Associations of age ‐adjusted coefficient of variation of R‐R intervals with autonomic and peripheral nerve function in non‐elderly persons with diabetes
ConclusionsDecreased CVRR at rest and during deep breathing was associated with lower BMI, SMI, and knee strength and a higher proportion of impaired standing balance among non-elderly inpatients with diabetes. Decreased CVRR at rest appeared more strongly associated with a greater orthostatic BP decline, higher resting heart rate, longer QTc, lower urinary tract dysfunction, and sensory symptoms than a decreased CVRR during deep breathing. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 17, 2023 Category: Endocrinology Authors: Kazuhiro Sugimoto,
Hirozumi Miyaoka,
Takashi Sozu,
Naohiro Sekikawa,
Ryota Wada,
Yuko Watanabe,
Akira Tamura,
Toshiro Yamazaki,
Setsu Ohta,
Susumu Suzuki Tags: ORIGINAL ARTICLE Source Type: research
Relationship between elevated circulating thrombospondin ‐1 levels and vascular complications in diabetes mellitus
ConclusionsElevated circulating TSP-1 levels are closely related to DVC, especially in diabetic nephropathy and diabetic cardiovascular disease. Circulating TSP-1 detection might be helpful in the timely diagnosis and treatment of DVC. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 12, 2023 Category: Endocrinology Authors: Na Guo,
Linlin Yang,
Xiaozheng Wan,
Dongze Qiu,
Wenwen Sun,
Huijuan Ma Tags: Original Article Source Type: research
Characteristics of individuals who developed type 2 diabetes from prediabetes despite undergoing interventions, and evaluation of the performance of urinary myo‐inositol as a risk factor for developing diabetes
ConclusionParticipants who developed type 2 diabetes from prediabetes despite undergoing interventions were characterized by high glycemic control markers and low I.I. As noninvasive measurement of ΔUMI is associated with I.I. and diabetes onset, it could be a useful indicator for identifying individuals with a high risk of diabetes ons et. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 11, 2023 Category: Endocrinology Authors: Fumio Yamagata,
Rei Ogata,
Yoko Koda,
Mayumi Yamamoto,
Atsuko Suga,
Noriko Kanauchi,
Takuji Kohzuma,
Shoji Kawazu Tags: Original Article Source Type: research
Long ‐term safety and efficacy of SGLT2 inhibitor use in older east Asians with type 2 diabetes
The recent randomized clinical trial demonstrated that SGLT2i generally reduces HbA1c and fat mass without affecting muscle mass and strength or cognitive function in heathy older Japanese with type 2 diabetes and normal activity of daily living and no cognitive impairment. However, the safety and efficacy of long-term SGLT2i use in older individuals with type 2 diabetes with frailty, who have higher risk of heart failure (HF) and chronic kidney disease (CKD), remains to be investigated. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been shown in cardiovascular outcome trials to reduce the risk of heart failure ...
Source: Journal of Diabetes Investigation - October 10, 2023 Category: Endocrinology Authors: Yoshihiro Takahashi,
Yutaka Seino,
Daisuke Yabe Tags: COMMENTARY Source Type: research
High sensitivity C ‐reactive protein and prediabetes progression and regression in middle‐aged and older adults: A prospective cohort study
ConclusionsLow levels of hs-CRP are associated with a high incidence of regression from prediabetes to normoglycemia and reduced odds of progression to diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 7, 2023 Category: Endocrinology Authors: Zi ‐Jian Cheng,
Yan‐Fei Wang,
Xi‐Yuan Jiang,
Wen‐Yan Ren,
Shu‐Feng Lei,
Fei‐Yan Deng,
Long‐Fei Wu Tags: Original Article Source Type: research
Fermented soybean foods and diabetes
The number of patients with type 2 diabetes mellitus is increasing, and its prevention and management are important. Fermented soybean food modifies the gut microbiota-related metabolites by modifying dysbiosis. Fermented soybean foods also have antioxidant, anti-inflammatory, and anti-diabetic effects. AbstractThe number of patients with type 2 diabetes mellitus is increasing, and its prevention and management are important. One of the factors contributing to the increased incidence of type 2 diabetes mellitus is the change in dietary habits, including a Westernized diet. Fermented foods are foods that are transformed by ...
