Oxidative stress suppresses PHB2 ‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway
ConclusionOur study suggested that PHB2-mediated mitophagy can protect β-cells from apoptosisvia the Nrf2/PHB2 pathway under oxidative stress. Antioxidants may protect β-cell from oxidative stress by prompting PHB2-mediated mitophagy. PHB2-mediated mitophagy as a potential mechanism takes part in the oxidative stress induced β-cell injury. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 24, 2024 Category: Endocrinology Authors: Shan Liu,
Rui Zhang,
Lan Zhang,
Aige Yang,
Yuqing Guo,
Lei Jiang,
Huijuan Wang,
Shunjiang Xu,
Huimin Zhou Tags: Original Article Source Type: research
Perspectives on genetic studies of type 2 diabetes from the genome‐wide association studies era to precision medicine
This review summarizes recent advances in the genetics of type 2 diabetes, and discusses the perspective of future investigations for understanding the genetic architecture of type 2 diabetes and its clinical applications. AbstractGenome-wide association studies (GWAS) have facilitated a substantial and rapid increase in the number of confirmed genetic susceptibility variants for complex diseases. Approximately 700 variants predisposing individuals to the risk for type 2 diabetes have been identified through GWAS until 2023. From 2018 to 2022, hundreds of type 2 diabetes susceptibility loci with smaller effect si...
Source: Journal of Diabetes Investigation - January 23, 2024 Category: Endocrinology Authors: Minako Imamura,
Shiro Maeda Tags: REVIEW Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 23, 2024 Category: Endocrinology Tags: Issue Information Source Type: research
Comparison of efficacy and safety of insulin degludec/liraglutide and insulin glargine U ‐100/lixisenatide in individuals with type 2 diabetes mellitus using professional continuous glucose monitoring
ConclusionsA TIR of>70% was achieved for both fixed-ratio combinations without significant differences. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 23, 2024 Category: Endocrinology Authors: Yuji Kawaguchi,
Yuriko Hajika,
Maho Rinka,
Koji Masumoto,
Jun Sawa,
Kenji Hamazaki,
Yasuro Kumeda Tags: Original Article Source Type: research
Elevated small dense low ‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio is associated with an increased risk of metabolic dysfunction associated fatty liver disease in Chinese patients with type 2 diabetes mellitus
ConclusionsElevated levels of SHR is independently associated with an increased risk of MAFLD in patients with T2DM. SHR may be taken as practical indicators to assess the risk of MAFLD in T2DM patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 22, 2024 Category: Endocrinology Authors: Shouxing Yang,
Jing Xu Tags: Original Article Source Type: research
Association between glycemia risk index and arterial stiffness in type 2 diabetes
ConclusionGlycemia risk index assessed by continuous glucose monitoring is associated with increased arterial stiffness in type 2 diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 22, 2024 Category: Endocrinology Authors: Lingli Cai,
Wenqi Shen,
Jiang Li,
Bin Wang,
Ying Sun,
Yi Chen,
Ling Gao,
Fei Xu,
Xinhua Xiao,
Ningjian Wang,
Yingli Lu Tags: Original Article Source Type: research
Epac2 activation mediates glucagon ‐induced glucogenesis in primary rat hepatocytes
ConclusionsEpac signaling plays a role in mediating the glucogenic action of glucagon in the hepatocytes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2024 Category: Endocrinology Authors: Yusuke Shiozaki ‐Takagi,
Nobuaki Ozaki,
Yukiyasu Toyoda Tags: Original Article Source Type: research
Deciphering the causal tapestry between cardiorespiratory fitness and type 2 diabetes mellitus
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2024 Category: Endocrinology Authors: Fu ‐Shun Ko,
Yun‐Kai Yeh,
Fu‐Shun Yen,
Chii‐Min Hwu Tags: Commentary Source Type: research
Development and validation of a prediction model for self ‐reported hypoglycemia risk in patients with type 2 diabetes: A longitudinal cohort study
ConclusionsThe study developed 3 and 6 month hypoglycemia risk prediction models for patients with type 2 diabetes. The discrimination and calibration of the two prediction models were good, and might help to improve clinical decision-making and guide patients to more reasonable self-care and hypoglycemia prevention at home. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 20, 2024 Category: Endocrinology Authors: Hongmei Xu,
Hangqing Yu,
Zhengnan Cheng,
Chun Mu,
Di Bao,
Xiaohui Li,
Qiuling Xing Tags: Original Article Source Type: research
Microvascular permeability and texture analysis of bone marrow in diabetic rabbits with critical limb ischemia based on dynamic contrast ‐enhanced magnetic resonance imaging
ConclusionsThe early stages of diabetic bone marrow with CLI can be evaluated by DCE-MRI for microvascular permeability. Texture analysis based on DCE-MRI could act as an imaging discriminator and new radiological analysis tool for critical limb ischemia in diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 19, 2024 Category: Endocrinology Authors: Liu Yang,
Donghang Li,
Yuchen Yan,
Qi Yang,
Liang Li,
Yunfei Zha Tags: Original Article Source Type: research
Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10)
This study aimed to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective study. In the study, 6,338 patients with diabetes who had been treated by diabetes specialists were registered in 2007–2009. Of these, patients with type 2 diabetes who could be evaluated for DSPN were ana lyzed using thet-test, χ2-test and logistic regression analyses. DSPN was diagnosed using the Simple Diagnostic Criteria for Diabetic Polyneuropathy proposed by the Diabetic Neuropat...
