin Health, creators of the Whole Body Digital Twin service for reversing, improving, and preventing chronic metabolic diseases, announced securing $50 million in funding to continue expanding its groundbreaking technology and clinical service solutions for more members across the United States.
Twin Health introduced the Whole Body Digital Twin, a dynamic model of each individual’s unique metabolism, powered by artificial int...
Source: EMR and HIPAA - January 4, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Health IT Funding Health IT Fundings Health IT Investment Helena ICONIQ Growth Jahangir Mohammed Kevin Johnson Peak XV Sofina Temasek Twin Health Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Assessing Pentadecanoic Acid In Vitro
The work on pentadecanoic acid noted here is interesting, but should be taken with a grain of salt given that it is performed in vitro. In general, one should expect any given set of mechanisms in the cell to be associated with many different means of manipulation. It is interesting to see a fatty acid capable of touching on the same mechanisms as rapamycin, but remember that the ability to influence the same mechanistic targets does not necessarily translate to the same ability to produce a modest slowing of aging in animal studies. So the usual advice stands here, to wait for the animal studies before getting too excited...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Diabetes and liver disease: urgent screening needs highlighted by personal tragedy
The American Diabetes Association recently released screening guidelines for liver disease in individuals with type 2 diabetes. Notably, 70 percent of people with type 2 diabetes have liver disease, and the most common form is non-alcoholic fatty liver disease. Ultimately, this can lead to cirrhosis and cancer. According to the American Cancer Society, the rates
Read more…
Diabetes and liver disease: urgent screening needs highlighted by personal tragedy originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 5, 2023 Category: General Medicine Authors: Sarah Bauer, MD Tags: Conditions Diabetes Gastroenterology Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Metabolism in Age-Related Disease
In this age of excess calories, in which a large proportion of the population is significantly overweight, research into lipid metabolism in the context of aging tends overlap with research into lipid metabolism in the context of obesity. People of normal weight still undergo complex changes in lipid metabolism and lipid transport throughout the body with age, however. These lead to prominent, important issues such as atherosclerosis, localized excesses of cholesterol and associated lesions in the arterial walls, for example. Looking at these conditions through the lens of lipid metabolism is looking at just one part of a ...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Gradia Health Secures $4.2M in Seed Funding to Improve Ongoing Care for Patients with Chronic Conditions
The Platform is set to Reinvigorate Patient-Physician Communication Pathways by Partnering Directly with Brick-and-Mortar Practices to Deliver Superior Virtual Care Beyond the Doctor’s Office
Gradia Health, the integrated concierge care platform designed for clinics to support patients with chronic conditions, today announced its seed funding totaling $4.2M. The round was led by Adrian Fenty at MaC Venture Capital with participation from YCombinator, Soma Capital, Atlanta Ventures, and several angel investors, including Gene Lee (Ramp), Eric Feldman (Bolt), David Tsao (BillionToOne), Austen Allred (Bloomtech), Juan Bene...
Source: EMR and HIPAA - July 27, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Adrian Fenty Andrew Zelaya Atlanta Ventures Austen Allred BillionToOne Bloomtech Bolt Chronic Conditions David Tsao Eric Feldman Gene Lee Golden Gradia Gradia Health Health IT Funding Healt Source Type: blogs
The Drug-Free Treatment For Non-Alcoholic Fatty Liver Disease (NAFLD)
As NAFLD treatments are limited, scientists looked into whether diet and exercise can improve patients' lives. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 20, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Droplet Accumulation in Aging and Age-Related Disease
Researchers here consider dysregulation of lipid metabolism at the cellular level as an aspect of aging that causes downstream issues. Like many manifestations of aging observed in cells in aged tissues, why this happens is a matter for debate, setting aside situations such as the environment of a fatty liver or atherosclerotic plaque in which there is a localized excess of lipids to explain the overload inside cells. In a number of neurodegenerative conditions, the presence of cells loaded with lipid droplets is a prominent feature. It remains to be seen as to whether new classes of therapy under development, capable of c...
Source: Fight Aging! - July 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