Source: Journal of Diabetes Investigation - October 6, 2023 Category: Endocrinology Authors: Yoshitaka Hashimoto,
Masahide Hamaguchi,
Michiaki Fukui Tags: Review Source Type: research
Sympathetic skin response for early detection of type 2 diabetic peripheral neuropathy and nephropathy
ConclusionSympathetic skin response is a more sensitive method than nerve conduction studies for the early diagnosis of diabetic peripheral neuropathy. Abnormal sympathetic skin response might serve as an indicator for early diabetic nephropathy. Additionally, diabetic peripheral neuropathy may occur earlier than diabetic nephropathy in the development of type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - October 5, 2023 Category: Endocrinology Authors: Hongying Liu,
Sheng Tan,
Zhenyu Ma,
Qingchun Gao,
Weihong Yang Tags: Original Article Source Type: research
Epigenetic regulation of core genes linking to diabetic nephropathy progression: Lesson from FinnDiane type 1 diabetes study
Reduced methylation at key transcription factor binding sites might contribute to the progression of diabetic nephropathy in type 1 diabetes through the activation of insulin signaling and other pathways. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 30, 2023 Category: Endocrinology Authors: Hirofumi Makino,
Keizo Kanasaki Tags: Commentary Source Type: research
Corrigendum to Effects of switching from liraglutide to semaglutide or dulaglutide in patients with type 2 diabetes: A randomized controlled trial
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 29, 2023 Category: Endocrinology Tags: Corrigendum Source Type: research
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia
ConclusionsHypomagnesemia is highly prevalent in individuals withHNF1B syndrome, and those withHNF1B deletion are more susceptible to developing hypomagnesemia compared with those with intragenic mutations. The genotype –phenotype associations inHNF1B syndrome have significant implications for endocrinologists in terms of genotype detection, treatment decisions and prognosis assessment. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 23, 2023 Category: Endocrinology Authors: Yanfei Wang,
Xiaoyu Xiao,
Qiuqiu Lin,
Rong Song,
Xiaozhou Wang,
Yiji Liang,
Jingsong Chen,
Xiaojun Luan,
Zhiguang Zhou,
Yang Xiao,
Yaoming Xue,
Jingyi Hu Tags: ORIGINAL ARTICLE Source Type: research
Decreased serum musclin concentration is independently associated with the high prevalence of sarcopenia in Chinese middle ‐elderly patients with type 2 diabetes mellitus
ConclusionsThe serum musclin concentration is an independent protective factor for sarcopenia in Chinese middle-elderly patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2023 Category: Endocrinology Authors: Lei Fu,
Qing Zhang,
Juan Liu,
Xiaoqing Yuan,
Xinhua Ye Tags: Original Article Source Type: research
Association between serum uric acid ‐to‐high‐density lipoprotein cholesterol ratio and insulin resistance in patients with type 2 diabetes mellitus
ConclusionElevated UHR is significantly correlated with insulin resistance, which can be used as an indicator of insulin resistance in patients with type 2 diabetes mellitus. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2023 Category: Endocrinology Authors: Xinhe Zhou,
Jing Xu Tags: Original Article Source Type: research
Identification and validation of voltage ‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy
ConclusionsFive hub genes were significantly correlated with immune cell infiltration and might be crucial to DN development. This study provides insight into the mechanisms involved in the pathogenesis of DN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 22, 2023 Category: Endocrinology Authors: Jiaqun Lin,
Mengjie Weng,
Jing Zheng,
Kun Nie,
Siyi Rao,
Yongjie Zhuo,
Jianxin Wan Tags: ORIGINAL ARTICLE Source Type: research
Role of glycosylphosphatidylinositol ‐anchored high‐density lipoprotein binding protein 1 in hypertriglyceridemia and diabetes
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1) is a crucial molecule for the translocation of lipoprotein lipase from parenchymal cells to luminal surface of capillary endothelial cells, and maintenance of lipolytic activity. The null mutation of GPIHBP1 and the production of GPIHBP1 autoantibody induce severe hypertriglyceridemia and recurrent episodes of acute pancreatitis. In patients with type 2 diabetes, the circulating GPIHBP1 levels might not correlate well with triglyceride-rich lipoproteins, and rather well-reflect the microvascular complications, such diabetic reti...
Source: Journal of Diabetes Investigation - September 21, 2023 Category: Endocrinology Authors: Naoko Kurooka,
Jun Eguchi,
Jun Wada Tags: Review Article Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - September 21, 2023 Category: Endocrinology Tags: Issue Information Source Type: research