Source: Journal of Diabetes Investigation - January 12, 2024 Category: Endocrinology Authors: Hideki Kamiya,
Tatsuhito Himeno,
Atsuko Watarai,
Masayuki Baba,
Rimei Nishimura,
Naoko Tajima,
Jiro Nakamura Tags: Special Research Report Source Type: research
Overnutrition in the early postnatal period influences lifetime metabolic risk: Evidence for impact on pancreatic β‐cell mass and function
Diabetes causes substantial morbidity and mortality worldwide, as well as high societal cost. Risk of metabolic disease in adulthood increases in people with accelerated childhood growth trajectory. This review explores the metabolic impact of postnatal overnutrition in humans and in rodent models, with specific attention to the connection between accelerated childhood growth and future adiposity, insulin resistance, β-cell mass and β-cell dysfunction. AbstractOverconsumption of energy-rich foods that disrupt caloric balance is a fundamental cause of overweight, obesity and diabetes. Dysglycemia and the resulting cardiov...
Source: Journal of Diabetes Investigation - January 10, 2024 Category: Endocrinology Authors: Joshua JN Burton,
Laura C Alonso Tags: Review Source Type: research
Advancements and challenges in pancreatic islet transplantation: Insights from the Collaborative Islet Transplant Registry
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - January 9, 2024 Category: Endocrinology Authors: Eun Young Lee,
Kun ‐Ho Yoon Tags: Commentary Source Type: research
Resistant starch and type 2 diabetes mellitus: Clinical perspective
Starch is a significant source of carbohydrates and resistant starch, which is a non-viscous fermentable fiber, has shown to enhance glucose metabolism. The efficacy of resistant starch as a medical nutrition therapy for type 2 diabetes needs further investigation. AbstractThe immediate and well-documented benefits of carbohydrate restriction include improved glycemic control in individuals with diabetes mellitus. Starch, a significant source of carbohydrates, is categorized as rapidly digestible, slowly digestible, or resistant starch (RS). RS, which is a non-viscous fermentable fiber, has shown promise in animal studies ...
Source: Journal of Diabetes Investigation - January 8, 2024 Category: Endocrinology Authors: Min Kyung Kim,
Juri Park,
Doo ‐Man Kim Tags: Review Source Type: research
New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes of the Japan Diabetes Society (English version)
The diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 Diabetes of the Japan Diabetes Society. AbstractThe diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 Diabetes of the Japan Diabetes Society. All of the following three criteria must be met for ‘a definitive diagnosis of SPIDDM’: (1) presence of anti-islet autoantibodies at some point in time during the disease course; (2) absence o...
Source: Journal of Diabetes Investigation - January 8, 2024 Category: Endocrinology Authors: Akira Shimada,
Eiji Kawasaki,
Norio Abiru,
Takuya Awata,
Yoichi Oikawa,
Haruhiko Osawa,
Hiroshi Kajio,
Junji Kozawa,
Kazuma Takahashi,
Daisuke Chujo,
Shinsuke Noso,
Tomoyasu Fukui,
Junnosuke Miura,
Kazuki Yasuda,
Hisafumi Yasuda,
Akihisa Im Tags: Special Research Report Source Type: research
